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All Journal PHARMACON Biology, Medicine, & Natural Product Chemistry Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Inovasi Farmasi Indonesia Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Well Being Jumat Ekonomi: Jurnal Pengabdian Masyarakat Journal of Social Responsibility Projects by Higher Education Forum PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Jurnal Lentera International Journal of Science and Environment Journal of Engineering Science and Technology Management Business and Economic Publication Jurnal Ilmiah Multidisiplin Indonesia Komunita: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Media Akademik (JMA) Assoeltan: Indonesian Journal of Community Research and Engagement Contemporary Journal of Applied Sciences (CJAS) Journal of Social Science and Multidisciplinary Analysis Jurnal Intelek Insan Cendikia SEARCH: Science Education Research Gotong Royong Jurnal Pengabdian Kepada Masyarakat Al-Amin Interaksi : Jurnal Pengabdian Kepada Masyarakat Jurnal Informatika dan Kesehatan International Journal of Contemporary Sciences (IJCS) Jurnal Hasil Inovasi Masyarakat (JHIM) Jurnal Bioteknologi & Biosains Indonesia (JBBI) Khidmah Nusantara Jurnal Cendekia Ilmiah Joong-Ki Amaluna: Jurnal Pengabdian Masyarakat Galen: Jurnal Ilmu Farmasi dan Kesehatan Journal Health of Indonesian HelFin Journal Multicore International Journal of Multidisciplinary (MIJM) International Journal of Science and Society (IJSS) Jurnal Kajian dan Inovasi Ilmu (JKII) Mitra Jurnal Pengabdian Masyarakat Multidisiplin (MJPMM) JES-TM Social and Community Service Abdimas Paspama Jurnal Bioteknologi & Biosains Indonesia Journal of Advanced Pharmaceutical Research Sciences and Sustainability Jurnal Pengabdian Inovatif Multidisipliner Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Profixa: International Journal of Economic and Business Research
Yuneka Saristiana
Prodi Pendidikan Profesi Apoteker, Fakultas Ilmu Kesehatan, Universitas Kadiri
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Prediction of Sinensetin from Kumis Kucing (Orthosiphon aristatus) as Aspulvinone Dimethylallyltransferase Inhibitor for Anticancer Agent Prasetyawan, Fendy; Arifin, Chandra; Astutik, Widhi; Rohmah, Eka Hayati; Kadir, Mujtahid Bin Abd; Ariawan, M Wahyu; Marhenta, Yogi Bhakti; Mildawati, Ratna; Saristiana, Yuneka; Rofiq, Abd
Multicore International Journal of Multidisciplinary (MIJM) Vol. 1 No. 1 (2025): May
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mijm.v1.i1.3

Abstract

Sinensetin, a polymethoxylated flavone found in Orthosiphon aristatus (commonly known as Kumis Kucing), was evaluated in silico for its potential inhibitory activity against Aspulvinone Dimethylallyltransferase, an enzyme implicated in cancer-related biosynthetic pathways. The SMILES structure of sinensetin was retrieved from PubChem and analyzed using the PASS online prediction tool (www.way2drug.com). The results showed a high probability of activity (Pa = 0.865) and a very low probability of inactivity (Pi = 0.016), indicating that sinensetin is likely to act as a potent inhibitor of the enzyme. These findings suggest that sinensetin could be a promising anticancer agent candidate by targeting Aspulvinone Dimethylallyltransferase. Further studies are recommended to validate this prediction through molecular docking and biological assays.
Prediction of Scabertopin from Tapak Liman (Elephantopus scaber) for Antileukemic Saristiana, Yuneka; Prasetyawan, Fendy; Salmasfattah, Novynanda; Ilmi, Tsamrotul; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Multicore International Journal of Multidisciplinary (MIJM) Vol. 1 No. 1 (2025): May
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mijm.v1.i1.5

Abstract

Leukemia remains a significant global health challenge, necessitating the exploration of novel therapeutic agents with improved efficacy and safety profiles. Elephantopus scaber (commonly known as Tapak Liman) is a medicinal plant traditionally used for various ailments, including cancer. Scabertopin, a sesquiterpene lactone isolated from E. scaber, has attracted scientific interest due to its potential antileukemic properties. This study aims to predict the antileukemic activity of Scabertopin through an in silico approach. The compound's chemical structure was retrieved in SMILES format from the PubChem database and analyzed using the PASS (Prediction of Activity Spectra for Substances) online tool. The prediction results indicated a high probability of antileukemic activity, with a Pa (probability of activity) value of 0.822 and a Pi (probability of inactivity) value of 0.004. These findings suggest a strong likelihood that Scabertopin exhibits antileukemic effects, supporting its potential as a candidate for further pharmacological and clinical investigations. The use of computational prediction tools provides an efficient and cost-effective preliminary screening method for identifying promising bioactive compounds from natural sources. This study contributes valuable insights into the therapeutic potential of Scabertopin and highlights the importance of traditional medicinal plants in drug discovery for leukemia treatment.
Pharmacokinetics and Druglikeness of Amoxicillin Drug using SwissADME Prasetyawan, Fendy; Saristiana, Yuneka; Mildawati, Ratna; Rhomah, Eka Hayati; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Multicore International Journal of Multidisciplinary (MIJM) Vol. 1 No. 2 (2025): November
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mijm.v1.i2.3

