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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Damianus Journal of Medicine Prosiding Seminar Biologi The Indonesian Biomedical Journal Biomedical Journal of Indonesia Syntax Literate: Jurnal Ilmiah Indonesia Manuju : Malahayati Nursing Journal SRIWIJAYA JOURNAL OF MEDICINE PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat SABDAMAS PREPOTIF : Jurnal Kesehatan Masyarakat Amalee: Indonesian Journal of Community Research & Engagement Jurnal Manajemen Bisnis dan Kewirausahaan Science Midwifery Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Bakti Masyarakat Indonesia Journal of Community Service and Empowerment Jurnal Kesehatan Tambusai Journal of Sustainable Community Development (JSCD) Journal of Health Research Science Jurnal WIDYA LAKSMI (Jurnal Pengabdian Kepada Masyarakat) Sehat Rakyat: Jurnal Kesehatan Masyarakat Prosiding Seri Seminar Nasional NUSANTARA: Jurnal Pengabdian Kepada Masyarakat Tarumanagara Medical Journal Safari : Jurnal Pengabdian Masyarakat Indonesia Jurnal Pengabdian Ilmu Kesehatan Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan Ebers Papyrus Jurnal Muara Medika dan Psikologi Klinis Prosiding Seminar Nasional COSMIC Kedokteran Jurnal Serina Abdimas KREATIF: Jurnal Pengabdian Masyarakat Nusantara Jurnal Pengabdian Ilmu Kesehatan
Shirly Gunawan
Bagian Farmakologi, Fakultas Kedokteran Universitas Tarumanagara Jakarta
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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HUBUNGAN KADAR INSULIN PUASA DENGAN KADAR GULA DARAH PUASA DAN KENDALI HBA1C PADA KELOMPOK LANSIA Gunawan, Shirly; Kosasih, Robert; Santoso, Alexander Halim; Wijaya, Dean Ascha; Kurniawan, Joshua; Satyanegara, William Gilbert
Ebers Papyrus Vol. 31 No. 2 (2025): EBERS PAPYRUS
Publisher : Fakultas Kedokteran Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/237m8209

Abstract

Pendahuluan: Diabetes melitus merupakan penyebab utama morbiditas global, dengan prevalensi yang terus meningkat, terutama pada populasi lansia. Pengukuran gula darah puasa (GDP) dan HbA1c sering digunakan untuk mengevaluasi kontrol glikemik, namun memiliki keterbatasan dalam mencerminkan dinamika sekresi dan sensitivitas insulin. Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan antara kadar insulin puasa dengan GDP dan HbA1c terutama pada populasi lansia. Metode: Desain studi penelitian ini adalah potong lintang pada 41 lansia di Panti Santa Anna pada November 2023. Analisis statistik menggunakan uji Spearman. Hasil: Analisa korelasi Spearman-rho antara kadar insulin puasa dengan kadar gula darah puasa menunjukkan tidak adanya hubungan bermakna antara kadar insulin puasa dengan kadar gula darah puasa, namun penelusuran secara klinis menunjukkan korelasi positif lemah (p: 0,329, r: 0.156). Kadar insulin puasa terhadap kadar HbA1c juga menunjukkan tidak adanya hubungan bermakna, namun secara klinis berkorelasi positif lemah (p: 0,256, r: 0,182). Kesimpulan: Penelitian ini ingin melihat korelasi positif secara klinis antara kadar insulin puasa dan parameter metabolik diabetes, yang dapat tersamarkan oleh mekanisme kompensasi resistensi insulin serta proses inflamasi dan gangguan metabolik. Penelitian lebih lanjut diperlukan untuk memahami hubungan sebab-akibat antara kedua parameter tersebut dengan kadar insulin puasa secara mendalam sehingga dapat mengoptimalkan target pengobatan dan mencegah komplikasi lebih lanjut.
Optimizing geriatric health through early detection in a nursing home at South Tangerang City Gunawan, Shirly; Amimah, Ranindita Maulya Ismah; Adnan, Naufal Ikbar Rian; Sinaga, Oktri Lentina; Maharani , Syifa Shabrina; Leonita , Stefani; Yosafat, Fernando; Arinanda , Septian; Pratiwi, Adelia Helmi; Syarifah , Anisa Ulaya
Journal of Community Service and Empowerment Vol. 7 No. 1 (2026): April
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/jcse.v7i1.44378

