p-Index From 2021 - 2026
5.987
P-Index
This Author published in this journals
All Journal BALI MEDICAL JOURNAL (BMJ) Medicina journal of internal medicine Sport and Fitness Journal Buletin Udayana Mengabdi Jurnal Farmasi Udayana E-Jurnal Medika Udayana Jurnal Veteriner Majalah Ilmiah Fisioterapi Indonesia Majalah Obat Tradisional MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) Journal Of Vocational Health Studies Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Epidemiologi Kesehatan Komunitas Indonesian Journal for Health Sciences (IJHS) ISM (Intisari Sains Medis) : Jurnal Kedokteran Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal of Clinical and Cultural Psychiatry Jurnal Health Sains Jurnal Kepelatihan Olahraga Open Access Indonesian Journal of Medical Reviews Jurnal Pengabdian kepada Masyarakat Wahana Usada Warmadewa Minesterium Medical Journal Medika Respati : Jurnal Ilmiah Kesehatan Journal of Global Pharma Technology Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Jurnal Penyakit Dalam Indonesia Paradharma: Jurnal Aplikasi IPTEK Gema Kesehatan Physical Therapy Journal of Indonesia Kinesiology and Physiotherapy Comprehensive Biosaintifika: Journal of Biology & Biology Education Indonesian Journal of Pharmacology and Therapy
Claim Missing Document
Check
Articles

Found 4 Documents
Search
Journal : Journal of Global Pharma Technology

The Comparative Effect of Liquid and Tablet Preparation of Purple Sweet Potato (Ipomoea batatas L) Extract to Lipid Profile, MDA, and SOD Level in Male Wistar Rats After Given High-Cholesterol Diet I Wayan Putu Sutirta Yasa; I Made Jawi; Putu Astawa
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (521.788 KB)

Abstract

Background: Recent developments in tablet preparation of extract have brought advantages to keep active ingredients from plants in stable forms physically and chemically. This study aims to compare the liquid and tablet preparation of purple sweet potato (Ipomoea batatas L.) extract to lipid profile, MDA, and SOD level in rats after given high-cholesterol diet. Methods: A randomized pre- and post-test control group experimental study was conducted during 4 weeks among 21 male Wistar rats. They were divided into 3 groups in this study namely: control (only high-cholesterol diet), Treatment 1 (T1) group (high-cholesterol diet and 200mg/day tablet of purple sweet potato extract), and Treatment 2 (T2) group (high-cholesterol diet and liquid form of purple sweet potato tubers extract about 2 mL/day). Lipid profile, MDA, and SOD level examination were performed twice from retro orbital sinus blood drawn and analyzed using ANOVA in SPSS version 17.Results: Mean value of lipid profile was significantly lower in T2 group (Cholesterol 84.48 ± 3.38; LDL 23.05 ± 2.32; HDL 63.39 ± 1.56; and triglycerides 96.03 ± 3.82; P < 0.05) after study period. The mean value of MDA was also significantly lower in T2 group (1.25 ± 0.09; P < 0.05) and SOD level was significantly higher in T2 group (73.72 ± 4.14; P < 0.05) in the end of study. Conclusion: Liquid preparation of purple sweet potato extract showed a better efficacy in reducing lipid profile and MDA level, as well as enhancing SOD level in rats given high-cholesterol diet.Keywords: Lipid Profile, Liquid, MDA and SOD Level, Purple Sweet Potato, Tablet.
