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All Journal VALENSI PHARMACON Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia JURNAL ILMIAH PERSPEKTIF Majalah Obat Tradisional KOVALEN: Jurnal Riset Kimia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Biologi Tropis Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ CARADDE: Jurnal Pengabdian Kepada Masyarakat JIMR - Journal of Islamic Medicine Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Jamu Indonesia Jurnal Mandala Pharmacon Indonesia Lentera Acitya Journal Of Health Majalah Farmasetika Indian Journal of Forensic Medicine & Toxicology Yumary: Jurnal Pengabdian kepada Masyarakat Prima Abdika: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Kepada Masyarakat Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Farmasi Sains dan Praktis Jurnal Sains dan Teknologi Farmasi Indonesia Journal of Pharmaceutical and Sciences. Jurnal Kesehatan Lentera Acitya Jurnal Pengabdian Farmasi dan Sains Jurnal Akademika Kimia Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Joni Tandi, Joni
Program Studi S1 Farmasi, Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu
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Subchronic Toxicity Test of Purple Leaves Ethanol Extract (PLEE) on the Histopathological Picture of the Lymph of Wistar Rats and Antioxidant Activity Darmayanti; Niluh Puspita Dewi; Mariyani; Joni Tandi; Meike Rachmawati; Yuliet Susanto
Jurnal Penelitian Pendidikan IPA Vol 10 No 7 (2024): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i7.8070

Abstract

This study aims to determine the toxic effects of purple leaf ethanol extract on lymph organs at doses of 500; 2.000; and 5.000 mg/kgBB administered for 28 days and and to determine the antioxidant activity of purple leaf Graptophyllum pictum (L.) This study is an experimental study with a random group design, using 20 test animals divided into 4 groups consisting of two treatment groups, namely in the normal control group given Na-CMC 0.5% and the experimental group given PLEE (k1: dose 500 mg/kgBB, k2: dose 2.000 mg/kgBB and k3: dose 5.000 mg/kgBB hematoxylin-eosin staining (HE) using a computer-connected Motic BA210 microscope with 40X magnification in 5 fields of view and antioxidant test using DPPH method with UV-Vis Spectrophotometer at 516 nm wavelength with concentration 20, 40, 60, 80, and 100 ppm. The results showed that leaf ethanol extract was toxic at a dose of 2.000 mg/kgBB – 5.000 mg/kgBB against the diameter of lymphatic organ pulp, organ index and organ weight, there were symptoms of toxicity and purple leaf ethanol extract had strong antioxidant activity with 66.26 μg/mL.
UJI TOKSISITAS SUB KRONIS EKSTRAK DAUN UNGU TERHADAP GAMBARAN HISTOPATOLOGI GINJAL TIKUS PUTIH JANTAN I Made Dipayana; Niluh Puspita Dewi; Magfira; Joni Tandi; Wayan Wirawan; Meike Rachmawati; Nur Azizah
Jurnal Penelitian Pendidikan IPA Vol 10 No 8 (2024): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i8.8312

Abstract

Traditional herbal medicine has become increasingly popular as an alternative to conventional medical treatments. Although the plant offers numerous health benefits, caution should be exercised regarding its long-term use. Long-term use of traditional herbal remedies can have detrimental effects on the kidneys. This study was designed to assess the histological changes in the kidneys of male rats following 28 days of purple sage leaf extract administration and to identify potential harmful effects. The study utilized 20 male Wistar rats and utilized a randomized group design for the experimental methodology. Rats were categorized into four distinct groups, consisting of one control group and three treatment groups. The control group received solely sodium chloride, whereas the treatment group 1 (P1) received 500 mg/kg BB of purple sage ethanol extract. Treatment group 2 received up to 2000 mg/kg BB of purple sage ethanol extract, while treatment group 3 received up to 5000 mg/kg BB. The oral examination was conducted for a duration of 28 days. The treatment groups showed an increase in weight and organ index of the right kidney. The findings suggest a potential for toxicity resulting from the administration of purple sage leaf extract over a duration of 28 days.
Determination of specific and non-specific standardization parameters for ethanol extract of purple leaves (Graptophyllum pictum (L) Griff ) Rivani Tampang; Syafika Alaydrus; Niluh Puspita Dewi; Joni Tandi
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8812

