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All Journal VALENSI PHARMACON Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia JURNAL ILMIAH PERSPEKTIF Majalah Obat Tradisional KOVALEN: Jurnal Riset Kimia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Biologi Tropis Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ CARADDE: Jurnal Pengabdian Kepada Masyarakat JPSCR : Journal of Pharmaceutical Science and Clinical Research JIMR - Journal of Islamic Medicine Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Jamu Indonesia Jurnal Mandala Pharmacon Indonesia Lentera Acitya Journal Of Health Majalah Farmasetika Indian Journal of Forensic Medicine & Toxicology Yumary: Jurnal Pengabdian kepada Masyarakat Prima Abdika: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Kepada Masyarakat Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Farmasi Sains dan Praktis Jurnal Sains dan Teknologi Farmasi Indonesia Jurnal Kesehatan Lentera Acitya Journal of Public Health and Pharmacy Jurnal Pengabdian Farmasi dan Sains Jurnal Akademika Kimia Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Joni Tandi, Joni
Program Studi S1 Farmasi, Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Specific and Non-Specific Safety Testing of Red Gedi Leaf Ethanol Extract (Abelmoschus manihot L. Medik) Tandi, Joni; Susanto, Yuliet; Handayani, Tien Wahyu; Magfirah, Magfirah; Tuldjanah, Muthmainah
Jurnal Jamu Indonesia Vol. 11 No. 1 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i1.417

Abstract

Red gedi leaves (Abelmoschus manihot (L.) Medik) are traditionally used for their antidiabetic, antioxidant, and hepatoprotective properties. This study aimed to characterize the specific and non-specific quality parameters of red gedi leaf ethanol extract based on Herbal Pharmacopoeia standards. Extraction was performed by maceration using 96% ethanol, yielding 6.72%. Phytochemical screening confirmed the presence of flavonoids, saponins, tannins, quinones, and steroids, with a high total flavonoid content of 56.97 ± 3.75 mg/g. Non-specific parameters, including water content, drying loss, ash values, microbial contamination, and heavy metal levels (Pb and Cd), complied with the required standards. Organoleptic evaluation showed a viscous extract with brownish color, slightly astringent taste, and characteristic odor. These results indicate that red gedi leaf ethanol extract meets Herbal Pharmacopoeia quality requirements and has potential for development as a standardized antioxidant herbal product.
Acute Toxicity Nanoemultion of Ethanol Extract of Clove Leaves (Syzygium aromaticum L.) Muthmainah Tuldjanah; Putri Natalia Laurenza Ladjeba; Rezky Yanuarty; Ayu Wuladari; Joni Tandi; Muaadzatul Izzah Sudarman
Jurnal Penelitian Pendidikan IPA Vol 12 No 2 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i2.12783