Abstract

Amoxicillin, a widely utilized semi-synthetic penicillin derivative, remains a cornerstone in treating various bacterial infections. Despite its extensive clinical application, a comprehensive in silico assessment of its pharmacokinetic and "druglikeness" properties using modern computational tools can provide valuable complementary insights. This study employed the SwissADME web platform to meticulously analyze the computed descriptors, physicochemical characteristics, ADME profile, druglikeness, and medicinal chemistry aspects of amoxicillin. The chemical structure of amoxicillin, represented by its SMILES string, was retrieved from the PubChem database and subsequently input into SwissADME for analysis. The results indicate that amoxicillin possesses a molecular weight of 365.40 g/mol and a hydrophilic nature, as evidenced by its consensus LogP value of -0.39 and high water solubility predictions. Its Topological Polar Surface Area (TPSA) is 158.26 Ų, and it contains 4 hydrogen bond donors and 6 hydrogen bond acceptors. While the in silico prediction for gastrointestinal (GI) absorption was "Low" (likely due to the high TPSA and hydrophilicity, suggesting reliance on active transport mechanisms in vivo), amoxicillin fully complies with Lipinski's Rule of Five, indicating good oral bioavailability potential. Furthermore, it is predicted not to permeate the Blood-Brain Barrier (BBB) and shows no inhibitory activity against major CYP450 enzymes (CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4) or P-glycoprotein, minimizing potential drug-drug interactions. The absence of PAINS and Brenk alerts signifies a clean chemical profile regarding assay interference and toxicity flags. Although some stricter druglikeness filters were violated due to its polar nature, amoxicillin's overall in silico profile, combined with its established clinical efficacy, highlights the complex interplay of physicochemical properties and biological transport mechanisms. This study reaffirms amoxicillin's favorable attributes from a computational perspective, serving as a valuable reference for understanding established antibiotics and guiding future antimicrobial design.
EDUKASI SWAMEDIKASI PENGGUNAAN OBAT ASAM URAT PADA PEMERIKSAAN KESEHATAN BERKALA Mildawati, Ratna; Prasetyo Nugroho, Bandhi; Prasetyawan, Fendy; Kristjono, Ary; Saristiana, Yuneka
Jurnal LENTERA Vol. 4 No. 2 (2024): Jurnal LENTERA
Publisher : Stikes Yarsi Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57267/lentera.v4i2.369

Abstract

Self-medication or self-medication is the use of drugs or self-soothing forms of behavior to treat a perceived or real illness. Most Indonesians practice self-medication or use drugs to cure diseases, including gout and cholesterol. Aim: To increase understanding of how to self-medicate using gout and cholesterol medication. The method used is lectures related to education through leaflets and PPTs, discussions and questions and answers. The results of the Self-Medication Education after the pretest and posttest were that of the 32 participants, 5 were in the good category, 10 were adequate and 17 were poor, to 28 were good and 4 were sufficient, so that in this activity it can be concluded that there is an understanding of the community to carry out self-medication for gout and the importance of carrying out regular examinations so that they can detect early if there is an increase in uric acid
Spesialisasi Profesi Apoteker Untuk Optimalisasi Pharmaceutical Care Dalam Pendidikan Apoteker Advanced Practice Prasetyawan, Fendy; Saristiana, Yuneka; Fadel, Muhammad Nurul; Besan, Ema Jayanti; Ardianto, Nanda; Zahra, Ilhawa
SEARCH: Science Education Research Journal Vol. 2 No. 2 (2024): April 2024
Publisher : IAIN Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47945/search.v2i2.1342