Abstract

this study aims to determine the standardization of specific parameters (organoleptic and chemical content) and non-specific parameters (ash content, water content, drying loss, heavy metal contamination, Yeast Mold Number (AKK), microbial contamination / Total Plate Count (ALT)). The results showed that the specific parameters of the organoleptic properties of 96% ethanol extract of purple leaves (Grapthophyllum pictum (L) Griff) were black, shaped like a paste, a distinctive purple leaf odor and a bitter taste. The results of phytochemical screening of 96% purple leaf ethanol extract contained alkaloids, flavonoids, and tannins. However, the saponin test was negative for saponins. Non-specific parameters of 96% ethanol extract of cherry leaves were water content of 5.96%, total ash content of 16.86%, drying loss of 17.26%, heavy metals As and Cd were not detected, the presence of metals in Pb was 0.12 mg / kg, microbial contamination (Alt) and yeast mold numbers (Akk) were not found colonies. Based on these results, it can be concluded that the standardization test of specific and non-specific parameters, the ethanol extract of purple leaves has met the quality standards of simple drugs.
MACROSCOPIC AND MICROSCOPIC GASTROPROTECTIVE ACTIVITY OF MUCOADHESIVE GRANULE FORMULATIONS OF CLOVE LEAF ETHANOL EXTRACT Dhitania Ivana Harliwong; Ayu Wulandari; Niluh Puspita Dewi; Sririzqi Muthmainnah; Joni Tandi; Putu Intan
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8949

Abstract

Gastric ulcers can be triggered by excessive HCl secretion, and the regenerative capacity of mucosal cells can be weakened by high alcohol levels and anti-inflammatory drugs, including NSAIDs. Gastrin functions to stimulate the secretion of gastric juice, particularly HCl and pepsinogen This study aims to evaluate the macroscopic and microscopic gastroprotective activity of clove leaf ethanol extract mucoadhesive granule formulations. The study used 25 rats divided into five groups: normal control, negative control, positive control, clove leaf ethanol extract group, and mucoadhesive granule formulation of clove leaf ethanol extract group. All groups except the normal control were administered acetylsalicylic acid. Treatments were conducted over 9 days, with surgical examination and observations performed macroscopically and microscopically on day 10. Macroscopic assessments revealed ulcer damage improvement in the positive control, extract, and mucoadhesive granule groups, all scored at 1. Microscopic assessments also indicated a significant difference between the negative control and the positive control, extract, and mucoadhesive granule groups, showing better gastric repair, scored at 0.5. Therefore, it can be concluded that the administration of the mucoadhesive granule formulation of clove leaf ethanol extract exhibits gastroprotective activity comparable to that of the clove leaf ethanol extract.
Acute Toxicity Test of Gastroretentive Mucoadhesive Granule Preparation of Earthworm Flour (Lumbricus rubellus) Magfirah; Novalia Merue; Joni Tandi; Utami Islamiati
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8952

Abstract

Earthworms (Lumbricus rubellus) contain the compound lumbricin, which is beneficial for treatment, and its use is still simple, leading to the innovation of gastroretentive mucoadhesive granule formulations. However, its security has not yet been fully supported by research. This research aims to determine the toxic effects caused by earthworm granule preparations in terms of toxicity symptoms and the determination of the LD50 value. This research used 20 male white rats that were randomly divided into 4 groups. One control group was given Aquadest, and three treatment groups were given earthworm granules at doses of 500 mg/kgBB (P1), 2000 mg/kgBB (P2), and 5000 mg/kgBB (P3) with a single oral administration. The research results indicate that the preparation of earthworm granules (Lumbricus rubellus) causes toxic symptoms such as decreased locomotor activity, piloerection, and increased grooming frequency in line with the increase in dosage, but does not result in the death of the test animals. (LD50). Based on the research findings, it can be concluded that the LD50 value of the earthworm granules (Lumbricus rubellus) is >5000 mg/kgBB and falls into the practically non-toxic category with an LD50 range of 5–15 g/kgBB
Test of the Effectiveness of Earthworm Flour (Lumbricus rubellus) Gastroretentive Mucoadhesive Granule Formulation on Male White Rats (Rattus norvegicus) Infected with Salmonella typhi Magfirah; Stely Gracia Bengkati; Joni Tandi; Viani Anggi
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8953

