Article Per Year (5 Year)
p-Index From 2021 - 2026
7.254
P-Index
This Author published in this journals
All Journal JURNAL PENELITIAN SAINTIKA Science and Technology Indonesia Sinkron : Jurnal dan Penelitian Teknik Informatika Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Jambura Journal of Health Sciences and Research Jurnal Dunia Farmasi Indonesian Journal of Pharmaceutical and Clinical Research Journal of Pharmaceutical and Health Research Jurnal Indah Sains dan Klinis Journal of Fundamental and Applied Pharmaceutical Science FORTE JOURNAL Mejuajua JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Sains dan Teknologi Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Miracle Journal Jurnal Riset Rumpun Matematika dan Ilmu Pengetahuan Alam (JURRIMIPA) Jurnal Natural Journal of Pharmaceutical and Sciences. Molekul: Jurnal Ilmiah Kimia GEMBIRA (Pengabdian Kepada Masyarakat) PEDAMAS (Pengabdian Kepada Masyarakat) Journal of Innovative and Creativity Jurnal Indah Sains dan Klinis Jurnal Praba: Jurnal Rumpun Kesehatan Umum
Nilsya Febrika Zebua, Nilsya Febrika
Faculty Of Pharmacy, Universitas Tjut Nyak Dhien, Medan, 20123, Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

Published : 53 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 53 Documents
Search

 2   3   4   5   6 
Analisis Farmakokinetik Klinik Dosis Obat Pasien Hipertensi Komplikasi Gagal Di RSUD Dr. Pirngadi Medan Nilsya Febrika Zebua; Peri Aisyah Zubaidi; Sumardi; Suprianto; Shofian Syarifuddin; Risma Yeni
Jurnal Indah Sains dan Klinis Vol 4 No 1 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i1.06

Abstract

Background: Hospitals are health service providers providing emergency care, outpatient and inpatient. Hypertension occurs when blood pressure is above normal. Clinical conditions that require dialysis treatment have a tendency to kidney failure. This effort is related to the field of clinical pharmacokinetics. Objective: The study was conducted to analyze the dose of drug administration in conditions complicated by kidney failure in hypertensive patients. Methods: The study went through a sampling stage of data from hypertensive patients complicated by kidney failure, data according to inclusion criteria, calculation of creatinine clearance, analysis of dose adjustments and creatinine clearance. Results: The study obtained 170 data, which met the inclusion criteria of 30 data. Drugs with a narrow therapeutic index and worsening kidney function that patients received included: digoxin, captopril, ranitidine, furosemide, ciprofloxacin, and cefriaxone in 2, 13, 9, 12, 3, and 8 cases respectively. Conclusion: According to dose adjustment calculations for patient creatinine clearance, it was found that the drug exceeded the individual dose in 6 out of 9; 8 of 13; and 2 cases each using ranitidine, captopril, digoxin
Comparative Evaluation Of Transdermal Patch Formulations From Ethanol Extract Of Soursop Leaves (Annona Muricata L.) Using Pvp–Ethyl Cellulose And Chitosan Polymer Systems Ernawaty Ginting; Syarifah Nadia; Nilsya Febrika Zebua; Nurul Karimah; Laila Nirwana Sari; Cindy Agustina; Manuella sinaga
Jurnal Praba : Jurnal Rumpun Kesehatan Umum Vol. 4 No. 3 (2026): September : Jurnal Praba : Jurnal Rumpun Kesehatan Umum
Publisher : STIKES Columbia Asia Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62027/praba.v4i3.960

