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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA MEDIA KONSERVASI Hemera Zoa Jurnal Sain Veteriner Jurnal Veteriner JURNAL ANATOMI FISIOLOGI Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter BIOTROPIA - The Southeast Asian Journal of Tropical Biology Jurnal Peternakan Indonesia JITRO (Jurnal Ilmiah dan Teknologi Peternakan Tropis) Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) Bioma : Jurnal Biologi Indonesia Buletin Anatomi dan Fisiologi (Bulletin of Anatomy and Physiology) ARSHI Veterinary Letters FITOFARMAKA: Jurnal Ilmiah Farmasi EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup JFIOnline Jurnal Ilmu Kefarmasian Indonesia JCPS (Journal of Current Pharmaceutical Sciences) Jurnal Aisyah : Jurnal Ilmu Kesehatan Journal of Parasite Science Jurnal Kedokteran Hewan Jurnal Veteriner Nusantara
HERA MAHESHWARI
IPB University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Public Health Veterinary Other

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Neurogical deficit score dan gambaran hematologi tikus model strok iskemik dengan metode middle cerebral artery occlusion Perdhana, Ika Satya; Hardiansyah, Muhamad Evans; Maheshwari, Hera; Mohamad, Kusdiantoro
ARSHI Veterinary Letters Vol. 9 No. 3 (2025): ARSHI Veterinary Letters - August 2025
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.9.3.83-84

Abstract

Stroke is a neurological disorder caused by impaired blood flow to specific regions of the brain, often resulting in paralysis and functional deficits in the affected area. Among its subtypes, ischemic stroke is the most prevalent in the general population. This study aimed to establish a rat model of ischemic stroke induced by middle cerebral artery occlusion (MCAO). Eight male Sprague-Dawley rats aged 8–10 weeks were randomly assigned to two groups: control and treatment group. In the treatment group, the middle cerebral artery was occluded for 45 min. Neurological assessment using the Bederson scale revealed a neurological deficit score (NDS) of 1, characterized by contralateral flexion after left-brain injury. Hematological analysis demonstrated significantly higher white blood cell (WBC) counts (p < 0.05), whereas red blood cell (RBC) counts, hemoglobin concentration, and hematocrit values were significantly lower (p < 0.05) than those in the control group. These findings indicate that the MCAO method with a 45-minute occlusion successfully induced a mild neurological deficit accompanied by distinct hematological alterations, thereby providing a reproducible animal model for ischemic stroke research.
Co-Authors . Herdis . Safrida . Yulnawati A. Suprayogi A. Wijaya A.S. Satyaningtijas ACHMAD FARAJALLAH Agik Suprayogi Agus Wijaya Ainul Khadija Saleema Akhiruddin Maddu Amelia Hana Amelia Ramadhani Anshar Anak Agung Gede Sugianthara Anak Agung Istri Sri Wiadnyani Andhika Yudha Prawira Andre, Daniel Latief Andriyanto Andriyanto Arief Boediono Aryani Satyaningtijas Asmarani Kusumawati Bambang Kiranadi Bambang Kiranadi Bambang Purwantara Claude Mona Airin D. R. Ekastuti Damhuri Damiana Rita Ekastuti Danang Dwi Cahyadi David Anwar Dawanto, Jirfan Debby Jacqualine Jochebed Rayer Desrayni Hanadhita Desrayni Hanadhita Desrayni Hanadhita Diah Nugrahani Pristihadi Dirwan Rahman Divo Jondriatno Dondin Sajuthi Dwi Nurhidayah Zubaidah E Mulyati Effendi, E Mulyati Ekowati Handharyani Elok Budi Retnani ERIC HAYES Ernes Andhesfa Etih Sudarnika Eva Harlina Evi Juliati Evi Juliati Gani F. B. Harlimawan Fadhila Satvika Faisal Tanjung Fitri, Arni Diana Forman Erwin Siagian Fredi Kurniawan Ganjar Maulana Nugraha Gilang Kala Maulana Gilang Kala Maulana, Gilang Kala Hadi S Alikodra Hardiansyah, Muhamad Evans Hendry, Altaff heny Nitbani Herdis - Huda Salahuddin Darusman Huda Salahudin Darusman Huda Shalahudin Darusman Husna Husna, Mar’atul Husna, Rina Siti Nurul I wayan Teguh Wibawan ikhwan wirahadikesuma Ikhwan Wirahadikesuma Ira Agustina Dewi Gandasari Irfan Nurhidayat Irwan Oktoni Isdoni Bustaman Jefri Naldi Julianto . Juliati Gani, Evi Juliati, Evi Jumadin, La Kasiyati Kasiati koekoeh santoso Koekoeh Santoso Koekoeh Santoso Koekoeh Santoso Kusdiantoro Mohamad La Jumadin Lili Darlian Listya M.I, Mega LUTHFIRALDA SJAHFIRDI Luthfiralda Sjahfirji Luthfiralda Syahfirdi Lynette Ong Huey Mar’atul Husna Maria Fatima Palupi Maria Fatima Palupi Maria Fatima Palupi Maria Fatima Palupi Maria Prihtamala Omega Maryce Agusthinus Walukou Mega Listya M.I Meta Levi Kurnia Mirnawati Bachrum Sudarwanto Mokhamad Fakhrul Ulum, Mokhamad Mozes R. Tolihere MUHAMMAD ADIB MUSTOFA Muhammad Darjat Darulfalah Muhammad Gunawan Muhammad Rizal Muhammad Zhaahir Mulyati Effendi MULYATI EFFENDI Nambut, Yohanes Baptisto Nastiti Kusomorini Nastiti Kusumorini NASTITI KUSUMORINI NASTITI KUSUMORINI Nelda Fliza Zora Niken Ulupi Nikki Aldi Nugroho, Setyo Widi Nuri Ardiani P. Achmadi Perdhana, Ika Satya Permana, Nadine Hanifa Pudji Achmadi Pudji Astuti Pudji Astuti PUDJI ASTUTI Pudji Astuti Pudji Astuti Purnomo, Rachmatullah Hadi Putri Indah Ningtias Putri Krida Gita P. Putri, Fatimatus Sa’diyah Putri, Maritrana R. Tarigan Rachmatullah Hadi Purnomo Rahma Anisa Rahman, Muhammad Luthfi Reviany Widjajakusuma Reviany Widjajakusuma Reviany Widjajakusuma Ridi Arif Rina Siti Nurul Husna Rini Anjarwati Kusuma Risa Tiuria Rivany Widjajakusuma Ronald Tarigan Ronald Tarigan Ronald Tarigan Ronald Tarigan Rosdianto, Aziiz Mardanarian Rosdianto, Aziiz Mardanarian Rudramurti, Win Satya Safrida Safrida Sandra Hapsari Sarmin - Sasmita, Annissa Nuridfi Sattabongkoch Maneewong Slamet Widiyanto Srihadi Agungpriyono Sumiaty Aiba Supratikno . Tarigan, Ronald Teguh Budipitojo Trini Suryowati Tuty Laswardi Yusuf Umi Cahyaningsih Utami, Dian Maulia W. Manalu Wasmen Manalu Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Wisnugroho Agung Pribadi Yan, Teo Qin YENI KEZIA BEKALANI Yulnawati - Yulvian Sani Yusfiati Yusfiati Yusias Hikmat Diani