Abstract

Lumbricus rubellus contains lumbricin which is efficacious for treating typhoid fever. The aim of the research was to determine the effectiveness of gastroretentive mucoadhesive granule preparations from earthworm flour. This study used 30 male Wistar rats which were divided into 6 groups which were given orally, the normal and negative control groups were given Na-CMC, the positive control group was given chloramphenicol, and the treatment group was given doses of 200 mg/kgBW, 400 mg/kgBW and 800 mg/kgBW. mg/kgBB gastroretentive mucoadhesive granules earthworm flour. The results of body temperature measurements, on day 7 the control group obtained results of ±37.08, ±39.00 and ±38.09 respectively, and the treatment group obtained results of ±38.09, ±38.09 and ±38.07 respectively. On day 21, the control group obtained results of ±37.08, ±39.00 and ±38.09, respectively, and the treatment group obtained results of ±38.09, ±38.09 and ±38.07, respectively. The Widal test results on the 7th day were positive and after 14 days of administering the preparation on the 21st day the results were negative. It was concluded that the effective dose for typhoid fever therapy was a dose of 400 mg/kgBW.
Pengaruh Ekstrak Bunga Kecombrang (Etlingera elatior (Jack)) Terhadap Gambaran Histopatologi Lambung Pada Tikus Putih Jantan (Rattus norvegicus) Yang Diindukasi Streptozotocin Matra Novalia Palipadang; Syafika Alaydrus; Joni Tandi; Utami Islamiati; Ficanata Adhiguna Toding; Vianda Managanta
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1293

