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All Journal Jurnal Penelitian Saintek INOTEKS : Jurnal Inovasi Ilmu Pengetahuan, Teknologi, dan Seni EKSAKTA: Journal of Sciences and Data Analysis SPEKTRUM INDUSTRI International Conference on Engineering and Technology Development (ICETD) Medical Journal of Indonesia Rekayasa Mesin Journal Industrial Servicess The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) JURNAL DINAMIKA VOKASIONAL TEKNIK MESIN Seminar Nasional Teknologi Informasi Komunikasi dan Industri Prosiding SENTIKUIN (Seminar Nasional Teknologi Industri, Lingkungan dan Infrastruktur) Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Respirologi Indonesia Jurnal Ilmu dan Teknologi Kesehatan Pharmaceutical Journal of Indonesia Majalah Patologi Indonesia Jurnal Ilmiah Teknik Industri Kumawula: Jurnal Pengabdian Kepada Masyarakat Health Information : Jurnal Penelitian Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Ilmiah Kesehatan Jurnal Ners jurnal Teknik Industri - Unisi Jurnal Rekayasa Industri (JRI) Indonesian Journal of Global Health research BioEksakta : Jurnal Ilmiah Biologi Unsoed Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang JOURNAL LA MEDIHEALTICO Journal of Engineering and Applied Technology Narra J Jurnal Perak Malahayati : Pengabdian Kepada Masyarakat Jurnal Rekayasa, Teknologi, dan Sains Jurnal Ilmiah Kesehatan (JIKA) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Indonesian Journal of Applied and Industrial Sciences (ESA) Jurnal Pustaka Dianmas Jurnal Bakti Masyarakat Manajemen Jurnal Difusi Ipteks Legowo Jurnal Penelitian dan Pengabdian Kepada Masyarakat (JPPM) Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Jurnal Polimesin Jurnal Akuntansi Pajak dan Manajemen Folia Medica Indonesiana
Heri Wibowo
Jurusan Pendidikan Teknik Mesin, Fakultas Teknik, Universitas Negeri Yogyakarta
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Comparison of inflammatory mediator cytokine responses to inactivated virus platform COVID-19 vaccines between elderly and young adult populations Hayati, Taureni; Kartinah, Neng T.; Wibowo, Heri; Purwoko, Reza Y.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1380

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has encouraged global vaccine research, yet vaccine effectiveness in the elderly remains a concern due to immunosenescence. The aim of this study was to compare the cytokine response elicited by an inactivated virus-based COVID-19 vaccine between elderly and young adults, focusing on key cytokines involved in cellular and humoral immunity: tumor necrosis factor-alpha (TNF-α), interleukin (IL)-2, IL-6, IL-10, and interferon-gamma (IFN-γ). A cross-sectional study was conducted in the Jakarta-Bogor region of Indonesia from January 2023 to December 2023. The study population was divided into two age cohorts: elderly (60−85 years) and younger adults (30−40 years). Blood samples were collected twice, after the first booster dose and four weeks after the second booster dose. Serum cytokine concentrations were measured using Luminex assays with microparticles conjugated to monoclonal antibodies against TNF-α, IL-2, IL-6, IL-10, and IFN-γ. Comparisons of the cytokine levels were conducted using Student’s t-tests or Mann-Whitney U tests as appropriate. A total of 74 individuals were included, with 37 each in the elderly and young adult groups. The results showed significant differences in cytokine responses between the two age groups. After the first booster, the levels of IL-6 and IFN-γ were significantly higher in young adults compared to the elderly. After the second booster, the levels of IL-6 were still significantly higher in the young adult group compared to the elderly group (p=0.001). Data indicated that after the second booster dose, the levels of TNF-α increased significantly in the young adult group only (p=0.004), while the levels of IL-2 (p=0.040) and IFN-γ (p=0.006) increased in the elderly group only compared to after the first dose. IL-10 levels increased in both groups (both had p=0.020). This study highlights that young adults had stronger pro-inflammatory responses, while the elderly relied more on IL-2 and IFN-γ for T-cell immunity, suggesting the need for vaccination strategies for the elderly to optimize immune responses.
Effects of traditional music therapy on the psycho-neuro-immuno-endocrine aspect of burnout syndrome in healthcare workers: A randomized controlled trial Ardani, Yanuar; Shatri, Hamzah; Koesnoe, Sukamto; Yunir, Em; Wiguna, Tjhin; Wibowo, Heri; Sawitri, Dian R.; Sarwono, Sugeng J.; Masyur, Muhtaruddin; Ricardo, William; Katarina, Matilda; Anggono, Rendi F.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1686