COMPARISON THE ANTIHYPERTENSIVE AND ANTIOXIDANT POTENTIAL BETWEEN YOUNG MAHOGANY SEEDS EXTRACT WITH MATURE MAHOGANY SEEDS EXTRACT IN RATS WITH HYPERTENSION I Wayan Putu Sutirta Yasa; Putu Astawa; I Made Jawi
Journal of Global Pharma Technology Volume 09 Issue 05
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (424.564 KB)

Abstract

Mahogany seeds have been used in the community as an antihypertensive and antioxidant. Antihypertensive and antioxidant efficacy of mature mahogany seeds has been proven in hypertensive rats. The purpose of this study was to compare the antihypertensive and antioxidant effect of mature mahogany seeds extract with young mahogany seeds extract. This study is a laboratory experimental design with pre-test and post-test design control groups, with Wistar rats as samples. Thirty rats were divided into 5 groups, each group consist of 6 rats. The control group was given saline every day as a rat model of hypertension. 1-4 treatment groups were each given NaCl and water extract of young mahogany seeds for treatment 1, the ethanol extract of young mahogany seeds as treatment 2, water extract of mature mahogany seeds as treatment 3 and ethanol extract of mature mahogany seeds as treatments 4. Dosages of extract mahogany seeds is 100 mg / head / day for 4 weeks. Before treatment, evaluation of rat blood pressure with special sphygmomanometer was held, and examination of blood MDA as a pre-test data. Further evaluation of MDA and SOD blood pressure are at the end of the study. The data were tested by ANOVA to see the difference between the groups. The results showed a decrease in blood pressure and levels of MDA were significant in all treatments (p <0.05) compared with control as well as an increase in SOD were significantly (p <0.05). The ethanol extract of mature mahogany seeds showed the most excellent antihypertensive and antioxidant properties (p <0.05). From these results, it can be concluded that the ethanol extract of mature mahogany seeds is better than young mahogany seeds extract as an antihypertensive and antioxidant in hypertensive rats.Keywords – antioxidants, hypertensive rats, mature and young mahogany seeds
Comparison of the effects of ethanol extract with aqueous extract of purple sweet potato tuber in expression of SOD-2, SOD-3, and eNOS on human vascular endothelial cells exposed by H2O2 in-Vitro I Made Jawi; I G K Arijana; I Wayan Putu Sutirta Yasa; AAN Subawa
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Aqueous extract of purple sweet potato tubers have antioxidant potential in animal and human vascular endothelial, through increased expression of superoxide dismutase. This study aims to prove the comparison between ethanol extract and aqueous extract of purple sweet potato tubers increasing the expression of superoxide dismutase -2, superoxide dismutase -3, and endothelial nitric oxide synthase in human vascular endothelium. This study was an experimental study of the vascular endothelial cells which underwent oxidative stress in vitro, which is protected by ethanol extract or aqueous extract of purple sweet potato tuber at various concentrations. Observation of the superoxide dismutase -2, superoxide dismutase -3, and endothelial nitric oxide synthase in endothelial cells is done using the method immunohistochemistry with monoclonal antibodies. The results showed an increase in superoxide dismutase - 2, superoxide dismutase -3, and endothelial nitric oxide synthase was significantly (p < 0.05) in endothelium protected by ethanol extract or water extract of purple sweet potato tubers. The ethanol extract only showed its effect at concentration of 1.5625 µg/ml for superoxide dismutase -2 and superoxide dismutase -3. The effect of aqueous extract were at a concentration of 1.5625–3.125µg/ml. From these results it can be concluded that the ethanol extract or aqueous extract of purple sweet potato tubers can protect endothelial cells from oxidative stress through increased expression of superoxide dismutase -2 and superoxide dismutase -3. The ethanol extract requires much lower concentrations to show its effect compared with aqueous extracts. Keywords: Aqueous extract or ethanol  extract of purple sweet potato, Superoxide dismutase, Human umbilical vein endothelial cells.
