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Journal : Medula

The Activity of Notika Leaves (Archboldiodendron calosericeum KOBUSKI) Against Tumors Necrosis Factor Alpha (TNF-) Levels in Rats Nuralifah Nuralifah; Parawansah Parawansah; Fadhliyah Malik; Nining Yulianti
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.23816

Abstract

Inflammation is a response process to tissue injury and infection. The inflammatory response causes the release of pro-inflammatory mediators such as IL-1, IL-6 and TNF-α which are the main cytokines in the acute inflammatory response. Plants that have the potential to be anti-inflammatory are notika leaves (Archboldiodendron calosericeum KOBUSKI). This research was conducted to determine the anti-inflammatory activity of the ethanol extract of notika leaves against the levels of Tumor Necrosis Factor Alpha (TNF-a) in wistar mice. This study used a post test only control group design. Using 5 treatment groups, namely positive control (diclofenac sodium), negative control (NaCMC 0.5%), 100 mg/kgBW extract test group, 200 mg/kgBW extract group and 300 mg/kgBW extract group. In vivo tests were carried out by induction of inflammatory substances, administering preparations and measuring TNF-α levels using the ELISA method. Data were analyzed using the One Way ANOVA test. The results showed that the mean levels of TNF-α in the positive control group (0.475 ng/L), negative control (0.816 ng/L), extract dose 100 mg/kgBW (0.67 ng/L), extract dose 200 mg/kgBW (0.7285 ng/L) and extract dosage of 300 mg/kgBW (0.7785 ng/L). The conclusion obtained is that the ethanol extract of notika leaves has anti-inflammatory activity against the levels of Tumor Necrosis Factor Alpha (TNF-a) in Wistar rats based on the reduction in levels with negative control and the best dose was 100 mg/kgBW.
Co-Authors ,, Suryani Aan Zurniwatih P Adryan Fristiohadi Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Afriana, Dian Agustina Amaliah, Nur Syafitri Andriyani, Elfi Andryani Ningsih Angriani Fusvita Annisa Fatinah Gani Annisaa, Nur Apriyanto Apriyanto Apriyanto, Apriyanto Arba, Muhammad Arfan Arfan Armadany, Fery Indradewi Asasutjarit, Rathapon Asniar Pascayantri Asniar Pascayantri Asniar Pascayantri Aspadiah, Vica Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Astrid Indalifiany Azis, Muhammad Israwan Badia, Esti Bafadal, Mentarry Bambang Bambang Bangkit Saputra Baru Sadarun Baru Sadarun Carla Wulandari Sabandar Chatarina Umbul Wahyuni Chichi Fauziyah Dian Afriana Dian Munasari Dian Munasari Dian Munasari Solo Dian Munasari Solo Dwi Arini Jufri Elma Winarti Fahria Nadiryati Sadimantara Fahria Nadiryati Sadimantara Fahriah Nadiryati Sadimantara Fahriah Nadiryati Sadimantara Faisal Faisal Fatima, Nur Fea, Waode Aisyah Fery Indradewi Armadany Firasmi Sangadji Firdayanti Firdayanti Fitrah Fajriani Haming Fitrawan, La Ode Muhammad Fredy Talebong Fristiohady, Adryan Gusti Ray Sadimantara Gusti Ray Sadimantara Gusti Ray Sadimantara Halik Halik Halik Halik, Halik Handoyo, Muhammad Hariana Hartawaty, Siska Septy Haruna, Lidya Agriningsih Hasanah, Nur Uswatun Hendra Febriansyah Herda Dwi Saktiani Herdianawati Ringgu Hilman, Seprian Holidin, Wiwin I Sahidin I Sahidin I Sahidin I Sahidin I Sahidin Idrus, Loly Subhiaty Ilyas Y, Muhammad Ilyas Y., Muhammad - Indalifiany, Astrid Indri Wulandari Indri Wulandari, Indri Irma Irnawati Irnawati Irnawati Irnawati Jabbar, Asriullah Jannah, Sitti Raodah Nurul Jufri, Dwi Arini Jumriani Jumriani Junli Hong Kardin, Laode Karmilah Kirana, Rezky Marwah La Ode Muh. Fitrawan La Ode Muhammad Fitrawan La Ode Muhammad Julian Purnama La Ode Muhammad Julian Purnama Loly Subhiaty Idrus Lubis, Adryan Fristiohady Mahmudah, Rifa’atul Malaka, Muhammad Hajrul Meilany, Elvianti Mesi Leorita Mesi Leorita, Mesi Mini Bekti Ningsih Mini Bekti Ningsih Mochammad Imron Awalludin Mubarak Mubarak Mubarak Mubarak Mubarak Mubarak Mubarak Muh. Ilyas Yusuf Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Ilyas Y Muhammad Ilyas Y Muhammad Ilyas Y Muhammad Ilyas Y Muhammad Ilyas Y Muhammad Ilyas Y. Muhammad Ilyas Yusuf Muhammad Ilyas Yusuf Muhammad Ilyas Yusuf Muhammad Israwan Azis Muhammad Israwan Aziz Mulviana, Astrawanda Munasari, Dian Mursanti, Wa Ode Indah Arum NASRUDIN Nasrudin Nasrudin Nasrudin Nasrudin Nasrudin Newulasindo, Sri Madani Ningsi, Andryani Ningsih, Aprilia Surya Nining Yulianti Nirwati Rusli Nita Trinovitasari Nohong Nohong, Nohong Nur Annisaa Nur Hikmah Nur Hikmah Nur Illiyyin Akib Nur Illiyyin Akib Nuralifah Nuralifah, Nuralifah Nurfadillah Siddiqah Nurfenti Nurfenti Nurfenti, Nurfenti Nurhikma Nurhikma Nurhikma, Nurhikma Nurjeddah Fariane Nurramadhani A. Sida Okwani, Yustian Parawansah Parawansah Pascayantri, Asniar Purnama, La Ode Muhammad Julian Putri, Olivia Dicha Rahayu, Faulia Fajar Rahmat Muliadi Rahmat Muliadi Rahmat Muliadi RAHMAT MULIADI, RAHMAT Rasak, Adriatman Rezky Marwah Kirana RH. Fitri Faradilla Rina Andriani Ringgu, Herdianawati Rini Hamsid Rini Hamsidi Rosmaria, Rosmaria Rusli, Nirwati Ruslin Ruslin, Ruslin SADIMANTARA, I GUSTI RAY Sahidin Sahidin . Sahidin F. Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin, Idin Saktiani, Dwi Nur Salem, Sri Rahayu Saputri, Nita Saranani, Muhammad Aqsal Azriel Fajar Saripuddin Saripuddin Sarry, Elita Puspita Seprian Hilman Septrilia, Shara Sida, Nurramadhani A. Siti Helmyati Sitti Masyithah Amaluddin Solo, Dian Munasari Sri Madani Newulasindo Sulsiah, Sulsiah Sunandar Ihsan, Sunandar Suryani Suryani Susanty, Sry Tanzil, Dwi Lestari Khaulani Tias, Ayuning Timung, Yusni Oktaviani Ulfa Ulfa Ulfa Ulfa Vica Aspadiah W Wahyuni, W W. Wahyuni Wa Ode Nurfinti Wa Ode Salma Wa Ode Sitti Musnina Wa Ode Sitti Zubaydah WAHYUNI wahyuni wahyuni Wahyuni Wahyuni Wiwin Holidin Y, Muhammad Ilyas Yani, Rica Dwi Yodha, Agung Wibawa Mahatva Yuliansyah Yuliansyah Yustian Okwani Yuyun Asna Sari Zakhrafia, Ainun Zulkifli Halid