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All Journal PROSIDING SEMINAR NASIONAL Jurnal Penelitian Saintek Indonesian Journal of Cancer Chemoprevention Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Biomedika Jurnal Kesehatan Pharmacon INDONESIAN JOURNAL OF PHARMACY Science and Technology Indonesia Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Journal of Nutraceuticals and Herbal Medicine Martabe : Jurnal Pengabdian Kepada Masyarakat JPSCR : Journal of Pharmaceutical Science and Clinical Research Indonesian Community Journal Abdi Geomedisains Jurnal Farmasi Sains dan Praktis Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Jurnal Farmasi Klinik dan Sains Journal of Pharmaceutical and Sciences. Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia Pharmacon: Jurnal Farmasi Indonesia
Andi Suhendi
Universitas Muhammadiyah Surakarta
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Optimasi Metode Ekstraksi Albumin Dari Ikan Gabus (Channa striata) Muhammad Haqqi Hidayatullah; Munawwarah Munawwarah; Andi Suhendi
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 3 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i3.66952

Abstract

Ikan gabus (Channa striata) memiliki kadar protein yang tinggi dengan kandungan utamanya adalah albumin. Sehingga diperlukan metode dan kondisi ekstraksi yang sesuai agar mendapatkan rendemen dan kandungan albumin yang optimal. Penelitian ini bertujuan untuk mendapatkan metode ekstrkasi yang optimal antara perebusan biasa, microwave-assisted extraction (MAE) dan ultrasonic-assisted extraction (UAE) dengan parameter kadar albumin. Ekstraksi dilakukan dengan perbandingan daging ikan gabus dan akuades (1 : 1). Variasi waktu ekstraksi yaitu 5, 10 dan 15 menit. Kadar albumin ditetapkan dengan metode Lowry. Rendemen ekstrak yang dihasilkan dari 3 metode ekstraksi pada waktu ekstraksi 5 menit berurutan 2,419; 1,293 dan 1,575 %b/b. Kurva baku Albumin didapatkan persamaan regresi linier yaitu y = 3,38x + 0,7396 dengan nilai r = 0,997. Kadar albumin yang diperoleh dari 3 metode ekstraksi pada waktu ekstraksi 10 menit secara berurutan adalah 47,009 + 1,046; 44,792 + 5,372 dan 28,946 + 2,260 %b/b. Berdasarkan data tersebut, metode ekstraksi yang memberikan kadar albumin yang terbesar adalah metode perebusan dengan waktu 10 menit.
Pengaruh Fraksinasi Kromatografi Cair Vakum terhadap Kandungan Fenolik, Flavonoid, dan Aktivitas Penghambatan α-Glukosidase Daun Nangka (Artocarpus heterophyllus Lam.): - Istiara Subekti; Tanti Azizah Sujono; Andi Suhendi; Arifah Sri Wahyuni; Aditya Naova Sofyan
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1733

Abstract

Artocarpus heterophyllus Lam leaves are recognized as a promising source of bioactive compounds with potential antidiabetic activity. This study aimed to evaluate the effects of vacuum liquid chromatography (VLC) fractionation on the distribution of phenolic and flavonoid compounds and their α-glucosidase inhibitory activity. Crude ethanolic extract was fractionated by VLC into polar, semipolar, and nonpolar fractions. Total phenolic content (TPC) and total flavonoid content (TFC) were determined using the Folin–Ciocalteu and aluminum chloride colorimetric assays, respectively, while α-glucosidase inhibitory activity was evaluated using a p-nitrophenyl-α-D-glucopyranoside-based assay. The crude extract exhibited the highest TPC (4.70 ± 0.37 mg GAE/g extract) and TFC (5.63 ± 0.11 mg QE/g extract), whereas both parameters decreased markedly after fractionation. Consistently, the crude extract showed the strongest α-glucosidase inhibitory activity, as indicated by the lowest IC₅₀ value, while the nonpolar fraction exhibited the weakest activity. These findings demonstrate that VLC fractionation redistributed rather than enhanced the bioactive constituents responsible for α-glucosidase inhibition. The crude extract therefore represents a promising natural source of α-glucosidase inhibitors and supports the potential utilization of Artocarpus heterophyllus Lam for the development of plant-derived antidiabetic agents.
Uji Aktivitas Sitotoksik Daun Benalu Jeruk (Dendrophthoe glabrescens) terhadap Garis Sel Kanker Payudara: Studi In Silico: - Aditya Naova Sofyan; Rizal Maarif Rukmana; Andi Suhendi
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1417

