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All Journal Jurnal Review Pendidikan dan Pengajaran (JRPP) Jurnal Informasi dan Teknologi Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Sains dan Teknologi Laboratorium Medik International Journal of Engineering, Science and Information Technology Jurnal Kolaboratif Sains Journal Of Human And Education (JAHE) Jurnal Pengabdian Masyarakat DEDIKASI Journal of Community Dedication Innovative: Journal Of Social Science Research Jurnal Kemitraan Responsif untuk Aksi Inovatif dan Pengabdian Masyarakat Journal of World Future Medicine, Health and Nursing Jurnal Medika Farmaka Jurnal Sipakatau Journal of Pharmacopoeia Research of Scientia Naturalis Journal of Pharmacopoeia
Dadang Muhammad Hasyim
STIKes Karsa Husada Garut
Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Veterinary Other

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Journal : Research of Scientia Naturalis

 1 
Inorganic Nanoparticles for Drug Delivery Systems: Design and Challenges Hasyim, Dadang Muhammad; Fujita, Miku; Vandika, Arnes Yuli
Research of Scientia Naturalis Vol. 1 No. 4 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/scientia.v1i4.1578

Abstract

Inorganic nanoparticles have gained attention in drug delivery systems due to their unique properties, including high surface area, biocompatibility, and the ability to encapsulate therapeutic agents. These characteristics make them promising candidates for enhancing drug efficacy and targeting. This research aims to explore the design parameters and challenges associated with inorganic nanoparticles in drug delivery applications. The focus is on understanding how modifications in nanoparticle design can optimize performance and address existing limitations. A comprehensive literature review was conducted alongside experimental assessments of various inorganic nanoparticle formulations. Key parameters such as size, surface charge, and drug loading capacity were evaluated to assess their impact on drug delivery efficiency. In vitro studies were performed to analyze drug release profiles and cellular uptake.The findings indicate that specific design modifications significantly influence drug delivery performance. For example, smaller nanoparticles with positive surface charges exhibited enhanced cellular uptake and higher drug loading capacities. However, challenges such as stability, scalability, and regulatory hurdles remain prevalent in the field. Inorganic nanoparticles hold great potential for advancing drug delivery systems, but addressing associated design challenges is crucial. Continued research in this area will facilitate the development of more effective and safer drug delivery solutions, ultimately improving therapeutic outcomes for patients.  
The Role of Applied Statistics in Drug Development and Clinical Trials Rahmah, Sitti; Fawait, Aldi Bastiatul; Hasyim, Dadang Muhammad
Research of Scientia Naturalis Vol. 1 No. 6 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/scientia.v1i6.1584

Abstract

Background: The integration of applied statistics in drug development and clinical trials is essential for ensuring the efficacy and safety of new pharmaceuticals. Statistical methods play a critical role in designing studies, analyzing data, and interpreting results, thereby influencing regulatory decisions and clinical practices. Objective: This study aims to examine the role of applied statistics in the drug development process, particularly within clinical trials. The focus is on identifying key statistical techniques and their impact on trial outcomes and decision-making. Methodology: A comprehensive review of literature was conducted, analyzing various statistical methods employed in clinical trials, including sample size determination, randomization techniques, and data analysis methods. Case studies were included to illustrate the application of these methods in real-world scenarios. Results: Findings indicate that robust statistical methodologies significantly improve the reliability of clinical trial results. Proper sample size calculations ensure adequate power to detect treatment effects, while randomization techniques minimize bias. Additionally, advanced data analysis methods enhance the interpretation of trial outcomes, leading to more informed regulatory approvals. Conclusion: This research highlights the indispensable role of applied statistics in drug development and clinical trials. Emphasizing the importance of sound statistical practices not only improves trial integrity but also contributes to the overall success of new drug therapies. Continued advancements in statistical methods will further enhance the efficiency and effectiveness of clinical research.
Co-Authors Abdul Rosid Ahmad Izuddin Aldi Bastiatul Fawait Fawait Andy Rachman ansori ansori Ardi, Abdullah Arief Budi Pratomo Arnes Yuli Vandika Asmaret, Desi Astuti, Aldiana Azhariah Rachman Baiq Ayu Aprilia Mustariani Bansaleng, Yessikah Feiby Brevmana Anugrah Primulyanto Cecep Hilman Dani Sujana Dede Suharta Desty Endrawati Subroto Devi Rahmah Sope Dhaniswara, Erwin Diah Wardani Dina Nirwana Suwinda, Dina Nirwana Suwinda Dito Anurogo, Dito Eka Selvi Handayani Eka Selvi Handayani, Eka Selvi Elang Mohamad Atoilah Elvina Triana Putri Eny Retna Ambarwati Erlinawati, Noor Diah Euis Kusumarini Firman Muharam Fitriah Handayani Fujita, Miku Gina Nafsa Mutmainna, Gina Nafsa Mutmainna Habibi Hafid, Hendra Hamzah Puadi Ilyas, Hamzah Puadi Hendra Nusa Putra Hesti Renggana Hiola, Siti Fatmah Irma Muti Irmanida Batubara Iwan Aprianto Izuddin, Ahmad Judijanto, Loso Kusumarini, Euis La Ode Maksar Muhuruna Legito Liza Rastiti Melinda Arismawati Mena Sari Mina Pertiwi Moh. Imron Rosidi Muntasir, Muntasir Muslimin Muslimin Najamuddin Petta Solong Natalia Lisma Br Sembiring Nazaruddin Ahmad Norma Winata Novelti, Novelti Novycha Auliafendri Nuralfin Anripa Nurul Oktafian Farhan Ramdani, Hasbi Taobah Ramson Rikson Maruwahal Sijabat Rian Novita Ridayani, Ridayani Riniati, Wa Ode Rukhmana, Trisna S. Sumihatul Ummah MS, S. Sumihatul Ummah Salma Nurin Fadilah Santi Yuliasari Saputra, Abiyasa Eka Siti Aisyah Hanim, Siti Aisyah Sitti Rahmah Solehuddin, Moh. STIKES Karsa Husada Garut Subroto, Desty Endrawati Sulaeman Sulaeman Sulaminingsih, Sulaminingsih Sumerli A, Chevi Herli Supriatnini, Ai Susatyo Adhi Pramono, Susatyo Adhi Sutrisno Sutrisno Sutrisno Sutrisno Syamsu Rijal Syamsul Anwar Syamsul Anwar, Syamsul Tarru, Harni Eirene Tarru, Reni Oktaviani Wiwid Suryono Yogi Rahman Nugraha Zahara Farhan Zakka, Umar Zani, Benny Novico