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Ethanol Extract of Grass Jelly Leaves: Bioactive Analysis and In silico Study on Estrogen Receptor Alpha Related to MCF-7 Breast Cancer Irpani, Abdul Mulki; Yuliantini, Anne; Bintang, Muhammad Ilham; Sella, Arinda Tri Pramay; Sodik, Jajang Japar
Sciences of Pharmacy Volume 5 Issue 3 (2026)
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502619

Abstract

Breast cancer is a major cause of mortality among women and requires the development of alternative therapies derived from natural products. This study aimed to profile bioactive compounds in the ethanol extract of gras jelly leaves (Cyclea barbata Miers) and evaluate their predicted interactions with estrogen receptor alpha (ERα), a key regulator of proliferation in ER-positive MCF-7 breast cancer cells using an in silico approach. LC–HRMS analysis followed by database matching tentatively annotataed 44 major compounds based on peak intensity after data filtering. Molecular docking and simulation results indicated that several compounds exhibited favorable predicted binding affinity toward estrogen receptor targets. Among them, (3β,24R,24′R)-fucosterol epoxide demonstrated the most stable interaction. These findings suggest that the compound showed promising interaction stability toward the estrogen receptor in computational analysis. However, further in vitro and in vivo studies are required to validate its biological activity.
Co-Authors Abdul Mulki Irfani Abdul Mulki Irpani Adinda, Deistha Afief, Arief R. Afria Hilda Restu Agustin, Ia Nurfauziah Ajeng Pramesti Akhamad Priyadi Ani Anggriani, Ani Aqila Fadia, Andira Arif Rubianto Aris Suhardiman Asep Kamal Sahroni Astira Kosmawati Bintang, Muhammad Ilham Budiana, Wempi Dadang Juanda Deden Indra Dinata, Deden Indra Deni Iskandar Destia Tresna Prima Elvira Najwa Zain Nabawi Fajarrini, Uvika Nurul Fatmawati, Eva Fatmawati, Fenti Fenti Fatmawati Fenti Fatmawati Fikri Mourly Wahyudi Garnadi Jafar, Garnadi Hasimun, Patonah Helen Fitri Novianti Hilda Restu, Afria Hilman Mulyana, Hilman Ida Lisni Ika Kurnia Sukmawati Ilham Bintang, Muhamad Irfani, Abdul Mulki Isviyanti, Isviyanti M. Ramadhan, Saputro Maharani, Ilmi Intan Mamay M Sobandi Mamay Maulana Sobandi Marita Kaniawati Marliani, Lia Maulana Sobandi, Mamay Merylance Stefany Sanggo Mia Nisrina Anbar Fatin Muhamad Reza Pahlevi Muhamad Reza, Pahlevi Muzaki, Yoga Adi Restu Nita Selifiana Nurfitria, Rizki Siti Patonah, Patonah Pratama, Reza Priyadi, Akhmad Purwaniati, Purwaniati - Putriyanti, Al-fira Ratu Fania Aprilyanti Reza Pratama Reza, Pratama Riyadi, Imam Roganda Situmorang Roni, Asep Rusi Rismawanti Ruswanti, Seffi Sabarudin, Cecep Saidah Mutmainah, Siti Selifiana , Nita Selifiana, Nita Sella, Arinda Tri Pramay Siti Pandanwangi TW Sukmawati, ika kurnia Sumbara Sumbara Sutrisno, Entris Wahyudin Widhya Aligita Yakobus Lau De Yung Sinaga Yuli Astuti Yuliantini, Anne Zaelani, Diki Ziska, Rahma Zuniarto, Ahmad Azrul