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All Journal Media Ilmu Keolahragaan Indonesia JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Journals of Ners Community Oto Rhino Laryngologica Indonesiana Jurnal Respirasi (JR) Jurnal Keperawatan Priority SCRIPTA SCORE Scientific Medical Journal Indonesian Journal of Global Health research JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH JOURNAL LA MEDIHEALTICO KESANS : International Journal of Health and Science Jurnal Neuroanestesi Indonesia Promotor: Jurnal Mahasiswa Kesehatan Masyarakat Narra X
Harahap, Juliandi
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Journal : Jurnal Neuroanestesi Indonesia

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Comparison of Changes in Cortisol Levels in the Blood of Patients Undergoing Craniotomy Using Continuous Infusion Lidocaine and Fentanyl Syaputra, Adhika; Irina, Rr Sinta; Lubis, Andriamuri Primaputra; Harahap, Juliandi
Jurnal Neuroanestesi Indonesia Vol 13, No 1 (2024)
Publisher : https://snacc.org/wp-content/uploads/2019/fall/Intl-news3.html

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24244/jni.v13i1.565

Abstract

Background and Objectives: Craniotomy is a surgical procedure that involves part of the skull, temporarily removing it to expose the brain and carrying out intracranial procedures. The surgery can be considered as the standard model for assessing cortisol as a stress response. Cortisol in the blood can cause hemodynamic and physiological changes in the body such as increased heart rate, increased blood pressure, and also increased blood sugar levels. Some literature showed that continuous infusion of fentanyl and lidocaine - has an effect in maintaining the responses to stress, namely the level of cortisol in the blood. The aim aimed to determine the comparison of changes in cortisol levels in the bloodpatients undergoing craniotomy using continuous infusion lidocaine and continuous infusion fentanyl.Subject and Method: This research used a double-blind randomized controlled trial (RCT) with a pre-test and post-test with a control group design. This study divided the samples into 2 groups. Continuous infusion of lidocaine and continuous infusion of fentanyl were then checked for cortisol levels in the patient's blood before and after undergoing craniotomy.Results: The result of 28 samples that underwent craniotomy, 6 samples were excluded, so the total number of samples analyzed was 22 samples. Differences in mean cortisol levels before and after surgery in the lidocaine and fentanyl groups were 193.90 nmol/L and 153.90 nmol/L respectively with a P value of 0.021.Conclusion: In the study, it was found that cortisol levels increased in both fentanyl and lidocaine groups after a craniotomy. There is a significant difference between the two groups of fentanyl and lidocaine, where statistically the fentanyl group was better at maintaining blood cortisol levels after craniotomy than the lidocaine group.
Co-Authors Afriadi Afriadi Alharbi, Olayan Alia, Dina Alona, Ivana Alviani, Aisyah Alvionita, Vinny Amelia, Putri Amirah, Asriwati Aprianti Lubis, Nenni Dwi Ardiana Ardiana, Ardiana Asriwati, Asriwati Aznan Lelo Begum Suroyo, Razia Beni Satria Chairani Chairani Damayanti, Heditya Destanul Aulia, Destanul Dewi, Ika C. Dimyati, Yazid Dwi Aprianti Lubis, Nenni Effendy, Ismail ELMAN BOY Erawati, Susina Fathia Meirina, Fathia Fitriani, Arifah Devi Fujiati, Isti Ilmiati Hanidi, Hanidi Harahap, Erika Maryanti Haryuna, Tengku Siti Hajar Hendri Wijaya, Hendri Hidayatul Fitria Irina, Rr Sinta Jamaluddin Jamaluddin Jenny Bashiruddin Kathy, Kathy Keumala Sari, Dina Khairun Nisa Kiking Ritarwan Kusumawati, R. Lia Lestari, Tria Diana Lita Sri Andayani Lubis, Andriamuri Primaputra Lubis, Mahrani Lubis, Masnelly Lubis, Nenni Dwi Aprianti Mayangsari, Ika Dwi Mayasari, Dyah Fitrah Miadi, Yesindi Nakita Mukhtar, Fatima AS. Mustika Sari, Yulin Nasution, Ramadhani Syafitri Nur Aini Olga R. Siregar, Olga R. Priyono, Harim Putri Chairani Eyanoer, Putri Chairani Putri, Monica Dwi Qalbi, Kamila Harisah Ranakusuma, Respati Ridho, M Rina Amelia Rini Savitri Daulay, Rini Savitri Rita Evalina Rohana Sofyana, Cut Saing, Johannes Harlan Samodra, Yoseph Leonardo Samosir, Fauzan Azmi Hasti Habibi Santi Syafril, Santi Sembiring, Rosita Juwita Silitonga, Nency Respina Sinaga, Bintang Yinke Magdalena Siregar, Jelita Siska Mayasari Lubis, Siska Mayasari Soetjipto, Damayanti Sosmira, Eri Sri Sumartiningsih Suistaya, Novi A. Supartono, Natasha SUROYO, RAZIA BEGUM Syamsidah Lubis, Syamsidah Syaputra, Adhika Tako, Frida Welhelmina Tamin, Susyana Tanjung, Ika Citra Dewi Tanjung, Sri Maryani Tarigan, Amira Permatasari Theo, Deli Umar Zein Umar Zein Wahyuni, Arlinda Sari Warli, Syah Mirsya Warto, Nirza Widayat Alviandi Wijaya, Vincent Wisman Dalimunthe, Wisman Yetty Machrina Yuansyah, Romi yulia, Luh Anggreni Yunanda, Yuki Yuniati Yuniati Yusni Yusni Zachreini, Indra Zebua, Markus Sastra Eli Zizlavsky, Semiramis