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Biorhythm Analysis Of The Analgesic Effect Of Paracetamol In Inpatients With COVID-19 At The Hospital Yuneka Saristiana; Fendy Prasetyawan; Adiyansyah Lukman Hakim; Althaf Rajahala B Sinun; Deo Rudita Febrian Waly
Journal Health of Indonesian Vol. 2 No. 01 (2024): Journal Health of Indonesian, january 2024
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/health.v2i01.109

Abstract

The global COVID-19 pandemic has posed unprecedented challenges to global health, impacting healthcare institutions worldwide. Dr. Soedomo Regional General Hospital in Trenggalek has been actively involved in treating COVID-19 patients, emphasizing the need for improved care standards and effective symptom management. Paracetamol, a commonly used medication, is a key focus in this endeavor. This study investigates the chronopharmacology of paracetamol in COVID-19 patients, emphasizing the importance of timing in therapeutic interventions. The research, conducted at Dr. Soedomo Regional General Hospital, involves 100 COVID-19 patients undergoing paracetamol therapy. The analysis includes demographic data, paracetamol administration at different times, and the resulting body temperature changes. The findings reveal that the body's response to paracetamol varies significantly depending on the time of administration. Notably, at 4:00 PM, a more pronounced decrease in body temperature is observed, suggesting a heightened effectiveness of therapy. This phenomenon is attributed to the body's circadian rhythm, influencing physiological functions over a 24-hour period. This study lays the groundwork for the "right time, right dose" concept in clinical practice. Considering the circadian rhythm is essential in designing personalized and effective treatment protocols, aiming for optimal outcomes. Despite limitations, including a small sample size, this research provides valuable insights into the circadian aspects of drug efficacy, paving the way for more tailored treatment approaches.
Descriptive Analysis the Analgesic Activity of Chloroform Fraction from Acorus Calamus L. Leaf Extract on Male White Mice (Mus Musculus) Induced by Acetic Acid Fendy Prasetyawan; Yuneka Saristiana; Ibrahim Fadlannul Haq; Ibrahim Irsyadul Ibad; Ibrahim Iskandar Alfaris
Journal Health of Indonesian Vol. 2 No. 01 (2024): Journal Health of Indonesian, january 2024
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/health.v2i01.110

Abstract

Pain management is a critical aspect of pharmaceutical research, and Acorus calamus L., commonly known as jeringau, has garnered attention for its potential analgesic properties. This study focuses on evaluating the analgesic activity of the chloroform fraction from ethanol extract of jeringau leaves (Acorus calamus L.) on male white mice induced by acetic acid. Chronic and acute pain significantly impacts individuals' quality of life, emphasizing the need for effective and safe analgesic alternatives. While Acorus calamus leaf extract has shown pharmacological potential, especially the chloroform fraction, a dedicated investigation into its analgesic effects on animal models is lacking. Male white mice, recognized for their reproducible and measurable responses to painful stimuli, serve as relevant subjects in this study. The population of 25 mice, aged 2-3 months and weighing 20-30 grams, is divided into 5 treatment groups, including negative and positive controls. The study employs three dosages of the chloroform fraction, administered orally, with observations made on writhing behavior following intraperitoneal injection of 0.5% acetic acid. Statistical analysis will evaluate significant differences between treatment groups, providing insights into the analgesic potential. Results indicate that Dosage III (44.8 mg/40g BW) exhibits the highest analgesic efficacy at 73.99%, showcasing a dose-dependent response. The mechanism involves flavonoids inhibiting the cyclooxygenase enzyme, aligning with established analgesic actions. Ibuprofen, the positive control, and jeringau leaf extract demonstrate analgesic effects, reinforcing traditional knowledge. This research contributes to scientific understanding, establishing a foundation for further exploration.
Optimizing COVID-19 Therapy: Analysis of Prescription Profiles in Non-Comorbid Inpatients to Enhance Treatment Strategies and Clinical Outcomes Fendy Prasetyawan; Yuneka Saristiana; Faisal Akhmal Muslikh; Ratna Mildawati; Ilhawa Zahra
Journal Health of Indonesian Vol. 1 No. 02 (2023): Journal Health of Indonesian, July 2023
Publisher : Journal Health of Indonesian