Abstract

Burnout syndrome (BOS) is an occupational phenomenon highly prevalent among healthcare workers, particularly physicians and nurses. Despite its prevalence, no single therapy universally addresses all cases of BOS. The aim of this study was to develop a novel approach to managing BOS through traditional music therapy, evaluated from psychosomatic, neurological, immunological, and endocrine perspectives. The study involved 80 participants who were randomly assigned to either the intervention or control group. The intervention group received traditional music therapy for 10–15 minutes, three times a week, over four weeks. Key outcomes were assessed at weeks 2 and 4. Measurements included the Maslach Burnout Inventory (MBI), heart rate variability (HRV), saliva cortisol, saliva β-endorphin, saliva immunoglobulin A (IgA), and serum FOXP3. Instruments included the MBI-HSS questionnaire and HRV measuring devices. Over four weeks, significant improvements were observed in the MBI scores (p=0.001), HRV (p=0.001), and FOXP3 delta (p=0.035) in the intervention group compared to the control group. However, no significant differences were found for cortisol, β-endorphin, or IgA. These findings suggest that traditional music therapy positively impacts the psychological, neurological, and immunological aspects of BOS and potentially influences immunological and endocrine responses. Future research should explore the effects of longer intervention durations, test varying doses, and examine the combination of music therapy with other non-pharmacological treatments to enhance its therapeutic potential.
Effect of the modified Atkins diet on NLRP3, caspase-1, IL-1β, and IL-10 in patients with tetralogy of Fallot undergoing open-heart surgery: A randomized controlled trial Yanuarso, Piprim B.; Djer, Mulyadi M.; Hendarto, Aryono; Pudjiadi, Antonius H.; Rachmadi, Lisnawati; Wibowo, Heri; Advani, Najib; Murni, Indah K.; Kekalih, Aria; Sukardi, Rubiana; Dilawar, Ismail; Susanti, Dhama S.; Supriatna, Novianti
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.2138

