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All Journal Universa Medicina Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Biomedika dan Kesehatan SULTANIST: Jurnal Manajemen dan Keuangan Maker: Jurnal Manajemen Jurnal ABDINUS : Jurnal Pengabdian Nusantara Jurnal Pengabdian kepada Masyarakat Nusantara International Journal Of Science, Technology & Management (IJSTM) Journal of Management and Entrepreneurship Research International Journal of Community Service JUARA: JURNAL WAHANA ABDIMAS SEJAHTERA Jurnal Indonesia Sosial Sains Room of Civil Society Development AMMA : Jurnal Pengabdian Masyarakat Room of Civil Social Development
Sisca Sisca, Sisca
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PROFIL SUBKLAS IGG PADA INDIVIDU PENERIMA VAKSIN COVID19 PLATFORM VEKTOR VIRUS Mahardieni, Karlina; Samira, Jihan; Hartanti, Monica Dwi; Sisca, Sisca; Kurniawan, Yani; Hidayat, Syarif
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 1 (2025): Volume 12 Nomor 1
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i1.16313

Abstract

Respon imun pasca vaksinasi COVID19 beragam dikarenakan proses pembuatan vaksin yang dipercepat untuk mengatasi pandemi COVID19 yang ada. Tujuan penelitian adalah untuk mendapatkan data respon imun seluler individu pasca vaksinasi COVID19 vektor virus sebagai data penunjang kebijakan vaksinasi COVID19 di Indonesia. Metode penelitian yang akan dilaksanakan adalah penggunaan bahan baku tersimpan (BBT) berupa plasma dari individu yang menerima vaksin COVID19 vektor virus yang diambil pada enak titik waktu yang berbeda. Metode Elisa digunakan untuk menilai kadar subklas immunoglobulin G yang ada dalam plasma individu yang menerima vaksinasi COVID19. Uji repeated one-way ANOVA atau Uji Firedman digunakan untuk menganalisa rerata beda kadar subklas IgG pada 4 kelompok berdasarkan waktu. Hasil menunjukkan bahwa subklas IgG1 mendominasi kadar keseluruhan subklas IgG pada keenam titik point waktu.  Terdapat perbedaan yang bermakna kadar IgG1 dan IgG2 berdasarkan waktu (p<0,0001), namun tidak ditemukan perbedaan yang bermakna pada subklas IgG3 (p=0,276) dan IgG4 (p=0,967). Penelitian ini menunjukkan bahwa kadar subklas IgG1 dan IgG2 dapat dijadikan penanda peningkatan imunitas individu penerima vaksin COVID19 vektor virus.
Effects of low-dose filtered kretek cigarette smoke on bronchial smooth muscle in male Sprague-Dawley rats Tjahyadi, David; Parwanto, Edy; Sisca, Sisca; Xavierees, Endrico; Jaya Edy, Hosea; Digambiro, Reza Aditya; Oladimeji, Ashaolu Victoria; Tjahyadi, Joey Joshua Vidova; Gabrielle, Laurentia
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.263-275

Abstract

BackgroundKretek cigarettes contain less nicotine and tar than conventional cigarettes. Exposure to cigarette smoke occurs mainly in the respiratory tract, resulting in histometric changes. The aim of this study was to evaluate the effect of filtered kretek cigarette smoke on bronchial histometric measurements in male Sprague-Dawley rats. MethodsAn experimental laboratory study was conducted involving 18 male Sprague-Dawley rats, aged 2-3 months, ranging from 150 to 250 grams in body weight. They were randomized into group 1 (controls) and experimental groups 2 and 3. Group 2 was exposed to filtered cigarette smoke at a dose of 1 stick/day and group 3 to 2 sticks/day. Treatment time for all groups was 30 days. Observation of bronchial histometric measurements of the lumen include, length, width, area, and perimeter. In addition, the bronchial mucosal and smooth muscle layers were also measured. The one way-ANOVA test was used to analyze the data. ResultsThe mean area and mean perimeter of the bronchial lumen of the rats were significantly greater in group 1 than in groups 2 and 3 (p=0.000). The mean bronchial smooth muscle area of the rats in group 1 was smaller than the mean in group 2, which was in turn smaller than the mean in group 3 (p=0.000). Apparently the rats in the treatment groups had undergone bronchoconstriction. ConclusionExposure to filtered kretek cigarette smoke at a dose of 1 stick/day as well as 2 sticks/day for 30 days caused bronchial mucosal hyperplasia and bronchoconstriction in male rats.
Exploring the Relationship Between Sod1, 2 And 3 Gene Polymorphisms With Post-Covid19 Symptoms Thabit, Jihan Samira; Sisca, Sisca; Hartanti, Monica Dwi; Prasetyaningsih, Noviani; Kogoya, Alvionita; Devita, Arleen; Bela, Isa; Effendi, Ida
Jurnal Indonesia Sosial Sains Vol. 5 No. 04 (2024): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v5i04.1097

