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SCOPING REVIEW ON RISK FACTORS ASSOCIATED WITH HYPERTENSION IN INDONESIA Hulu, Victor Trismanjaya; Saragih, Julwansa; S, Buenita; Damanik, Derma Wani; Zebua, Arianus; Yunia, Eva Anita; Rifai, Achmad; Dewi, Rani Sartika
Jurnal Ilmiah Keperawatan Vol 8 No 2 (2025): Jurnal Mutiara Ners
Publisher : Program Studi Ners UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Background: Hypertension is a global health problem that contributes significantly to deaths from cardiovascular disease. Unhealthy lifestyles, including excessive salt consumption, physical inactivity, and obesity, are the primary factors. Without management, hypertension can lead to serious complications such as heart disease, stroke, and kidney failure. Objective: This study aims to investigate, summarise, and identify various scientific evidence related to hypertension risk factors. Methods: This study employed a scoping review approach organised according to the PRISMA protocol. The Population– Concept–Context (PCC) framework was utilised as an initial guideline in formulating research questions and searching for relevant articles. The literature search process was conducted using several databases, including Google Scholar and Scopus. The included articles had to meet the inclusion criteria, which were limited to open-access journals published between 2020 and 2025. From a total of 512 articles found, only 14 met the selection criteria and were suitable for analysis. The data extraction process was conducted by eight people on the 14 selected articles, followed by qualitative data analysis. Results: The findings indicate that factors such as age, gender, length of employment, consumption of salt, sugary drinks, high-fat foods, elevated total cholesterol levels, low vegetable intake, lack of physical activity, stress, and abdominal circumference that exceeds the recommended play a role in increasing the risk of hypertension. Conclusion: These factors trigger fluid retention, insulin resistance, dyslipidemia, and central obesity that together raise blood pressure and accelerate vascular damage.
Mortality Risk Factors in Continuous Ambulatory Peritoneal Dialysis Patients Widiaputro, Dandi; Gunawan, Atma; Rifai, Achmad
Clinical and Research Journal in Internal Medicine Vol. 7 No. 1: Volume 7 No 1, May 2026
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2026.007.01.03

Abstract

Background: Chronic Kidney Disease (CKD) is a common kidney disorder among elderly individuals and is a leading cause of global mortality. Patients undergoing Continuous Ambulatory Peritoneal Dialysis (CAPD) are at high risk of complications and mortality. Therefore, analyzing risk factors for mortality in CAPD patients is crucial. Aim: To identify mortality risk factors in CAPD patients. Methods: This study was an observational retrospective study design. The sample consisted of CAPD patients at Saiful Anwar Hospital in Malang, with data collection from August 1st, 2019 to July 31st, 2023. Information collected included demographic data, medical history, and laboratory parameters. Data were analyzed using chi-square tests, t-tests, Kolmogorov-Smirnov tests, and multiple logistic regression to evaluate relationships, normality, risk factor effects, and the mortality rate of CAPD patients. Results: There were 377 subjects who met the inclusion criteria, consist of deceased (n=89) and alive (n=288) subjects. Older age significantly increased mortality risk with an odds ratio (OR) of 1.277 (95% CI: 1.260-1.294; p = 0.007). Diabetes mellitus increased mortality risk in CAPD patients, with an OR of 3.185 (95% CI: 1.427-7.105; p = 0.005). Heart failure increased mortality risk in CAPD patients, with an OR of 4.201 (95% CI: 2.170-8.133; p = 0.000). Decreased potassium levels increased mortality risk in CAPD patients, with an OR of 1.352 (95% CI: 1.020-1.792; p = 0.036). Conclusion: Older age, diabetes mellitus, heart failure, and decreased potassium levels increase mortality risk in CAPD patients.
Comparative Analysis of Cognitive Dysfunction in Chronic Kidney Disease Patients Undergoing Hemodialysis Versus Continuous Ambulatory Peritoneal Dialysis (CAPD) Sagala, Ida Meita; Rifai, Achmad; Gunawan, Atma
Clinical and Research Journal in Internal Medicine Vol. 7 No. 1: Volume 7 No 1, May 2026
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2026.007.01.05

