Kadek Karang Agustina
Department Of Public Health, Faculty Of Veterinary Medicine, Udayana University, Denpasar, Indonesia

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Pathogenesis studies of African swine fever virus isolates from Bali and East Nusa Tenggara as a basis for inactivated vaccine development Tenaya, I Wayan Masa; Agustina, Kadek Karang; Suada, Ketut; Sukada, Made; Mufa, Romy Muhammad Dary; Apsari, Ida Ayu Pasti; Dwinata, I Made; Ardana, Ida Bagus Komang; Damriyasa, Made; Sari, Tri Komala; Astawa, Nyoman Mantik; Supartika, Ketut Eli; Wirata, Ketut; Suarsana, Nyoman; Suartha, Nyoman
Jurnal Medik Veteriner Vol. 9 No. 1 (2026): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol9.iss1.2026.150-160

Abstract

African swine fever (ASF) is a highly contagious and lethal disease of pigs for which no effective vaccine is currently available. This study evaluated the pathogenicity of field African swine fever virus (ASFV) isolates from Bali and East Nusa Tenggara and assessed their potential for inactivated vaccine development using spleen-derived antigens. Based on the qPCR results, among all ASFV isolates tested, only the Bali isolate, designated B1, exhibited the highest DNA concentration, suggesting that this sample contained the highest ASFV titer. Consequently, the B1 isolate was selected and processed into chemically treated (CT-ASFV) and non-treated (NCT-ASFV) formulations. In the pathogenesis trials, pigs inoculated with NCT-ASFV developed acute ASF and died within 12 days, whereas those receiving CT-ASFV exhibited no clinical signs of ASF and showed no evidence of viral replication. In the vaccination trial, pigs immunized with CT-ASFV emulsified in Montanideā„¢ ISA 50 V2 demonstrated survival in two out of three animals (67%) following challenge with a virulent strain, while all control animals succumbed to infection. Despite the absence of detectable humoral responses as determined by ELISA, the observed protection suggests a potential role for cell-mediated immunity. These findings indicate that the B1 isolate was highly virulent and represents a promising candidate for the development of an inactivated ASF vaccine. Further evaluation in larger-scale field trials is warranted.
Co-Authors Adhiputra, I Ketut Agus Indra Adiwinata, Putu Diva Ady Fendriyanto, Ady Ahmad Harits Fitra Mauladi Aida Lousie Tenden Rompis Anak Agung Ayu Mirah Adi Anak Agung Gde Oka Dharmayudha Anak Agung Komang Suardana Andriawino Berdionis Sanam Anne Dawdoya Arinata, I Ketut Teguh Astrid Laboure Parahita Cesarina Pascalia dos Santos Alegria Daniella Everetta Desak Wiga Puspita Dewi Desy Ariani Ferdianti, Desy Ariani Dewa Akbar Maulana Dewa Made Dwi Parwata Dewi Titis Angganingrum Dimas Indra Dwi Purnama Dina Elviana DWI SURYANTO Elis Mandari Emerensia Patryconsitha Aman Emia Pepa Yosa Br Ginting Erma Pradnyani, Putu Gede Widiantara Gunawan, I Wayan Nico Fajar Gusti Ayu Yuniati Kencana Gusti Made Widyantara Handayani, Ni Made Harjana, Ngakan Putu Anom Hendra Irawan I Gede Mahardika I Gede Raka Mas Tanaya I Gusti Agung Ayu Suartini I