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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Inovasi Farmasi Indonesia Abdimas Galuh : Jurnal Pengabdian Kepada Masyarakat Well Being PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) International Journal of Science and Environment Journal of Engineering Science and Technology Management Business and Economic Publication Jurnal Ilmiah Multidisiplin Indonesia Komunita: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Media Akademik (JMA) Assoeltan: Indonesian Journal of Community Research and Engagement Contemporary Journal of Applied Sciences (CJAS) Journal of Social Science and Multidisciplinary Analysis Jurnal Intelek Insan Cendikia SEARCH: Science Education Research Gotong Royong Jurnal Pengabdian Kepada Masyarakat Al-Amin Interaksi : Jurnal Pengabdian Kepada Masyarakat Jurnal Informatika dan Kesehatan International Journal of Contemporary Sciences (IJCS) Jurnal Bioteknologi & Biosains Indonesia (JBBI) Khidmah Nusantara J-CEKI Joong-Ki Amaluna: Jurnal Pengabdian Masyarakat Galen: Jurnal Ilmu Farmasi dan Kesehatan Journal Health of Indonesian HelFin Journal International Journal of Science and Society (IJSS) Jurnal Kajian dan Inovasi Ilmu (JKII) Mitra Jurnal Pengabdian Masyarakat Multidisiplin (MJPMM) JES-TM Social and Community Service
Yuneka Saristiana
Prodi Pendidikan Profesi Apoteker, Fakultas Ilmu Kesehatan, Universitas Kadiri
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The Comparative Effectiveness of Angiotensin II Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors in Outpatient Hypertensive Patients at Community Health Centers Fendy Prasetyawan; Yuneka Saristiana; Faisal Akhmal Muslikh; Wisnu Haryo Widyoko; Chandra Arifin; Abd Rofiq
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 3 (2024): January 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v2i1.8346

Abstract

Hypertension, often termed "The Silent Disease" due to its asymptomatic nature, remains a global health concern. This study investigates the comparative effectiveness of Angiotensin II Receptor Blockers (ARBs) and Angiotensin-Converting Enzyme Inhibitors (ACEIs) in managing hypertension, focusing on Valsartan and Candesartan (ARBs) and Ramipril and Captopril (ACEIs). Analyzing retrospective data from Community Health Centers in Solo City, the research aims to provide nuanced insights into outpatient care scenarios. The meticulous statistical analysis, utilizing SPSS and t-tests, uncovers notable differences, particularly favoring Valsartan and Ramipril within their respective drug classes. These findings carry substantial implications for healthcare practitioners, aiding in the development of precise treatment guidelines. Understanding the comparative clinical effectiveness, safety profiles, and tolerability of ARBs and ACEIs ensures a more personalized approach to hypertension management
Exploring the Macroscopic and Microscopic Characteristics of Acalypha indica L. Simplisia Powder in the Context of Pharmabotanical Studies Yuneka Saristiana; Anita Dwi Setyarini; Yunita Dian Permatasari; Hasriyani; Arikha Ayu Susilowati; Fendy Prasetyawan
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 3 (2024): January 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v2i1.8347

Abstract

Botanical studies form a cornerstone in pharmacy, providing insights into the therapeutic potential of medicinal plants. Acalypha indica L., commonly known as "Anting-anting," holds a significant place in traditional medicine. This research focuses on the macroscopic and microscopic analysis of Acalypha indica L. simplisia, aiming to contribute to its pharmacognostic profile and enhance the standardization of herbal formulations. The exploration encompasses its historical context, traditional uses, chemical constituents, and in vitro anti-arthritis activity. The study employs advanced tools, including optical and electron microscopes, for a comprehensive examination. The macroscopic analysis involves meticulous observation of external features, while the microscopic examination delves into cellular and tissue structures. This research aligns with contemporary pharmacognosy, bridging traditional knowledge with scientific approaches, fostering a deeper understanding of medicinal plant potential
PREVENTION OF GASTROPROTECTIVE ACTIVITY OF CHINESE BETEL EXTRACT (PEPEROMIA PELLUCIDA L.) ON THE HISTOPATHOLOGICAL FEATURES OF THE STOMACH IN A MOUSE MODEL OF GASTROENTERITIS Savitri, Lisa; Prasetyawan, Fendy; Saristiana, Yuneka; Juwita, Syntia Tanu; Amanda, Cornelia; Mebung, Konradus Klala
Jurnal Bioteknologi dan Biosains Indonesia Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jbbi.11.2.8156

