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All Journal HAYATI Journal of Biosciences International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Berkala Ilmiah Pertanian Jurnal Farmasi Klinik Indonesia Majalah Kedokteran Gigi Indonesia The Indonesian Biomedical Journal Science and Technology Indonesia Molecular and Cellular Biomedical Sciences (MCBS) JBN (Jurnal Bedah Nasional) EMBRIO : Jurnal Kebidanan Biota Majalah Patologi Indonesia Jurnal Ilmu Bedah Indonesia MAHESA : Malahayati Health Student Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Cancer Makara Journal of Health Research Tarumanagara Medical Journal Mulawarman Dental Journal Jurnal Widya Medika
Ahmad Faried
Fakultas Kedokteran Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Analisis Imunoekspresi Programmed Death Ligand 1 (PD-L1) dan Indeks Proliferasi Ki-67 pada Tumor Astrositik Difus Billy Parulian Lubis; Hasrayanti Agustina; Hermin Aminah Usman; Bethy Surjawathy Hernowo; Sri Suryanti; Ahmad Faried; Hendrikus Bolly
Majalah Patologi Indonesia Vol. 29 No. 2, Mei 2020
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i2.418

Abstract

BackgroundDiffuse astrocytic tumours (DAT) is a diffuse infiltrative astrocytoma tumor accompanied by molecular parameters in the form or absence ofIsocitrate Dehydrogenase (IDH) gene mutations. The DAT category without the examination of the IDH gene mutation is classified as NotOtherwise Specified (NOS). Ki-67 is a marker for DAT proliferation so that it can assess the degree of DAT. Diffuse astrocytic tumoursbehavior is influenced by proliferative ability and the presence of a tumor microenvironment. The tumor microenvironment PD-L1 factorinfluences DAT behavior and allows the development of target therapy in DAT cases. This study aimed to analyze the relationship betweenPD-L1 and Ki-67 imunoexpression in the histopathological degree of DAT.MethodsCross-sectional study of 30 paraffin blocks of DAT NOS cases from 2014-2018 in the Department of Anatomical Pathology RSUP dr. HasanSadikin, Bandung. The sample consisted of 15 cases of grade II, 7 cases of grade III and 8 cases of grade IV, carried outimmunohistochemical staining with GFAP, PD-L1 and Ki-67. Assessment of PD-L1 immunoexpression was carried out by the histoscoremethod. The Ki-67 assessment was assessed based on its distribution, which was <10% and ≥10%. PD-L1 and Ki-67 immunoexpressionwith histopathological degrees in DAT were statistically analyzed by Kolmogorof Smirnov test, however association betweenimmunoexpression of PD-L1 and Ki-67 were analyzed by chi-square test.ResultsThere was a significant relationship between PD-L1 immunoexpression and histopathological degree in DAT (p=0.005). There was asignificant relationship between Ki-67 immunoexpression and DAT histopathology degree and with PD-L1 (p=0.001 and p=0.010).ConclusionPD-L1 immunoexpression and proliferation rates affect the degree of DAT. Proliferation rate of DAT is influenced by PD-L1 so that in thisstudy, PD-L1 and Ki-67 can be used as a marker of prognosis predictors.
