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Journal : Jurnal Respirasi (JR)

Age and Diabetes Mellitus Associated with Hematological Disorders and Peripheral Neuropathy in MDR-TB Patients Treated with the BPaL/M Regimen Tako, Frida Welhelmina; Sinaga, Bintang Yinke Magdalena; Harahap, Juliandi; Daulay, Rini Savitri; Siregar, Jelita; Samodra, Yoseph Leonardo
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.241-249

Abstract

Introduction: Tuberculosis (TB) is a disease with a significant treatment burden. Current multidrug-resistant (MDR)-TB therapy uses the bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaL/M) combination. This combination is effective with a short treatment duration. Linezolid is one of the components of the BPaL/M regimen. However, despite its effectiveness, it has side effects that impact treatment management and success. This study aimed to find the association between characteristics and comorbidities with the incidence of linezolid side effects in patients with MDR-TB treated with the BPaL/M regimen. Methods: This was a retrospective analytic study of MDR-TB patients receiving BPaL/M combination. Data were collected from medical records and analyzed using Fisher's exact test to analyze the association between patient characteristics and comorbidities with the incidence of linezolid side effects, namely hematological disorders, peripheral neuropathy, and visual disturbances. Results: There was no significant association between overall patient characteristics and the incidence of linezolid adverse events. However, the results of bivariate analysis showed a significant association in age >50 years old with the incidence of hematological disorders, as well as in patients who have diabetes mellitus (DM) with the incidence of peripheral neuropathy as a side effect of linezolid. Conclusion: Monitoring of MDR-TB patients aged >50 years old and those with DM to minimize the incidence of side effects during treatment is essential. This effort is expected to support the success of the national TB control and treatment program.
Co-Authors Afriadi Afriadi Alharbi, Olayan Alia, Dina Alona, Ivana Alviani, Aisyah Alvionita, Vinny Amelia, Putri Amirah, Asriwati Aprianti Lubis, Nenni Dwi Ardiana Ardiana, Ardiana Asriwati, Asriwati Aznan Lelo Begum Suroyo, Razia Beni Satria Chairani Chairani Damayanti, Heditya Destanul Aulia, Destanul Dewi, Ika C. Dimyati, Yazid Dwi Aprianti Lubis, Nenni Effendy, Ismail ELMAN BOY Erawati, Susina Fathia Meirina, Fathia Fitriani, Arifah Devi Fujiati, Isti Ilmiati Hanidi, Hanidi Harahap, Erika Maryanti Haryuna, Tengku Siti Hajar Hendri Wijaya, Hendri Hidayatul Fitria Irina, Rr Sinta Jamaluddin Jamaluddin Jenny Bashiruddin Kathy, Kathy Keumala Sari, Dina Khairun Nisa Kiking Ritarwan Kusumawati, R. Lia Lestari, Tria Diana Lita Sri Andayani Lubis, Andriamuri Primaputra Lubis, Mahrani Lubis, Masnelly Lubis, Nenni Dwi Aprianti Mayangsari, Ika Dwi Mayasari, Dyah Fitrah Miadi, Yesindi Nakita Mukhtar, Fatima AS. Mustika Sari, Yulin Nasution, Ramadhani Syafitri Nur Aini Olga R. Siregar, Olga R. Priyono, Harim Putri Chairani Eyanoer, Putri Chairani Putri, Monica Dwi Qalbi, Kamila Harisah Ranakusuma, Respati Ridho, M Rina Amelia Rini Savitri Daulay, Rini Savitri Rita Evalina Rohana Sofyana, Cut Saing, Johannes Harlan Samodra, Yoseph Leonardo Samosir, Fauzan Azmi Hasti Habibi Santi Syafril, Santi Sembiring, Rosita Juwita Silitonga, Nency Respina Sinaga, Bintang Yinke Magdalena Siregar, Jelita Siska Mayasari Lubis, Siska Mayasari Soetjipto, Damayanti Sosmira, Eri Sri Sumartiningsih Suistaya, Novi A. Supartono, Natasha SUROYO, RAZIA BEGUM Syamsidah Lubis, Syamsidah Syaputra, Adhika Tako, Frida Welhelmina Tamin, Susyana Tanjung, Ika Citra Dewi Tanjung, Sri Maryani Tarigan, Amira Permatasari Theo, Deli Umar Zein Umar Zein Wahyuni, Arlinda Sari Warli, Syah Mirsya Warto, Nirza Widayat Alviandi Wijaya, Vincent Wisman Dalimunthe, Wisman Yetty Machrina Yuansyah, Romi yulia, Luh Anggreni Yunanda, Yuki Yuniati Yuniati Yusni Yusni Zachreini, Indra Zebua, Markus Sastra Eli Zizlavsky, Semiramis