Abstract

Gastroenteritis is a common gastrointestinal disorder characterized by inflammation of the stomach and small intestine, often leading to symptoms such as diarrhea, vomit-ing, and abdominal pain. This study investigates the gastroprotective effects of Pepe-romia pellucida (Chinese betel) extract on histopathological features of the stomach in a mouse model of gastroenteritis. Male Swiss strain mice, aged 2-3 months, were treated with different doses of P. pellucida extract (100, 300, and 500 mg/kg BW) for 7 days after inducing gastroenteritis with Escherichia coli infection. Histopathological ex-amination showed that the extract significantly reduced cell degeneration, necrosis, and polymorphonuclear leukocyte infiltration in the stomach compared to the negative control group. The highest dose (500 mg/kg BW) exhibited the most prominent gastro-protective effect. These results suggest that P. pellucida possesses promising thera-peutic potential for gastroenteritis, possibly due to its bioactive compounds such as flavonoids, tannins, and saponins. Further studies are needed to explore the underly-ing mechanisms and optimize its therapeutic application.
Analisis Tingkat Pengetahuan dan Perilaku Swamedikasi Obat Analgesik Di Apotek Sumber Urip Jaya: Analysis of Knowledge Level and Self-Medication Behavior of Analgesic Drugs at Sumber Urip Jaya Pharmacy, Kediri Probosiwi, Neni; Ilmi , Tsamrotul; Laili , Nur Fahma; Saristiana, Yuneka; Sukmawati , Datin An Nisa
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol. 6 No. 1 (2024): Volume 6 No.1 (2024)
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/jafi.v6i1.6487

Abstract

Swamedikasi merupakan tindakan dalam memilih dan menggunakan obat tanpa resep dokter untuk mengatasi masalah kesehatan atau gejala tertentu yang dirasakan. Tujuan penelitian ini untuk analisis tingkat pengetahuan dan perilaku swamedikasi obat analgesik di Apotek Sumber Urip Jaya. Sampel yang digunakan pada penelitian ini sebanyak 105 responden. Instrumen penelitian berupa kuesioner pengetahuan yang terdiri dari 10 pertanyaan domain kepercayaan swamedikasi, 3 pertanyaan cara mendapatkan obat, 3 pertanyaan cara menggunakan obat, 3 pertanyaan cara penyimpanan obat, dan kuesioner perilaku swamedikasi sebanyak 10 pertanyaan. Penelitian ini dilakukan pada bulan Maret – Mei dan dilakukan di Apotek Sumber Urip Jaya. Analisis data menggunakan SPSS versi 16.0 dengan menggunakan uji chisquare. Hasil penelitian menunjukkan  sebagian besar berusia 36-45 tahun, dengan pendidikan terakhir SMA  dan berprofesi sebagai wiraswasta, mayoritas responden pada indikator kepercayaan swamedikasi (91,42%), cara mendapatkan obat (85,71%), cara penyimpanan obat (86,67%). Nilai signifikansi 0,000 yang artinya terdapat hubungan yang signifikan antara tingkat pengetahuan dan perilaku swamedikasi di apotek Sumber Urip Jaya.
Edukasi Menjaga Pola Hidup Sehat Tentang Penyakit Diabetes Melitus dan Hipertensi Pada Era COVID-19 Di Car Free Day Kota Kediri Prasetyawan, Fendy; Karingga, Devangga Darma Karingga; Saristiana, Yuneka; Mildawati, Ratna; Astutik, Widhi
Interaksi : Jurnal Pengabdian Kepada Masyarakat Vol. 1 No. 1 (2024): Interaksi - Juni
Publisher : PT. Faaslib Serambi Media