Co-Authors . SETIAWAN Achadiyani Achmad Adam Adriani Lawrencia Novalia Afiat Berbudi Agung B Sutiono Agung Budi Sutiono Agung Budi Sutiono Agung Budi Sutiono Agus Dwi Sastrawan Ajeng Diantini, Ajeng Ali Budi Harsono Alya Mardhotillah Azizah Amarila Malik Amelia Ganefianty Amira Puti Karima Andi Wijaya ANDI WIJAYA Angliana Chouw Angliana Chouw, Angliana Arwinder Singh Gill Astrid Tamara Maajid Budiman Ban Bolly, Hendrikus Masang Bayu W. Putera Benny Atmadja Wirjomartani Benny Isakh Beny Atmadja Wirjomartani Bethy Surjawathy Hernowo Billy Parulian Lubis Billy Yosua Costantin Pongajow Bilzardy Ferry Cynthia R. Sartika Cynthia Retna Sartika Cynthia Retna Sartika, Cynthia Retna Daniel Happy Putra Danny Halim Dedy Kurniawan Derrett, Sarah Dhuha, Alief Dian Ratih Laksmitawati Diana Krisanti Jasaputra Didik Priyandoko Dimas Erlangga Luftimas Dimyati Achmad Dumingan, Alvian Dwi A. P. Dewi Dwi Davidson Rihibiha Endang Sjamsudin Endang Sjamsudin Ermi Girsang Ervi Afifah Fahmi, Ismail Farid Yudoyono Farilaila Rayhani Firman Fuad Wirakusumah Firman Fuad Wirakusumah Firman Priguna Tjahjono Ganefianty, Amelia Gill, Arwinder Singh Ginting, Chrismis Novalinda Haifa, Rima Hanna Gunawan Hanna Sari W Kusuma Hanna Sari Widya Kusuma Hapsari, Putie Harry Murti Harry Murti Hasrayanti Agustina Heda Melinda Nataprawira Hendrikus Bolly Hendrikus Masang Ban Bolly Hendrikus Masang Ban Bolly Hermin Aminah Usman Hiroshi Koyama Huda, Fathul I M Kariasa I Made Kariasa I Nyoman Ehrich Lister Ida Parwati Indah, Astrina Rosaria Indra Bachtiar Ismail Fahmi Jeffrey ., Jeffrey Jefri Henky Julia Riswandani Julius July Kahdar Wiriadisastra Kalih Sarjono Keri Lestari Kharisma, Surti Wulan Leri Septiani Maman Abdurrahman Maryani, Euis McAllister, Susan MEILINAH HIDAYAT Melia, Regina Melisa Intan Barliana Mirna Sobana Mochammad Aris Widodo MUCHTAN SUJATNO Muhammad Agus Muljanto Muhammad Firdaus Muhammad Firdaus Muhammad Kusdiansah Muhammad Z. Arifin Muhammad Zafrullah Arifin Muhammad Zafrullah Arifin Munandar, Denna Eriani Mutakin Mutakin Nabilla Farah Naura Nainggolan, Ita Margaretha Nida Suryana Nina Puspitaningrum Noverina, Rachmawati NUGRAHA SUTADIPURA Oskar Ady Widarta Prayoga SURYADARMA Priandana Adya Eka Saputra Priandana Adya Eka Saputra Purwaningtyas, Yoggi Ramadhani Qlintang, Sandy Rachmawati Noverina Rachmawati Noverina Rachmawati Noverina Raden Roro Ratuningrum Anggorodiputro Raden Yohana, Raden RAHMAT, DENI Ratih Rinendyaputri Ratih Rinendyaputri Rayhani, Farilaila Renaldi Prasetia Reni Ghrahani Rilianawati Rilianawati Rima Haifa Rini Andriani Rizal Azis Rizal Rizal Rizal Rizal Rizki, Kiki Ahmad Rizkiditia Nugraha Hadian Rizky Abdulah Robert Sinurat Rully Hanafi Dahlan Sarah Derrett Sarah Sumayyah Sarjono, Kalih Seila Arumwardana Sevline Esthetia Ompusunggu Singh, Arwinder Sobana, Mirna Soeprajogo, Adolf Setiabudi Sri Suryanti Sri Suryanti Subangkit, Mawar Sugiarto, Yosafat Kurniawan Sunarno Sunarno Susan McAllister Sutiman Bambang Sumitro Sutiono, Agung B Syahril Samad, Syahril Syamsiar, Syamsiar Takayuki Ohira Takeshi Kawase Teguh Marfen Djajakusumah, Teguh Marfen Teresa Liliana Wargasetia The Fransiska Eltania Tinambunan, Nicholas Christian Tono Djuwantono Tono Djuwantono Tono Djuwantono Trajanus Laurens Yembise Tri Hanggono Achmad Triharsiwi, Dwi Nur Tuti Wahmurty Sapi'i Utama, Hieronimus Adiyoga Nareswara Vinna Kurniawati Sugiaman, Vinna Kurniawati Wahyu Widowati WAHYU WIDOWATI Wahyu Widowati Wahyu Widowati Widarta, Oskar Ady Wireni Ayuningtyas Wireni Ayuningtyas Yarman, Indra Prasetya Yosafat Kurniawan Sugiarto Yudi Mulyana Hidayat Yulius Hermanto Yuni Elsa Hadisaputri Yusuf Hariady Hariady Yusuf Sulaeman Effendi