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All Journal Althea Medical Journal Medical Journal of Indonesia The Indonesian Biomedical Journal Sari Pediatri Paediatrica Indonesiana Health Notions Medicinus : Jurnal Kedokteran Oto Rhino Laryngologica Indonesiana World Nutrition Journal Jurnal Health Sains Proceedings of the International Conference on Nursing and Health Sciences eJournal Kedokteran Indonesia Jurnal Muara Medika dan Psikologi Klinis
Rini Sekartini
Departemen Ilmu Kesehatan Anak, Fakultas Kedokteran Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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The Auditory brainstem response latencies in children with global developmental delay at Dr. Cipto Mangunkusumo Hospital Muhammad Ade Rahman; Tri Juda Airlangga; Fikry Hamdan Yasin; Rini Sekartini; Achmad Rafli; Ferdi Afian
Oto Rhino Laryngologica Indonesiana Vol. 56 No. 1 (2026): VOLUME 56, NO. 1 JANUARY - JUNE 2026
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v56i1.790

Abstract

Background: Global developmental delay (GDD) affects multiple developmental domains and remains a major concern in early childhood. The auditory system plays a key role in language development, and the Auditory Brainstem Response (ABR) test provides an objective measure of auditory pathway maturation. However, data on ABR wave latencies among children with GDD who have normal predicted hearing thresholds are limited. Purpose: To describe absolute and interwave latencies of ABR waves I, III, and V, and to compare latencies of ABR waves across demographic and perinatal clinical characteristics in children with GDD. Method: A cross-sectional analytical study was conducted using medical record data from 70 children aged 6 months to 5 years with GDD at Dr. Cipto Mangunkusumo Hospital between January 2021 and May 2025. All subjects had normal predicted hearing thresholds (≤30dB) in ABR result and passed Distortion Product Otoacoustic Emission (DPOAE) screening. Comparations between risk factors (age, gender, gestational age, birth weight, NICU admission, asphyxia, and hyperbilirubinemia) and ABR latencies were analyzed using t-test or Mann–Whitney test. Result: Most subjects were male (71.4%) with a median age of 25 months. The language domain was most frequently affected (92.9%). Male subjects had a significantly longer absolute latency of wave V in the left ear compared to females (6.10±0.31 ms; p < 0.05). Conclusion: Male gender with normal predicted hearing threshold had significant difference in the left-ear wave V latency compared to female. ABR is a valuable tool for early detection of auditory pathway maturation delay in at-risk children.
Soy Isolate Protein Formula: the usage beyond allergy indication Zakiudin Munasir; Rini Sekartini
World Nutrition Journal Vol. 4 No. S1 (2020): Special Issue : Soy Plant-based and Fiber in Children’s Gut Health, Growth & D
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V04.S1.0005

Abstract

The usage of soy isolate protein formula for infants was recommended by Indonesian Pediatrics Association (IDAI) through the recommendation of Cow’s Milk Protein Allergy (CMPA) management in 2014. Soy Infant Formula (SIF) has been being used for Infants with Cow’s Milk Protein Allergy (CMPA) as well as for several other related medical indications such as post diarrhea lactose intolerance, galactosemia and primary lactase deficiency1. At early stage of soy formula, it had several deficiencies, infant acceptability, growth, and incomparable with milk-base formula. Current SIF is made from soy protein isolate that contain 2,2 – 2,6 g of protein per 100 calories, it is higher than milk-based formula and both showed same growth and development in Infants2. It contains different fibers, phytate, digestibility, protease inhibitor and proteins. SIF is easily digestible and contain high amino acid content fortified with L-methionine, L-carnitine and taurine. High content of phytate is overcome with zinc and iron fortification as well as increased levels of calcium and phosphor3. American Academy of Pediatrics recommends isolated soy protein-based formulas as a safe and effective alternative for providing appropriate nutrition for normal growth and development for term infants whose nutritional needs are not being met from maternal breast milk or cow’s milk-based formulas3,4.
The narrative review of recent studies in understanding the relationship between gut (microbiota)-brain axis, nutrition and cognitive function Taufiq Fredrik Pasiak; Tjhin Wiguna; Rini Sekartini; Juwalita Surapsari; Tonny Sundjaya; Erika Wasito; Ray Wagiu Basrowi; Melissa Stephanie Kartjito
World Nutrition Journal Vol. 6 No. S2 (2023): Special Issue : expert perspectives on the interconnections between immunity,
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V06.S2.0004