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Implementasi edukasi pola hidup sehat terkait diabetes melitus dan hipertensi selama pandemi COVID-19 melibatkan persiapan, pelaksanaan, dukungan, dan kolaborasi. Materi edukasi komprehensif disampaikan melalui sesi tatap muka dan virtual serta media sosial. Evaluasi menunjukkan peningkatan signifikan dalam pengetahuan, sikap, dan perilaku kesehatan peserta. Program ini mendorong adopsi pola makan seimbang, aktivitas fisik rutin, dan manajemen stres efektif. Kolaborasi dengan organisasi kesehatan dan komunitas lokal memperluas jangkauan program. Meskipun dihadapi tantangan seperti pembatasan sosial dan akses terbatas, solusi adaptif telah diterapkan untuk memastikan kelangsungan program. Evaluasi kontinu dan adaptasi strategi mendukung upaya program dalam mencapai perubahan positif dalam kesehatan masyarakat.
ANALISIS KRONOFARMAKOLOGI PENGGUNAAN PARACETAMOL PADA PASIEN COVID-19 DI RSUD DR. SOEDOMO TRENGGALEK Prasetyawan, Fendy; Saristiana, Yuneka; Muslikh, Faisal Akhmal; Mildawati, Ratna; Oktadiana, Isma; Arifin, Chandra; Rofiq, Abd; Febriana, Laela; Besan, Emma jayanti; Fadel, Muhammad Nurul
Journal of Social Science and Multidisciplinary Analysis Vol. 1 No. 1 (2024): Journal of Social Science and Multidisciplinary Analysis (Jossama), February 20
Publisher : Noble Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The global COVID-19 pandemic has presented complex challenges to global health. Dr. Soedomo Regional General Hospital in Trenggalek has actively engaged in managing COVID-19 patients. This study aims to analyze the chronopharmacology of paracetamol usage in COVID-19 patients at the hospital, focusing on the body's biological response to the drug at various time points within the 24-hour cycle. In the treatment of COVID-19, the use of paracetamol has become a primary strategy for addressing symptoms such as fever. However, it is crucial to understand how the timing of paracetamol administration can influence the body's response to the treatment. A chronopharmacological study involving 100 patients analyzed body temperature before and after therapy at three different times: 08:00 AM, 04:00 PM, and 10:00 PM. The results revealed a significant decrease in body temperature after therapy, particularly at 04:00 PM. These findings support the concept of "the right time, the right dose" in clinical practice. Analysis of the body's circadian rhythm emphasizes the need to consider the timing of drug administration to achieve optimal outcomes. Despite the limited sample size, this research provides a foundation for the development of more precise practical guidelines for administering paracetamol to COVID-19 patients.
The Comparison of The Use of Antiviral Drugs Favipiravir and Remdesivir on The Outcome of Covid-19 Patients at RSM Ahmad Dahlan Fendy Prasetyawan; Lisa Savitri; Yuneka Saristiana; Shinta Mayasari; Novyananda Salmasfattah
J-CEKI : Jurnal Cendekia Ilmiah Vol. 4 No. 2: Februari 2025
Publisher : CV. ULIL ALBAB CORP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56799/jceki.v4i2.7888

Abstract

This study aims to compare the usage patterns, effectiveness, and therapy outcomes of two antiviral drugs, Favipiravir and Remdesivir, in the treatment of COVID-19 at Muhammadiyah Ahmad Dahlan Hospital, Kediri City. A total of 71 medical records of patients treated with Favipiravir and 50 treated with Remdesivir were analyzed, focusing on patient demographics, drug usage, and therapy outcomes. The patient characteristics reveal that Favipiravir was more commonly used in older patients (aged >65 years), while Remdesivir was more frequent in younger patients (aged 0-5 years). In terms of drug usage, Favipiravir was prescribed to 58.7% of patients, compared to 41.3% for Remdesivir. Both antivirals demonstrated high recovery rates, with Favipiravir achieving a 100% recovery rate and Remdesivir 98%. Evaluation of drug effectiveness showed that Favipiravir was superior in reducing CRP levels (34.78) compared to Remdesivir (7.74), while Remdesivir had a shorter average length of stay (5.68 days) than Favipiravir (8.67 days). These findings suggest that while Favipiravir is more effective in reducing inflammation, Remdesivir is more efficient in accelerating patient recovery. Both drugs play significant roles in COVID-19 management, with their use tailored to patient needs.
Chronopharmacological Study Of Angiotensin-Converting Enzyme Inhibitor Ramipril In Hypertensive Patients In A Hospital: Analysis Of Efficacy And Tolerability Based On Administration Time Variations Fendy Prasetyawan; Faisal Akhmal Muslikh; Yuneka Saristiana; Ratna Mildawati; Chandra Arifin; Abd Rofiq; Dewi Retno Puspitosari
Jurnal Ilmiah Multidisiplin Indonesia (JIM-ID) Vol. 3 No. 02 (2024): Jurnal Ilmiah Multidisiplin Indonesia (JIM-ID), July 2024
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/esaprom.v3i02.4752