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study explores the clinical characteristics, treatment patterns, and outcomes of COVID-19 inpatients without comorbidities, aiming to contribute valuable insights to the management of the disease. Through meticulous data collection from medical records of 468 confirmed COVID-19 patients admitted to Gambiran Regional General Hospital between April and June 2020, 36 patients meeting inclusion criteria were identified. The research findings reveal a higher incidence of COVID-19 among males and a prevalent age group of 31-40 years. Notably, elderly individuals and those with underlying health conditions face a greater risk of severe outcomes, underscoring the importance of tailored interventions for vulnerable populations. The study highlights a diverse treatment approach, with a significant proportion of patients receiving supplements to bolster immune function. Antiviral medications like Favipiravir are also utilized to inhibit viral replication, although definitive treatment for COVID-19 remains elusive. Antibiotics play a crucial role in preventing bacterial respiratory infections, while supportive medications help alleviate symptoms commonly associated with the disease. Importantly, the findings emphasize the multifaceted nature of COVID-19 management and the need for targeted interventions to optimize patient outcomes. By elucidating the therapeutic landscape and clinical course of COVID-19 inpatients without comorbidities, this study contributes to the growing body of knowledge surrounding the disease. These insights can inform clinical decision-making, resource allocation, and public health strategies aimed at combating the ongoing pandemic.
Unveiling the Mysteries of Pharmacoreincarnation: A Study on the Spiritual and Metaphysical Dimensions of Using Psychoactive Drugs for Accessing Past Life Memories Fendy Prasetyawan; Nanda Ardianto; Yuneka Saristiana; Wahyu Ariawan; Faisal Akhmal Muslikh; Yunita Dian Permatasari
Journal Health of Indonesian Vol. 1 No. 02 (2023): Journal Health of Indonesian, July 2023
Publisher : Journal Health of Indonesian

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The research delves into the multifaceted realm of psychoactive drugs, spirituality, and the exploration of past life memories, known as "pharmacoreincarnation." Psychoactive substances like psilocybin, LSD, and DMT have gained attention for their profound alterations in consciousness and subjective experiences, often described as mystical or spiritual. Belief in reincarnation persists globally, fueled by anecdotal testimonials and cultural traditions. The study aims to explore pharmacoreincarnation through a comprehensive literature review and interdisciplinary perspective. Academic databases such as PubMed, PsycINFO, Scopus, and Google Scholar will be utilized to access relevant articles published in English within the last two decades. Thematic analysis will identify recurring themes and patterns across the literature, synthesizing findings to develop a coherent understanding of pharmacoreincarnation. The methodology involves systematic literature search, screening, and review processes to extract pertinent information aligned with the research objective. The synthesized findings will be organized into logical sections within the literature review, ensuring clarity and rigor. Peer review and revision will validate the quality and accuracy of the review before finalization. The study anticipates contributing significantly to knowledge on pharmacoreincarnation and its implications for consciousness studies, spirituality, and therapeutic practices. By embracing an interdisciplinary approach, it aims to unravel the underlying mechanisms of such experiences and their broader implications for personal identity and reality.
Patterns of Antihypertensive Medication Utilization Among Hypertensive Patients: A Review of Single-Therapy Practices in Outpatient Primary Healthcare Centers Fendy Prasetyawan; Yuneka Saristiana; Faisal Akhmal Muslikh; Chandra Arifin; Abd Rofiq; Elsa Mahardika Putri; Anis Akhwan Dhafin
Journal Health of Indonesian Vol. 2 No. 02 (2024): Journal Health of Indonesian, Edition July 2024
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/health.v2i02.115

Abstract

Hypertension, often referred to as "The Silent Disease," presents a significant global health challenge due to its asymptomatic nature and association with severe cardiovascular complications. Effective management of hypertension primarily relies on the administration of antihypertensive drugs, either as monotherapy or combination therapy. This study investigates the utilization patterns of single antihypertensive drugs among hypertensive patients in the outpatient setting of Puskesmas "X" in Solo City. Utilizing a retrospective approach, data from patient medical records were analyzed to examine drug usage patterns and patient responses to therapy. Results revealed a noteworthy preference for combination therapy, with approximately 64.18% of patients opting for this approach. Combination therapy strategies were favored due to their additive and synergistic effects, potential for reducing side effects, and enhanced blood pressure control. Specifically, amlodipine from the calcium channel blocker (CCB) group emerged as the most commonly prescribed single antihypertensive drug, while the combination of amlodipine with candesartan from the angiotensin receptor blocker (ARB) group was the predominant combination therapy. These findings align with previous research, emphasizing the significance of combination therapies in hypertension management..
Chronopharmacological Insights: Enhancing Acetaminophen Administration Timing for Inpatient COVID-19 Management Fendy Prasetyawan; Yuneka Saristiana; Anis Akwan Dhafin; Okky Intan Mawarni; Asrizal Azis; Ema Tri Wulan
Journal Health of Indonesian Vol. 2 No. 02 (2024): Journal Health of Indonesian, Edition July 2024
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/health.v2i02.116