Abstract

Clove leaves have been widely used as traditional medicine. Clove leaves are rich in saponins, flavonoids, tannins, sterols, and essential oils. To improve the function of clove leaves, one of them is by reducing the sample size into nanoemulsion form. Nanoemulsions were prepared using the sonication method and exhibited an average droplet size of 13.3 nm. The purpose of this study was to determine the toxic properties, the dose that can cause toxic effects, and the LD50 value of nanoemulsion administration of ethanol extract of clove leaves. This study used 25 male white rats which were divided into five groups, namely a control group (nanoemulsion base) and four treatment groups receiving oral doses of 5, 50, 300, and 2000 mg/kg BW. The LD50 value was calculated using AOT425 StatPgm in accordance with OECD TG 425 (Up and Down Procedure). Mortality summary: control 0/5; 5 mg/kg BW 0/5; 50 mg/kg BW 0/5; 300 mg/kg BW 0/5; 2000 mg/kg BW 5/5. The results showed an LD50 of 798.5 mg/kg BW and, based on the GHS, it falls under Acute Toxicity (Oral) Category 4 (300–2000 mg/kg BW). Clinical signs such as piloerection, grooming, and weakness appeared mainly in the early observation phase (from 30 minutes to 4/8/12 hours) in each dose group and were reversible.
Co-Authors Afriani S Afrizal Agustinus Widodo Ahmad, Mirnawati Alaydrus, Syafika Alaydus, Syafika Andini, Tuti Allawiah Anggi, Viani Anita Purwantari Aril, Moh Arynesta, Teddy Asrifa Asrifa Astria, Nani Astuti, Dewi Qurrotul Ayu Martina Ayu Wuladari AYU WULANDARI Ayu Wulandari Azwaajum Mutahharah Basilingan, Aprince Bella Melinda Bengkati, Stely Gracia Cinda Pradita Sudar Claresta, Jong A. Darmayanti David Pakaya David Pakaya Debora Rislianti Lakiu Dewi Astuti Dewi, Alfia Dian S. Waruwu Diana Pratiwi, Franciska Dipayana, I Made Erdy Prasetyo Fahri, Mohammad Fahruddin Fahruddin Faisal Rahmat Nugraha Fajar Alan Fatma, Nurul Feiverin Tibe Gabriella Bamba Ratih Lintin Gintu, Tri Juniver Gusti Ayu Gusti Ayu, Gusti Handayani KR Handayani, Kiki Rizki Handayani, Tien W. Handayani, Tien Wahyu Handayani, Tien Wahyuni Harliwong, Dhitania Ivana Hastuti L Ida Yanti Palinggi Insani, Nabila Nurul Intan, Putu Irwan Irwan Islamiati, Utami Jong A. Claresta Kurnia Gatot Novrianto L, Wahyudin H Lakiu, Debora Rislianti Lexy Kareba Lidongi, Putri Marcelita Lina Hardianti Rukmana M, Yulan Magfira Magfirah Magfirah, Magfirah Magfiroh Magfiroh Maria Kanan Mariyani Mariyani, Mariyani Marsella, Mimi Marzela Dewi Meike Rachmawati Merue, Novalia Moh Rizky Moh. Roem Muaadzatul Izzah Sudarman Muhammad Agus Muljanto Muthi’ah H Z Muthmainah Tuldjanah Muthmainah Tuldjanah Muthmainnah, Sririzqi Na'i, Alpina Nadila Nadila Nadila, Nadila Nadira Nani Astria Ni Made Irma Mariani Ni Putu Setiawati Ni Wayan Ika Purwasih Niluh Puspita Dewi Niluh Puspita Dewi Niluh Puspita Dewi Niluh Puspita Dewi, Niluh Puspita Niswatulfahriyati Niswatulfahriyati Nur Azizah Nur Ikhwan Nurhikmah Nurhikmah Nurmadinah Nurmadinah Nurul Ulzmi Ovan Nugroho Pegia Parobe, Alda Iglesias Pasang, Sisilia Baan Polakitan, Grace Lovita Polibaon, Tresya J. Puspita Dewi, Niluh Putri Natalia Laurenza Ladjeba Putri, Debby Aulia R, Yana Novika Rahmawati D Rahmawati Salsa Dinurrosifa Rajadenda, Afwa Al Rasmiyanti, Ni Kadek Evy Recky Patala Rezky Yanuarty Rezky Yanuarty Riani, Ni P. I. Riani, Ni Putu Intan Rio Mariani Risna Yanti Rizaldy Lalu Ronaldy Nobertson Rusdi, Grasela Ruterlin, Valen Safitri, Nabila Umi Salsabila, Unik Hanifah Sasdila, Sasdila Seblin Tonapa Rammang Sene, Ikhsan Hi. Amir Solehah, Puput Octaviani Sri Mulyani Sri Mulyani Sri Mulyani Sri Mulyani Sabang Suarsana, I Made Agus Sujati, Ni Wayan Surat, Megawati R. surisna, surisna Syafika Alaydrus Tampang, Rivani Tamunu, Jeine Sweet Natasya Tandy, Putri Adam Tarusu, Fikhta Agnesya Tiara Anastasya Ticoh, Febriyani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien Wahyu Handayani Tien, Tien Wahyu Handayani Toding, Ficanata Adhiguna Tonapa Rammang, Seblin Towulu, Dessy Gracelia Tuldjanah, Muthmainah Uigianto, Imelda Utami, Indah Kurnia Valen Ruterlin Veronika Veronika Viani Anggi Vidya Christin Vivi Gretia Triposa Wahyu Handayani, Tien Wahyu Nur Afandi WAYAN WAYAN Wirawan W Wirawan, Resky Chandra wirawan, Wayan Yana Novika R Yanti Palinggi, Ida Yanuarty, Rezky Yasinta Rakanita Yuli Fitriana Yuliet Yuliet Yulistien Yusuf Yunlis Silintowe Kenta Yusriadi Yusriadi Yustin Yustin Zulfaidah