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Journal : Biosfer: Jurnal Pendidikan Biologi

Anticancer mechanism of Pisangulin angulata through in silico and development as teaching material Agus Muji Santoso; Bayu Guruh Binangkit; Mohamad Amin; Sutiman Bambang Sumitro; Betty Lukiati; Mumun Nurmilawati; Poppy Rahmatika Primandiri; Ida Rahmawati; S Sulistiono; Yayoi Kodama
Biosfer: Jurnal Pendidikan Biologi Vol 12 No 1 (2019): Biosfer: Jurnal Pendidikan Biologi
Publisher : Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (366.066 KB) | DOI: 10.21009/biosferjpb.v12n1.45-57

Abstract

This study aims to reveal the anticancer mechanism of the bioactive compound of Pisangulin angulata and to assess the feasibility of that results as teaching material. This research includes descriptive explorations. In the first stage, an in silico analysis was performed by molecular docking method between physalin compounds and GLI1 protein. The second steps of this study aim to develop teaching materials based research using the Analysis, Reorganizing, Piloting Class, and Evaluating (ARPE models). Feasibility test was carried out by experts and practitioners. Think Pair Share was used in the pilot project. Student motivation and misconception were recorded using SMI and CRI instrument. This study reveals that physalin B has higher activities than controls. The type of chemical bond that is formed between GLI1 amino acids residues with physalin is hydrogen bonds and hydrophobic bonds. The visualization of the types of bonds in that molecular docking between GLI1 amino acid residues and physalin has a high degree of feasibility (89) and can be used to enrich Chemistry for Biology lectures. The visualization of these chemical bonds can increase learning motivation and can improve the understanding of the concept of chemical bonds.
Application of the asicc learning model in human physiological system to improve students' critical thinking and creative thinking skills Setiani, Dila Elpin; Purwoko, Budi; Sulistiyowati, Tutut Indah; Primandiri, Poppy Rahmatika; Santoso, Agus Muji
Biosfer: Jurnal Pendidikan Biologi Vol. 17 No. 2 (2024): Biosfer: Jurnal Pendidikan Biologi
Publisher : Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/biosferjpb.44325