Abstract

Background: Soursop leaves (Annona muricata L.) contain bioactive compounds including acetogenins, flavonoids, alkaloids, and tannins, which possess antioxidant, anti-inflammatory, and antitumor activities. Transdermal patch delivery systems offer significant advantages by bypassing hepatic first-pass metabolism, enabling controlled drug release, and improving patient adherence. Two independent formulation strategies were pursued: (1) a hydrophilic–hydrophobic PVP–Ethyl Cellulose (EC) matrix system, and (2) a chitosan-based biopolymer matrix system. Objectives: This study aimed to formulate and comparatively evaluate transdermal patches of soursop leaf ethanol extract using PVP K-30/ethyl cellulose (Study 1) and chitosan (Study 2) as polymer systems, and to determine the optimal formulation for each system based on physicochemical characteristics and in vitro diffusion performance. Methods: Ethanol extracts were prepared by maceration with 96% ethanol. Study 1 evaluated three PVP:EC ratios (F1: 1:1, F2: 1:2, F3: 1:3). Study 2 evaluated three chitosan concentrations (F1: 250 mg/50%, F2: 225 mg/45%, F3: 200 mg/40%). Both systems incorporated PEG 400 as plasticizer and oleic acid as penetration enhancer. Patches were evaluated for organoleptic properties, thickness, pH, folding endurance, and in vitro diffusion using Franz diffusion cells with phosphate buffer pH 7.4, measured by UV-Vis spectrophotometry at 266 nm. Results: Both polymer systems produced patches meeting pharmacopoeial physical requirements. Study 1: pH 5.26–5.47, thickness 0.1 mm, folding endurance >300; optimal formula F3 (PVP:EC = 1:3) achieved the highest cumulative diffusion of 119.087 µg/cm² at 360 min (R² calibration = 0.99909). Study 2: pH 4.30–4.59, thickness 0.35 mm, folding endurance >300; optimal formula F3 (chitosan 40%) achieved the highest cumulative diffusion of 327.44 µg/cm at 360 min with cumulative release of 0.655%. A clear inverse relationship between chitosan concentration and diffusion rate was established. Conclusion: Soursop leaf ethanol extract can be successfully formulated into transdermal patches using both PVP–EC and chitosan polymer systems. The chitosan-based system (F3: 40%) demonstrated superior total drug diffusion, while the PVP–EC system (F3: 1:3) produced a thinner, more uniform patch with controlled diffusion. Both formulations are promising candidates for further in vivo and stability studies.
Comparison Between The Suspension and Capsule Preparation from Waste of Avocado Seeds As Antidiarrhea in Induced Mouse Saputri, Muharni; Zebua, Nilsya Febrika; Asih, Fivi Nur; Putri, Ghera Fakhira
Journal of Fundamental and Applied Pharmaceutical Science Vol. 2 No. 2 (2022): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v2i2.13504

