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All Journal VALENSI Jurnal Farmasi Udayana PHARMACON Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia JURNAL ILMIAH PERSPEKTIF Majalah Obat Tradisional KOVALEN: Jurnal Riset Kimia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Biologi Tropis Jurnal Ilmiah Manuntung Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ CARADDE: Jurnal Pengabdian Kepada Masyarakat JPSCR : Journal of Pharmaceutical Science and Clinical Research JIMR - Journal of Islamic Medicine Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Jamu Indonesia Jurnal Mandala Pharmacon Indonesia Lentera Acitya Journal Of Health Majalah Farmasetika Indian Journal of Forensic Medicine & Toxicology Yumary: Jurnal Pengabdian kepada Masyarakat Prima Abdika: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Kepada Masyarakat Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Farmasi Sains dan Praktis Jurnal Sains dan Teknologi Farmasi Indonesia Jurnal Kesehatan Lentera Acitya Journal of Public Health and Pharmacy Jurnal Pengabdian Farmasi dan Sains Jurnal Akademika Kimia Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Joni Tandi, Joni
Program Studi S1 Farmasi, Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu
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Effectiveness Test of Mangrove Leaf (Rhizophora Apiculata) on Decreasing Blood Glucose Levels and Pancreas Histopatology Streptozotocin Induced Male White Rats Tandi, Joni; Fahri, Mohammad; Fatma, Nurul; Anggi, Viani; Patala, Recky; Handayani, Tien Wahyu
Jurnal Penelitian Pendidikan IPA Vol 9 No 6 (2023): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i6.3789

Abstract

Hyperglycemia, a symptom of diabetes mellitus, can lead to oxidative stress, which is indicated by elevated malondialdehyde levels. Mangrove (Rhizophora apiculata) contains secondary metabolites of alkaloids, flavonoids, saponins and tanins, this can lessen how much oxidative stress there is in DM. This study intends to demonstrate the efficacy of mangrove extracts in lowering blood glucose levels and detecting pancreatic damage. The study used 30 male Wistar rats which were divided into 6 groups (group I: normal control, group II: negative and group III: positive control given glibenclamide 0.45 mg) and the test group (trial group). group IV: level 25 mg/kg BW, group V: level 50 mg/kg BW and VI: level 75 mg/kg BW) The DM model was made by streptozotocin induction. Pancreatic damage seen at 700 magnification saw pancreatic β cells as well as the islets of Langerhans' endocrine cells. The results of research on ethanol from mangrove leaves at levels of 75 mg/kg BW are substances that are effective at lowering blood sugar levels, which on average were 105 mg/dL with a hazard value of 1.2. When compared with glibenclamide mangrove extract is not equivalent to glibenclamide but has lowered glucose levels.
Subchronic Toxicity Test of Purple Leaves Ethanol Extract (PLEE) on the Histopathological Picture of the Lymph of Wistar Rats and Antioxidant Activity Darmayanti; Dewi, Niluh Puspita; Mariyani; Tandi, Joni; Rachmawati, Meike; Susanto, Yuliet
Jurnal Penelitian Pendidikan IPA Vol 10 No 7 (2024): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i7.8070

Abstract

This study aims to determine the toxic effects of purple leaf ethanol extract on lymph organs at doses of 500; 2.000; and 5.000 mg/kgBB administered for 28 days and and to determine the antioxidant activity of purple leaf Graptophyllum pictum (L.) This study is an experimental study with a random group design, using 20 test animals divided into 4 groups consisting of two treatment groups, namely in the normal control group given Na-CMC 0.5% and the experimental group given PLEE (k1: dose 500 mg/kgBB, k2: dose 2.000 mg/kgBB and k3: dose 5.000 mg/kgBB hematoxylin-eosin staining (HE) using a computer-connected Motic BA210 microscope with 40X magnification in 5 fields of view and antioxidant test using DPPH method with UV-Vis Spectrophotometer at 516 nm wavelength with concentration 20, 40, 60, 80, and 100 ppm. The results showed that leaf ethanol extract was toxic at a dose of 2.000 mg/kgBB – 5.000 mg/kgBB against the diameter of lymphatic organ pulp, organ index and organ weight, there were symptoms of toxicity and purple leaf ethanol extract had strong antioxidant activity with 66.26 μg/mL.
UJI TOKSISITAS SUB KRONIS EKSTRAK DAUN UNGU TERHADAP GAMBARAN HISTOPATOLOGI GINJAL TIKUS PUTIH JANTAN Dipayana, I Made; Dewi, Niluh Puspita; Magfira; Tandi, Joni; Wirawan, Wayan; Rachmawati, Meike; Azizah, Nur
Jurnal Penelitian Pendidikan IPA Vol 10 No 8 (2024): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i8.8312