Abstract

The concept of the gut (microbiota)-brain axis, which influences the development and function of the gastrointestinal, immune, neuroendocrine, and metabolic systems, is gaining popularity. Recent animal studies have demonstrated that the gut (microbiota)-brain axis also plays a role in establishing cognitive function. It is known that a disruption in the environment's microbiota balance can increase disease susceptibility in children. Historically, it has been hypothesized that neurodevelopmental disorders are the results of a disruption in children’s health. However, it is becoming clear that the gut microbiota and the central nervous system communicate in both directions, which could explain how microbiota affects cognitive function. Dietary factors also play important role in the central nervous system via the gut (microbiota)-brain axis, demonstrating the importance of nutrition in optimizing cognitive function. This narrative review of recently published studies and current knowledge aims to elucidate the relationship between the gut (microbiota)-brain axis and cognitive function, as well as the variables that may influence it.
Exploring key cognitive indicators for practical use by parents in community setting Tjhin Wiguna; Rini Sekartini; Taufiq Fredrik Pasiak; Ray Wagiu Basrowi; Melissa Stephanie Kartjito
World Nutrition Journal Vol. 6 No. S2 (2023): Special Issue : expert perspectives on the interconnections between immunity,
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V06.S2.0005

Abstract

The identification of child development milestones, specifically cognitive abilities, requires parental/caregiver awareness and knowledge. With the existence of multiple cognitive abilities such as attention and focus, memory, language, psychomotor skills, logic, reasoning, decision-making, problem-solving, social/emotional, there are multiple indicators to measure children's cognitive abilities. Pediatricians are the most knowledgeable and trusted authority to routinely screen and monitor the development of healthy children. Therefore, it is crucial that parents understand their children's developmental milestones so if they encounter anomalies, they can immediately consult with the professionals. This review compiles recently published research and current knowledge to examine potential key indicators of cognitive development in infants and children that can be utilized by parents and communities in an easily understood manner.
Total Omega-3 Fatty Acid, Eicosapentaenoic Acid (EPA), and Docosahexaenoic Acid (DHA) are Positively Associated with Sleep Duration in Children Aged 3–5 Years: A Preliminary Study Marsella Dervina Amisi; Dian Novita Chandra; Ninik Mudjihartini; Rini Sekartini
The Indonesian Biomedical Journal Vol 18, No 3 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i3.4102

Abstract

BACKGROUND: Sleep is essential for children’s growth and development, yet sleep disturbances remain common among preschoolers. Insufficient sleep has been linked to cognitive impairments, behavioral problems, and increased risk of obesity. Nutritional factors, particularly omega-3 fatty acids, may play a role in sleep regulation. Although previous studies have suggested that Eicosapentaenoic Acid (EPA) and Docosahexaenoic acid (DHA) are associated with improved sleep outcomes, yet data on omega-3 status and its relationship with sleep duration among Indonesian preschoolers remain scarce. Therefore, this study was conducted to analyse the association between Omega-3 fatty acids levels and sleep duration among preschool children in Indonesia.METHODS: A cross-sectional survey was conducted among 72 children aged 3–5 years old. Sleep duration and disturbances of subjects were assessed using the Children’s Sleep Habits Questionnaire–Abbreviated (CSHQ-A). Omega-3 fatty acids levels, including α-linolenic acid (ALA), EPA, and DHA, were measures using gas chromatography.RESULTS: The median sleep duration was 11 hours (range 9–13.5 hours). Based on CSHQ-A scores, 93.1% of subjects experienced sleep disturbances. Mean total omega-3 fatty acid concentration was 225.47±80.9 µmol/L. Significant positive corelations were observed between sleep duration and total omega-3 fatty acid (r=0.298; p=0.011), EPA (r=0.233; p=0.049), and DHA (r=0.260; p=0.028).CONCLUSION: Omega-3 fatty acid levels, particularly EPA and DHA, were positively associated with sleep duration in preschool children. These findings provide preliminary evidence of the role of omega-3 in sleep regulation and underscore the importance of considering nutritional factors in efforts to improve sleep quality during early childhood.KEYWORDS: omega-3 fatty acids, DHA, EPA, ALA, sleep duration, preschool children
Faktor Risiko Kejadian Masalah Perilaku Emosional pada Anak Prasekolah Usia 36 – 72 Bulan di Kampung Melayu Vella Ananda; Rini Sekartini
Sari Pediatri Vol 28, No 1 (2026)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp28.1.2026.42-9