Abstract

The coronavirus disease 19 (COVID-19) has become a challenge for the media world. Even though they have been declared cured, some Covid-19 survivors still have health complaints. Abnormal symptoms, signs, or clinical parameters that persist two weeks or more after the onset of COVID-19 and do not return to their initial healthy state are potentially considered long-term effects of the disease. Although such changes are primarily reported in people with severe and critical illness, lasting effects also occur in individuals with mild infections that do not require hospitalization. This study aims to explore the role of antioxidants on the pathogenesis of Covid19 and its relationship with SOD1, 2 and 3 genomic variations. Getting alternative biomarkers for long covid19 detection. Research Method: The research sample is blood and questionnaires that will be taken from respondents affected by Covid19 a maximum of 6 months before data collection is held. Furthermore, DNA isolation, DNA amplification, cutting with restriction enzymes, and DNA band documentation with gel electrophoresis will be carried out. Symptoms related to systemic are the most common symptoms found in respondents with Long Covid19. A total of 8 respondents had systemic related symptoms, namely weakness, lethargy and sweating, while skin-related complaints were found in three respondents and one respondent had lung-related complaints. The average SOD activity value of respondents was 2.19 U/ml. In this study, more symptoms of long COVID-19 were found associated with systemic and cardiovascular symptoms. The complaints were not differentiated by the sex of the respondents. The output draft will be processed immediately after getting other results.
Pengukuran suhu, pH dan kadar substrat terhadap aktivitas enzim Galactose-1-Phosphate Uridyltransferase Sisca, Sisca; Parwanto, Edy; Hartanti, Monica Dwi; Tjahyadi, David
Jurnal Indonesia Sosial Sains Vol. 5 No. 07 (2024): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v5i07.1177

Abstract

Galactose-1-phosphate uridyltransferase (GALT) is an important enzyme involved in galactose metabolism. Understanding the factors influencing GALT activity is critical to elucidate its physiological role and potential therapeutic implications in galactosemia. In developing new drugs, chicken intestine/liver powder can be used as an enzyme source, GALT, to treat galactosemia. Therefore, it is necessary to research the characterization of the GALT enzyme in chicken intestine and liver powder. In this study, we investigated the influence of temperature, pH, and substrate level on GALT enzyme activity using an experimental approach in vitro. The optimum pH extraction results show that the optimum pH for the extraction of the chicken intestine and liver GALT is pH 7, with activity values ​​of 0.47 units/mL and 0.3953 units/mL, respectively. The optimum temperature for the extraction of chicken intestine and liver GALT is 37℃ with substrate hydrolysis capabilities of 0.48 U/mL and 0.57 U/mL, respectively. Meanwhile, the optimum substrate content is 400x. These insights provide a valuable foundation for further research aimed at comprehensively understanding GALT function, developing targeted interventions for disorders of galactose metabolism, and possible application in the development of new drugs for galactosemia
Self-Sampling for Cervical Cancer: a Scoping Review Murthi, Aditya Krishna; Kurniawan, Yani; Yunitra, Imelda; Halim, Catherine; Sisca, Sisca
Jurnal Indonesia Sosial Sains Vol. 6 No. 8 (2025): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v6i8.1839

