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All Journal Majalah Kedokteran Bandung Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Folia Medica Indonesiana Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education The Indonesian Biomedical Journal Jurnal Penelitian Kesehatan Suara Forikes Journal Of Vocational Health Studies Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya EMBRIO : Jurnal Kebidanan Jurnal Kreativitas PKM Care : Jurnal Ilmiah Ilmu Kesehatan ISM (Intisari Sains Medis) : Jurnal Kedokteran Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Indian Journal of Forensic Medicine & Toxicology Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL Narra J Indonesian Andrology and Biomedical Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Strada Jurnal Ilmiah Kesehatan (SJIK)
I'tishom, Reny
Departemen Biologi Kedokteran Fakultas Kedokteran Universitas Airlangga
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Biomolecular and Health Science Journal

 1 
A Systematical Review of The Effect of Ketogenic Diet on Bcl-2 (B-cell lymphoma-2) Expression as An Apoptosis Marker in Cancer Treatment Vania Islamey Kusuma; Reny I’tishom; Ema Qurnianingsih; Purwo Sri Rejeki
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.30173

Abstract

Introduction: Ketogenic diet seems to be in a great demand nowadays as a lot of people are interested in adopting it into their lifestyle. It is also found that the ketogenic diet shows several beneficial effects including cancer prevention. However, the detail mechanism still remains unknown. Therefore, this review was aimed to find out the effect of ketogenic diet on Bcl-2 (B-cell lymphoma-2) expression in cancer.Methods: We searched published literatures in PubMed through 2011-2020 using specific keywords. The literatures were filtered according to inclusion and exclusion criteria. Animal model, total sample size, underlying condition/inflammatory process occurs, details of the intervention/diet including diet contents in control group and high-fat group, and the duration of the intervention, Bcl-2 results, and p-value were extracted.Results: 7 studies were included in this review. Bcl-2 expression found decrease in 5 out of 6 studies. Similar result also obtained in Bcl-2 protein level, which measured by western blot. Bcl-2 protein level shows a decrease in 2 out of 3 studies.Conclusion: This review shows that high-fat diet that contained in ketogenic diet most likely lead to decrease in Bcl-2 expression. Therefore, indicating the ability of ketogenic diet to affect cancer progression by inducing apoptosis process.
Co-Authors A. Marlinata Abadiyah Zakiah Kustantina Abdurachman Abdurachman Addia Salsabila Ade Septiari Rahman Adha, Ahmad Zaidan Ni'am Abu Aditiawarman Aditiawarman, Aditiawarman Ahmad Basori Ahmad Ricardo Silalahi Ahmad Ricardo Silalahi Ahmad Ricardo Silalahi Alphania Rahniayu Ami Ashariati Anak Agung Istri Dalem Cinthya Riris Anak Agung Istri Dalem Cinthya Riris Anak Agung Renjani Kanya Kumari Andi Yasmin Wijaya Andri Rezano Anggi Dearni Silalahi Anggita Putri Samara Annas, Jimmy Yanuar Anny Setijo Rahaju, Anny Setijo Arif Rananda Arifa Mustika Arrasy Khawarizmi Ashon Sa’adi Aslama, Fathiy Zakaria Asmalinda, Wita Astri Dewayani Atmaja, Maxwell Aucky Hinting Ayik Rochyatul Jannah Ayik Rochyatul Jannah Azarine Ariqoh Arysanti Bahyshidqi Bambang Purwanto Budi Sutikno Caesariska Deswima Christian Christopher Sunnu Clara Alverina Daniel Widiyanto David Setyo Budi Diana, Alis Nur Dienanta, Savira Butsainah Dita Mega Utami Doddy M Soebadi Dwiki Noni Armyta Dzakiyyah, Nurul Ebnudesita, Faiza Rahma Eddy Bagus Wasito Era Fazira Etik Yuliarini Widodo Evy Wulandari Evy Wulandari Faiza Rahma Ebnudesita Faiza Rahma Ebnudesita Faizah Sugiarto Fedik Abdul Rantam Feranita Kumalasari Fitri Indah Pratiwi Fitria Nengsih Gadis Meinar Sari Gondo Mastutik Hamdani Lunardhi Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** Hanna Tabita Hasianna Silitonga Hendy Hendarto HERAWATI, LILIK Hermina Novida, Hermina Heru Fajar Trianto Hudi Winarso Inda Corniawati Indra Alfaray, Ricky Intan Indah Permatasari IRWANTO Isnin Anang Marhana James Alfedo Jannah, Ayik Rochyatul Jefry Albari Tribowo Jihadna Prima Santika Ruslan Musanip Kartika Afrida Fauzia Kevin kevin Khaerunnisa, Siti Lionardy Yodianto Lukman Hakim Magfira Febrianty Lacindung Maria Magdalena Awi Mochamad Amin Mochammad Abdul Aziz, Mochammad Abdul Mohammad Anam Al-Ari Mohammad F. Qorib Mohammad Fathul Qorib Muhammad Miftahussurur Mustafa, Mohammad R. Nathania Nathania Nathania Nila Kurniasari Ninik Darsini Nurul Jannatul Wahidah Nurul Jannatul Wahidah Nurwasis Nurwasis Nyilo Purnami Purnama, Michael Purwanti, Dwi Puspitasari, Renny N. Qurnianingsih, Ema Rafida Anshori Raharjo, Rahmawati Rejeki, Purwo Sri Reryd Arindany Wiryawan, Reryd Arindany Ria Margiana Ria Margiana Rima Wirenviona Rima Wirenviona Rizaldi, Fikri Rize Budi Amalia Rizkiliano, Ibrahim Hanif Rochmah Kurnijasanti Rossy Sintya Marthasari S.Pd. M Kes I Ketut Sudiana . Safira Nur Izzah Salsabila Rahma Nurani Putri Salsabila, Unik Hanifah Sandra Dewi Sitaresmi Savira Butsainah Dienanta Savira Butsainah Dienanta Savitri, Camilia Metadea Aji Selvina Cindy Kusumaningrum Shahnaz Azzahra Siti Khaerunnisa Soebadi, Doddy Soetojo Sofia Zahra Kamila Sri A. Sudjarwo Sri Agus Sudjarwo Sri Purwaningsih Sri Ratna Dwiningsih Steven Sheng Looi Sudana, Nathan Kunta Sudjarwo, Sri A. Suhartono Taat Putra Sunaryo Hardjowijoto Supardi Supardi Susanti, Nurul Fatimah Suyono, Seso Sulijaya Syahnural Syahnural Syarifah, Anis Satus Tanojo, Tjahjo Djojo Tjahjo Djojo Tanojo Tjahjo Djojo Tanojo Tutus Rachkutho Vania Islamey Kusuma wahjoe djatisoesanto Wahyul Anis Widjayanti, Yhenti Widya Juwita WINARTO Winona May Hendrata Yassin, Tita Rudini Yaudiwati, Rina Yohana djurumana Yoshio Yamaoka, Yoshio Yudith Annisa Ayu Rezkitha, Yudith Annisa Ayu Yudiwati, Rina Yuliawati, Tri Hartini Zuhria, Ismi