Abstract

Cardiopulmonary bypass in tetralogy of Fallot (TOF) corrective surgery induces hyperinflammation by activating NLRP3, caspase-1, and interleukin-1β (IL-1β), subsequently triggering an interleukin-10 (IL-10) response. Despite its known metabolic and anti-inflammatory effects, the impact of the modified Atkins diet (MAD) in pediatric cardiac surgery remains unexplored, with no studies on its use in TOF patients undergoing open-heart surgery. The aim of this study was to assess the effect of MAD on the expression of NLRP3, caspase-1, IL-1β, and IL-10, in TOF patients undergoing open-heart surgery. A double-arm, randomized-controlled trial was conducted with 44 TOF patients. The treatment group (n=22) received the MAD, a low-carbohydrate, high-fat regimen with unrestricted fat and protein intake for at least 14 days preoperatively, while the control group (n=22) followed a standard diet without carbohydrate restriction. Blood plasma and infundibulum heart tissues were collected for analysis. Whole blood samples were collected using a winged infusion needle before the intervention, an Abbocath infusion needle after 14 days of intervention, and a syringe without a needle connected to an arterial line in patients undergoing open-heart surgery at 6, 24, and 48 hours post-surgical correction. Infundibulum heart tissues were collected during the open-heart surgery. This study demonstrated significant differences in NLRP3 protein expression (p=0.015), caspase-1 protein expression (p=0.001), and IL-10 levels between before intervention and 6-, 24-, and 48-hours post-surgery in the MAD group compared to the control group. In contrast, no significant differences in IL-10 levels were observed in the control group between before intervention and 48 hours post-surgery (p=0.654). In conclusion, MAD may modulate perioperative inflammation in TOF patients undergoing open-heart surgery by downregulating NLRP3 and caspase-1 expression while sustaining IL-10 levels. Despite reduced NLRP3 and caspase-1 expression, unchanged IL-1β levels indicate alternative regulatory mechanisms.
Co-Authors -, Hidayat . Sulastri Achmad Arifin Agung W. Ahmad Sidiq Ahsanul Fakhr, Ardani Akmala, Vaza Aldho Jaya P. Aldino, Rio Yuri Aldyth Gunanto P. Alghifari, Fajar Alida Roswita Harahap Amanatin, Elsa Lutmilarita Andari, Ni Nyoman Destri Andrian Riyadi Anggono, Rendi F. Anggraini, Meilani Anggraini, Melani Anggraini, Melani Ani Retno Prijanti Ani Retno Prijanti Anna Rozaliyani Antonius H. Pudjiadi Apri Budianto, Apri Ardani, Yanuar Ardhias Mahendra P. Aria Kekalih Ariyanto Ariyanto Arleni Bustami Aryono Hendarto Asysyifa, Nisrina Bambang Heru Budianto Bima Lantip B. Clarinta Putri, Rizky Damayanti, Triya Dante Saksono Harbuwono Desi Yunita Dewi Sukmawati Dian R. Sawitri, Dian R. Dicky Levenus Tahapary Didik Nurhadiyanto Dilawar, Ismail Dinda Zulwi Amalia Tifani E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Edy Purnomo Em Yunir, Em Emy Khikmawati Ernawati Evy Yunihastuti Fadhillah, Muhamad Rizqy Fakhri, Ardani Ahsanul Fattah, Kemas Muhammad Abdul Ferry Sandra Findra Setianingrum Fredy Surahmanto Gantini, Ria Syafitri Evi Gede Wirya Kusuma Duarsa Gusti Khatimah, Nurul Hamdani Nurbahri Hayati, Taureni Hidayat - Hidayat, Entus Hikmat, Ujang Saeful Hutabarat, Hernayati I Wayan Agus Hariyanto Ida Parwati Ilman, M.Noer Indah Setiawati Irfan Wahyudi Iris Rengganis Irwansyah Irwansyah Joedo Prihartono Julian Jusman, Sri Widia Azraki Katarina, Matilda Khatimah, Nurul Gusti Kusmardi Kusmardi Kusmarinah Bramono Kwarta, Cytyta Putri Lesmana, Aditya Candra Liem, Isabella Kurna Liem, Isabella Kurnia Lio, Tiara Mayang Pratiwi Lisnawati Rachmadi M. Rafi Marcellus Simadibrata Marcellus Simadibrata Marcelly Widya Wardana Masyur, Muhtaruddin Mawardi, Prasetya Melani Anggraini Mohamad Sadikin Muhamad Hasan Sebyar Muhammad Fedryansyah, Muhammad Muhammad Noer Ilman Mujiyono Mujiyono Mujiyono Mujiyono Mulyadi M. Djer Mulyani, Ayu Murdani Abdullah Murni, Indah K. Najib Advani Neng T. Kartinah Novi H Nugraha, Ardi Maulana Nur Azizah Nur Irawati Nuraeni, Hanny Siti Nurbahri, Hamdani Nuri Dyah Indrasari Nurrahmah, Sheila Nurwati, R. Nunung Parhusip, Santi Sumihar Rumondang Piprim B. Yanuarso, Piprim B. Ponco Birowo Pradipta, Saraswati Prasetio, Mukhamad Andri Prihatno Kusdiyarto Primadhani, Suci Widya Primariadewi Rustamadji Priyo Tri Iswanto Putera, Raka Hilmi Syah Putri Damayanti Putri, Rizky Clarinta Rachim, Hadiyanto Abdul Raharja, Putu Angga Risky Rahmat Efendi Rani Wardani Hakim Ratnawati, Mamik Reza Y. Purwoko Ricardo, William Rio Yuri Aldino Ririn Probowati, Ririn Riski Amanda, Clara Riskiyanto, Aldy Risty Yasmin Bonita Riswan Dwi Djatmiko Rona Kartika Rozaliyan, Anna Rubiana Sukardi, Rubiana Sarwono, Sugeng J. Savitri, Monika Sawitri Prohatini, Monika Septiasari, Yeti setianingrum, suci Sidiq , Ahmad Soleha, Winna Sresta Azahra Suhendro Suhendro Sukamto Koesnoe Sulastri Sulastri Supanto, Muhammad Supriatna, Novianti Supriono , Untung Susanti, Dasmi Susanti, Dhama S. Susatyo, Jeffry Adijaya SUTOPO Suyatna, Fransiscus Dhyanagiri Syari, Lucky Novita Tahapary, Dicky L Tjhin Wiguna Triana, Novi Utomo, Yoga Wahyu Wahyu Gunawan Wahyu, Fransiska Wahyurini, Dyahati Wawaimuli Arozal Widodo Apriliyanto Wijaya, Rheza Paleva Windy Keumala Budianti Wresti Indriatmi B. Makes Yonita, Ariska Yusra Yusra