Abstract

The global COVID-19 pandemic has posed unprecedented challenges to global health. Dr. Soedomo Regional General Hospital in Trenggalek, which is involved in the management of COVID-19 patients, has witnessed a long journey in responding to and treating individuals infected with the SARS-CoV-2 virus. The use of acetaminophen has been a primary focus in efforts to improve standards of care and understanding symptom management in COVID-19 patients. Chronopharmacological analysis of acetaminophen use in COVID-19 patients at Dr. Soedomo Hospital aims to provide insight into how the timing of drug administration can affect therapeutic responses. There is evidence that the body's circadian rhythm can influence the metabolism and pharmacological effects of drugs, but this perspective has not been fully explored in the context of COVID-19. This study involved an analytical observational approach with a Cross-Sectional design and retrospective data collection method from the medical records of COVID-19 patients treated at Dr. Soedomo Regional Hospital in Trenggalek District. The results of the study showed that acetaminophen therapy at 16.00 WIB resulted in a more significant reduction in body temperature compared to other times. A deeper understanding of the body's circadian rhythm can help optimize the benefits of therapy and reduce potential side effects. Although there are limitations to this study, these results provide a basis for the development of more targeted and personalized treatment strategies. The clinical implications of this research can help in determining the optimal timing for administering therapy to achieve desired effects in COVID-19 patients.
Strategizing Antiviral Medication Usage for Chronic Kidney Disease Patients with SARS-CoV-2: Insights from Inpatient Pharmacy Practices at Hospital Settings Yuneka Saristiana; Leny Witaning Kusumati; Neni Probosiwi; Tsamrotul Ilmi; Nur Fahma Laili; Fendy Prasetyawan
Journal Health of Indonesian Vol. 2 No. 02 (2024): Journal Health of Indonesian, Edition July 2024
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/health.v2i02.120

Abstract

The emergence of the SARS-CoV-2 virus in 2020 led to the onset of the COVID-19 pandemic, posing significant challenges globally. As of December 19, 2021, the worldwide confirmed cases surpassed 273 million, with a devastating death toll exceeding 5.3 million. Indonesia reported its first case on March 2, 2020, and has since faced escalating numbers, necessitating urgent attention.Chronic kidney disease (CKD) has emerged as a commonly occurring comorbidity among COVID-19 patients, drawing attention due to the vulnerability of CKD patients to medical complications. Understanding the use of antiviral drugs in CKD patients with COVID-19 is essential, considering the risks of drug toxicity and interactions. This study aims to investigate the frequency of antiviral drug usage in COVID-19 patients with CKD, providing insights into treatment strategies and guiding medical practitioners. Conducted at Dr. Soedomo Trenggalek Regional Hospital, the research utilizes a cross-sectional, non-experimental design and purposive sampling method. Data collection involves patients' medical records, focusing on demographics, antiviral drug usage, disease severity, treatment duration, mortality rates, and potential side effects. The demographic analysis reveals that the majority of COVID-19 patients with CKD are aged 50 and above, with males comprising 74% of the cohort. Age and gender influence disease severity, with older individuals and males at higher risk. Antiviral drug usage predominantly includes favipiravir (64%) and remdesivir (36%), underscoring their importance in treatment protocols. Decisions regarding antiviral therapy in CKD patients with COVID-19 require careful consideration of benefits, risks, and patient characteristics.
Unveiling Pagodroma Nivea's Fossil Healing Power: A Journey Through Farmacoantarctic Chronicles And Bioactivity Studies Yuneka Saristiana; Yunita Dian Permatasari; Anita Dwi Setyarini; Hasriyani, Hasriyani; Neni Probosiwi; Fendy Prasetyawan
Journal Health of Indonesian Vol. 2 No. 02 (2024): Journal Health of Indonesian, Edition July 2024
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/health.v2i02.122