Abstract

Background: The increasing prevalence of impaired cognitive function in patients with chronic kidney disease (CKD) represents a significant global health concern. Hemodialysis (HD) and Continuous Ambulatory Peritoneal Dialysis (CAPD) are two commonly employed treatment modalities for CKD; however, their effects on cognitive function in this patient population require further investigation. Aim: To compare the impairment of cognitive function between patients with CKD undergoing HD and those undergoing CAPD. Methods: This study employed a cross-sectional design utilizing observational methods conducted at Dr. Saiful Anwar Hospital from August 2024 to January 2025, involving 139 patients with CKD, comprising 50 patients undergoing CAPD and 89 patients undergoing HD. Cognitive function was assessed using the Montreal Cognitive Assessment-Indonesian version (MoCA-INA). Results: The prevalence of cognitive impairment was found to be 28.9% in patients undergoing HD and 40% in patients undergoing CAPD. The results of the comparative analysis indicated a significant difference between the cognitive scores of the CAPD group and those of the HD group, with a p-value of 0.008. Based on the comparison test of the degree of cognitive impairment, no significant differences were found between the HD and CAPD groups in the mild cognitive impairment (p = 0.471), moderate cognitive impairment (p = 0.317), and severe cognitive impairment (p = 0.480). Conclusion: There was a significant difference in the cognitive impairment scores between the CAPD group and the HD group.
Asthma in Patients with Chronic Kidney Disease Undergoing Dialysis: A Narrative Review Rifai, Achmad; Nahak, Malisa Sherly Theresia
Clinical and Research Journal in Internal Medicine Vol. 7 No. 1: Volume 7 No 1, May 2026
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2026.007.01.11

Abstract

Asthma and chronic kidney disease (CKD) are chronic disorders with substantial morbidity and increasingly recognized overlap. This narrative review summarizes the current evidence on the relationship between asthma and CKD, with emphasis on patients undergoing dialysis. Available data indicate that asthma, particularly when severe or poorly controlled, is associated with a higher risk of CKD, whereas CKD more consistently modifies pulmonary physiology and worsens control of pre-existing asthma than clearly causing new-onset asthma. The interaction is supported by several mechanisms, including systemic inflammation, immune dysregulation, endothelial injury, oxidative stress, disordered acid-base balance, and fluid overload. In advanced CKD, anemia, uremia, metabolic disturbances, and volume excess may mimic or aggravate respiratory symptoms, while dialysis adds further complexity through rapid intravascular volume shifts, complement activation, membrane bioincompatibility, and electrolyte changes that can influence lung mechanics and airway reactivity. Management generally follows standard asthma therapy based on inhaled corticosteroids and bronchodilators, but treatment must be individualized according to kidney function, dialysis status, polypharmacy, and the risk of medication-related adverse effects. Careful integration of respiratory assessment, renal monitoring, and volume management is therefore essential in this population.
Infectious Granuloma at the Peritoneal Dialysis Catheter Exit Site: A Case Report of MRSA-Associated Complication in a Young CAPD Patient Rifai, Achmad; Manugan, Reizal Audi
Clinical and Research Journal in Internal Medicine Vol. 7 No. 1: Volume 7 No 1, May 2026
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2026.007.01.13