Abstract

Latar belakang. Masalah perilaku emosional pada anak dapat berlanjut menjadi gangguan kejiwaan saat dewasa. Penelitian terdahulu menunjukkan adanya faktor risiko internal (jenis kelamin, riwayat kelahiran prematur, dan status perkembangan) dan faktor eksternal (pola asuh, tingkat pendidikan ibu, serta sosioekonomi).Tujuan. Penelitian ini bertujuan untuk mengetahui hubungan faktor risiko internal dan eksternal dengan kejadian masalah perilaku emosional pada Anak Prasekolah Usia 36 – 72 Bulan di Kampung Melayu.Metode. Desain penelitian ini adalah studi potong lintang dengan 71 sampel anak prasekolah di kelurahan Kampung Melayu. Instrumen yang digunakan meliputi KMPE, PSDQ, dan KPSP. Hasil. Prevalensi masalah perilaku emosional didapatkan 70,4% (n=50) dan 29,6% (n=21) yang termasuk kategori normal menggunakan Kuesioner Masalah Perilaku Emosional (KMPE). Ditemukan bahwa tidak ada hubungan yang bermakna antara masalah perilaku emosional dengan jenis kelamin (p = 0,623), riwayat prematur (p = 0,163), tingkat pendidikan ibu (p = 0,450), status sosioekonomi (p = 0,469), dan pola asuh orang tua (p = 0,884). Status perkembangan memiliki hubungan terhadap masalah perilaku emosional sebanyak 93,8% anak berkategori kemungkinan menyimpang atau meragukan memiliki masalah perilaku emosional (OR = 8.57; p = 0.020).Kesimpulan. Anak prasekolah dengan gangguan perkembangan memiliki risiko sembilan kali lebih tinggi mengalami masalah perilaku emosional sehingga perlu pemantauan rutin dan skrining berkala masalah perilaku emosional anak prasekolah setiap tiga sampai enam bulan sekali.
Masalah Psikososial dan Praktik Transfusi Darah pada Remaja dengan Talasemia Mayor di Rumah Sakit Cipto Mangunkusumo pada Masa Pandemi COVID-19 Ayu Sasmita Rany; Rini Sekartini; Hanifah Oswari; Fitri Primacakti; Hardiono D Pusponegoro; Haryanti Fauzia Wulandari
Sari Pediatri Vol 28, No 2 (2026)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp28.2.2026.130-7

Abstract

Latar belakang. Pandemi COVID-19 berpotensi meningkatkan masalah psikososial dan mengganggu praktik transfusi pada remaja dengan talasemia mayor. Gambaran keduanya di Indonesia selama pandemi belum diketahui.Tujuan. Mengetahui gambaran masalah psikososial dan dampak pandemi COVID-19 terhadap praktik transfusi pada remaja talasemia mayor di Rumah Sakit Cipto Mangunkusumo, Jakarta.Metode. Studi potong lintang pada 121 pasien talasemia mayor usia 10–<18 tahun. Penilaian psikososial menggunakan SDQ dan CDI. Analisis komparatif berpasangan dilakukan untuk menilai perbedaan frekuensi transfusi dan rerata Hb pretransfusi sebelum dan selama pandemi.Hasil. Sebanyak 11,6% subjek memiliki total skor SDQ abnormal, dengan masalah emosi (18,2%) dan conduct (9,9%) sebagai temuan terbanyak. Suspek depresi ditemukan pada 19% subjek. Tidak terdapat perbedaan bermakna pada frekuensi transfusi sebelum dan selama pandemi, tetapi terdapat perbedaan bermakna pada pola interval transfusi (p=0,017), rerata Hb pretransfusi (p=0,043), dan volume darah yang didapatkan lebih rendah daripada kebutuhan (p<0,001).Kesimpulan. Masalah emosi dan conduct merupakan masalah psikososial paling umum pada remaja talasemia mayor selama pandemi. Pandemi berdampak pada pola interval transfusi, rerata Hb pretransfusi, dan volume darah yang didapatkan pasien.
Association of eating behavior and diet quality among students in Taruna Nusantara Senior High School, Indonesia Barkah Triatmoko; Dian Novita Chandra; Helda Khusun; Indriya Laras Pramesthi; Rini Sekartini
World Nutrition Journal Vol. 9 No. 1 (2025): WNJ. Volume 9 Issue 1, Agustus 2025
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V09.i1.0009