Abstract

Indonesia is entering an aging population phase, characterized by a significant rise in the number of elderly individuals. As they age, they are more prone to diverse health problems that require holistic care. Detecting health issues early is vital to prevent worsening conditions, reduce illness and disability, and improve the quality of life of the elderly. The activity focuses on empowering elderly residents and staff in nursing homes to identify health issues at an early stage. This community service activity applied a descriptive qualitative approach. By conducting interviews, observations, and examinations, the team identified the main complaints and health conditions experienced by most elderly residents in nursing homes. A total of 75 elderly residents underwent health screenings, including 60 females (80%) and 15 males (20%), with an average age of 78.92 years. The screenings covered medical record reviews, interviews, vital sign checks, and health education sessions. Hypertension, dyslipidemia, diabetes mellitus, hyperuricemia, and cataracts were identified as the five most common illnesses among elderly residents. The predominant complaints reported were muscle pain, headaches, skin injuries/bruises, and itchy skin. Through early detection, holistic assessment, and risk factor identification, elderly health can be optimally maintained, quality of life enhanced, and aging experienced with greater independence, comfort, and meaning.
Effect of Penta Herbs Forte on Antioxidant Capacity and Cardiac Protein Carbonyl Levels in a Hypoxia-Induced Rat Model Widiarto, Sentanu; Gunawan, Shirly; Limanan, David; Ferdinal, Frans; Yulianti, Eny
Biomedical Journal of Indonesia Vol. 12 No. 2 (2026): Vol 12, No 2, 2026, In Press
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i2.304

Abstract

Introduction. Hypoxia, a state of inadequate oxygen supply in tissues, can induce the generation of reactive oxygen species (ROS), leading to oxidative stress and damage to biomolecules such as proteins. This damage can be quantified by measuring protein carbonyl levels. Penta Herbs Forte (PHF), a polyherbal formulation composed of Andrographis paniculata, Blumea balsamifera, Phyllanthus urinaria, Zingiber officinale, and Curcuma xanthorrhiza, is rich in bioactive compounds with known antioxidant properties. This study aimed to evaluate the antioxidant activity of PHF extract and its effects on cardiac protein carbonyl levels in hypoxia-induced rats. Methods. This experimental study included 32 male Sprague-Dawley rats, divided into eight groups: control and treatment groups under normoxia, 1-day hypoxia, 7-day hypoxia, and 14-day hypoxia, either with or without PHF extract administration. Antioxidant capacity was determined using the ABTS and DPPH assays, and cardiac protein carbonyl levels were measured using a spectrophotometer. Results. PHF extract showed an antioxidant activity yielding LC50 values of 22.135 μg/mL (ABTS) and 105.04 μg/mL (DPPH), indicating strong antioxidant potential. PHF-treated groups exhibited lower cardiac protein carbonyl levels than their respective controls across all hypoxic durations. Conclusion. Administration of PHF extract reduced cardiac protein carbonyl levels via its antioxidant activity, suggesting its potential as an exogenous antioxidant source to protect against hypoxia-induced oxidative damage.
Exploring Associations Lipid Profiles, Body Composition, Anthropometry, and Osteoarthritis Index Dinali, Diana; Dzakwan, Muhammad Fikri; Bustam, Steve Geraldo; Gunawan, Shirly; Santoso, Alexander Halim; Firmansyah, Yohanes
Biomedical Journal of Indonesia Vol. 12 No. 2 (2026): Vol 12, No 2, 2026, In Press
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i2.307

Abstract

Introduction. Osteoarthritis (OA) is a joint disorder and is considered one of the leading causes of disability worldwide. It is commonly associated with aging and characterized by chronic pain, joint stiffness, and limitations in daily activities. This study aimed to evaluate the association between lipid profile and body composition with the severity of OA, as measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score. Methods. This cross-sectional study involved 67 community-dwelling older adults. Assessments included fasting lipid profiles (HDL, LDL, total cholesterol, Apo A, Apo B, and triglycerides), body fat distribution and muscle mass, anthropometric measurements (body mass index, waist circumference, and hip circumference), and handgrip strength. Associations between variables were analyzed using Spearman’s correlation test with a significance level of 5%. Results. Correlation analysis demonstrated associations between lipid profile levels and worsening OA symptoms. Higher Apo B levels were associated with increased trunk fat (r=0.47, p<0.001) and greater joint pain (r=0.35, p=0.004). Lower HDL levels were associated with increased visceral fat (r=−0.37, p=0.002) and greater joint stiffness (r=0.26, p=0.038). Greater upper extremity muscle mass was associated with less severe pain (r=−0.38, p<0.001), while higher body mass index and waist circumference were associated with higher WOMAC scores (r=0.32, p=0.009). Conclusion. These findings support the concept that OA is a systemic condition influenced by metabolic and biomechanical pathways. OA management should therefore include metabolic control, optimization of body composition, and routine monitoring of lipid profiles and anthropometric indices as part of non-pharmacological therapy and preventive strategies.
Implementation of Integrated Health Services for Post-Disaster Communities in Agam Regency, West Sumatra, Indonesia Shirly Gunawan; Noer Saelan Tadjudin; Alexander Halim Santoso; Yohanes Firmansyah; Daniel Goh; Belinda Angie; Anggita Tamaro; Irvan Baharits Al Basith; Djulia Djulia; RA Rengganis Ularan; Hetty Karunia Tanjungsari; Mei Ie; Alicia SariJuwita
Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan (Abdigermas) Vol. 4 No. 1 (2026): Jurnal Ilmiah Pengabdian Kepada Masyarakat Bidang Kesehatan (Abdigermas)
Publisher : CV Media Inti Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/abdigermas.v4i1.647