Abstract

Traditional herbal medicine has become increasingly popular as an alternative to conventional medical treatments. Although the plant offers numerous health benefits, caution should be exercised regarding its long-term use. Long-term use of traditional herbal remedies can have detrimental effects on the kidneys. This study was designed to assess the histological changes in the kidneys of male rats following 28 days of purple sage leaf extract administration and to identify potential harmful effects. The study utilized 20 male Wistar rats and utilized a randomized group design for the experimental methodology. Rats were categorized into four distinct groups, consisting of one control group and three treatment groups. The control group received solely sodium chloride, whereas the treatment group 1 (P1) received 500 mg/kg BB of purple sage ethanol extract. Treatment group 2 received up to 2000 mg/kg BB of purple sage ethanol extract, while treatment group 3 received up to 5000 mg/kg BB. The oral examination was conducted for a duration of 28 days. The treatment groups showed an increase in weight and organ index of the right kidney. The findings suggest a potential for toxicity resulting from the administration of purple sage leaf extract over a duration of 28 days.
Determination of specific and non-specific standardization parameters for ethanol extract of purple leaves (Graptophyllum pictum (L) Griff ) Tampang, Rivani; Alaydrus, Syafika; Dewi, Niluh Puspita; Tandi, Joni
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8812

Abstract

this study aims to determine the standardization of specific parameters (organoleptic and chemical content) and non-specific parameters (ash content, water content, drying loss, heavy metal contamination, Yeast Mold Number (AKK), microbial contamination / Total Plate Count (ALT)). The results showed that the specific parameters of the organoleptic properties of 96% ethanol extract of purple leaves (Grapthophyllum pictum (L) Griff) were black, shaped like a paste, a distinctive purple leaf odor and a bitter taste. The results of phytochemical screening of 96% purple leaf ethanol extract contained alkaloids, flavonoids, and tannins. However, the saponin test was negative for saponins. Non-specific parameters of 96% ethanol extract of cherry leaves were water content of 5.96%, total ash content of 16.86%, drying loss of 17.26%, heavy metals As and Cd were not detected, the presence of metals in Pb was 0.12 mg / kg, microbial contamination (Alt) and yeast mold numbers (Akk) were not found colonies. Based on these results, it can be concluded that the standardization test of specific and non-specific parameters, the ethanol extract of purple leaves has met the quality standards of simple drugs.
MACROSCOPIC AND MICROSCOPIC GASTROPROTECTIVE ACTIVITY OF MUCOADHESIVE GRANULE FORMULATIONS OF CLOVE LEAF ETHANOL EXTRACT Harliwong, Dhitania Ivana; Wulandari, Ayu; Dewi, Niluh Puspita; Muthmainnah, Sririzqi; Tandi, Joni; Intan, Putu
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8949

Abstract

Gastric ulcers can be triggered by excessive HCl secretion, and the regenerative capacity of mucosal cells can be weakened by high alcohol levels and anti-inflammatory drugs, including NSAIDs. Gastrin functions to stimulate the secretion of gastric juice, particularly HCl and pepsinogen This study aims to evaluate the macroscopic and microscopic gastroprotective activity of clove leaf ethanol extract mucoadhesive granule formulations. The study used 25 rats divided into five groups: normal control, negative control, positive control, clove leaf ethanol extract group, and mucoadhesive granule formulation of clove leaf ethanol extract group. All groups except the normal control were administered acetylsalicylic acid. Treatments were conducted over 9 days, with surgical examination and observations performed macroscopically and microscopically on day 10. Macroscopic assessments revealed ulcer damage improvement in the positive control, extract, and mucoadhesive granule groups, all scored at 1. Microscopic assessments also indicated a significant difference between the negative control and the positive control, extract, and mucoadhesive granule groups, showing better gastric repair, scored at 0.5. Therefore, it can be concluded that the administration of the mucoadhesive granule formulation of clove leaf ethanol extract exhibits gastroprotective activity comparable to that of the clove leaf ethanol extract.
Acute Toxicity Test of Gastroretentive Mucoadhesive Granule Preparation of Earthworm Flour (Lumbricus rubellus) Magfirah; Merue, Novalia; Tandi, Joni; Islamiati, Utami
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8952