Abstract

Background: Poor adolescent diet quality is influenced by family eating habits, media promoting unhealthy foods, and body image pressures, leading to disordered eating, neglect of health considerations, and obesity. Even in controlled environments like boarding schools. Objective: This study aims to assess association between eating behavior and dietary quality among students in Taruna Nusantara Senior High School (TN-SHS), Indonesia. Methods: A cross-sectional study with 200 subjects aged 15-18 was conducted in January 2024. Participants were purposively sampled from TN-SHS boarding school. Data was collected using the Dutch Eating Behavior Questionnaire (DEBQ) and Diet Quality Index International (DQI-I), along with sociodemographic information, nutritional status, and physical activity. Analysis was performed using SPSS 29, employing multiple linear regression to examine the relationship between eating behaviors and diet quality. Results: There was strong relationship between eating behavior and diet quality on different days, revealing that restrained eating correlates with better diet quality on average days (r=0.158, p=0.026), while external eating is linked to poorer diet quality. The association between eating behavior and diet quality on weekdays is weaker than on weekends. External eating consistently reduces diet quality across all periods (β=–1.380 to –1.854, p<0.01). Males exhibiting lower diet quality (β=–3.021 to –4.904, p≤0.002) and higher pocket money associated with improved diet quality, particularly on weekends (β=–3.633, p=0.021). Conclusion: The study findings highlight the importance of managing external eating behaviors such as emotional eating, social eating, mindless eating, and binge eating, and suggest avenues for targeted interventions to promote healthier dietary habits.
Co-Authors Abdul Latief Achmad Ushuluddin Adam Adam Adantio Rashid Santoso Adelina Haryono Aditia Reza Aditya, Clarissa J. Ahmad Suryawan Ali Alhadar Ali Sungkar Alia Arianti Alida R. Harahap Alim, Edward Goei Almitra Rindiarti Amalia Setiawati Aman B. Pulungan Aman B. Pulungan Amin Soebandrio Anandika Pawitri Andintia Aisyah Santoso Andry Juliansen Andy Martahan Andreas Angela BM Tulaar Anindya, Isti Annisa R. Yulman Ardi Findyartini, Ardi Ardita Puspitadewi Ari Prayitno Ari Prayogo Aria Kekalih Ariani Dewi Widodo Ariyanto, Ibnu Agus Armeilia, Rilie Asmoko Resta Asrawati Nurdin Astri Adelia Astri Dewina Ayu Sasmita Rany Bambang Supriyatno Bambang Tridjaja AAP, Bambang Tridjaja Barkah Triatmoko Basrowi, Ray Wagiu Batubara, Jose Benjamin Ngatio Bernie E. Medise Bernie Endyarni Medise Besral . Bintang Pratiwi Catharina Sambo Cathrine Cathrine Centauri Centauri Chandra, Dian Novita Christine Natalita Christopher Silman Citra Aryudi Clarissa Josephine Aditya Corrie W. Wawolumaja Corrie Wawolumaja Corrie Wawolumaya Corrie Wawolumaya Corry Wawolumaya Corry Wawolumaya Cynthia Cynthia Daisy Widiastuti Damara Andalia Daniel Nugraha Aji Darmawan, Anthony C. Dave Anderson Desi Astari Dewi Friska Diah Pitaloka DMP Dian Kusumadewi Dian Milasari