Abstract

Abstract Penelitian ini membahas pengembangan profesi apoteker di Indonesia menjadi Apoteker Spesialis dan Advanced Practice. Inisiatif ini dilaksanakan oleh Pengurus Pusat Ikatan Apoteker Indonesia (PP IAI), Kolegium Ilmu Farmasi Indonesia (KIFI), dan perguruan tinggi, dengan mengacu pada model pengembangan yang dirumuskan oleh International Pharmaceutical Federation (FIP). Proses ini mengadopsi dan mengadaptasi standar internasional untuk disesuaikan dengan kebutuhan dan kondisi lokal di Indonesia. Melalui pendekatan "adopt and adapt," mekanisme Rekognisi Pembelajaran Lampau (RPL) diintegrasikan dalam sistem registrasi online yang diperkenalkan oleh KIFI, mempermudah proses pendaftaran dan administrasi program pengembangan profesi. Penyesuaian kurikulum, metode pengajaran, dan sistem evaluasi dilakukan untuk menjamin relevansi dan kualitas pendidikan yang diberikan. Pengakuan internasional terhadap kompetensi apoteker Indonesia tidak hanya meningkatkan daya saing tenaga kerja tetapi juga membuka peluang kolaborasi internasional dan peningkatan kualitas layanan kesehatan. Inisiatif ini berdampak signifikan pada sistem kesehatan nasional dengan meningkatkan kompetensi apoteker dalam berbagai peminatan spesialis, termasuk farmasi nuklir, farmasi interna, farmasi neonatus dan anak, farmasi intensif, dan farmasi onkologi. KIFI bekerja sama dengan berbagai pihak untuk memastikan bahwa program pendidikan dan sertifikasi yang diselenggarakan memenuhi standar nasional dan internasional. Pengembangan ini menunjukkan komitmen Indonesia untuk meningkatkan kualitas pendidikan dan praktik farmasi, memastikan apoteker siap menghadapi tantangan kesehatan masa depan, dan memperkuat posisi Indonesia di kancah internasional. Dengan kolaborasi yang erat antara semua pemangku kepentingan, Indonesia dapat mencetak apoteker yang kompeten, profesional, dan siap berkontribusi pada peningkatan kualitas hidup masyarakat serta penguatan sistem kesehatan nasional.
Sosialisasi Penyakit Populer dikalangan muda-mudi melalui Penerapan Pola Hidup Sehat Ratna Mildawati; Ary Kristijono; Fendy Prasetyawan; Yuneka Saristiana; Bandhi Prasetya Nugroho
Jurnal Pengabdian Kepada Masyarakat Al-Amin Vol. 2 No. 1 (2024): January 2024
Publisher : STAI Al-Amin Gersik Kediri Lombok Barat-NTB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54723/jpa.v2i1.136

Abstract

Joint disease is a non-communicable disease that is often experienced by teenagers and middle-aged people. This disease is mostly suffered by the age group over 15 years which causes various complications. The aim of this program is to increase public knowledge, especially teenagers and middle-aged people, and understanding of gout and cholesterol, especially regarding how to prevent it, so that it can help improve the quality of public health. The method of this activity is carried out by means of online and offline education and socialization which is carried out in three stages. The first stage is preparation of activities, the second stage is implementation of activities, and the third stage is implementation of evaluation activities and preparation of reports. The implementation of this activity includes the stages of providing material, question and answer and ending with a posttest. The results after being given the material and the posttest showed an increase in knowledge and understanding about popular diseases according to the posttest score. It is hoped that this socialization will be able to prevent popular diseases that most young people experience, so that it can improve the quality of public health.
Strategi Pencegahan COVID-19: Peningkatan Imunitas Tubuh Melalui Edukasi Konsumsi Teh Kombucha Akhmal, Faisal; Fendy Prasetyawan; Yuneka Saristiana; Ratna Mildawati; Anis Akhwan Dhafin
Jurnal Pengabdian Kepada Masyarakat Al-Amin Vol. 2 No. 1 (2024): January 2024
Publisher : STAI Al-Amin Gersik Kediri Lombok Barat-NTB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54723/jpa.v2i1.138

Abstract

The COVID-19 pandemic, triggered by the coronavirus 2 (SARS-CoV-2), demands a rapid and effective response to protect the global community. This article discusses prevention strategies with a focus on boosting the body's immunity through education and the consumption of kombucha tea. COVID-19 varies in symptoms and impacts, requiring a holistic approach. Kombucha tea, a result of fermenting sweet tea with a SCOBY, provides high nutrition and health benefits, particularly in strengthening the immune system. Community outreach activities are conducted to disseminate information to healthcare professionals and students, discussing the benefits of kombucha tea in enhancing immunity during the pandemic. The methods of these activities involve preparation, implementation of educational sessions, and participant satisfaction evaluations. Research findings highlight the potential of kombucha tea, especially its antioxidant and anti-inflammatory compounds, in enhancing the body's resilience against SARS-CoV-2. This strategy can be reinforced by emphasizing overall healthy lifestyles. Despite its promise, challenges in implementation require effective education and cross-sector collaboration. The conclusion emphasizes the importance of a holistic approach and education in building the foundation of public health amid the pandemic.
Utilization of Antiviral Medications in COVID-19 Patients with Chronic Kidney Disease in Hospital Saristiana, Yuneka; Prasetyawan, Fendy; Muslikh, Faisal Akhmal; Dhafin, Anis Akhwan; Mildawati, Ratna; Putri, Elsa Mahardika; Raharjo, Susilo Margining
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 1 (2023): November 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i1.7284