Abstract

Critical thinking and creative thinking skills are needed to improve the quality and competitive human resources. Therefore, the application of appropriate learning models is expected to stimulate students' critical thinking and creative thinking skills. This research aims to improve critical thinking and creative thinking skill scores using the ASICC learning model. This type of research is classroom action research which is carried out in 2 cycles, with 3 meetings in each cycle. Data on students' critical thinking and creative thinking skills were collected using essay tests on science learning materials. Data analysis was carried out by comparing the N-gain scores in cycle 1 and cycle 2 for students' critical thinking and creative thinking skills. The results of the research revealed that there was an increase that occurred in cycle 2, namely 5.6% in the aspects of moderate critical thinking skills and high creative thinking, as well as in the aspects of critical thinking skills and high creative thinking by 5.6%. Meanwhile, in the previous cycle, these two aspects did not have a high category. Another result found from this research is that students who have low critical thinking skills do not necessarily have low creative thinking skills. This is because students who have low critical thinking skills may have moderate creative thinking skills or vice versa. Thus, the application of the ASICC learning model is effective in improving the scores of critical thinking skills and creative thinking skills of students at Junior High School 5 Kertosono.
Co-Authors AA Sudharmawan, AA Aan Nurfahrudianto Abraham Dimas Bayu Aji Afandi, Zainal Afifah, Inayah Nur Agus Fatony Tohari Agus Syahrani Agus Syahrani Ahmad Fauzan Aidina Ristyawan Aldi Pratama Alfiana Hidayati Alia Bihrajihant Raya Alia Bihrajihant Raya Amalia Sani Siamin Fitri Anang Wahid M.Diah Angga Yuanisyak Anggraeni Dyah S Anggraeni Dyah Sulistiowati Anisa Fatimatul Firdhausi Apta Adi Wahyu Arbaiyah, Siti Arganata, Febryan Dimas Arifin Dwi Saputro ARSANTI DWI UTAMI, ARSANTI DWI Astri Rino Oktivasari Bachtiar, Willy Balqis balqis Bayu Guruh Binangkit Bea Hana Siswati Bella Putri Damayanti Betty Lukiati Budhi Utami Budi Purwoko Cepi Triatna, Cepi Chairul Effendi Desvian, Algananda Reza Dewi Rahajoe Dewi Rossylia Wati Diding Nurdin, Diding Dila Elpin Setiani Dwi Ari Budiretnani Dwi Lianawati Elis Irmayanti Elly Setyowati Endang Sri Mujiwati Enggar Wahyuningtyas Ericka Darmawan Evi Rinata F. Fatnatin Fadlilatin Nailah Fahriza, M Raffi Faruq, Umar Al Febri Nurcahyo Dwiyantoko Febriana Irawati Finda Meyditia Finda Meyditia Gilang Taufan Insani Guruh Sukma Hanggara Hana Agustina Hana Refri Gunawan Hanik Pratiwi Hendy Setiawan Hendy Setiawan Herawati, Elysabet Herlina, Lien Herman Wayudi Antoni Herry Cahya Kurniawan Heru Budiono Hesti Istiqlaliyah Hesti Mei Wulandari Ibnu Qoyim, Ibnu Ida Rahmawati IDA RAHMAWATI Ika Furi Handayani Inayah Nur Afifah Insani, Gilang Taufan Irma Setiawan Kusuma Islamiati Rachmah Istiqlaliyah, Hesty Jannah, Ro'ikatul Jannah, Ro’ikatul Jeni Jeni Jeni Johar Permana Khoiriyah Krisnawati Krisnawati Kusanagi, Kanako N. Lailatul Riska Linda Elyanawati Rahayu M. Ibnu Mundir Made Ayu Dusea Widyadara - Universitas Nusantara Kediri, Made Ayu Dusea Widyadara Maria Ulfa Miftachul Rizal Misnar Moch. Nurul Hadi Mochammad Ardian Suryaji Mohamad Amin Mohamad Amin Mohammad Amin Mohammad Amin Muhamad Sholafudin Muhammad Najibulloh Muzaki Mukhammad Annafinurika Mumun Nurmilawati Mustofa, Mohammad Annan Makruf Nadzifah, Bintang Khoirun Nanang Wahyudin Nanang Wahyudin Nia Talia Salsabela D.M. nurasih, amalia Nurmala As'ari Nurul Widayati Nurul Widayati Okvitasari, Astri Rino Papib Handoko Pardede, Akim Manaor Hara Poppy R Primandiri Poppy Rahmatika Primandiri Poppy Rahmatika Primandiri Putri, Yayanti Rahma Qonita Nur Rohmania Qonita Nur Rohmania Rahmawati Ratnasari, Deny Reni Bekti Anila Retno Syahriawati DewI rima siburian Rina Firliana Rini Indriati Risky Aswi R, Risky Rizhal Hendi Ristanto Rofik Masruri Rohmania, Qonita Nur Ronny Lesmana Rr. Forijati -, Rr. Forijati Ryan Marcell Wibisono Sari, Devi Anita Sari, Nindi Novita Seagames Waluyo Seika Nur Rosida Setiani, Dila Elpin Setyowidodo, Irwan Shilvi Nur Azizah Silvi Listia Dewi Siti Aizah Siti Lailatus Sa’adah Siti Zubaidah Slamet Hariyadi Suciati Suciati Sucipto Sucipto Sujarwoko Sujarwoko Sukawati, Yunita Sulastri Sulastri Sulistiono Sulistiono Sulistiono Sulistiyowati, Tutut Indah Sutikno Sutikno Sutiman Bambang Sumitro Tri Julianto TUTUT INDAH SULISTIYOWATI Tutut Sulistiyowati Tykha Amanda Riskia Putri Vina Churotul Laili Vingki Dewi Aristina Violyna Sofiananda Wahid Ibnu Zaman Wati, Dewi Rossylia Widodo Widodo widya, tri yulian Wiji Arianti Willy Bachtiar Yanuar Dwi Prastyo Yayoi Kodama Yuliani Yuliani Yulianna Puspitasari Zunaidah, Farida Nurlaila