Abstract

Cervical cancer remains a major global health concern, particularly in low- and middle-income countries (LMICs), where barriers such as limited healthcare access, cultural stigma, and logistical challenges hinder routine screening. Human papillomavirus (HPV) self-sampling has emerged as a promising alternative to clinician-collected sampling, offering the potential to improve screening coverage and reduce the burden of cervical cancer. This scoping review aims to synthesize current evidence on the feasibility, effectiveness, and acceptability of HPV self-sampling, with a focus on its impact on screening uptake, psychological outcomes, and diagnostic accuracy. Following the PRISMA-ScR guidelines, a systematic search was conducted across PubMed, Google Scholar, and Scopus, resulting in the inclusion of five studies: four randomized controlled trials and one umbrella review. Findings indicate that self-sampling reduces anxiety associated with cervical screening, improves participation among underserved populations, and demonstrates high diagnostic concordance with clinician-collected samples. Behavioral interventions, such as pay-it-forward models, show potential to enhance sample return and feedback rates. However, challenges remain regarding effective triage strategies for HPV-positive cases, especially in resource-limited settings. The review supports the integration of self-sampling into national screening programs, emphasizing the need for culturally tailored approaches and continued research on cost-effective triage methods.
Driving Green Innovation for Sustainable Performance: An Empirical Study of Micro Enterprises in North Sumatra, Indonesia Sisca, Sisca; Wijaya, Andy; Setyawati, Christina Yanita; Sudirman, Acai
Journal of Management and Entrepreneurship Research Vol. 6 No. 4 (2025)
Publisher : Universitas Islam Nahdlatul Ulama Jepara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34001/jmer.2025.12.06.4-77

Abstract

Objective: This study aimed to investigate the key factors driving the adoption of green innovation and how the adoption relates to the enhancement of sustainable business performance in North Sumatra context. Research Design & Methods: A quantitative design was applied through structural equation modeling (SEM) with SmartPLS software, based on data previously collected from 371 Micro, Small, and Medium Enterprises (MSMEs) in food and beverage (F&B) sector. Findings: The results showed that organizational factors, human resources, and technology were significant drivers in implementing green innovation. The adoption of this innovation has been proven to contribute positively to the social and environmental aspects of sustainable performance, although it did not have a significant impact on the economic aspect. Implications & Recommendations: This study provided valuable insights on green innovation, a topic that has received limited scholarly focus in the context of North Sumatra MSMEs. It also offered more insights into previously unanswered questions regarding the determinants of green innovation adoption and their potential role in fostering sustainable performance among MSMEs. Contribution & Value Added: Theoretically, this study expanded the use of Resource-Based View (RBV) by emphasizing the importance of internal resource management directed toward environmentally sound innovation to achieve sustainable competitive advantage. Practically, the results provided strategic guidance for MSMEs and policymakers in designing resource-based policies to encourage transformation toward sustainability.
Penyuluhan dan Pelayanan Kesehatan Sebagai Upaya Memperbaiki Manajemen Hipertensi Pada Lansia Di Kelurahan Jembatan Lima Kecamatan Tambora Jakarta Sisca, Sisca; Hartanti, Monica Dwi; Setyaningrum, Dyah Ayu Woro; Lestari, Indah Widya; Ilona, Florinda; Chendrasari, Julian; Parwanto, ML Edy
Jurnal ABDINUS : Jurnal Pengabdian Nusantara Vol 4 No 1 (2020): Volume 4 Nomor 1 Tahun 2020
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/ja.v4i1.13977

Abstract

The incidence of hypertension increases with age. Alterations in function and structure in peripheral vascular system are thought to be the cause of high prevalence of hypertension in the elderly. Holistic, patient-centered management of hypertension is needed to prevent deaths from heart failure. This community service aimed to find out the level of knowledge about hypertension in residents of Jembatan Lima Sub-district, Tambora District, West Jakarta. Using a questionnaire, the level of knowledge was studied in 48 participants cross-sectionally. Blood pressure measurements were also carried out to describe the incidence of hypertension in that area. There was a low level of knowledge about hypertension among participants and this had an impact on increasing the risk of hypertension. Fifty-two percent of participants had normal blood pressure, whereas 48% participants were diagnosed as hypertension. Based on demographic data of participants obtained during the event, age, sex, education level and type of work were significantly increasing the risk of hypertension. Results from this community service conclude that the lack of knowledge of hypertension especially in the elderly can increase the risk of hypertension. In order to improve the quality of managing hypertension in the elderly in Jembatan Lima Village, Tambora District, West Jakarta, it is recommended that counseling and discussion groups to be held annually, especially among the elderly.
The Role of Green Innovation to Achieve Sustainable Business Performance of MSMEs in the Covid-19 Pandemic Sisca, Sisca; Wijaya, Andy
International Journal of Science, Technology & Management Vol. 4 No. 1 (2023): January 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i1.750