Abstract

Background: Hyperglycemia induced by streptozotocin (STZ) increases oxidative stress and inflammatory responses that may lead to gastric mucosal damage. Kecombrang flower (Etlingera elatior (Jack)) contains flavonoids and other secondary metabolites with antioxidant, anti-inflammatory, and antihyperglycemic properties that are potentially gastroprotective. Objective: This study aimed to evaluate the effect of ethanol extract of kecombrang flower on the histopathological profile of the stomach in male white rats (Rattus norvegicus) induced by streptozotocin and to determine the most effective dose. Methods: This experimental in vivo study employed a posttest-only control group design. Twenty-five male rats were divided into five groups (n=5): normal control, negative control (STZ-induced), positive control (STZ + glibenclamide), extract 50 mg/kg body weight (BW), and extract 100 mg/kg BW. Streptozotocin was administered intraperitoneally at 40 mg/kg BW. Gastric tissues were examined histopathologically using hematoxylin-eosin staining and assessed based on degeneration, necrosis, and inflammation scoring. Data were analyzed using Kruskal–Wallis followed by Mann–Whitney test with Bonferroni correction (p<0.05). Results: Phytochemical screening confirmed the presence of alkaloids, flavonoids, saponins, and tannins in the extract. Statistical analysis showed significant differences among groups in degeneration (p=0.013) and inflammation (p=0.047), but not in necrosis (p=1.000). The 100 mg/kg BW dose demonstrated the most prominent protective effect, with lower degeneration and inflammation scores and an average gastric damage score of 1, comparable to the positive control group. Conclusion: Ethanol extract of kecombrang flower at a dose of 100 mg/kg BW effectively reduced gastric histopathological damage in streptozotocin-induced male rats, indicating its potential gastroprotective activity through antioxidant and anti-inflammatory mechanisms.
Co-Authors Afriani S Afrizal Agustinus Widodo Ahmad, Mirnawati Alaydrus, Syafika Alaydus, Syafika Andini, Tuti Allawiah Anita Purwantari Aril, Moh Arynesta, Teddy Asrifa Asrifa Astuti, Dewi Qurrotul Ayu Martina Ayu Wuladari Ayu Wulandari Ayu Wulandari AYU WULANDARI Azwaajum Mutahharah Basilingan, Aprince Bella Melinda Cinda Pradita Sudar Claresta, Jong A. Darmayanti David Pakaya David Pakaya Debora Rislianti Lakiu Dewi Astuti Dewi, Alfia Dhitania Ivana Harliwong Dian S. Waruwu Diana Pratiwi, Franciska Erdy Prasetyo Fahruddin Fahruddin Faisal Rahmat Nugraha Fajar Alan Feiverin Tibe Ficanata Adhiguna Toding Ficanata Adhiguna Toding Gabriella Bamba Ratih Lintin Gintu, Tri Juniver Gusti Ayu Gusti Ayu, Gusti Handayani KR Handayani, Kiki Rizki Handayani, Tien W. Handayani, Tien Wahyu Handayani, Tien Wahyuni Hastuti L I Made Dipayana Ida Yanti Palinggi Insani, Nabila Nurul Irwan Irwan Islamiati, Utami Jong A. Claresta Kurnia Gatot Novrianto L, Wahyudin H Lakiu, Debora Rislianti Lexy Kareba Lidongi, Putri Marcelita Lina Hardianti Rukmana M, Yulan Magfira Magfira Magfirah Magfirah, Magfirah Magfiroh Magfiroh Maria Kanan Mariyani Marsella, Mimi Marzela Dewi Matra Novalia Palipadang Meike Rachmawati Moh Rizky Moh. Roem Muaadzatul Izzah Sudarman Muhammad Agus Muljanto Muthi’ah H Z Muthmainah Tuldjanah Na'i, Alpina Nadila Nadila Nadila, Nadila Nadira Nani Astria Polontalo Ni Made Irma Mariani Ni Putu Setiawati Ni Wayan Ika Purwasih Niluh Puspita Dewi Niluh Puspita Dewi Niluh Puspita Dewi Niluh Puspita Dewi, Niluh Puspita Niswatulfahriyati Niswatulfahriyati Novalia Merue Nur Azizah Nur Ikhwan Nurhikmah Nurhikmah Nurmadinah Nurmadinah Nurul Ulzmi Ovan Nugroho Pegia Parobe, Alda Iglesias Pasang, Sisilia Baan Polakitan, Grace Lovita Puspita Dewi, Niluh Putri Natalia Laurenza Ladjeba Putri, Debby Aulia Putu Intan R, Yana Novika Rahmawati D Rajadenda, Afwa Al Rasmiyanti, Ni Kadek Evy Recky Patala Rezky Yanuarty Rezky Yanuarty Riani, Ni P. I. Riani, Ni Putu Intan Rio Mariani Risna Yanti Rivani Tampang Rizaldy Lalu Ronaldy Nobertson Rusdi, Grasela Ruterlin, Valen Safitri, Nabila Umi Salsabila, Unik Hanifah Sasdila, Sasdila Seblin Tonapa Rammang Solehah, Puput Octaviani Sri Mulyani Sri Mulyani Sri Mulyani Sri Mulyani Sabang Sririzqi Muthmainnah Stely Gracia Bengkati Suarsana, I Made Agus Sujati, Ni Wayan Surat, Megawati R. surisna, surisna Syafika Alaydrus Syafika Alaydrus Tamunu, Jeine Sweet Natasya Tarusu, Fikhta Agnesya Tiara Anastasya Ticoh, Febriyani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien, Tien Wahyu Handayani Tonapa Rammang, Seblin Towulu, Dessy Gracelia Tuldjanah, Muthmainah Uigianto, Imelda Utami Islamiati Utami, Indah Kurnia Valen Ruterlin Veronika Veronika Vianda Managanta Viani Anggi Vidya Christin Vivi Gretia Triposa Wahyu Handayani, Tien Wahyu Nur Afandi WAYAN WAYAN Wayan Wirawan Wirawan W Wirawan, Resky Chandra Yana Novika R Yanti Palinggi, Ida Yanuarty, Rezky Yasinta Rakanita Yuli Fitriana Yuliet Yuliet Yulistien Yusuf Yunlis Silintowe Kenta Yusriadi Yusriadi Yustin Yustin Zulfaidah