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Dysregulation of Cell Adhesion Molecules in Ectopic Pregnancy: The Roles of E-Cadherin and Integrins in Tubal Implantation Hilizza Awalina Zulfa; Nur Bebi Ulfah Irawati; Luluk Hermawati; I Made Arya Subadiyasa; Nimas Ayu Nirwanti
Journal of Midwifery and Reproduction Vol. 10 No. 1 (2026)
Publisher : Universitas Muhammadiyah Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/jmr.v10i1.1825

Abstract

Ectopic pregnancy is a pathological condition characterized by implantation of the embryo outside the uterine cavity, occurring in the fallopian tube. The pathogenesis of ectopic pregnancy is multifactorial and involves impaired embryo transport as well as alterations in the tubal microenvironment. Cell adhesion molecules (CAMs), particularly E-cadherin and integrins, play important roles in cell–cell adhesion, cell–extracellular matrix (ECM) interactions, and epithelial integrity. This review aimed to analyze the role of CAMs, particularly E-cadherin and integrins, in embryo adhesion and implantation within the fallopian tube in ectopic pregnancy. A literature review was conducted through searches of PubMed, Scopus, and Google Scholar using the keywords “ectopic pregnancy”, “tubal pregnancy”, “cell adhesion molecules”, “embryo-tubal attachment”, and “tubal microenvironment.” The literature primarily included publications from 2016 to 2026. Eligible articles were critically analyzed and narratively synthesized. The findings show that integrin β1 appears to play an important role in trophoblast adhesion to the tubal epithelium, whereas E-cadherin contributes to the maintenance of cell–cell adhesion and epithelial integrity through interactions with the catenin complex and the actin cytoskeleton. The interplay among CAM alterations, inflammation, and ECM remodeling may create a tubal microenvironment conducive to abnormal embryo implantation.
The Role of Balanced Nutrition Knowledge in Influencing Nutritional Status and Health Risks: A Literature Review Luluk Hermawati; Nur Bebi Ulfah Irawati; Hilizza Awalina Zulfa; Wulan Azva Diana
International Journal of Medicine and Public Health Vol 2, No 1 (2025): April
Publisher : Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62870/inomed.v2i1.31567

Abstract

Balanced nutrition is a key factor in maintaining health and preventing various nutrition-related diseases. An imbalance between nutrient intake and requirements can lead to malnutrition, either in the form of undernutrition or overnutrition. This condition contributes to an increased risk of non-communicable diseases such as obesity, diabetes, and hypertension. Good nutritional knowledge plays a crucial role in shaping healthy eating patterns and maintaining optimal nutritional status. Additionally, various factors such as dietary reference intake, nutrient absorption physiology, and intake control also influence an individual's nutritional balance. Physical activity also plays an important role in maintaining energy balance and body weight, thereby helping to prevent malnutrition and health disorders.This article reviews various aspects of balanced nutrition, including fundamental concepts, factors influencing nutritional status, health risks associated with nutritional imbalances, and the role of physical activity in maintaining nutritional balance. A deeper understanding of these aspects is expected to raise awareness of the importance of balanced nutrition in daily life.
Soil-Transmitted Helminth Infections: Transmission Pathways, Host Susceptibility, and Risk Factor Nur Bebi Ulfah Irawati; Hilizza Awalina Zulfa; Luluk Hermawati; Putri Damayanti; Silvia Fitrina Nasution; Lola Febriana Dewi
International Journal of Medicine and Public Health Vol 3, No 1 (2026): April
Publisher : Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62870/inomed.v3i1.39228

Abstract

Soil-transmitted helminth (STH) infections continue to pose a significant public health challenge in tropical and subtropical regions, particularly in areas with poor sanitation and hygiene. Understanding transmission pathways, host susceptibility, and associated risk factors is essential for explaining epidemiological patterns and designing effective control strategies. This article synthesizes current evidence on STH transmission pathways, host susceptibility, and associated environmental and behavioral risk factors based on epidemiological and immunological studies. STH transmission occurs through fecal–oral ingestion of infective eggs and percutaneous skin penetration by infective larvae in hookworm infections. Environmental contamination of soil and water, inadequate sanitation, and behaviors such as open defecation, walking barefoot, poor hand hygiene, and unsafe food handling increase exposure risk. Host susceptibility is influenced by age, immune regulation, nutritional status, genetic factors, and gut microbiota, resulting in heterogeneous infection intensity and clinical outcomes. Effective control of STH infections requires integrated approaches combining WASH interventions, health education, nutritional support, and regular deworming programs, while accounting for host biological variability to improve targeted prevention strategies.
Impact of Maternal Knowledge, Socioeconomic Factors, Social Support, and Policies on Exclusive Breastfeeding: A Comprehensive Literature Review Luluk Hermawati; Nur Bebi Ulfah Irawati; Hilizza Awalina Zulfa
International Journal of Medicine and Public Health Vol 2, No 2 (2025): October
Publisher : Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62870/inomed.v2i2.32063

