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Journal : International Journal of Health Science and Technology

In Silico Study of Brazilin from Secang Wood (Caesalpinia Sappan L) as a Candidate for Splenomegaly Therapy Youngest, Racy; Rusdianto, Rusdianto; Kamisah, Yusof; Maskoen, Ani Melani; Safitri, Ratu
International Journal of Health Science and Technology Vol. 6 No. 3 (2025): April
Publisher : Universitas 'Aisyiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31101/ijhst.v6i3.4032

Abstract

Brazilin is a flavonoid found in secang (sappan) wood extract (Caesalpinia sappan L) currently undergoing clinical trials in phase 2 for the treatment of thalassemia patients. It is recognized for its antioxidant effects and its efficacy as a strong iron chelator, facilitating the binding and excretion of excess iron in the bloodstream of patients with thalassemia. This flavonoid compound may serve as a Janus kinase 2 (JAK2) inhibitor through the EPO/EPOR/JAK2/STAT5 pathway, which is responsible for splenomegaly (enlarged spleen). This study aims to investigate the mechanism by which sappan wood metabolite chemicals (brazilin) inhibit JAK2 in silico. This inhibition is expected to reduce splenomegaly in thalassemia patients and serve as an alternative to ruxolitinib (conventional medications). The pharmacokinetic profile of the ligand is predicted according to Lipinski's rule, while the binding energy (ΔG), initiation constant, and chemical bonds are examined using molecular docking with AutoDock v.4.25. This study successfully determined that brazilin, with a binding energy of -8.37 kcal/mol, is comparable to ruxolitinib, which has a binding energy of -8.71 kcal/mol. This finding shows that brazilin derived from sappan wood contains bioactive chemicals with potential JAK2 inhibitory activities. This finding establishes a foundation for further research aimed at developing new therapeutic agents for the treatment of splenomegaly in β-thalassemia and associated disorders.
Co-Authors . Syamsulbahri Acep Fatchuroji Achmad Nurmandi Adestu, Zakiyya Salwa Agung Prasetya Agusta, Rendra Agustin, Yuli Aini, Ratri Zhohratun Akbar, Hairil Alamsyah Elang Nusa Herlambang, Alamsyah Elang Nusa Aluyah, Cik Amaliyah , Tsabitah Amaliyah, Tsabitah Angelia Sebayang, Fransisca Ani Melani Maskoen Animalesto, Gloria Apriliani, Fanis Arfiansyah , Ferry Asfar, Akbar Ash-Shiddieqiey, Muh Nu’man Ayunda, Rahmi Aziz SR, Abdul Bassi, Aliming Budi, Anang Setyo Cahyaningtyas, Cindy Dwi Christine Wulandari Damayanti, Ayu Elysia Darmin Darmin, Darmin Desfitrina Diah Wahyuni Dwi Anggorowati Rahayu Dwijayanti, Endah Dzulkifli Nurul Huda Elfrida Ratnawati Encilia, Encilia Endik Deni Nugroho Eva Desembrianita fatimah Fatimah Fatmala, Eva Fauzia, Ana Ferdian, Pamungkas Rizki Fikri Permana, Muhammad Fitriani, Ika Fitriani Frenia, Zidni Valida Chastity Gema Wahyudewantoro, Gema Hafsah, Umi Hamdani, Fathul Hanum, Farrah Fadhillah Hariyanti, Salsa Alviana Putri Hasanuddin, Fenny Hastuti Hastuti Hidayat, Arnur Hidayat, Fayzabila Shofwa I Ketut Mahardika I Wayan Krisna Eka Putra I Wayan Treman Ida Ayu Putu Sri Widnyani Iin Narwanti Indarti, Khofifah Indra Gumay Febryano Indra Muda, Indra Indrawati Indrawati Ismail, Muhammad Nur Khatir Jasin, Mochammad Jayadi Jayadi Jiniari Apriska Dewi, Jiniari Apriska Judijanto, Loso Jumaniar, Jamiatul Juslan Kamisah, Yusof Kasah, Iwang Jouvanda Kunto Wibowo Kusumawardhani, Budi Kuswandono, Kuswandono Lestari, Rimadina Sukmasuci Loilatu, Mohammad Jafar Lukman, Syahid Mamat, Noorhidayah Binti Mardhiyyah, Lailatul Marlina, Sitti Mash'ud, Imam Maulidia, Ananda Putri Miranda, Yussy Mohamed, Muhammad Azimuddin Muhamad Damanhuri, Muhd Ibrahim Muhamad Yani, Muhamad Muliana, Siti Mulyadi Mulyadi Nana Supriatna Netti Aryani Ningsih, Silvi Putri Ayu Nofirman, Nofirman Nugraha, Petera Nur Ahmad, Nur Nurhaman, Ujang Nurinsiyah, Ayu Savitri Nurrahma, Yoan Melly Palupi, Lutfia Indah Petir Pudjantoro, Petir Prabowo, Diky Pramudya Dwi Aristya Putra Pratama Siswanto, Alvin Putra Putra, Gea Permana Antara putra, Heriansyah Dwi Qodri, Agmal Rabbani, Calista Naya Rachman, Lucky Juniar Rahmadani, Nur Izati Rahmawati, Rahmawati Ramadhan, Tegar Zaeni Rasyid, Lisa Aisyiah Ratu Safitri Rena Tri Hernawati Ridlo, Zainur Rasyid Risky, Sartini Rizky, Dyah Astiari Rohmawati, Ifatur Rokhmayanti, Rokhmayanti Rusdaya Basri, Rusdaya Sajati, Fatah Abdul Salfiana, Salfiana Samsul Bakri Saputra, Rengga Saputri, Anastasya Eka Sa’diyah, Halimatus Shidiq, Fajrin Sirait, Eka Ria Novita Sari Siti Helmyati Siti Zubaidah Slamet Budi Yuwono Sri Wahyuni Suhada, Isa Sukendi Sukendi Sukma, Fena Dheta Sulung, Cahya Ajeng Valenta Tresna Sunuwati, Sunuwati Supeno Susanti, Maya Sushadi, Pangda Sopha Syaiful , Muhammad Syaiful Rizal Tang, Jusman Ulin Nuha, Ulin Utami, Budi Barata Kusuma Vella, Anisyah Wafiyah, Lutfiyatul Wicaksono, Iwan Widayanti, Anis Widayanti, Ayu Wulandari, Elok Utami Putri Yanuarizal, Alfain Wahid Yohanna, Yohanna Yona Ratri, Anindhita Youngest, Racy Yustika Sari, Rossa Zahra, Mutiara Shofia Zulfadhli Zulfadhli Zulfikar Ali Ahmad