Abstract

The COVID-19 pandemic has presented a substantial global health challenge, affecting diverse patient populations, particularly those with chronic kidney disease. Hospitals are presently dependent on two antiviral medications, favipiravir and remdesivir, to mitigate the impact of this disease on patients with chronic kidney disease. This study aims to evaluate the utilization of favipiravir and remdesivir in COVID-19 patients with chronic kidney disease in a hospital setting. This research will employ a retrospective approach to gather data from the medical records of COVID-19 patients with chronic kidney disease who received treatment with favipiravir or remdesivir in the hospital. Considering the prevalence of favipiravir usage at 64% and remdesivir at 36%, this research aims to provide a comprehensive understanding of the effectiveness and associated risks of toxicity linked to these two medications in COVID-19 patients with chronic kidney disease
Farmakoantartika Literature Study: Bioactivity of Pagodroma nivea on Fossil Deposits from Mujito Saristiana, Yuneka; Prasetyawan, Fendy; Mildawati, Ratna; Muslikh, Faisal Akhmal; Dhafin, Anis Akhwan; Raharjo, Susilo Margining; Arifin, Candra; Rofiq, Abd
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 2 (2023): December 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i2.7593

Abstract

This report investigates the biodiversity of marine animals, focusing on extinct sponge species near Lesbos Island based on Aristotle's descriptions. Mujito, introduced in the literature review, is from the GeoMaud expedition in Antarctica. Various instrumental analysis methods, such as ESI mass spectrometry and NMR, contribute to a comprehensive understanding of the compounds, particularly in the context of Alzheimer's research. The pharmacantarctic literature study concludes that Antarctic Mumijo, particularly from Mujito fossil deposits, holds significant biomedical potential. It exhibits organic components like wax esters with notable biomedical activities, particularly in treating bone diseases. Additionally, Mumijo's composition resembles non-fossil samples, with wax esters dominating and unique components like α-glyceryl fatty alcohol ethers indicating neuroprotective potential. The research suggests promising applications in Oriental medicine, addressing wounds, skin diseases, tuberculosis, respiratory diseases, and neurological conditions like Parkinson's and Alzheimer's. Overall, Antarctic Mumijo showcases diverse biomedical prospects, emphasizing its organic components' therapeutic value
Forensic Pharmacy Case Study: Identification of Hazardous Mercury Content as a Whitening Agent in Beauty Cream Products Ardianto, Nanda; Prasetyawan, Fendy; Saristiana, Yuneka; Muslikh, Faisal Akhmal; Mildawati, Ratna; Dhafin, Anis Akhwan; Arifin, Candra; Rofiq, Abd
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 2 (2023): December 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i2.7594