Abstract

This study aims investigate the potential of phytochemical compounds from citrus mistletoe leaves (Dendrophthoe glabrescens) leaves as anticancer candidates using an in silico approach. Phytocemical constituents identified by LC-MS and screened using Lipinski’s Rule of Five. Followed by Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) prediction using ProTox-3.0. The docking protocol was validated with root mean square deviation (RMSD) values of 1.80 Å for epidermal growth factor receptor (EGFR) (PDB ID: 1M17) and 0.69 Å  for estrogen receptor-α (ER-α) (PDB ID: 1A52). Tenylidone exhibited the strongest binding affinity toward EGFR (-8.12 kcal/mol), followed by quercetin (−7.48 kcal/mol) and kaempferol (−7.43 kcal/mol). For estrogen receptor alpha, fisetin showed the strongest affinity among the tested D. glabrescens compounds (−8.21 kcal/mol), followed by nomelidine (−8.16 kcal/mol) and tenylidone (−7.95 kcal/mol). Kaempferol showed the most favorable predicted acute toxicity profile among the leading compounds, with an estimated LD50 of 3919 mg/kg and toxicity class 5. Overall, tenylidone and fisetin were prioritized for epidermal growth factor receptor and estrogen receptor alpha, respectively, while kaempferol showed a favorable predicted safety profile.
Antioxidant Activity of DPPH and ABTS Methods, from Jackfruit Leaf Extract and Fraction (Artocarpus heterophyllus) with ELISA Reader Istiara Subekti; Tanti Azizah Sujono; Andi Suhendi
Pharmacon: Jurnal Farmasi Indonesia Vol. 22 No. 1 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i1.10549