Abstract

Research on the bioactivity of Antarctic organisms has garnered significant attention due to the continent's unique environmental conditions and the potential therapeutic value of its inhabitants. This study delves into the bioactivity of Pagodroma nivea, commonly known as the Snow Petrel, found in Antarctica, aiming to explore its medicinal potential. Despite previous research highlighting the bioactivity of various organisms in extreme environments, specific investigations into Pagodroma nivea remain scarce. Farmacoantarctic Research offers a promising avenue for exploring the therapeutic properties of Antarctic organisms, including Pagodroma nivea, traditionally used for medicinal purposes by local communities. Understanding the biochemical adaptations of organisms to Antarctica's extreme conditions is crucial, as these adaptations may yield bioactive compounds with pharmacological potential. The research not only seeks to uncover the bioactivity of Pagodroma nivea but also aims to contribute to drug development and environmental conservation efforts. In a parallel discussion, the study examines Mumijo, a traditional remedy found in various regions, including Antarctica. Chemical analysis of Mumijo extract, particularly the ester wax fraction, reveals its potential biomedical applications, including wound healing, skin diseases, and neuroprotection. The presence of glycerol-related ethers in Antarctic Mumijo suggests further avenues for exploration in neuroprotection and antimicrobial properties. By investigating the bioactivity of Antarctic organisms like Pagodroma nivea and Mumijo, this research offers insights into their therapeutic potential and underscores the importance of conservation efforts to preserve these unique ecosystems.
ANALISIS PERENCANAAN DANA ANGGARAN PADA PENGELOLAN PELAYANAN IBU HAMIL DI PUSKESMAS SURUH TAHUN 2023 Prasetyawan, Fendy; Saristiana, Yuneka; Muslihk, Faisal Akhmal; Mildwati, Ratna
HelFin Journal Vol. 1 No. 2 (2024): Juli
Publisher : Fakultas Vokasi Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/helfin.v1i2.5906

Abstract

Penelitian ini bertujuan untuk menganalisis perencanaan dana anggaran pada pengelolaan pelayanan ibu hamil di Puskesmas Suruh tahun 2023. Kesehatan ibu hamil merupakan indikator penting dalam penilaian kesehatan masyarakat, mempengaruhi kesejahteraan ibu serta kesehatan dan perkembangan bayi yang dikandung. Penyediaan layanan kesehatan yang optimal bagi ibu hamil menjadi prioritas dalam program kesehatan di berbagai daerah, termasuk di Puskesmas Suruh. Berdasarkan data dari Peraturan Daerah Kabupaten Trenggalek Nomor 5 Tahun 2022, alokasi anggaran untuk layanan kesehatan ibu hamil adalah Rp 71.812.500, dengan persentase 11,20% dari total anggaran sebesar Rp 640.747.000 yang dialokasikan untuk penyediaan layanan tingkat daerah kabupaten. Layanan ini mencakup pemeriksaan rutin, penyuluhan kesehatan, pemberian suplemen, dan penanganan komplikasi kehamilan. Implementasi anggaran dilakukan dengan mempertimbangkan berbagai aspek, termasuk pengadaan sarana dan prasarana, pelatihan tenaga kesehatan, serta kegiatan monitoring dan evaluasi. Melalui analisis SWOT (Strengths, Weaknesses, Opportunities, Threats), penelitian ini mengidentifikasi kekuatan seperti dukungan dari pemerintah dan ketersediaan tenaga kesehatan yang kompeten, serta kelemahan seperti keterbatasan anggaran dan masalah administratif. Peluang yang dapat dimanfaatkan meliputi program pemerintah yang mendukung dan kerjasama dengan sektor swasta, sedangkan ancaman termasuk perubahan kebijakan anggaran dan bencana alam. Kesimpulan dari penelitian ini menekankan pentingnya perencanaan dana anggaran yang baik dan implementasi yang transparan untuk meningkatkan kualitas pelayanan kesehatan ibu hamil di Puskesmas Suruh, yang diharapkan dapat memberikan dampak positif bagi kesejahteraan ibu dan anak serta masyarakat secara keseluruhan.
Cost-Effectiveness Analysis of Immunosuppressant Drug Methylprednisolone at Gembleb Farma Trenggalek Pharmacy Service Fendy Prasetyawan; Yuneka Saristiana; Tsamrotul Ilmi; Widhi Astutik; Chandra Arifin; Abd Rofiq; Eka Hayati Rhomah
International Journal of Science and Society (IJSS) Vol. 1 No. 2 (2025): December
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/v9v9ke75