Abstract

Earthworms (Lumbricus rubellus) contain the compound lumbricin, which is beneficial for treatment, and its use is still simple, leading to the innovation of gastroretentive mucoadhesive granule formulations. However, its security has not yet been fully supported by research. This research aims to determine the toxic effects caused by earthworm granule preparations in terms of toxicity symptoms and the determination of the LD50 value. This research used 20 male white rats that were randomly divided into 4 groups. One control group was given Aquadest, and three treatment groups were given earthworm granules at doses of 500 mg/kgBB (P1), 2000 mg/kgBB (P2), and 5000 mg/kgBB (P3) with a single oral administration. The research results indicate that the preparation of earthworm granules (Lumbricus rubellus) causes toxic symptoms such as decreased locomotor activity, piloerection, and increased grooming frequency in line with the increase in dosage, but does not result in the death of the test animals. (LD50). Based on the research findings, it can be concluded that the LD50 value of the earthworm granules (Lumbricus rubellus) is >5000 mg/kgBB and falls into the practically non-toxic category with an LD50 range of 5–15 g/kgBB
Test of the Effectiveness of Earthworm Flour (Lumbricus rubellus) Gastroretentive Mucoadhesive Granule Formulation on Male White Rats (Rattus norvegicus) Infected with Salmonella typhi Magfirah; Bengkati, Stely Gracia; Tandi, Joni; Anggi, Viani
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8953

Abstract

Lumbricus rubellus contains lumbricin which is efficacious for treating typhoid fever. The aim of the research was to determine the effectiveness of gastroretentive mucoadhesive granule preparations from earthworm flour. This study used 30 male Wistar rats which were divided into 6 groups which were given orally, the normal and negative control groups were given Na-CMC, the positive control group was given chloramphenicol, and the treatment group was given doses of 200 mg/kgBW, 400 mg/kgBW and 800 mg/kgBW. mg/kgBB gastroretentive mucoadhesive granules earthworm flour. The results of body temperature measurements, on day 7 the control group obtained results of ±37.08, ±39.00 and ±38.09 respectively, and the treatment group obtained results of ±38.09, ±38.09 and ±38.07 respectively. On day 21, the control group obtained results of ±37.08, ±39.00 and ±38.09, respectively, and the treatment group obtained results of ±38.09, ±38.09 and ±38.07, respectively. The Widal test results on the 7th day were positive and after 14 days of administering the preparation on the 21st day the results were negative. It was concluded that the effective dose for typhoid fever therapy was a dose of 400 mg/kgBW.
Analysis Pork Contamination in Beef Meatballs through Polymerase Chain Reaction in Palu City Polibaon, Tresya J.; Mariyani; Tandi, Joni; Handayani, Tien Wahyu; Dinurrosifa, Rahmawati Salsa; Sene, Ikhsan Hi. Amir
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.9006

Abstract

The need for halal products is essential, particularly among various processed beef products like meatballs, which are popular among nearly the entire community. These products are susceptible to issues of meat counterfeiting for greater economic gain. This study aims to determine the smallest DNA concentration that can still be detected and to assess whether there is any pork contamination in meatballs circulating in Palu City using Polymerase Chain Reaction (PCR). This test uses four DNA samples obtained from fresh meat to test the specificity of the primer: wild boar, rat, and goat DNA samples as comparisons, and pig DNA as a positive control. The presence of DNA bands in the agarose gel electrophoresis visualization results indicates that DNA amplification has occurred, meaning that the sample can be detected. The analysis results showed that the primer used (Cyt-b) had good specificity for detecting pork DNA, while the absolute pork DNA concentration of 0.01 ng/µL and the reference meatball DNA with a concentration of 0.01% are the smallest limits that can still be detected using PCR. Of the four meatball samples from Palu City, one sample produced a DNA band, indicating that the sample contains or is contaminated with pig DNA. This method is valid as it meets the specificity test and demonstrates a good detection limit.
Optimalisasi Potensi Tanaman Herbal Lokal Melalui Pelatihan Pembuatan Minyak Gosok di Desa Petiro, Kabupaten Poso Joni Tandi; Tien Wahyu Handayani; Vivi Gretia Triposa
PaKMas: Jurnal Pengabdian Kepada Masyarakat Vol 5 No 2 (2025): November 2025
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54259/pakmas.v5i2.4075