Abstract

Introduction: Exit-site infection (ESI) is one of the most frequent complications in CAPD patients and can progress to peritonitis if inadequately managed. Granulomatous ESI caused by MRSA remains sparsely reported in the literature. Case Presentation: A 20-year-old woman with end-stage kidney disease secondary to lupus nephritis, on CAPD for two years, presented with a five-day history of a moist, erythematous nodule (±1 cm) at the Tenckhoff catheter exit site with purulent discharge. The modified Schaefer exit-site score was ≥7, confirming active infection. There was no peritoneal involvement. Management and Outcome: Gram staining revealed Gram-positive cocci (3+), and culture confirmed MRSA susceptible to levofloxacin and TMP-SMX. Empirical oral ciprofloxacin 500 mg twice daily and topical gentamicin were initiated. Clinical improvement was observed at day seven. Therapy was then transitioned to oral TMP-SMX (cotrimoxazole 480 mg once daily) for an additional seven days. MRSA carrier screening via nasal and throat swabs was planned. Discussion: Empirical ciprofloxacin deviated from ISPD guidelines recommending anti-staphylococcal penicillin or first-generation cephalosporin. Transition to TMP-SMX post-culture was appropriate and guideline-concordant. The favorable outcome highlights the importance of microbiological confirmation and targeted therapy. Conclusion: MRSA-associated infectious granuloma at the CAPD exit site can present in young patients without systemic features. Timely microbiological workup, guideline-directed antibiotic therapy, and MRSA decolonization are essential to prevent progression to peritonitis.
Co-Authors - STMIK Nusa Mandiri Jakarta, Rizki Aulianita - UBSI, Muizzu Muhaimin Abdul Rojak, Syaifur Rahmatullah Achmad Slamet Adi Gunawan, Adi Ahmad Nurkhin aida fitria Alfian Fatahillah, Izet Ali, Noor Faqih Udin Angga Tinova Yudha, Angga Annisa Hidayatun Anton Irawan Ardyansyah, Faisal Arief Maulana Ariyanto, Rio Febri Asrori Asrori Ate, Keleng Atma Gunawan Azifa, Annisa Andra Azmi, Aulia Ulul Azzah Soniati, Diana A’ziiz Amali, Fajri Bangun, Sri Melda Br Bangun, Sri Melda Br. Baswara, Satsya Yoga Camelia, Noer Dini Caroline, Stefany Damanik, Derma Wani Delita Ayu, Mite Delita Br Panjaitan Dewi, Rani Sartika Dianita Nursiami Dwi CAS, Insana Melia Dwi Intani, Andini Dwi Ratnaningsih, Dwi Dwi Septiani Eflin Giawa Eka Daryanto Eko Budi Koendhori, Eko Budi Fachrizal Jodi, Faris Fajar Imaduddin Fakhruddin Fakhruddin Fakhruddin Fakhruddin Felix Kasim Fikarwin Zuska Folanida Ginting, Desideria Yosepha Haliza, Nazwa Nur Hanayanti, Citra Siwi Harahap, Fatma Sylvana Dewi Haryanto, Ahmad Farid Hasan Mayditia Hasibuan, Rizki Kurniaty Hery Widijanto Heryanti, Febrina Heryanto, Tanto Hita Pandita, Hita Ilham Fiqri, Muhammad Ima Widiyanah Imam Nawawi, Imam Indah Dwi Astorini Indriani, Restutri Irmawati Irmawati Isandarsyah, Teuku Yan Waliana Muda Islami, M. Irfan Ismail, Mahsun Jamal Maulana Hudin Jefri Pratama Susanto, Jefri Pratama Joko Sutarto Ketut Purwantoro Khoirul Umam Kudiantoro Widianto, Kudiantoro Kurnianingsih, Novi Liesmayani, Elvi Era Liliek Desmawati Lubis, Basyariah Lutfiadi, Lutfiadi Madina, Nura Safira Maman Rachman Manugan, Reizal Audi Marzuki, Mochammad Jalalul Mazen, Mazen Mintarsih Arbarini Mohammad Fahrur Rozi Mohammad Mohammad Muarifuddin Muarifuddin, Muarifuddin Mustari, Zir Nuriyah Nabella, Ratih Intania Nadir Nadir, Nadir Nahak, Malisa Sherly Theresia Nana Sulaksana Narenda, Alfa Nauval, Radhiya Niam, Sufa’ah Hurumun Noviani, Lona Noviar Armanda Nurdin Nugroho, Pamuji Fitria Nur Samsu Nurhayati Nurhayati Nurlaely HS Pakendek, Adriana Pakpahan, Dosni Ana Ragita Pangestika, Isnaeni Parinduri, Anggi Isnani Pepy Dwi Endraswari, Pepy Dwi Pradnya Paramarta Raditya Rendra Pratama, M. Thoriq Maulidi Pratiwi, Mutiara Nur Purwandi, Agustri Putra, Citra Permana Putri, Youlinda Loviyani Rahma, Nisa Dian Rahmi, Nur Silviyah Rambey, Harris Ratieh Widhiastuti Ray, Miza Fazlina Retno Muslinawati Ristiani, Riya Rayi Riyan Asviyanda Rizki Aulianita - STMIK Nusa Mandiri Jakarta Rony, Zahara Tussoleha S, Buenita Safa Putri Wulan Sari Sagala, Ida Meita Sakinah, Asha Salis, Abdul Rozaq Samsudi Samsudi Saragih, Julwansa Sari, Indry Purnama Satiti, Ika Ayu Dewi Sekar Anggayuh Laras Septian Dwi Nurwanto Septian, Akbar SETYA CHENDRA WIBAWA Setyabudhi, Verina Siregar, Rahmi Wahida Sita Anggraeni, Sita SITI MAHMUDAH Siwi Hanayanti, Citra Sri Hartanto Suhaimi Suhaimi Sukmawati Anggraeni Putri, Sukmawati Anggraeni Sulastri, Murni Sulinantin, Sri Sungkowo Edy Mulyono Syaifur Rahmatullah, Syaifur Teguh Kurniawan Tidel, Caesar Totok Rochana Tri Joko Raharjo Tri Suminar Tyas Setiyorini Utsman Utsman, Utsman Victor Trismanjaya Hulu W, Suparta Wahyono, Sapto Wardani, Win Yuli Wasliati, Balqis Widiaputro, Dandi Widiawati, Lenny Widyaningsih, Fadlilah Wijaya, R. A. E. Winarti Wulandari, Ayuni Putri Yanuar Ramadhan Yanuar Ramadhan Yasin, Fahri Hananto Yuani Setiawati Yunia, Eva Anita Yuniati . Zebua, Arianus