WATER EXCTRACT OF PURPLE SWEET POTATO INCREASE SUPEROXIDE DISMUTASE, CATALASE GENES AND DECREASE MDA LEVEL IN MULTIPLE ORGANS OF DIABETIC WISTAR RATS Bagus Komang Satriyasa; I Made Jawi
Journal of Global Pharma Technology Volume 09 Issue 05
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Objective: The purpose of this study was to prove the water extract of purple sweet potatoes can increase superoxide dismutase (SOD) gene expression and catalase (CAT) and decrease malondialdehyde (MDA) in vital organs of diabetic rats. Method: This study was randomized experimental design with posttest only control group design. Sample divided into 2 groups: control and treatment groups, respectively 18 diabetic Wistar rats. The control group will be given streptozotocin. The treatment group was given streptozotocin and water extract of purple sweet potato 4 cc/day. This treatment is carried out for 2 months. Result: Water extract of purple sweet potato was proven significantly increased mRNA expression of aorta and kidney SOD but decreased SOD mRNA expression in the liver (p <0.05). This water extract also increases SOD mRNA expression in cardiac but not statistically significant (p> 0.05). Water extract of purple sweet potatoes also found significantly increased renal and cardiac expression of CAT mRNA (P <0.05), but not statistically significant (p> 0.05). Conclusion: Purple sweet potatoes extract to decrease the expression of liver CAT mRNA non-significantly, and decrease MDA in liver and kidney of diabetic Wistar rats significantly (P <0.05).
Co-Authors A.N. Mahendra A.W. Indrayani Adi Saputra Agung Bagus S. Satyarsa Agung Nova Mahendra Agung Wahyu Permadi Agung Wiwiek Indrayan Agung Wiwiek Indrayani Aman, I Gusti Made Aman, IGM Amaral, Meriana Barreto Anak Agung Gede Angga Puspa Negara Anak Agung Ngurah Subawa Anom Suardika Ardo Sabir, Ardo Arisandy Achmad Aryana, I Gust Putu Suka Astawastini, I Dewa Ayu Mas Manik Astika, I Nyoman Astini, Dewa Ayu Agung Alit Suka Bagus Komang Satriyasa Budayasa, Anak Agung Gede Raka Cokorda Agung Wahyu Purnamasidhi Cokorda Bagus Jaya Lesmana Dany Hilmanto Desak Ketut Ernawati Desak Made Puja Astuti Desak Made Widyanthari Desak Made Wihandani Desak Putu Citra Udiyani Dewa Ayu Putu Sri Ista Dewanti Dewa Ngurah Suprapta Dewa Ngurah Suprapta Dewi, L. P. M. K. Dewi, Ni Wayan Eka Rahayu Dewi, Ni Wayan Eka Rahayu Dewi, Ni Wayan Sucindra Diaz, Leonardo Alpha Dimas Agusta Divasta, I G Mahapraja Dixon E.M. Taek Bete Dyah Kanya Wati Eka Putra Setiawan Elvina Veronica Endang Sri Widiyanti Eva Dharma Yanti Febrianda, Larasati Hanifa Gaga Irawan Nugraha Gede Agung Dhimasena Widyananda Gita Almira Putri Gitari, Ni Made Grudug, Kadek Agastya Widya Sedana Guna, I. M. A. W. Gusti Made Agung Mega Utama Hairudin - Hamsu Kadriyan Hervina Hervina I Dewa Ayu Inten Dwi Primayanti I Dewa Made Sukrama I Dewa Sutjana I Gede Widhiantara I Gusti Ayu Artini I GUSTI AYU MANIK ERMAYANTI I Gusti Bagus Wirawan I Gusti Kamasan Arijana I Gusti Made Gde Surya Chandra Trapika I Kadek Arya Gangga Permana I Ketut Suastika I Made Ady Wirawan I Made Agus Gelgel