Abstract

Exclusive breastfeeding during the first six months of an infant’s life is the primary recommendation from WHO and UNICEF, as it has been proven to offer significant health benefits for both infants and mothers. However, the coverage of this practice remains suboptimal in many countries, including Indonesia, due to various multidimensional factors. This article aims to systematically review the scientific literature from the past ten years (2015–2025) on the factors influencing the success of exclusive breastfeeding, with a focus on maternal knowledge, socioeconomic factors, social support, and policies. The review findings indicate that education level, maternal understanding of the benefits and techniques of breastfeeding, employment status, household income, and access to healthcare services play crucial roles in the success of exclusive breastfeeding practices. Several studies also highlight the importance of social support from family, friends, and community, as well as government policies such as maternity leave and educational programs that promote exclusive breastfeeding. Community-based interventions and supportive policy environments have also been shown to effectively increase exclusive breastfeeding rates. Therefore, a holistic approach is needed—not only to improve maternal knowledge, but also to address the social and policy-related factors that influence breastfeeding behavior.
The Role Of Pyruvate Kinase M2 In Aerobic Glycolysis Of Cancer Cells: Mechanisms And Potential Inhibitor Hilizza Awalina Zulfa; Nur Bebi Ulfah Irawati; Luluk Hermawati; Wulan Azva Diana
International Journal of Medicine and Public Health Vol 1, No 2 (2024): October
Publisher : Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62870/inomed.v1i2.30912

