Claim Missing Document
Check
Articles

Anticancer Efficacy of a Combination of Curcuma longa L. Rhizome and Annona muricata L. Leaf Extracts Against T47D Cells Pebriani, Sonia Ardilla; Bhagawan, Weka Sidha; Prastiyanto, Muhammad Evy; Rukmana, Rizal Maarif; Pratiwi, Rarastoeti; Suhendi, Andi
Science and Technology Indonesia Vol. 11 No. 2 (2026): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.2.405-419

Abstract

Breast cancer remains one of the most prevalent malignancies worldwide. The use of combinations of natural products is increasingly recognized as a promising strategy for cancer treatment. Turmeric rhizome (Curcuma longa L.) and soursop leaves (Annona muricata L.) are two natural materials known for their anticancer potential. This study aimed to identify the phytochemical constituents of turmeric rhizome and soursop leaf extracts and to evaluate the anticancer activity of their combination against T47D breast cancer cells. Turmeric and soursop leaves were extracted with 96% ethanol using the maceration method. Raw material standardization was performed by measuring water content, ethanol-soluble content, and water-soluble content. The extract was standardized by thin-layer chromatography. T47D and Vero cell lines were used in this study. Compound identification was performed using Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry (LC/Q-TOF-MS). The candidate combination ratio was determined using the simplex lattice design approach in Design Expert 13 software. Cytotoxicity and antiproliferative effects were assessed using the MTT assay, while antimetastatic potential was evaluated through the scratch assay. Apoptosis and cell cycle arrest were analyzed by flow cytometry. IC_50 data were analyzed using one-way ANOVA, and post hoc testing was performed using Tukey’s multiple-comparison test. Antiproliferation and scratch assay data were analyzed using two-way ANOVA followed by the Bonferroni test. Apoptosis and cell cycle assay data were analyzed using one-way ANOVA followed by the Tukey post hoc test. Phytochemical profiling indicated the existence of fifteen chemicals in both turmeric rhizome and soursop leaf extracts. The candidate combination ratio of turmeric rhizome to soursop leaf extracts was 1:21, exhibiting cytotoxic activity with an IC50 value of 32.2 ± 2.5 ug/mL. The combined extract was associated with antiproliferative, anti-migratory, and pro-apoptotic responses and induced G2/M phase cell cycle arrest in T47D cells.
Co-Authors 'Aina Fahrina Anwar . Haryoto . Haryoto, . . MUHTADI . Muhtadi A Anifatussaa'dah Abdillah, Safira Mafaza Abdul Rohman Abidi, Subhan R Aflit Nuryulia Praswati Agus Triyono Agus Ulinuha Ahmad, Farhand Ainur Tri Hapsari Aisy, Inandrohatul Alida Rahmalia Damayanti Alvita Marshanda Purnama Puteri Amalinda Ayu Faroska Anifatussaa'dah, A Annissa, Yanis Nur Anwar, 'Aina Fahrina Ardalia Rinanda Oktaviani Arief Nurrochmad Arifah Sri Wahyuni Asti, Dhinar Aulia Tassya Fadhilla Auliya, Dhiyahul Aurum, Mursalina Nanda Basusena, Rahardian Surya Broto Santoso Burhanudin Ichsan Cahyaningrum, Safira Citra, Tia Mella Citradewi, Lia Intan Da'i, Muhammad Dedi Hanwar Dewi, Triana Ariska Didik Setiawan Djoko Wahyono Dwi Lestari Dwi Sarbini Dzafira, Laila Eka Prasnaparamita W Eky Wahyu Novarista Em Sutrisna Erindyah Retno Wikantyasning Erlya Ayusari Ramly Erna Herawati Erna Herawati, Erna Fadhilla, Aulia Tassya Fahriza Mei Trihatmoko Farah Salsabila Farid Adi Prasetya Faridita khoirun Nisa' Faroska, Amalinda Ayu Fauzi Ahmad Muda Fidhia Nur Rifaini Fitriani, Rizki Ainun Fortuna, Tista Ayu Frida Rosenova Gunawan Setyadi Hadi, Ismanurrahman Haliza Arzeti Nurseptiria Hamimatusalma Alkautsar Hamzah, Hasyrul Handayani, Vivi Resty Hapsari, Atikah Haryoto - Haryoto Haryoto Haryoto, H Haya Nabilah Utama Heni Lutfiyati, Heni Hesti Pawarti HI, Marsilia Rosa Sinensis Hidajah Rachmawati Hidayah Karuniawati Hidayati, Ria Husna Amalia Halwa Ichsan, Burhanudin Ida Maesaroh Ida Maesaroh, Ida Ika Trisharyanti Dian Kusumowati Jessica Rosalinda Joko Priyanto Wibowo Kasful Asra Sakika Keisya, Aulita Khairunnisa Azani Meilinasary, Khairunnisa Azani Kharisma Aulia Husna Khusnul Khotimah khusnul khotimah Kumalla, Novea Kusumastuti, Lina Ayu Laila Dzafira Lia Intan Citradewi Lina Ayu Kusumastuti Listiana Masyita Dewi M Muhtad Manggo, Tasya Faradillah Mariska Sri Harlianti Marsilia Rosa Sinensis HI Marsya, Vitania MAULANA, RIZA Muhammad Da'i Muhtad, M Muhtadi Muhtadi - Muhtadi Muhtadi Muhtadi, M Muslihah, Sayyidah Nurul Nida’ Nur Jannah Nisa', Faridita khoirun Nur Muhammad Arrizky Nurcahyanti Wahyuningtyas Nurcahyanti Wahyuningtyas, Nurcahyanti Nurseptiria, Haliza Arzeti Nurul Tri Anggraini Oktaviani, Ardalia Rinanda Pawarti, Hesti Pawarti, Hesti Pebriani, Sonia Ardilla Peni Indaryudha Peni Indaryudha, Peni Prastiyanto, Muhammad Evy Puspa, Fajrina Eka Putri, Ega Annisa Raafika Studiviani Rahardian Surya Basusena Ranatri Puruhita Rarastoeti Pratiwi Ria Utami, Primanitha Rifaini, Fidhia Nur Rizal Maarif Rukmana, Rizal Maarif Rizki Ainun Fitriani Rizky Ainun Fitriani Rosa Sayentina Amin Sabtanti Harimurti, Sabtanti Sari Haryanti Sayyidah Nurul Muslihah Selviana, S Siti Aisyah Siti Aisyah Studiviani, Raafika Subekti, Istiara Subhan R Abidi Tanti Azizah Sujono Tasysaningtyas, Thalia Fiandra Tia Mella Citra Tista Ayu Fortuna Trihatmoko, Fahriza Mei Utama, Haya Nabilah Vitania Marsya Vivi Resty Handayani Wahyu Utami Weka Sidha Bhagawan Widyastuti, Vera Yanis Nur Annissa