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All Journal BALI MEDICAL JOURNAL (BMJ) journal of internal medicine International Journal of Biosciences and Biotechnology Jurnal Ilmu dan Kesehatan Hewan Buletin Udayana Mengabdi COPING (Community of Publishing in Nursing) INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Jurnal Veteriner Jurnal Biologi Udayana Microbiology Indonesia Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Media Kedokteran Hewan Molecular and Cellular Biomedical Sciences (MCBS) ISM (Intisari Sains Medis) : Jurnal Kedokteran Journal of Global Pharma Technology Jurnal Medika Veterinaria Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
I NYOMAN MANTIK ASTAWA
Laboratorium Virologi, Departemen Penyakit Hewan, Fakultas Kedokteran Hewan, Universitas Udayana, Bali-Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Journal of Global Pharma Technology

 1 
Fatty Liver and Liver Malondialdehyde Expression in Severe Malnourished Wistar Rats that given Virgin Coconut oil Compared to Corn Oil in World Health Organization Formula I Gusti Ayu Putu Eka Pratiwi; Soetjiningsih .; I N. Mantik Astawa; I Gusti Ayu Trisna Windiani; I Gede Ngurah Harry Wijaya Surya
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: There is a lack of antioxidant in severe malnutrition, and it may lead to increase oxidative stress. Fatty liver is one of severe malnutrition (SM) cardinal features. Virgin coconut oil (VCO) contains high antioxidant capacity and medium chain triglyceride. It is supposed to improve those problems. Methods: Posttest only control group design study was done to observe whether VCO could decrease fatty liver and liver malondialdehyde (MDA) expression in 38 male wistar rat with SM. The rats were divided into two group which were VCO Group (Group A) and Control Group (corn oil (Group B)). They were given feeding World Health Organization (WHO) Formula for SM (Formula 75 and Formula 100) that contained VCO or corn oil. After being SM, this formula was fed until 28 days. In the 29th day, they were sacrificed, and liver samples were obtained for fatty liver analysis and MDA expression. Results: Fatty liver was less in Group A (mean 13.74 cell in 5 view field (SD 1.32) than Group B (mean 20.74 cell in 5 view field (SD 2.01), and it was statistically significant (p=0.000). Cut off point for determining low and high liver MDA expression based on o ROC curve were <2.9% (low) and ≥2.9% (high). Low MDA expression (<2.9%) was higher in Group A than Group B (p <0.05). Conclusions: This study found less fatty liver and low liver MDA expression in severe malnourished rat given VCO than corn oil.  Keywords: Virgin coconut oil, Fatty liver, Malondialdehyde, Severe malnutrition.
High Level of Uterine Endocervical Interleukin-8, Matrix Metalloproteinase-8, and Interleukin 1Β as a Risk Factor for Preterm Labor Suwardewa TGA; Suwiyoga K K; Mantik Astawa N; Sutirta Yasa IWP
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
Publisher : Journal of Global Pharma Technology

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The preterm birth is a birth that takes place on a gestational age between 20–36 weeks and six days. The preterm birth   is the leading cause of neonatal mortality and morbidity. Despite the current treatment procedures, the incidence of preterm birth has not changed in the last two decades. Incomplete understanding of the pathophysiological mechanisms underlying preterm labor is the major obstacle to prevent preterm birth. Recently, endocervical inflammation has been thought as a risk factor of a preterm labor. Several important substances such as endocervical IL-8, MMP-8, and IL-1β, has been considered to play a key role on preterm birth through cervical ripening. With those assumptions, the detection of a higher level of uterine endocervical IL-8, MMP-8, and IL-1β can be used to predict preterm labor. The design of this study is an observational case control study with a case group, which consisted of pregnant women with 20–36 weeks and six days of gestational age who had signs of labor, and the control group consisted of pregnant women with 20–36 weeks and six days of gestational age who had no signs of labor. The material used for this study is cervical mucous, and the enzyme-linked immunosorbent assay method was used to assess the level of IL-8, MMP-8, and IL-1β at laboratory of Veterinary Medicine of Udayana University Denpasar. In this study we used 48 samples, among which 24 were case group, and 24 as a control group. The mean age of the women, gestational age, and parity from both group are (27.04 vs 28.62 years old), (31.8 vs 29.50 weeks), and (0.96 vs 1.29) respectively, which are statistically homogenous (p > 0.05). Each level of interleukin-8, matrix metalloproteinase, and interleukin-1β suggests a risk factor of a preterm labor for: 35 times (OR = 35.00; CI 95% = 6.95–176.39; p = 0.001); 6.6 times (OR = 6.60; CI 95% = 1.25–34.95; p = 0.016), and 8.3 times (OR = 8.3; CI 95% = 2.15–32.3; p = 0.001), orderly. Among these cytokines, one that contributes most through a preterm birth is interleukin-8 (61%), followed by matrix metalloproteinase-8 (27%), and interleukin-1β (12%).Conclusion: Endocervical inflammation with high level of IL-8, MMP-8, and IL-1β is a risk factor for preterm labor. IL -8 gives the most contribution on preterm labor.Keywords: Preterm birth, Endocervical IL-8, MMP-8, and IL-1β.