Abstract

This study aims to evaluate the cost-effectiveness of the immunosuppressant drug methylprednisolone at Gembleb Farma Pharmacy in Trenggalek, East Java, Indonesia. The research was conducted on May 30, 2025, using a descriptive quantitative approach supported by interviews with the responsible pharmacist. Data collection involved daily sales records of methylprednisolone and clinical response outcomes among patients. Each patient typically received five tablets per treatment, and the pharmacy recorded an average daily sale of 250 tablets. Therefore, it was estimated that approximately 50 patients were served per day. From those, 45 patients—equivalent to 90%—experienced favorable clinical responses to methylprednisolone therapy. The cost per tablet was IDR 500, resulting in a total daily cost of IDR 125,000. The calculated Cost-Effectiveness Ratio (CER) per day was IDR 2,777.78 per effectively treated patient. This value remained consistent when scaled to monthly (IDR 3,750,000 for 1,350 effective patients) and annual estimates (IDR 45,625,000 for 16,425 effective patients), yielding the same CER value of IDR 2,777.78. The findings indicate that methylprednisolone provides a stable and predictable cost-effectiveness profile in outpatient pharmacy settings. These results may support decision-making in therapeutic planning, particularly in community pharmacies that aim to deliver effective yet affordable immunosuppressive therapies. Additionally, this cost-efficiency aligns with the goals of rational drug use and sustainable pharmaceutical services at the primary healthcare level. 
Co-Authors Abd Rofiq Abd Rofiq Abd Rofiq Abd Rofiq Achmad Wahdi Adiyansyah Lukman Hakim Adiyansyah Lukman Hakim Akhmal Muslikh, Faisal Alshol, Mohammad Firdaus Althaf Rajahala B Sinun Amanda, Cornelia Ana Amalia Anis Akhwan Dhafin Anis Akhwan Dhafin Anis Akwan Dhafin Anita Dwi Setyarini Anita Dwi Setyarini Arifani Siswidiasari Arikha Ayu Susilowati Arsiaty Sumule Ary Kristijono Ary Kristijono Asrizal Azis Astutik, Widhi Azis, Asrizal Baarik Lana Fadli Bandhi Prasetya Nugroho Bandhi Prasetya Nugroho Besan, Emma Jayanti Candra Arifin Chandra Arifin Chandra Arifin Chandra Arifin Chandra Arifin Charliandri Saputra Wahab Datin An Nisa Sukmawati Deo Rudita Febrian Waly Dewi Retno Puspitosari Dian Permatasari, Yunita Edda, Ilda Rambu Eka Hayati Rhomah Eka Nur Fatmawati Elfred Rinaldo Kasimo, Elfred Rinaldo Elsa Mahardika Putri Elsa Mahardika Putri Ema Jayanti Besan Ema Tri Wulan Emma Jayanti Besan Faisal Akhmal Faisal Akhmal Muslihk Faisal Akhmal Muslikh Faisal Akhmal Muslikh Faisal Akhmal Muslikh Febriana, Laela Fendy Prasetyawan Freitas, Maria Do Carmo Da Costa Hasriyani Hasriyani Hasriyani, Hasriyani Herman Ibrahim Fadlannul Haq Ibrahim Irsyadul Ibad Ibrahim Iskandar Alfaris Ilhawa Zahra Ilhawa Zahra Imran, Arlan K Indrayanti, Dian Isma Oktadiana Isma Oktadiana Juwita, Syntia Tanu Kadir, Mujtahid Bin Abd Kadir, Mujtahid Bin And Karingga, Devangga Darma Kholis, Muhammad Akbar Nur Laili , Nur Fahma Laili, Nur Fahma Leny Witaning Kusumati Lily Aina Lusiana Aprillia M. Wahyu Ariawan Marhenta, Yogi Bhakti Mebung, Konradus Klala Megasari, Elly Meri, Meri milda, ratna Mildawati, Ratna Mildwati, Ratna Muhammad Alviyan Shutiawan Muhammad Nurul Fadel Mujtahid Bin Abd Kadir Muslihk, Faisal Akhmal Nanda Ardianto Nanda Ardianto Nanda Ardianto Neni Probosiwi Nimas Ayu Rahardini Nina Nur Jannah Nisa Azzahra Dentika Novyananda Salmasfattah Novyananda Salmasfattah Nur Fahma Laili Octavian Ashido Nababan Octavian Ashido Nababan Okky Intan Mawarni Oktadiana, Isma Prayoga Fery Yuniarto Probosiwi , Neni Ratna Mildawati Ratna Mildawati Ratna Mildawati Ratna Mildawati Ratna Mildawati Ratna Mildawati Restyana, Anggi Rhomah, Eka Hayati Rika Wahyu Pujiastini Rochmad Krissanjaya Rofiq, Abd Rohmah, Eka Hayati Salmasfattah, Novyananda Salmasfattah, Novynanda savitri, Lisa Shinta Mayasari Shinta Mayasari Sugeng, Santoso Sukmawati , Datin An Nisa Susilo Margining Raharjo Tri Wulan, Ema Tsamrotul Ilmi Wahyu Ariawan Widhi Astutik Winartiana Wisnu Haryo Widyoko Wulan, Ema Tri Yanti, Novirma Yogi Bhakti Marhenta Yunita Dian Permatasari Yunita Dian Permatasari