Abstract

Diarrhea is one type of disease with the most sufferers every year. Thus, it is considered an endemic disease in Indonesia and the potential disease of Extraordinary Events accompanied by mortality. One of the plants that can be used as a traditional medicine for diarrhea is the avocado seed, as it contains tannins, alkaloids, flavonoids, steroids and glycosides, which act as antidiarrheals. This study aims to determine the antidiarrheal effect of avocado seed extract suspension on mice induced by Oleum ricini and the optimum concentration of avocado seed extract suspension and capsules with an antidiarrheal effect in white male mice induced by Oleum ricini. The dosage forms chosen were suspension and capsules. This study used an experimental method with a test sample of the avocado seed. Avocado seed Simplicia was extracted by the percolation method, then an oral suspension and capsule formulation were made from the avocado seed methanol extract. It was evaluated and tested for its effectiveness with mice to cure diarrhea. Normal data were analyzed by One Way ANOVA and Post Hoc Tuckey Method. The results of this study showed that the administration of a suspension of avocado seed methanol extract at a dose of 800 mg/KgBB had the most optimum effect as an antidiarrheal against white male mice with a stool weight of 0.39 grams and a duration of diarrhea for 74 minutes. Furthermore, the administration of avocado seed extract capsules at a dose of 75 mg/KgBB had the most optimum effect as antidiarrheal against white male mice with Loperamide as a positive control. Therefore, it can be concluded that all suspension formulations and capsules of avocado seed methanol extract met the requirements for preparation evaluation. Suspension and avocado seed methanol extract capsules can cure diarrhea in white male mice.
Co-Authors Abdi Wira Septama Afni Saufa Yarda Akmil Hidayah Alizha Aisyah Andre Aditya Andrian, Dedek Anggraeini, Dea Anggraini, Dea Anna Juniar Ari Usman Ari Usman, Ari Asih, Fivi Nur Aulia Milda Ayu Lestari, Eka BAKRI, TEDY KURNIAWAN Cindy Agustina Dacci, Kanne Dachi, Kanne dafitri salsabila Dahra, Aminatun Dea Amelia Adiatma Dea Anggraini Dessy Natalia Siahaan Desy Natalia Siahaan Desyandri Desyandri Dewi Hariman, Annisa Dikxi Putri Mulyana Effendy De Lux Putra, Effendy De Lux Elviana Elviana, Elviana Ernawaty Ginting Ernawaty Ginting Eva Sartika Dasopang Faisal Yusuf Fanny Rizki Sembiring Fathur Raihan Amri Febrianti, Yessi Fekbri Yanti Fujiko, Muflihah Furqaan Ali Kusuma Ginting, Ernawaty Hafizatun Suardi Hafizurrahman Hafizurrahman Hasri, Najwa Miladi Hidayat, Supran Ika Julianti Tambunan Ika Julianti Tambunan Imanuel Damanik Ira Eka Fahira Ira Nofriani JIHAN SAFIRA Julianti, Ika Kanne Dachi Khalisa Khalisa Khoiriyah Khairul Laila Nirwana Sari Lidia Muliani Linda Margata Lubis, Salmah Handayani Manuella sinaga Marcella Maran Gabean Masrina Prihatini Meutia Indriana Mey Linda Hasibuan Mierza, Vriezka Miska Raihana Miswati Furqani Muflihah Fujiko Muflihah Fujiko Muflihah Fujiko Muharni Saputri Nabila Aini Nabilah Dinda Ramadani Nadia, Syarifah Nerdy Nerdy Nerdy, Nerdy Nia Zulkarnain Ningrum, Siti Rahmi Novriansyah, Reza Nurmala Sari Nurmala Sari Nurul Amalia Nurul Anggraini Nurul karima Nurul Karimah NURUL KARIMAH Panjaitan, M Ridho Pangestu Pasaribu, Indah Peri Aisyah Zubaidi Pinanga, Yangie Dwi Marga Prasetyo, Bayu Eko Pravil Mistryanto Tambunan Puji Lestari Putri, Ghera Fakhira Qalbiah Nurmilad B Rahma Yulia Rahma Yulia Rahmi Ningrum, Siti Razali, Mariany Rijalul Ihsan Rina Ridara Rini Karlina Putri Zega Riska Julia Safriana Risma Yeni Rosniwaty Br. Bangun Said Haikal Alfajar salmah handayani Lubis Salman Salman Saputri, Muharni Saputri, Muharni Sara Ariska Purba Shadiq Suwailim Shahira Yasmin Shelva Filiana Sari Shofian Syarifuddin Siahaan, Ririyen Dessy N Siti Aisyah Siti Arum Widiyanti siti muliani julianty Siti Rahmi Ningrum Siti Raudah Siti Salmiyah Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sulika Hati Sumardi Sumardi Sumardi . Sumardi Sumardi Supran Hidayat Supran Hidayat Supran Hidayat Suprianto Suprianto SURBAKTI, CHRISTICA ILSANNA Suryaningsih, Evi Syadzna Malika Maimun Syafitri, Yuni Syarifah Lisa Andriati Syarifah Nadia Syarifah Nadia Tandra Alexandro Tari Putri Utami Rizki Tedy Kurniawan Bakri Tedy Kurniawan Bakri Ulpah, Ulpah Virda Widya Pratiwi Vivi Sofia Vonna Aulianshah Vriezka Mierza Winny Wastika Syahfitri Yanti , Fekbri Yessi Febriani Yuliasmi, Sri