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Journal : Jurnal Buana Farma

 1 
AKTIVITAS ANTIDIABETES FRAKSI ETANOL, ETIL ASETAT DAN N-HEXAN HERBA PEGAGAN (Centella asiatica L) TERHADAP MENCIT PUTIH JANTAN YANG DIINDUKSI ALOXAN Lestari, Sovi Ayu; Hidayat, Taufik Septiyan; Suharti
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1392

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels resulting from impaired insulin production or function. Conventional treatments often come with side effects and high costs, prompting the exploration of herbal-based alternatives. Centella asiatica L. (commonly known as pegagan) contains various bioactive compounds with potential antidiabetic properties. This study aimed to evaluate the antidiabetic activity of ethanol, ethyl acetate, and n-hexane fractions of Centella asiatica herb in male white mice (Mus musculus) induced with alloxan, and to determine the most effective fraction in lowering blood glucose levels. The research employed a completely randomized design (CRD) in an experimental setting. Male mice were randomly assigned to five groups: negative control (1% Na-CMC), positive control (glibenclamide), and three treatment groups receiving ethanol, ethyl acetate, or n-hexane fractions of Centella asiatica at a dose of 120 mg/kg body weight. Diabetes was induced using alloxan at a dose of 100 mg/kg body weight. Blood glucose levels were measured before and after treatment at specific time intervals. The results demonstrated that all fractions of Centella asiatica exhibited blood glucose-lowering activity in diabetic mice. Among the three, the ethanol fraction produced the most significant hypoglycemic effect. Phytochemical screening revealed that the ethanol fraction contained flavonoids, triterpenoids, and saponins, which are suspected to contribute to its antidiabetic activity. In conclusion, the ethanol fraction of Centella asiatica exhibits the highest potential as an antidiabetic agent compared to the ethyl acetate and n-hexane fractions.
Co-Authors A. Sriyanti A. Sriyanti, A. Adrian Tawai Afifah, Natasya Gita Agung Nusantara Alvionita, Mieke Andarwulan, Setiana Andi Ika Prasasti Abrar, Andi Ika Prasasti Ardian Kahfi Arfan Nusi Ariyanto, Ahmad Arsita Sari, Suci Asmaul Husna Atiqoh Atisa Aprilia Avrilia Ayunina AZIZAH AMAL Badaruddin Bagus Abdillah Baharuddin Cholid, Abd Diah Amelia Azzahra DIDIK PURWANTO Dwi Atmini , Ninik Edi Setiawan Edwita Eli Hendrik Sanjaya Emzia Fajri Endrizal Endrizal, Endrizal Erwin Jusuf Thaib evelyn wijaya Fadila, Sindy Fajri, Annisa Firdaus Firdaus Firdaus Firdaus Firdaus Firmantomo, Arnol Fitri, Anisa Fitriani Nur Friska, Della H., Ardia R. Hadi Hasibuan, Sofyan Harwanto Hasbi Hayati Hendri Mulyadi Herman Efrizal Hidayat, Taufik Septiyan Hilmirrahma Husnul Idris, Alya Cahyani Ima Andriyani Kardila Kartika Wijayanti Khairunnisa, Indah Kurnia, Anita Wanodiya Lalu Abdurrachman Wahid, Lalu Abdurrachman Lalu Moh Yuda Isnaini Layla Hafni Lestari, Sovi Ayu Liqanatul Putri Sholikah Lisnasari Andi Mattoliang M. Rully Sjahirul Alim M. Torero Rigel Centeury Malik, Elmy Selfiana MARDIANA Maria Ulpa Martha Ng Mayana Millenia Larasati Mimelientesa Irman Moh. Ifkhal Sianto Muhammad Muhyi, Muhammad Muhammad Rusmin, Muhammad Muhammad Rusydi H. Muhammad Yaumi Munir Munirah Mutia Kahanna Naharullah, Ahmad Sazky Nashrudin Latif Nicholas Renaldo Nur Kholis Nur Miftahul Jannah Nurhayati Nurhikmah Nursalam Pajriyanti, Vivi Paramitha Maylina Afifah Pashela, Perdana PUJI LESTARI Purwanto, Dedik Putra, Martinus Ludira Imok Putri, Amaliya Putri, Meisa Putri, Risma Aliviani Rayhana RENATO, ADRIAN Rizky Metro Siallagan Rizky, Rizky Novian Hariyadi Rosdiana Rusmawati, Retno Danu Sabariah Sasmita, Anggun Satuti, Luxmita Anna Singgih Prastawa Sinta Siti Sulaeha Sitti Nurhidayah IIyas Sosa, Sosa Hijria Audia St. Aswiah Suharti, et.al Sukirman Sumardi Surjani, Sri Heksi Indah SUYONO Teddy Chandra Tesia, Tesia Anggraini Melcan Tetty Rihardini Thamrin Tayeb Ujang Rohman, Ujang Veronica WAQIDIL HIDAYAH, WAQIDIL Wati, Yenny Wawan Gunawan Wawan Gunawan WIWIK MUHIDAYATI, WIWIK Yetty Oktayanty Yohanes Selvianus Tola Yoso Wiyarno Yufiarti Yulia Tiska Yuliana Irnawati, Prita Yulinda, Meli Yuneta Dwi Yunisari Yurisman Zarkasih, Khamim Zuli Oktavia, Eva