Abstract

This research investigates the chronopharmacological effects of Ramipril administration on hypertensive patients, focusing on the timing of drug intake. Studies conducted by Firli Choerun Nisa and Siti Rohmiati in 2022 provide the basis for this analysis. Using observational-analytic methods with cross-sectional designs, data were collected prospectively from 23 patients in each study. Firli Choerun Nisa's study at RSUD Singaparna Medika Citrautama, Tasikmalaya Regency, involved 14 patients in the light zeitgeber group and 9 in the dark zeitgeber group. Results indicated significant reductions in both systolic and diastolic blood pressures, with the dark zeitgeber group experiencing more substantial decreases. The SPSS analysis showed a p-value of 0.062, indicating no statistically significant difference between the groups. Siti Rohmiati's study at RSUD Dr. Soekardjo Tasikmalaya found similar results. The light zeitgeber group showed a systolic decrease of 9.9 mmHg and a diastolic decrease of 5 mmHg, while the dark zeitgeber group had decreases of 16.66 mmHg and 10.56 mmHg, respectively. The SPSS analysis also yielded a p-value of 0.062, supporting the conclusion of no significant difference in Ramipril's efficacy based on administration timing. The comprehensive analyses revealed that Ramipril effectively reduces blood pressure regardless of the administration time. Significant reductions in both the daytime and nighttime groups were noted, with trends suggesting a more pronounced effect during nighttime administration. These findings emphasize the importance of flexibility in medication timing, enhancing patient adherence without compromising therapeutic outcomes. In conclusion, the timing of Ramipril administration, whether in the morning or evening, does not significantly impact its effectiveness in managing hypertension. This flexibility offers practical benefits for clinical practice, supporting better patient adherence and optimized hypertension management. These studies contribute to the broader understanding of chronopharmacology, providing insights for improved treatment strategies in hypertensive care.
THE POTENTIAL ACTIVITY OF ASIATICOSIDE FROM AKAR MANIS (Glycyrrhiza glabra) AS HYPOLIPEMIC Prasetyawan, Fendy; Saristiana, Yuneka; Salmasfattah, Novyananda; Mildawati, Ratna; Mayasari, Shinta
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 3 No. 4 (2024): OCTOBER
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v3i4.1608

Abstract

Asiaticoside, a bioactive compound derived from Glycyrrhiza glabra (licorice root), has garnered attention for its potential as a hypolipemic agent. This study explores the lipid-lowering effects of asiaticoside, focusing on its mechanism of action and pharmacological properties. In silico analysis showed a high activation probability (pa=0.934) for asiaticoside, indicating its strong potential to interact with targets involved in lipid metabolism, such as PPAR-α, and reduce blood lipid levels. Additionally, its low inhibition probability (pi=0.003) suggests minimal risk for non-specific biological interference, making it a promising candidate for therapeutic use with a favorable safety profile. Asiaticoside’s antioxidant and anti-inflammatory properties further enhance its potential for cardiovascular protection by reducing oxidative stress, a key factor in atherosclerosis. While preliminary in silico results are promising, further in vitro and in vivo studies are required to confirm its efficacy, safety, and pharmacokinetics. Overall, asiaticoside represents a promising natural agent for managing hyperlipidemia and related metabolic disorders, offering an alternative to conventional synthetic therapies.
Education on the Use of Over-the-Counter Drugs as Preventive Health for Students at SMP Muhammadiyah 2 Kediri Fendy Prasetyawan; Lisa Savitri; Yuneka Saristiana; Novyananda Salmasfattah
Joong-Ki : Jurnal Pengabdian Masyarakat Vol. 4 No. 2: Februari 2025
Publisher : CV. Ulil Albab Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56799/joongki.v4i2.7743