Abstract

Cancer is defined as the uncontrolled growth of cells that can spread to other parts of the body, leading to significant health issues and affecting the quality of life patients. One hallmark of cancer is its ability to reprogram metabolism to support rapid cell proliferation, even under adverse conditions such as low oxygen levels. This article aims to explore how cancer cells predominantly utilize aerobic glycolysis, converting glucose into lactate, a process known as the Warburg Effect. This metabolic shift allows cancer cells to quickly generate energy and produce necessary biomass, including NADH, which is vital for maintaining redox balance and supporting continued proliferation. Pyruvate Kinase M2 (PKM2) is highlighted as a primary regulator of aerobic glycolysis in cancer cells. It facilitates the conversion of phosphoenolpyruvate (PEP) to pyruvate, which is crucial for lactate production. The low affinity of PKM2 for this conversion contributes to the metabolic advantages that cancer cells exploit. The review emphasizes the potential of targeting PKM2 as a therapeutic strategy for cancer treatment. Inhibiting PKM2 could disrupt the metabolic pathways that cancer cells rely on, with studies indicating that high doses of docosahexaenoic acid (DHA) can reduce PKM2 expression, presenting a promising direction for future research.
Analisis Hubungan Pengetahuan, Sikap, dan Praktik Pencegahan Demam Berdarah Dengue pada Mahasiswa Nur Bebi Ulfah Irawati; Luluk Hermawati; Silvia Fitrina Nasution; Hilizza Awalina Zulfa; Nur Ayu Virginia Irawati; Putri Damayanti
Jurnal Ners Vol. 10 No. 4 (2026): OKTOBER 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Demam Berdarah Dengue (DBD) masih menjadi masalah kesehatan masyarakat yang memerlukan upaya pencegahan berkelanjutan melalui pengendalian vektor dan perubahan perilaku. Penelitian ini bertujuan untuk menganalisis pengetahuan, sikap, dan praktik pencegahan DBD pada mahasiswa serta hubungan antara ketiga komponen tersebut. Penelitian ini menggunakan desain kuantitatif observasional analitik dengan pendekatan cross-sectional. Responden merupakan 138 mahasiswa berusia 17–20 tahun yang direkrut menggunakan consecutive sampling. Data dikumpulkan menggunakan kuesioner yang mencakup pengetahuan, sikap, dan praktik pencegahan DBD. Analisis dilakukan secara univariat dan bivariat menggunakan uji korelasi Spearman dengan tingkat kemaknaan p<0,05. Hasil penelitian menunjukkan bahwa 63,0% responden memiliki pengetahuan baik, 63,0% memiliki sikap positif, dan 91,3% memiliki praktik pencegahan DBD yang baik. Terdapat hubungan positif yang bermakna antara pengetahuan dan praktik pencegahan DBD dengan kekuatan hubungan lemah (ρ = 0,279; p = 0,001). Namun, tidak terdapat hubungan yang bermakna antara pengetahuan dan sikap (ρ = 0,057; p = 0,509) maupun antara sikap dan praktik (ρ = −0,046; p = 0,591). Pengetahuan merupakan salah satu aspek yang berkaitan dengan praktik pencegahan DBD, tetapi peningkatan pengetahuan dan sikap positif belum tentu secara konsisten diikuti oleh praktik yang lebih baik.
Co-Authors -, Erfira Abd Rahman Abdul Haris Kuspranoto Abdul Rahman Abdul Rasyid Ade Ichwan Sulthany Ade Ichwan Sulthany Adhayati, Baety Adinda Puspita Dewi Agus Sugiharto Agustianti, Erika Ainina Al Shadrina Alfuu Nur Harahap Alwi, Muhammad Azharan Amanah Eva Fidusia Amanah Eva Fidusia Amanah Eva Fidusia Amanah Eva Fidusia Fidusia Awalina Zulfa, Hilizza Damayanti , Putri Desti Asihanti Saputra Devy Ariany Dini Febriandriani Dwiyanti, Sophie Ekawati Rini Wulansa Ekawati Rini Wulansari Erfira Erfira Erfira Fauzi Erika Agustianti Erika Agustianti Erika Agustianti Erika Agustianti Erika Agustianti erni Trisnasari Erni Trisnasari Erni Trisnasari Ervina Julien Sitanggang Fathurrohim Fathurrohim Fidusia, Amanah Eva Firda Asma’ul Husna Fitria Mahrunnisa Fitria Tahta Alfina Furqoni , Abdul Hadi Furqoni, Abdul Hadi Galang Prahanarendra Ghea Farmaning Thias Putri Ghea Farmaning Thias Putri Ghina Mutiara Abas Hilizza Awalina Hilizza Awalina Zulfa Hilizza Awalina Zulfa Hilizza Awalina Zulfa Hilizza Awalina Zulfa Hilizza Awalina Zulfa Hilizza Awalina Zulfa Hilizza Awalina Zulfa Zulfa I Made Arya Subadiyasa Irawati, Nur Bebi Ulfah Kania Pradiva Maharani Kenny Cantika Abadi Layal, Kamalia Lola Febriana Dewi Lola Febriana Dewi Louisa Ivana Utami Lucky Brilliantina Maulana Hasymi Hutabarat Maytia Pratiwisitha Mery Nitalia Moh. Hafiyusholeh Muchtar Ali Setyo Yudono Muhamad Frendy Setyawan Muhammad Usman Munifatuzzahra Munifatuzzahra Muntasiroh, Laily Nasution, Silvia Fitrina Neshya Ruriana Putri Neshya Ruriana Putri, Neshya Ruriana Ni Luh Putu Eka Kartika Sari Nida Farida Nimas Ayu Nirwanti Ningrum Paramita Sari Nur Ayu Virginia Irawati Nur Ayu Virginia Irawati Nur Bebi Ulfah Irawati Nur Bebi Ulfah Irawati Nur Bebi Ulfah Irawati Nur Bebi Ulfah Irawati Nur Bebi Ulfah Irawati Nur Bebi Ulfah Irawati Nur Bebi Ulfah Irawati Ulfah Irawati Nur Lailatul Nofisah Nurlaely Mida Rachmawati Nurlaely Mida Rachmawati Nurlaely Mida Rachmawati Nurlaely Mida Rachmawati Nuryasin, Muhammad Farras Omat Rachmat Pratiwisitha, Maytia Putri Damayanti Putri Damayanti Putri Damayanti Putroue Keumala Intan Rachmat, Omat Rachmawati, Nurlaely Mida Ratno Susanto Ratu Nadia Renata Zhafira Putri Herlia Revi Naldi Rifdah Hanifah Rizky Kusuma Wardani Rizky Kusuma Wardani Roslina, Sri Rossa Amelia Rossa Amelia, Rossa Rukman Abdullah Salsabila Hafsah Hasanah Selfie Selfie Septyadis, Camila Zahra Silvia Fitrina Nasution Silvia Fitrina Nasution Siska Yulianti Siti Baitul Rohila Siti Darifah Siti Darifah Siti Darifah Siti Darifah Siti Darifah Siti Darifah Subadiyasa, I Made Arya Sulthany, Ade Ichwan Tricahyani Endah Yuniarti Twidy Tarcisia Twidy Tarcisia Umar Afandi Rahmad Nasution Utami, Louisa Ivana Wibowo, David Widyawati, Dwi Wulan Azva Diana Yana Aurora Prahitha Yuda Nabella Prameswari Yuda Nabella Prameswari Yuda Nabella Prameswari Yuniarti, Tricahyani Endah Zukhra, Shelly  Zulfa, Hilizza Awalina