GUSTI AYU FITRI DIASTARI I Gusti Ketut Suarjana I Gusti Ketut Suarjana I Gusti Made Krisna Erawan I Gusti Ngurah Bagus Trilaksana I Gusti Ngurah Bagus Trilaksana I Gusti Ngurah Kade Mahardika I Gusti Ngurah Sudisma I Kadek Swastika I Ketut Berata I Ketut Suada I Ketut Suada I Ketut Suada I Ketut Tomy Caesar Ramanda I Made Damriyasa I Made Dwinata I Made Gede Asta Ginawan I Made Gede Wijaya Kusuma I Made Kardena I Made Ricky Dwi Cahya I Made Subrata I Made Subrata I Made Subrata I MAde Sukada I Made Sukada I Made Sukada I Made Sukada I Made Sukada I Nengah Kerta Besung I NYOMAN ADI SURATMA I Nyoman Arsana, I Nyoman I Nyoman Bagus Tri Aribawa I NYOMAN MANTIK ASTAWA I Nyoman Suarsana I Nyoman Suartha I Putu Agus Kertawirawan, I Putu Agus I Putu Ardiawan I Putu Sampurna I Wayan Batan I Wayan Masa Tenaya I Wayan Masa Tenaya I Wayan Masa Tenaya, I Wayan Masa I Wayan Polos I Wayan Suardana I Wayan Suardana I Wayan Sudarmayasa I Wayan Sudira I Wayan Wahyudi, I Wayan I Wayan Wirata I.H. Utama I.W. Batan Ida Ayu Pasti Apsari Ida Ayu Putu Aselya Mardyawati Ida Bagus Dimas Kusumadarma Ida Bagus Kade Suardana Ida Bagus Kade Suardana Ida Bagus Kade Suardana Ida Bagus Komang Ardana Ida Bagus Krisna Pradnyadana Ida Bagus Made Oka Ida Bagus Ngurah Swacita Ida Bagus Ngurah Swacita Ida Bagus Ngurah Swacita Ida Bagus Oka Winaya Ida Bagus Windia Adnyana Indraningrat, Anak Agung Gede Janice Girardi Janice Girardi Joanita Auxilia de Sa Pereira Julita Dewitri Merthayasa Kate Druhan Ketut ELI Supartika KETUT SUADA Ketut Tono Pasek Gelgel Luh Made Sudimartini Luh Putu Pradnya Swari M.D. Rudyanto Made Damriyasa, Made Made Suma Anthara MAS DJOKO RUDYANTO Mufa, Romy Muhammad Dary MURNI SARI Natalia Natalia Ngakan Nyoman Cahaya Adi Ngakan Putu Anom Harjana Ngakan Putu Anom Harjana Ni Ketut Ayu Juliasih Ni Ketut Suwiti Ni Komang Dyah Purnamasari Ni Luh Gede Sudaryati Ni Made Ayudiningsih Astiti Sudewi Ni Nyoman Sri Budayanti Ni Putu Juni Ratna Dewi Ni Putu Tessa Arsaning Rahayu Ni Wayan Arya Utami Ni Wayan Arya Utami Ni Wayan Arya Utami, Ni Wayan Arya Nyoman Sadra Dharmawan Nyoman Sadra Dharmawan Nyoman Suartha Nyoman Tigeh Suryadi Pande Putu Januraga Prabarini Hanum Sari Putra, I Made Maha Putri Destarani Putu Agus Trisna Kusuma Antara Putu Arya Suryanditha Putu Ayu Sisyawati Putriningsih Putu Henrywaesa Sudipa Putu Sasmitha Devi Cahyani Putu Velyniawati Ribka Listia Br Tarigan, Ribka Listia Romy Muhammad Dary Mufa Romy Muhammad Dary Mufa Sabelina Fitriani Samuel Mura sang gede purnama Sang Gede Purnama Sang Gede Purnama Segantara, Luh Gede Victoria Setiabudy, Marta Sonia Dewi Citra Sembiring Sosiawan, I Gede Arya Mas Sri Kayati Widyastuti Sudiartawan, I Putu Sukada, Made Sukardika, Ketut Elok Sumarya, I Made Suputra, Gusde Wahyu Krisna Suryadi, Nyoman Tigeh Suwartama, Beny T. Sari Nindia Thea Sarassati, Thea Tjok Gde Oka Pemayun Tjok Gde Oka Pemayun Tjokorda Sari Nindhia TRI KOMALA SARI Uli Rehlitna Sembiring, Uli Rehlitna Vinensia Ghona Gani Widayantari, Anak Agung Ayu Sauca Sunia Widowati, I Gusti Ayu Rai - Wilson Lois, Wilson Wirata, Ketut Yanti, Ni Komang Semara