Abstract

This community service activity was conducted on September 20, 2024, to raise awareness among students about the safe and responsible use of over-the-counter (OTC) medications. The primary objective was to educate students on the types of OTC medications available, their proper use, potential side effects, and the importance of reading medication labels. The event involved 20 students, comprising 4 from Grade 8, 7 from Grade 9, and 9 from Grade 7, who actively participated in interactive discussions and Q&A sessions. The educational session was delivered using a combination of presentations, visual aids, and real-life examples to enhance comprehension. A post-activity evaluation through a quiz was conducted to assess the participants' understanding of the material. The results showed an average quiz score of 82.3%, with an accuracy rate of 87.6%, indicating a significant improvement in the students' knowledge of OTC medication use. The activity also included discussions on the importance of adopting healthy lifestyle habits as a preventive health measure, which resonated well with the students, reflecting their growing interest in maintaining overall health.
Co-Authors Abd Rofiq Abd Rofiq Abd Rofiq Abd Rofiq Achmad Wahdi Adiyansyah Lukman Hakim Adiyansyah Lukman Hakim Akhmal Muslikh, Faisal Alshol, Mohammad Firdaus Althaf Rajahala B Sinun Amanda, Cornelia Ana Amalia Anis Akhwan Dhafin Anis Akhwan Dhafin Anis Akwan Dhafin Anita Dwi Setyarini Anita Dwi Setyarini Arifani Siswidiasari Arikha Ayu Susilowati Arsiaty Sumule Ary Kristijono Ary Kristijono Asrizal Azis Astutik, Widhi Azis, Asrizal Baarik Lana Fadli Bandhi Prasetya Nugroho Bandhi Prasetya Nugroho Besan, Emma Jayanti Candra Arifin Chandra Arifin Chandra Arifin Chandra Arifin Chandra Arifin Charliandri Saputra Wahab Datin An Nisa Sukmawati Deo Rudita Febrian Waly Dewi Retno Puspitosari Dian Permatasari, Yunita Edda, Ilda Rambu Eka Hayati Rhomah Eka Nur Fatmawati Elfred Rinaldo Kasimo, Elfred Rinaldo Elsa Mahardika Putri Elsa Mahardika Putri Ema Jayanti Besan Ema Tri Wulan Emma Jayanti Besan Faisal Akhmal Faisal Akhmal Muslihk Faisal Akhmal Muslikh Faisal Akhmal Muslikh Faisal Akhmal Muslikh Febriana, Laela Fendy Prasetyawan Freitas, Maria Do Carmo Da Costa Hasriyani Hasriyani Hasriyani, Hasriyani Herman Ibrahim Fadlannul Haq Ibrahim Irsyadul Ibad Ibrahim Iskandar Alfaris Ilhawa Zahra Ilhawa Zahra Imran, Arlan K Indrayanti, Dian Isma Oktadiana Isma Oktadiana Juwita, Syntia Tanu Kadir, Mujtahid Bin Abd Kadir, Mujtahid Bin And Karingga, Devangga Darma Kholis, Muhammad Akbar Nur Laili , Nur Fahma Laili, Nur Fahma Leny Witaning Kusumati Lily Aina Lusiana Aprillia M. Wahyu Ariawan Marhenta, Yogi Bhakti Mebung, Konradus Klala Megasari, Elly Meri, Meri milda, ratna Mildawati, Ratna Mildwati, Ratna Muhammad Alviyan Shutiawan Muhammad Nurul Fadel Mujtahid Bin Abd Kadir Muslihk, Faisal Akhmal Nanda Ardianto Nanda Ardianto Nanda Ardianto Neni Probosiwi Nimas Ayu Rahardini Nina Nur Jannah Nisa Azzahra Dentika Novyananda Salmasfattah Novyananda Salmasfattah Nur Fahma Laili Octavian Ashido Nababan Octavian Ashido Nababan Okky Intan Mawarni Oktadiana, Isma Prayoga Fery Yuniarto Probosiwi , Neni Ratna Mildawati Ratna Mildawati Ratna Mildawati Ratna Mildawati Ratna Mildawati Ratna Mildawati Restyana, Anggi Rhomah, Eka Hayati Rika Wahyu Pujiastini Rochmad Krissanjaya Rofiq, Abd Rohmah, Eka Hayati Salmasfattah, Novyananda Salmasfattah, Novynanda savitri, Lisa Shinta Mayasari Shinta Mayasari Sugeng, Santoso Sukmawati , Datin An Nisa Susilo Margining Raharjo Tri Wulan, Ema Tsamrotul Ilmi Wahyu Ariawan Widhi Astutik Winartiana Wisnu Haryo Widyoko Wulan, Ema Tri Yanti, Novirma Yogi Bhakti Marhenta Yunita Dian Permatasari Yunita Dian Permatasari