Abstract

Forensic pharmacy is crucial in identifying hazardous substances like mercury in beauty products. Counterfeit items with mercury pose health risks, emphasizing the need for accurate identification methods. The research, employing content analysis, focuses on illegal cosmetics containing mercury, aiming to understand distribution patterns and assess associated health risks. This systematic approach provides valuable insights into public health issues, contributing to safer regulatory practices. The utilization of these products may pose serious health risks to consumers. The implicated products include Temulawak New Day & Night, CAC Glow, Natural 99, HN (Day & Night), SP Special UV Whitening, Dr Original Pemutih, Super DR Quality Gold SPF 30, Diamond Cream, Herbal Plus New Day & Night, Ling Zhi Day & Night, Sj Sin Jung, Tabita, and Krim Labella. In Indonesia, the use of mercury in cosmetic products is prohibited by legislation, such as Law Number 32 of 2009 on Environmental Protection and Government Regulation of the Republic of Indonesia Number 81 of 2016 on the Security of Industrial Chemicals. Additionally, BPOM, responsible for overseeing drugs, food, and cosmetics, has issued relevant regulations
Co-Authors Abd Rofiq Abd Rofiq Achmad Wahdi Achmad Wahdi Adiyansyah Lukman Hakim Akhmal, Faisal Ali Anhar Syi’bul Huda Alshol, Mohammad Firdaus Althaf Rajahala B Sinun Amanda, Cornelia Ana Amalia Anggun Wida Prawira Anis Akhwan Dhafin Anis Akhwan Dhafin Anis Akwan Dhafin Anita Dwi Setyarini Ardianto, Nanda Arifani Siswidiasari arikha ayu susilowati Arsiaty Sumule Ary Kristijono Asrizal Azis Asrizal Azis Astutik, Widhi Azis, Asrizal Baarik Lana Fadli Bandhi Prasetya Nugroho Besan, Ema Jayanti Besan, Emma Jayanti Candra Arifin, Candra Chadra Arifin Chandra Arifin Chandra Arifin Charliandri Saputra Wahab Cornelia Amanda Dara Sukma Ratmelya Datin An Nisa Sukmawati Deo Rudita Febrian Waly Dewi Retno Puspitosari Edda, Ilda Rambu Eka Hayati Rhomah Eka Hayati Rhomah Eka Nur Fatmawati Eka Nur Fatmawati Elfred Rinaldo Kasimo Elfred Rinaldo Kasimo, Elfred Rinaldo Elly Rachmawati Ratnaningrum Elsa Mahardika Putri Elsa Mahardika Putri Ema Tri Wulan Ema Tri Wulan Emma Jayanti Besan Emma Jayanti Besan Faisal Akhmal Muslihk Faisal Akhmal Muslihk Faisal Akhmal Muslikh Faisal Akhmal Muslikh Faisal Akhmal Muslikh Faisal Akhmal Muslikh Faisal Akhmal Muslikh Febriana, Laela Fendy Prasetyawan Freitas, Maria Do Carmo Da Costa Hakim, Adiyansyah Lukman Hartini, Putri Tri Hasriyani Hasriyani Hasriyani Hasriyani Hasriyani, Hasriyani Herman Herman Herman Husnunnisa Ibrahim Fadlannul Haq Ibrahim Irsyadul Ibad Ibrahim Iskandar Alfaris Ilhawa Zahra Imam Agus Faizal Imran, Arlan K Indrayanti, Dian Isma Oktadiana Juwita, Syntia Tanu Kadir, Mujtahid Bin Abd Kadir, Mujtahid Bin And Karingga, Devangga Darma Kharisul Ihsan Kholis, Muhammad Akbar Nur Khumaini, Eko Hidayaturrohman Konradus Klala Mebung Kristjono, Ary Laili , Nur Fahma Laili, Nur Fahma Leny Witaning Kusumati Lily Aina Lisa Savitri Lisa Savitri Lusiana Aprillia M Wahyu Ariawan M. Wahyu Ariawan Marhenta, Yogi Bhakti Mebung, Konradus Klala Megasari, Elly Meri, Meri Meri, Meri milda, ratna Mildawati, Ratna Mohammad Firdaus Alshol Muhammad Alviyan Shutiawan Muhammad Nurul Fadel Muhammad Nurul Fadel Mujtahid Bin Abd Kadir Mujtahid Bin Abd. Kadir Nanda Ardianto Nanda Ardianto Neni Probosiwi Nimas Ayu Rahardini Nina Nur Jannah Nisa Azzahra Dentika Novyananda Salmasfattah Novyananda Salmasfattah Novyananda Salmasfattah Nur Fahma Laili Nur Masyithah Zamruddin Octavian Ashido Nababan Okky Intan Mawarni Okky Intan Mawarni Oktadiana, Isma Prasetyo Nugroho, Bandhi prayoga fery yuniarto Probosiwi , Neni Putri, Elsa Mahardika Raharjo, Susilo Margining Ratna Mildawati Ratna Mildawati Ratna Mildawati Ratna Mildawati Wati Ratna Mildwati Restyana, Anggi Rhomah, Eka Hayati Rika Wahyu Pujiastini Rochmad Krissanjaya Rofiq, Abd Rohmah, Eka Hayati Salmasfattah, Novyananda Salmasfattah, Novynanda Shinta Mayasari Shinta Mayasari Sugeng Santoso Sukmawati , Datin An Nisa Susilo Margining Raharjo Tri Wulan, Ema Tsamrotul Ilmi Widhi Astutik Widhi Astutik Widhi Astutik Widhi Astutik Winartiana Wisnu Haryo Widyoko Wulan, Ema Tri Yanti, Novirma Yogi Bhakti Marhenta Yunita Dian Permatasari Yunita Dian Permatasari Zahra, Ilhawa Ziza Putri Aisyia Fauzi