Abstract

Oxidative stress caused by the accumulation of free radicals is a key factor in the development of degenerative diseases. Jackfruit leaves (Artocarpus heterophyllus), which are rich in polyphenolic compounds, have the potential as natural antioxidants. This study aims to activate the antioxidant activity of jackfruit leaf extracts and fractions. The study was conducted by extraction using the maceration method with 70% ethanol solvent and fractionated by vacuum liquid chromatography into polar, semi-polar and non-polar fractions. Antioxidant activity was measured in vitro, using 3 methods including DPPH, ABTS and FRAP which were read with an ELISA Reader with vitamin C as the reference standard. The results showed that the crude extract had strong antioxidant activity with an IC₅₀ value of 31.93 µg/mL (DPPH) and 29.59 µg/mL (ABTS), as well as the highest antioxidant equivalent ascorbic acid (AEAC) levels in the FRAP test. The polar fraction showed moderate antioxidant activity, while the semi-polar and non-polar fractions showed weak activity. These findings suggest that polar compounds such as flavonoids and phenolics play a role in the antioxidant effects of jackfruit leaves. In conclusion, jackfruit leaf extract and its polar fractions have significant antioxidant activity and show promise for further development as natural antioxidant agents in nutraceutical formulations aimed at preventing oxidative stress-related diseases.
Co-Authors 'Aina Fahrina Anwar . Haryoto . Haryoto, . . Muhtadi . MUHTADI A Anifatussaa'dah Abdillah, Safira Mafaza Abdul Rohman Abdul Rohman Abidi, Subhan R Aditya Naova Sofyan Aditya Naova Sofyan Aflit Nuryulia Praswati Agus Salim Maulana Agus Triyono Agus Ulinuha Agustono Wibowo Ahmad Fauzi Ahmad, Farhand Ahwan Ahwan Ainur Tri Hapsari Aisy, Inandrohatul Alida Rahmalia Damayanti Alvita Marshanda Purnama Puteri Amalinda Ayu Faroska Anifatussaa'dah, A Annissa, Yanis Nur Anwar, 'Aina Fahrina Ardalia Rinanda Oktaviani Arief Nurrochmad Arifah Sri Wahyuni Asti, Dhinar Aulia Tassya Fadhilla Auliya, Dhiyahul Aurum, Mursalina Nanda Basusena, Rahardian Surya Broto Santoso Burhanudin Ichsan Cahyaningrum, Safira Citra, Tia Mella Citradewi, Lia Intan Da'i, Muhammad Dedi Hanwar Devi Eka Nitoviani Dewi, Triana Ariska Didik Setiawan Didin Mujahidin Djoko Wahyono Dwi Lestari Dwi Sarbini Dzafira, Laila Eka Prasnaparamita W Eky Wahyu Novarista Em Sutrisna Erindyah Retno Wikantyasning Erlya Ayusari Ramly Erna Herawati Erna Herawati, Erna Fadhilla, Aulia Tassya Fahriza Mei Trihatmoko Fajrina Eka Puspa Farah Salsabila Farid Adi Prasetya Faridita khoirun Nisa' Faroska, Amalinda Ayu Fauzi Ahmad Muda Fidhia Nur Rifaini Fitriani, Rizki Ainun Frida Rosenova Gunawan Setyadi Hadi, Ismanurrahman Haliza Arzeti Nurseptiria Hamimatusalma Alkautsar Hamzah, Hasyrul Handayani, Vivi Resty Hapsari, Atikah Haryoto - Haryoto Haryoto Haryoto, H Haya Nabilah Utama Heni Lutfiyati, Heni Hesti Pawarti Hesti Pawarti HI, Marsilia Rosa Sinensis Hidajah Rachmawati Hidayah Karuniawati Hidayati, Ria Husna Amalia Halwa Ichsan, Burhanudin Ida Maesaroh Ida Maesaroh, Ida Ihwan Susila Ika Trisharyanti Dian Kusumowati Istiara Subekti Istiara Subekti Jessica Rosalinda Joko Priyanto Wibowo Kasful Asra Sakika Keisya, Aulita Khairunnisa Azani Meilinasary, Khairunnisa Azani Kharisma Aulia Husna Khusnul Khotimah khusnul khotimah Kumalla, Novea Kusumastuti, Lina Ayu Laila Dzafira Lia Intan Citradewi Lina Ayu Kusumastuti Listiana Masyita Dewi M Muhtad Manggo, Tasya Faradillah Mariska Sri Harlianti Marsilia Rosa Sinensis HI Marsya, Vitania MAULANA, RIZA Muhammad Da'i Muhammad Haqqi Hidayatullah Muhtad, M Muhtadi Muhtadi - Muhtadi Muhtadi Muhtadi, M Munawwarah Munawwarah Muslihah, Sayyidah Nurul Nida’ Nur Jannah Nindita Fransiska Rahmawati Nisa', Faridita khoirun Nur Muhammad Arrizky Nurcahyanti . Nurcahyanti Wahyuningtyas Nurcahyanti Wahyuningtyas, Nurcahyanti Nurseptiria, Haliza Arzeti Nurul Tri Anggraini Oktaviani, Ardalia Rinanda Pawarti, Hesti Pawarti, Hesti Pebriani, Sonia Ardilla Peni Indaryudha Peni Indaryudha, Peni Peni Indrayudha Prastiyanto, Muhammad Evy Puruhita, Ranatri Puspa, Fajrina Eka Putri, Ega Annisa Raafika Studiviani Rahardian Surya Basusena Rarastoeti Pratiwi Ria Utami, Primanitha Rifaini, Fidhia Nur Rizal Maarif Rukmana Rizal Maarif Rukmana, Rizal Maarif Rizki Ainun Fitriani Rizky Ainun Fitriani Rosa Sayentina Amin Sabtanti Harimurti, Sabtanti Safira Cahyaningrum Sari Haryanti Sayyidah Nurul Muslihah Selviana, S Siti Aisyah Siti Aisyah Studiviani, Raafika Subhan R Abidi Tanti Azizah Tanti Azizah Sujono Tasysaningtyas, Thalia Fiandra Tia Mella Citra Tista Ayu Fortuna Trihatmoko, Fahriza Mei Utama, Haya Nabilah Vera Widyastuti Vitania Marsya Vivi Resty Handayani Wahyu Utami Weka Sidha Bhagawan Widyastuti, Vera Yanis Nur Annissa