Wirasuta I Made Bakta I Made Dhita Prianthara I Made Dwi Ariyuda I Made Gde Sudyadnyana Sandhika I Made Krisna Dinata I MADE MULIARTA . I Made Sudarmaja I Nengah Sandi I Nyoman Adi Putra I Nyoman Adiputra I Nyoman Budi Hartawan I Nyoman Mangku Karmaya I NYOMAN MANTIK ASTAWA I Nyoman Wande I Pande Putu Deny Heriwijaya I Putu Adiartha Griadhi I Putu Astrawan . I Putu Eka Jaya I Putu Eka Widyadharma I Putu Gede Adiatmika I Putu Gede Andyka Yasa I Putu Gede Putra Darmawan I W. Sudarsa I Wayan Gede Artawan Eka Putra I Wayan Lolik Lesmana I Wayan Niryana I Wayan Putu Sutirta Yasa I Wayan Rosiana I Wayan Sugiritama I Wayan Suka Yasa I Wayan Sumardika I Wayan Weta I.A.A. Widhiartini I.G. Wiranatha I.G.A. Artini I.G.M. Aman I.G.M.G.S.C. Trapika Ida Bagus Gede Suparyatha Ida Bagus Ngurah Ida Bagus Ngurah Ida Bagus Putra Manuaba Ida Bagus Putu Putrawan Ida Bagus Subanada Ida Sri Iswari Imakulata Magi Loda Indra Lesmana J. A. Pangkahila Kamayoga, I Dewa Alit Ketut Agus Adrianta Ketut Budiasa Ketut Tirtayasa Kusuma, Anak Agung Ngurah Jaya La Ode Muhammad Gustrin Syah Lesmana, Cokorda Agung Bagus Jaya Losen Adnyan Luh Putu Ratna S Luh Putu Ratna Sundari Luh Putu Widiastini M. Irfan Made Agus Hendrayana Made Wiryana Maharianingsih, Ni Made Manuaba, I.A Ratih Wulansari Manuaba, Ida Bagus Tjakra Wibawa Mardaningrat, Kadek Herdana Vildan Moh. Ali Imron, Moh. Muh. Irfan Muhammad Irfan Muhammad Irfan Muthia Munawaroh Muthiah Munawaroh N Adiputra N. Adiputra N. Adiputra N.W. Tianing N.W.S. Dewi Nabasa, Gayus Erino Naw, Sin War Ni Eka Dewi Ambarawati Ni Eka Dewi Ambarawati Ni Ketut Susilawati Ni Luh Suriani Ni Made Ari Purwaningrum Ni Made Linawati Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Shinta Prasista Sari Ni Putu Sriwidyani Ni Putu Wirantari Ni Wayan Mutiara Warmasari Ni Wayan Saka Rahayu Ni Wayan Sinta Devi Arini Ni Wayan Sucindra Dewi Ode Mahesa Putra Oktovianus Fufu Pande Putu Karina Candra Pangala, Gustinara Bakti Permatasari, Anak Agung Ayu Putri Pramana, I Putu Yudi Pratiwi, Cokorda Agung Pratiwi, Kadek Prastiti Surya Prima S. Sudarsa Pujawan, I Made Naris Purnamawati, Susy Purnami, Ni Ketut Rai Puspitasari, Ni Putu Ayu Intan Putri, Kadek Wina Santhya Putu Angga Wiradana Putu Astawa Putu Ayu Sita Saraswati Putu Belly Sutrisna R. A.T. Kuswardhani Raka-Sudewi A. A. Regina Sesilia Noy Rita Maria Romdhoni, Achmad Chusnu Sang Ayu Arta Suyantari Sanjaya, Feliani Santosa, I Gusti Ngurah Putra Eka Sari, P. M. N. A. Sawitri, Anak Agung Sagung Silvana, Divika Sri Maliawan Sugijanto - Sugosha, M. J. Sukawati, C. B. A. C Sumawirawan, K. D. Sun, H. Sunny Suryawisesa, Ida Bagus Made Susy Purnawati Sutema, Ida Ayu Manik Partha Syahmirza Indra Lesmana Tang, Yen-An Thomas Eko Purwata Tirtha Yasa, I Nyoman Wawan Wahyuddin, Wahyuddin Wahyuni Novianti, I Gusti Ayu Sri Wayan Suardana Wibawa, I Gusti Ngurah Agung Satria Widhiantari, Ni Ketut Evitri Widia Danis Swari Widiarthini, Ida Ayu Alit Widiyanti, I Gusti Ayu Widnyana, M. Widowati, I Gusti Ayu Rai - Wiwekowati Wuga, Kristina Supartin Monika Yasa, I Nyoman Wawan Tirtha Yenny Kandarini Yogie Wiswadewa Yohanes Seran