Abstract

The use of herbal plants in modern medicine is increasing, notably for their antioxidant properties that effectively reduce free radicals. The growing "back to nature" trend, coupled with the high cost of modern pharmaceuticals, has encouraged communities to seek safer alternative treatments. This community service program was designed to enhance the capabilities of residents in Petiro Village, East Pamona District, Poso Regency to independently produce herbal massage oil as a sustainable health solution. Methodologically, the program employed a combination of lectures, practical demonstrations, and interactive discussions. Evaluation was conducted through pre-tests and post-tests administered to 22 participants to measure knowledge acquisition. The implementation process followed a systematic approach: preparation of raw materials, processing them into dry simplicia, and formulating massage oil using essential oils combined with natural herbs including ginger, turmeric, red betel leaf, garlic, and onion. Results demonstrated a remarkable improvement in community understanding, rising from 25% to 100% following the training intervention. This improvement encompassed comprehensive knowledge of the benefits, production techniques, and understanding of herbal massage oil ingredients. The training successfully fostered practical skills that participants could immediately apply. The significant knowledge transfer achieved has important implications for developing local herbal massage oil production as a sustainable enterprise, potentially improving both community health outcomes and economic prosperity in rural communities. Additionally, this initiative contributes to preserving traditional herbal knowledge while adapting it to contemporary health needs, creating a viable model for other rural communities seeking health self-sufficiency.
Innovative Oil from STIFA Pelita Mas for Glycemic Control and Tissue Regeneration in Diabetic Rats Joni Tandi; Muthmainah Tuldjanah; Tien Wahyu Handayani
Journal of Public Health and Pharmacy Vol. 6 No. 1: MARCH 2026
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v6i1.7192