Abstract

Background of study: The natural disaster in Agam Regency, West Sumatra, have disrupted access to health services and increased the risk of acute illness, exacerbating chronic illnesses, and causing psychosocial problems. This situation demands a rapid, integrated, and adaptive health response to the limitations of post-disaster facilities. This community service activity aims to improve access and quality of health services for disaster- affected communities through an integrated approach to medical services and logistics distribution. Methods: The program was implemented over three days at several locations and health posts in Agam Regency. Activities included cross-sector coordination, implementation of health services, daily evaluation, reporting, and planning for sustainability. Interventions included basic and advanced medical services, post-operative wound care, chronic disease management, home-visits, and medical assistance. Result: Health services were provided for more than 200 patients, predominantly with cases of hypertension, upper respiratory tract infections, dermatitis, musculoskeletal disorders, and diabetes mellitus. The home visit approach successfully reached vulnerable groups with limited mobility. Conclusion: The use of simple health technology and family involvement improved continuity of care and community empowerment. This program has supported physical health recovery in post-disaster communities and has the potential to be replicated in other disaster-affected areas.
Diabetes Predictive Scoring Model in Adults at Jakarta Based on Waist-to-Hip Ratio and Handgrip Strength Setiawan, Fiona Valencia; Wijaya, Bryan Anna; Gunawan, Shirly; Firmansyah, Yohanes
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 14 No. 1 (2026): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v14i1.52320

Abstract

Background: Diabetes mellitus is an escalating public health concern, particularly among productive-age populations in urban settings. This study aimed to evaluate the potential of WHR and HG as low-cost, non-invasive tools for early diabetes risk detection. Methods: A cross-sectional study was conducted among 539 productive-age adults (>18 years) across multiple districts in Jakarta during 2024–2025 using consecutive sampling. Fasting blood glucose, WHR, and HG were assessed. Multiple linear regression was applied to examine associations between WHR, HG, and fasting glucose. A binary logistic regression model with backward likelihood ratio selection was used to identify predictors of diabetes. Results: WHR showed a significant positive association with fasting glucose (B = 72.647; p = 0.001), while HG demonstrated a significant inverse association (B = –0.468; p = 0.047). Logistic regression analysis indicated that lower HG (B = –0.867; Exp(B) = 0.420; p = 0.001) and higher WHR (B = –2.413; Exp(B) = 0.090; p = 0.018) were independently associated with diabetes risk. The model constant was 4.535 (p < 0.001). Conclusion: A model integrating WHR and HG shows promise for early diabetes risk stratification among productive-age adults in Jakarta, supporting their utility in community-based screening.
Edukasi Pemanfaatan Tanaman Obat Tradisional untuk Kesehatan Lansia di Panti Werda Berbasis Edukasi Interaktif Shirly Gunawan; Bruce Edbert; Devi Putri Nabila; Elisya Shafa Ananda Maurika; Taufik Rizky Marhaen; Dodo Nugroho; Theresa Vanya Nabela Puspita Prameswari; Stephanie Amadea; Jennifer Oscar
Amalee: Indonesian Journal of Community Research and Engagement Vol. 7 No. 1 (2026): Amalee: Indonesian Journal of Community Research and Engagement
Publisher : LP2M INSURI Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37680/amalee.v7i1.9410

