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Journal : JOURNAL LA MEDIHEALTICO

In Vitro Anti-inflammatory Effect of Secretome from Umbilical Cord-derived Mesenchymal Stem Cells in COVID-19 Patient Blood: A Study on sIL-6R, sgp130, IL-1RA and Anti/pro Inflammatory Cytokines Asysyifa, Nisrina; Wibowo, Heri; Abdullah, Murdani; Liem, Isabella Kurna; Bustami, Arleni
Journal La Medihealtico Vol. 5 No. 5 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i5.1522

Abstract

COVID-19 exhibits a wide range of clinical manifestations which severity of the disease is linked to uncontrolled escalation of inflammatory mediators. Ongoing research has identified the immunomodulatory effects of the MSC-derived secretome as a potential therapy for COVID-19. However, the precise mechanism by which the secretome exerts its therapeutic effect on COVID-19 remains unclear. This study aims to investigate whether the components of the UC-MSC-derived secretome can alter the inflammatory characteristics of immune cells. To achieve this, an in vitro study will be conducted involving co-incubation of whole blood with secretomes, followed by LPS stimulation. A total of 12 blood samples from severe COVID-19 and healthy subjects were cultured into three groups (RPMI control, 3μl and 9μl secretome group) incubated for 24 hours. Then, the cultures were exposed to LPS for 48 hours. The levels of sIL-6R, sgp130, IL-1RA, IL-6, TNF-α, IFN-γ, and IL-10 were measured. Results showed that LPS increased IL-6, TNF-α, and IL-10 production, while reducing sIL-6R, and sgp130, but no changes seen in IFN-γ in secretome-incubated blood cultures. The post-LPS/pre-LPS ratio analysis was conducted to investigate the anti-inflammatory potential of secretome. It was found that the secretome provides its anti-inflammatory effects through the role of IL-1RA.
Co-Authors -, Hidayat . Sulastri Achmad Arifin Agung W. Ahmad Sidiq Ahsanul Fakhr, Ardani Akmala, Vaza Al Afif, Risky Aldho Jaya P. Aldino, Rio Yuri Aldyth Gunanto P. Alghifari, Fajar Alida Roswita Harahap Amanatin, Elsa Lutmilarita Andari, Ni Nyoman Destri Andrian Riyadi Anggono, Rendi F. Anggraini, Meilani Anggraini, Melani Anggraini, Melani Ani Retno Prijanti Ani Retno Prijanti Anna Rozaliyani Antonius H. Pudjiadi Apri Budianto, Apri Ardani Ahsanul Fakhri Ardani, Yanuar Ardhias Mahendra P. Aria Kekalih Ariyanto Ariyanto Arleni Bustami Aryono Hendarto Asysyifa, Nisrina Bambang Heru Budianto Bima Lantip B. Clarinta Putri, Rizky Damayanti, Triya Dante Saksono Harbuwono Desi Yunita Dewi Sukmawati Dian R. Sawitri, Dian R. Dicky Levenus Tahapary Didik Nurhadiyanto Dilawar, Ismail Dimyati, Arzaq Guruh Dinda Zulwi Amalia Tifani E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Edy Purnomo Em Yunir, Em Emy Khikmawati Ernawati Evy Yunihastuti Fadhillah, Muhamad Rizqy Fattah, Kemas Muhammad Abdul Ferry Sandra Findra Setianingrum Fredy Surahmanto Gantini, Ria Syafitri Evi Gede Wirya Kusuma Duarsa Gusti Khatimah, Nurul Hamdani Nurbahri Hayati, Taureni Hidayat - Hidayat, Entus Hikmat, Ujang Saeful Hutabarat, Hernayati I Wayan Agus Hariyanto Ida Parwati Ilman, M.Noer Indah Setiawati Irfan Wahyudi Iris Rengganis Irwansyah Irwansyah Joedo Prihartono Julian Katarina, Matilda Kemas Muhammat Abdul Fatah Khatimah, Nurul Gusti Kusmardi Kusmardi Kusmarinah Bramono Kwarta, Cytyta Putri Lesmana, Aditya Candra Liem, Isabella Kurna Liem, Isabella Kurnia Lisnawati Rachmadi M. Rafi Marcellus Simadibrata Marcellus Simadibrata Marcelly Widya Wardana Masyur, Muhtaruddin Mawardi, Prasetya Melani Anggraini Mohamad Sadikin Muhamad Hasan Sebyar Muhammad Fedryansyah, Muhammad Muhammad Luthfi Muhammad Noer Ilman Mujiyono Mujiyono Mujiyono Mujiyono Mulyadi M. Djer Mulyani, Ayu Murdani Abdullah Murni, Indah K. Najib Advani Neng T. Kartinah Novi H Nugraha, Ardi Maulana Nur Azizah Nur Irawati Nuraeni, Hanny Siti Nurbahri, Hamdani Nuri Dyah Indrasari Nurrahmah, Sheila Nurwati, R. Nunung Parhusip, Santi Sumihar Rumondang Piprim B. Yanuarso, Piprim B. Ponco Birowo Pradipta, Saraswati Prasetio, Mukhamad Andri Prihatno Kusdiyarto Primadhani, Suci Widya Primariadewi Rustamadji Priyo Tri Iswanto Putera, Raka Hilmi Syah Putri Damayanti Putri, Rizky Clarinta Rachim, Hadiyanto Abdul Raharja, Putu Angga Risky Rahmat Efendi Rani Wardani Hakim Ratnawati, Mamik Reza Y. Purwoko Ricardo, William Rio Yuri Aldino Ririn Probowati, Ririn Riski Amanda, Clara Riskiyanto, Aldy Risty Yasmin Bonita Riswan Dwi Djatmiko Rona Kartika Rozaliyan, Anna Rubiana Sukardi, Rubiana Sarwono, Sugeng J. Savitri, Monika Sawitri Prohatini, Monika Septiasari, Yeti setianingrum, suci Sidiq , Ahmad Soleha, Winna Sresta Azahra Sri Widia A. Jusman Suhendro Suhendro Sukamto Koesnoe Sulastri Sulastri Supanto, Muhammad Supriatna, Novianti Supriono , Untung Susanti, Dasmi Susanti, Dhama S. Susatyo, Jeffry Adijaya SUTOPO Suyatna, Fransiscus Dhyanagiri Syari, Lucky Novita Tahapary, Dicky L Tiara Mayang Pratiwi Lio Tjhin Wiguna Triana, Novi Utomo, Yoga Wahyu Wahyu Gunawan Wahyu, Fransiska Wahyurini, Dyahati Wawaimuli Arozal Widodo Apriliyanto Wijaya, Rheza Paleva Windy Keumala Budianti Wresti Indriatmi B. Makes Yonita, Ariska Yusra Yusra