Abstract

Introduction: Diabetes mellitus is a significant global health problem with increasing prevalence in Indonesia. Conventional management of diabetes mellitus is often accompanied by side effects and high costs, prompting the search for alternatives based on natural ingredients. STIFA Pelita Mas Herbal Oil is an innovative formulation that combines various efficacious natural ingredients, but its effectiveness on histopathological changes in pancreatic and kidney tissues due to diabetes has not been comprehensively explored. This study aims to evaluate the effectiveness and mechanism of action of STIFA Pelita Mas Herbal Oil on reducing blood glucose levels, repairing pancreatic tissue damage, and kidneys in a streptozotocin-induced rat model. Methods: This study used a quantitative approach with an experimental design on 30 male white rats (Rattus norvegicus) divided into 6 treatment groups. STIFA Pelita Mas Herbal Oil is made by combining simplicia (Shallots, Garlic, Ginger, Curcuma zanthorrhiza, Lemongrass red, and Piper ornatum leaves) with various oils (VCO, eucalyptus oil, citronella oil, olive oil, and cinnamomum cullilawan). Diabetes was induced using streptozotocin (40 mg/kg BW) intraperitoneally. The parameters measured included blood glucose levels and histopathological changes in the kidneys and pancreas with Hematoxylin-Eosin staining. Data were analyzed using One Way ANOVA followed by the LSD or Kruskal-Wallis test. Result: The results showed that all three herbal oil formulas were able to lower blood glucose levels, with formula 1 and formula 3 showing comparable effectiveness to glibenclamide on day 28. In histopathological observations of the kidneys, formula 3 showed the best effectiveness in repairing damage to renal tubule and glomerular cells with a damage score of 0, equivalent to normal controls. Similarly, in histopathological observations of the pancreas, formula 3 showed the highest effectiveness in repairing damage to pancreatic beta cells with a damage score of 0.2, not significantly different from normal and positive controls. Conclusion: Stifa Pelita Mas herbal oil, especially formula 3, has the potential as an effective antidiabetic agent in lowering blood glucose levels and repairing tissue damage in the kidneys and pancreas due to diabetes. Future research should focus on dose variations to see at what dose this oil is effective.
Co-Authors Afriani S Afrizal Agustinus Widodo Ahmad, Mirnawati Alaydrus, Syafika Alaydus, Syafika Andini, Tuti Allawiah Anggi, Viani Anita Purwantari Aril, Moh Arynesta, Teddy Asrifa Asrifa Astria, Nani Astuti, Dewi Qurrotul Ayu Martina AYU WULANDARI Ayu Wulandari Azwaajum Mutahharah Basilingan, Aprince Bella Melinda Bengkati, Stely Gracia Cinda Pradita Sudar Claresta, Jong A. Darmayanti David Pakaya David Pakaya Debora Rislianti Lakiu Dewi Astuti Dewi, Alfia Dian S. Waruwu Diana Pratiwi, Franciska Dipayana, I Made Erdy Prasetyo Fahri, Mohammad Fahruddin Fahruddin Faisal Rahmat Nugraha Fajar Alan Fatma, Nurul Feiverin Tibe Gabriella Bamba Ratih Lintin Gintu, Tri Juniver Gusti Ayu Gusti Ayu, Gusti Handayani KR Handayani, Tien W. Handayani, Tien Wahyu Handayani, Tien Wahyuni Harliwong, Dhitania Ivana Hastuti L Ida Yanti Palinggi Insani, Nabila Nurul Intan, Putu Irwan Irwan Islamiati, Utami Jong A. Claresta Kiki Rizki Handayani Kurnia Gatot Novrianto L, Wahyudin H Lakiu, Debora Rislianti Lexy Kareba Lidongi, Putri Marcelita Lina Hardianti Rukmana M, Yulan Magfira Magfirah Magfirah, Magfirah Magfiroh Magfiroh Maria Kanan Mariyani Mariyani, Mariyani Marsella, Mimi Marzela Dewi Meike Rachmawati Merue, Novalia Moh Rizky Moh. Roem Muhammad Agus Muljanto Muthi’ah H Z Muthmainah Tuldjanah Muthmainnah, Sririzqi Na'i, Alpina Nadila Nadila Nadila, Nadila Nadira Nani Astria Ni Made Irma Mariani Ni Putu Setiawati Ni Wayan Ika Purwasih Niluh Puspita Dewi Niluh Puspita Dewi Niluh Puspita Dewi Niluh Puspita Dewi, Niluh Puspita Niswatulfahriyati Niswatulfahriyati Nur Azizah Nur Ikhwan Nurhikmah Nurhikmah Nurmadinah Nurmadinah Nurul Ulzmi Ovan Nugroho Pegia Parobe, Alda Iglesias Pasang, Sisilia Baan Polakitan, Grace Lovita Polibaon, Tresya J. Puspita Dewi, Niluh Putri, Debby Aulia R, Yana Novika Rahmawati D Rahmawati Salsa Dinurrosifa Rajadenda, Afwa Al Rasmiyanti, Ni Kadek Evy Recky Patala Rezky Yanuarty Riani, Ni P. I. Riani, Ni Putu Intan Rio Mariani Risna Yanti Rizaldy Lalu Ronaldy Nobertson Rusdi, Grasela Ruterlin, Valen Safitri, Nabila Umi Salsabila, Unik Hanifah Sasdila, Sasdila Seblin Tonapa Rammang Sene, Ikhsan Hi. Amir Solehah, Puput Octaviani Sri Mulyani Sri Mulyani Sri Mulyani Sri Mulyani Sabang Suarsana, I Made Agus Sujati, Ni Wayan Surat, Megawati R. surisna, surisna Syafika Alaydrus Tampang, Rivani Tamunu, Jeine Sweet Natasya Tandy, Putri Adam Tarusu, Fikhta Agnesya Tiara Anastasya Ticoh, Febriyani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien, Tien Wahyu Handayani Toding, Ficanata Adhiguna Tonapa Rammang, Seblin Towulu, Dessy Gracelia Tuldjanah, Muthmainah Uigianto, Imelda Utami, Indah Kurnia Valen Ruterlin Veronika Veronika Viani Anggi Vidya Christin Vivi Gretia Triposa Wahyu Handayani, Tien Wahyu Nur Afandi WAYAN WAYAN Wirawan W Wirawan, Resky Chandra wirawan, Wayan Yana Novika R Yanti Palinggi, Ida Yanuarty, Rezky Yasinta Rakanita Yuli Fitriana Yuliet Yuliet Yulistien Yusuf Yunlis Silintowe Kenta Yusriadi Yusriadi Yustin Yustin Zulfaidah