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All Journal JURNAL PENELITIAN SAINTIKA Science and Technology Indonesia Sinkron : Jurnal dan Penelitian Teknik Informatika Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Jambura Journal of Health Sciences and Research Jurnal Dunia Farmasi Indonesian Journal of Pharmaceutical and Clinical Research Journal of Pharmaceutical and Health Research Jurnal Indah Sains dan Klinis Journal of Fundamental and Applied Pharmaceutical Science FORTE JOURNAL Mejuajua JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Sains dan Teknologi Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Miracle Journal Jurnal Riset Rumpun Matematika dan Ilmu Pengetahuan Alam (JURRIMIPA) Jurnal Natural Journal of Pharmaceutical and Sciences. Molekul: Jurnal Ilmiah Kimia GEMBIRA (Pengabdian Kepada Masyarakat) PEDAMAS (Pengabdian Kepada Masyarakat) Journal of Innovative and Creativity Jurnal Indah Sains dan Klinis
Nilsya Febrika Zebua, Nilsya Febrika
Faculty Of Pharmacy, Universitas Tjut Nyak Dhien, Medan, 20123, Indonesia
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Analisis Farmakokinetik Klinik Dosis Obat Pasien Hipertensi Komplikasi Gagal Di RSUD Dr. Pirngadi Medan Nilsya Febrika Zebua; Peri Aisyah Zubaidi; Sumardi; Suprianto; Shofian Syarifuddin; Risma Yeni
Jurnal Indah Sains dan Klinis Vol 4 No 1 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i1.06

Abstract

Background: Hospitals are health service providers providing emergency care, outpatient and inpatient. Hypertension occurs when blood pressure is above normal. Clinical conditions that require dialysis treatment have a tendency to kidney failure. This effort is related to the field of clinical pharmacokinetics. Objective: The study was conducted to analyze the dose of drug administration in conditions complicated by kidney failure in hypertensive patients. Methods: The study went through a sampling stage of data from hypertensive patients complicated by kidney failure, data according to inclusion criteria, calculation of creatinine clearance, analysis of dose adjustments and creatinine clearance. Results: The study obtained 170 data, which met the inclusion criteria of 30 data. Drugs with a narrow therapeutic index and worsening kidney function that patients received included: digoxin, captopril, ranitidine, furosemide, ciprofloxacin, and cefriaxone in 2, 13, 9, 12, 3, and 8 cases respectively. Conclusion: According to dose adjustment calculations for patient creatinine clearance, it was found that the drug exceeded the individual dose in 6 out of 9; 8 of 13; and 2 cases each using ranitidine, captopril, digoxin
Co-Authors Abdi Wira Septama Afni Saufa Yarda Akmil Hidayah Alizha Aisyah Andre Aditya Andrian, Dedek Anggraeini, Dea Anggraini, Dea Anna Juniar Ari Usman Ari Usman, Ari Asih, Fivi Nur Aulia Milda Ayu Lestari, Eka BAKRI, TEDY KURNIAWAN Dacci, Kanne Dachi, Kanne dafitri salsabila Dahra, Aminatun Dea Amelia Adiatma Dea Anggraini Dessy Natalia Siahaan Desy Natalia Siahaan Desyandri Desyandri Dewi Hariman, Annisa Dikxi Putri Mulyana Effendy De Lux Putra, Effendy De Lux Elviana Elviana, Elviana Ernawaty Ginting Ernawaty Ginting Eva Sartika Dasopang Faisal Yusuf Fanny Rizki Sembiring Fathur Raihan Amri Febrianti, Yessi Fekbri Yanti Fujiko, Muflihah Furqaan Ali Kusuma Ginting, Ernawaty Hafizatun Suardi Hafizurrahman Hafizurrahman Hasri, Najwa Miladi Hidayat, Supran Ika Julianti Tambunan Ika Julianti Tambunan Imanuel Damanik Ira Eka Fahira Ira Nofriani JIHAN SAFIRA Julianti, Ika Kanne Dachi Khalisa Khalisa Khoiriyah Khairul Lidia Muliani Linda Margata Lubis, Salmah Handayani Marcella Maran Gabean Masrina Prihatini Meutia Indriana Mey Linda Hasibuan Mierza, Vriezka Miska Raihana Miswati Furqani Muflihah Fujiko Muflihah Fujiko Muflihah Fujiko Muharni Saputri Nabila Aini Nabilah Dinda Ramadani Nadia, Syarifah Nerdy Nerdy Nerdy, Nerdy Nia Zulkarnain Ningrum, Siti Rahmi Novriansyah, Reza Nurmala Sari Nurmala Sari Nurul Amalia Nurul Anggraini Nurul karima Nurul Karimah Panjaitan, M Ridho Pangestu Pasaribu, Indah Peri Aisyah Zubaidi Pinanga, Yangie Dwi Marga Prasetyo, Bayu Eko Pravil Mistryanto Tambunan Puji Lestari Putri, Ghera Fakhira Qalbiah Nurmilad B Rahma Yulia Rahma Yulia Rahmi Ningrum, Siti Razali, Mariany Rijalul Ihsan Rina Ridara Rini Karlina Putri Zega Riska Julia Safriana Risma Yeni Rosniwaty Br. Bangun Said Haikal Alfajar salmah handayani Lubis Salman Salman Saputri, Muharni Saputri, Muharni Sara Ariska Purba Shadiq Suwailim Shahira Yasmin Shelva Filiana Sari Shofian Syarifuddin Siahaan, Ririyen Dessy N Siti Aisyah Siti Arum Widiyanti siti muliani julianty Siti Rahmi Ningrum Siti Raudah Siti Salmiyah Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sulika Hati Sumardi Sumardi Sumardi . Sumardi Sumardi Supran Hidayat Supran Hidayat Supran Hidayat Suprianto Suprianto SURBAKTI, CHRISTICA ILSANNA Suryaningsih, Evi Syadzna Malika Maimun Syafitri, Yuni Syarifah Lisa Andriati Syarifah Nadia Tandra Alexandro Tari Putri Utami Rizki Tedy Kurniawan Bakri Tedy Kurniawan Bakri Ulpah, Ulpah Virda Widya Pratiwi Vivi Sofia Vonna Aulianshah Vriezka Mierza Winny Wastika Syahfitri Yanti , Fekbri Yessi Febriani Yuliasmi, Sri