Abstract

Indonesia, with its rapidly growing elderly population (12% today, projected to reach 20% by 2045), faces major challenges in sustaining the quality of life of older adults. Comprehensive strategies are required to keep the elderly active, healthy, and productive, including the role of nursing homes that provide integrated health services. One promising approach is the use of traditional medicinal plants, globally recognized but remain relatively unfamiliar among the elderly. This community service program aims to educate elderly nursing home residents on the use of traditional medicinal plants. This activity adopted an educational approach using interactive games. Sixty-three elderly participants were divided into six groups. The program employed a descriptive qualitative approach supported by simple quantitative pre‑ and post‑test data to achieve a comprehensive understanding of its effectiveness. Initial knowledge was limited (83.33% scored 3–4), but after the educational intervention, four groups (66.67%) achieved excellent scores (9–10), one group (16.67%) attained good scores (7–8), and one group attained average scores (5-6). In the quiz, all questions (100%) were answered correctly. These findings highlight that interactive education can significantly improve elderly knowledge and motivation, offering a sustainable model for promoting the safe and effective use of traditional medicinal plants.
Co-Authors Adnan, Naufal Ikbar Rian Agatha Gracecia Nindra Clarissa Agus Limarta Ajeng Retno Setiawati Alexa Griffith Jaya Leslie Alexander Halim Santoso Alexander Halim Santoso Alfarisi, Mohamad Daffa Alicia Sarijuwita Alicia Sarjuwita Alicia Sarjuwita Allyssa, Jihan Putri Amimah, Ranindita Maulya Ismah Amin, Mohamad Shodiqul Anggita Tamaro Arinanda , Septian Averina, Frilliesa Bambang, Kresna Belinda Angie Bernadetha Vania Eveliani Bruce Edbert Bryan Anna Wijaya Bustam, Steve Geraldo Celline Angel Sinaja Chaidir Cokki, Cokki Daniel Goh David Limanan Devi Putri Nabila Dinali, Diana Djulia Djulia Dodo Nugroho Drew, Clement Dzahabiyyah, Tania Yumna Dzakwan, Muhammad Fikri Elisya Shafa Ananda Maurika Elly Mazida Eny Yulianti, Eny Erna Kristiyani Farihin Fadhilah Syarif Fia Fia Lie Fitriani, Gina Frans Ferdinal Gunaidi, Farell Christian Halim, Kenley Harsisnowo, Raden Hawari, Irawati Henyta, Henyta Herdiman, Alicia Hetty Karunia Tanjungsari Husada, Miftah Irawaty Hawari Irvan Baharits Al Basith Jap, Ayleen Nathalie Jennifer Oscar Johan Johan Kamalo, Angelica Joanna Charity Kasvana, Kasvana Keni Keni Kosasih, Robert Kurniawan, Joshua Leonita , Stefani Lerbin R. Aritonang R Liemitang, Gregorius Edward Listiono, Kevin Sanjaya Lo, Geoffrey Christian Lucius, Steven Hizkia Lumintang, Valentino Gilbert Luthfi Handayanti Maharani , Syifa Shabrina Marcella E. Rumawas Marcella Erwina Rumawas Marcella Erwina Rumawas Marshanda, Santy Massie, Andrew Christian Mei Ie Nathaniel, Fernando Nindi R, Desintha Cristy Noer Saelan Tadjuddin Noer Saelan Tadjudin Novendy Novendy Oentarini Tjandra Pandean, Felicia Paskalis Gunawan Pramana Jaya, I Made Satya Pratama, Raka Yoga Pratiwi, Adelia Helmi Pratomo, Farhan Prematellie Jaya Leslie Putri, Hadyan Prasetyaningtyas R. Aritonang R., Lerbin RA Rengganis Ularan Risnawaty, Widya Rumbay, Vaya Talenta Santoso, Alexander Halim Sari, Dwita Linda Sari, Karen Permata Satyanegara, William Gilbert Setiawan, Fiona Valencia Silaban, Hertina Silvia Dwi Mustika Sinaga, Oktri Lentina Sintia Seftiya Ningrum Sobiyanto, Mohammad Nuh Stephanie Amadea Sugiarto, Hans Susilodinata Halim Syarifah , Anisa Ulaya Tanuhariono, Ardhita Felicia Taufik Rizky Marhaen Teguh, Stanislas Kotska Marvel Mayello Theresa Vanya Nabela Puspita Prameswari Tiranda, Wisasti Gladys Chantika Tjongarta, Winny Triyana Sari Vamelda Agustin Vini Claudya Agustine Rajagukguk Vini Claudya Agustine Rajagukguk Widiarto, Sentanu Widya Risnawaty Wijaya, Bryan Anna Wijaya, Dean Ascha Yana Sylvana Yohanes Firmansyah Yosafat, Fernando Yunita, Fenny Zefanya, Belva Zita Atzmardina Zita Atzmardina