Dian Novita Chandra Diana Adriani Banunaek Diana Sunardi Dwi Putro Widodo Dyah Arum Kusumaningtyas Dyah Tunjungsari Eleonora Mitaning Christy Elina Waiman Elisa Harlean Elizabeth Melina Erick Wonggokusuma Erika Wasito Erwin Hendrata Eva Devita Harmoniati Eva Suryani Evan Regar Faisal Adam Fathan, Fariz Dwi Ferdi Afian Fijri Auliyanti Fikry Hamdan Yasin Fitri Primacakti, Fitri Ghifari Nurullah Gunawan, Talitha Dinda Hanifah Oswari Hannisa Rizka Setiawati Hardiono D Pusponegoro Hardiono Poesponegoro Harningtyas Jasmin Hartono Gunadi Hartono Gunardi Haryanti Fauzia Wulandari Helda Helda Helda Khusun Helda Khusun Henry Riyanto Herwanto Herwanto Hesti Lestari Hesti Lestari Hindra Irawan Satari Ika Citra Dewi Ikhsan Johnson Ikhsan Johnson Imam D Imam N Indriya Laras Pramesthi Intan Tumbelaka Irawan Mangunatmadja Irene Audrey Davalynn Pane Irene Yuniar, Irene Jeane Roos Ticoalu Jenni Kim Dahliana Jose RL Batubara Jusuf Kristianto Juwalita Surapsari Kartjito, Melissa Stephanie Kristiana Siste Kuntjoro Harimurti Levina Chandra Khoe Lily Rahmawati Listya Tresnanti Mirtha Luh Nyoman Alit Aryani M. Triadi Wijaya Maelissa P. Ririmasse Marsella Dervina Amisi Martin Hertanto Matahari Harumdini Maulina Rachmasari Medise, Bernie E. Melani Kumala Melissa Stephanie Kartjito Melyarna Putri MF Conny Tanjung Mirtha, Listya T. Muhammad Ade Rahman Muhammad Aini Muhammad Arvianda Kevin Kurnia Munasir, Zakiuddin Murti Andriastuti, Murti Nadya, Ruth Nahla Shihab Nashrul Ihsan Ninik Mudjihartini Ninik Mudjihartini Noorwati Sutandyo Nur Handayani Utami Nurdina, Nazlah Nuri Indahwati Nuri Purwito Adi Nycane Nycane oedjatmiko oedjatmiko Oktarina, Molly Dumakuri Olfriani, Ciho Partini Trihono Pasiak, Taufiq Fredrik Praevilia M Salendu Prastya, Reza Wahyu Dwi Pustika Amalia Pustika Amalia Wahidiyat, Pustika Amalia R.A. Deta Hanifah Rafli, Achmad Ranto, Huminsa Ratna Djuwita Ratna Djuwita Ray Wagiu Basrowi Ray Wagiu Basrowi Ray Wagiu Basrowi Renno Hidayat Resyana P. Nugraheni Retnaningdyah, Windri Retno Asti Werdhani Ria Andreinie Rini Andriani Rini Mulia Sari Ririn Hariani Risatianti Kolopaking Rismala Dewi Robert Sinto Ronny Suwento, Ronny Sabarinah Prasetyo Salindri Dara Rizkita Salma Oktaria Salsabila Yasmine Dyahputri Salsabila Yasmine Dyahputri Saptawati Bardosono Saptawati Bardosono Sarah Listyo Astuti Sari, Novika Purnama Setyanto, Darmawan Budi Siti Mirdhatillah Soedjatmiko Soedjatmiko Soedjatmiko Soedjatmiko Soedjatmiko Soedjatmiko Soedjatmiko Soedjatmiko Sri Hartati R. Suradijono Sri Rezeki Hadinegoro Sri Sukmaniah Sudigdo Sastroasmoro Sudiyanto Darmosubroto Sudung O Pardede, Sudung O Sudung Pardede Sukamto Koesnoe Surapsari, Juwalita Suzy Maria Taufiq Fredrik Pasiak Tazkya Amany Thjin Wiguna Titi S. Sularyo Tjhin Wiguna Tjhin Wiguna Tjhin Wiguna Tonny Sundjaya Trevino Pakasi Tri Juda Airlangga Trinovita Andraini Tutik Ernawati Vella Ananda Wahyuni Indawati Wahyuni Indawati, Wahyuni Wangke, Lydia Wasito, Erika Widjaja, Melanie William Cheng Wirahmadi, Angga Yoga Devaera Yogi Prawira Yulia Wigoeno Yulianti Wibowo Yulianti Wibowo Yuliarti, Klara Yusra Zakiudin Munasir