Abstract

The Covid-19 pandemic has had a major impact on economic growth in Indonesia, one of which is for Micro, Small and Medium Enterprises (MSMEs). Thus, MSMEs need to improve their business performance in a sustainable manner to achieve the desired economic growth, one of which is through the adoption of green innovation. The purpose of this study was to analyze the relationship between the adoption of green innovation and sustainable business performance of MSMEs especially during the Covid-19 Pandemic. The research subjects taken in this study were MSME actors in the food and beverage sector at Pematangsiantar City, totaling 371 MSMEs. The analysis technique used in this study was Structural Equation Modeling (SEM) using the Smart PLS program. The results of this study indicated that green innovation has a positive and significant influence on sustainable business performance, especially on social performance and environmental performance, while it has no significant effect on economic performance.
Sindroma Ovarium Polikistik (PCOS) Pada Remaja Wanita di Indonesia: Tantangan Baru dalam Kesehatan Reproduksi Wanita Murthi, Aditya Krishna; Wratsangka, Raditya; Sisca, Sisca; Kurniawan, Yani
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.245-249

Abstract

Adolescence is a crucial phase in individual growth and development, especially for young women, who experience significant physical and hormonal changes. These changes impact reproductive health, including the regularity of the menstrual cycle. Menstrual cycle irregularities can be an early manifestation of Polycystic Ovarian Syndrome (PCOS), one of the most common endocrine disorders in women of reproductive age. Hyperandrogenism, ovulatory disorders, and polycystic ovarian morphology characterize PCOS. Its prevalence in adolescents ranges from 6–10% and tends to increase with lifestyle changes such as a high-calorie diet, lack of physical activity, and psychological stress. Pathophysiologically, PCOS involves complex interactions among genetic, epigenetic, and environmental factors that disrupt the balance of hormones LH, FSH, and AMH and cause insulin resistance. This condition triggers hyperandrogenism, inhibits follicular maturation, and leads to chronic anovulation. The diagnosis of PCOS in adolescents requires caution based on the Rotterdam Consensus (2003) and the 2018 International Guidelines, taking into account similarities to the physiological symptoms of puberty. PCOS is strongly linked to obesity, metabolic syndrome, and family history, with insulin resistance playing a significant role in its development. Elevated Anti-Müllerian Hormone (AMH) levels indicate the severity of PCOS and are associated with metabolic disorders. Therefore, a preventive, holistic approach that promotes a healthy lifestyle is essential for adolescents, including education on balanced nutrition, increased physical activity, and stress management. These measures are expected to decrease the occurrence of PCOS and long-term complications such as infertility and metabolic syndrome in young women in Indonesia.
Co-Authors Acai Sudirman Alfred Pakpahan, Alfred Ambarita, Gita Theresia Andy Wijaya Arshandy, Eliza Arsita, Mita Bela, Isa Bella, Isa Butarbutar, Marisi Chendrasari, Julian Christina Yanita Setyawati, Christina Yanita Darwin Lie Daulay, Dina Agustin David David David Tjahyadi Debi Eka Putri Debora Nainggolan Devita, Arleen Dharma, Edy Dwi Ari Pujianto Efendi Efendi Effendi, Ida Eka Daryanto, Eka Erbin Chandra Ervina Ervina Fahri, Muhammad Imam Fitria Halim Gabrielle, Laurentia Ganeca Widyatama, Haryo Halim, Catherine Hendrick Sasimtan Putra Hengki Mangiring Parulian Simarmata Hutabarat, Defi Mariani Ilona, Florinda Jaya Edy, Hosea Khariri Khariri Kiki, Erina Kisno Kogoya, Alvionita Krishna Murthi, Aditya Lestari, Indah Widya Listyarini, Winny Lora Ekana Nainggolan Luluk Yunaini Mahardieni, Karlina Mailoli, Jesica Marto Silalahi Marudut Mulia Siregar, Victor ML Edy Parwanto Monica Dwi Hartanti, Monica Dwi Musa Fernando Silaen Oladimeji, Ashaolu Victoria Orliando Roeslan, Muhamad Parwanto, Edy Prasetyaningsih, Noviani Raditya Wratsangka, Raditya Retno Widianti Reza Aditya Digambiro Robert Tua Siregar Robertus, Thomas Samira, Jihan Setyaningrum, Dyah Ayu Woro sherly sherly Simanjuntak, Delima Asyanti Simarmata, Hengki Mangiring Parulian Simatupang, Febriyanti Sinaga, Fitri Yanti Sugara, Heru Syarif Hidayat THABIT, JIHAN SAMIRA Tjahyadi, Joey Joshua Vidova Widyatama, Haryo Ganeca Xavierees, Endrico Yani Kurniawan, Yani Yunitra, Imelda