Co-Authors A. A. G. P. Wiraguna A.A. Wiradewi Lestari A.A.G. Sudewa AAG Budhitresna AAG Putra Ahmad Hamim Sadewa Aida Lousie Tenden Rompis Alberto Agustinho Pereira Da Costa Joao Anak Agung Ayu Mirah Adi Anak Agung Bagus Bramardipa Anak Agung Gede Sudewa Djelantik Anak Agung Keswari Krisnandika Anak Agung Ngurah Subawa Anak Agung Oka Wijaya Anak Agung Sagung Kendran and R. Kusnandi Andika Budi Kurnianto Anwar Santoso Arthawan Arthawan Bayu Setiabudi Berata , I Ketut Chandra Yowani Dewa Ayu Agus Sri Laksmi DWI SURYANTO Dyah Kanya Wati Faiziah - G.A.M.K. Dewi Gusti Ayu Mayani Kristina Dewi Gusti Ayu Yuniati Kencana Gusti Ngurah Narendra Putra Harjana, Ngakan Putu Anom HARTANINGSIH - Hartaningsih . I D. N. Wibawa I Dewa Made Sukrama I Gede Ngurah Harry Wijaya Surya I GEDE PUTU WIRAWAN I Gusti Agung Arta Putra I Gusti Agung Ayu Suartini I Gusti Agung Dewi Sarihati I Gusti Agung Trisna Windiani I Gusti Ayu Putu Eka Pratiwi I Gusti Made Krisna Erawan I Gusti Ngurah Kade Mahardika I Gusti Ngurah Sudisma I K. Sukardika I Kadek Swastika I Ketut Berata I Ketut Eli Supartika I Ketut Junitha I Ketut Suada I Ketut Suada I Ketut Suastika I Ketut Suastika I KETUT SUATA I Ketut Suatha I Ketut Suwiyoga I Made Bakta I Made Damriyasa I Made Dwinata I Made Galih Diparayoga I Made Jawi I Made Kardena I Made Subrata I Made Sudarmaja I Made Sukada i Nengah Wandia I Nyoman Agus Bagiada I Nyoman Budi Hartawan I Nyoman Polos I Nyoman Suarsana I Nyoman Suartha I Putu Sudiarta I W. Wita, I W. I Wayan Bebas I Wayan Gorda I Wayan Masa Tenaya I Wayan Megadhana I Wayan Putu Sutirta Yasa I Wayan Suardana I Wayan Wita I.A.P. Apsari I.B.K. Suardana I.H. Utama I.W. Batan Ida Ayu Pasti Apsari Ida Bagus Gede Suparyatha Ida Bagus Kade Suardana Ida Bagus Made Oka Ida Bagus Ngurah Swacita Ida Bagus Oka Winaya Ida Bagus Suardana Ida Bagus Subanada Ignatius Ferdi Yuatmadja Inna Narayani K. Sri Marhaeni Julyasih K. Suata K. Sukardika Kadek Karang Agustina Ketut Budiasa Ketut Santhia Adhy Putra Ketut Suata Ketut Tirtayasa Luh Dewi Anggreni Luh Putu Agustini LUH PUTU AGUSTINI Luh Putu Wrasiati M.D. Rudyanto M.Pd S.T. S.Pd. I Gde Wawan Sudatha . Made Damriyasa, Made Made Oka Ari kamayani, Made Oka Ari Made Wiryana Marissa Divia Dayanti Marson, Fransiska Gratia Sonita Mudinillah, Adam N. T. Suryadhi Ngakan Putu Anom Harjana Ni Luh Putu Eka Diarthini NI LUH PUTU MANIK WIDIYANTI Ni Made Krisna Dewi Ni Made Suaniti NINING HARTANINGSIH Nyoman Agus Bagiada Nyoman Tigeh Suryadi Oka Lely Palagan Senopati Sewoyo Purwitasari, Made Santi Putu Ayu Asri Damayanti Putu Ayu Sisyawati Putriningsih Rasmaya Niruri Rasmaya Niruri S. Soetjiningsih, S. S. Sotjiningsih S.K. Widyastuti sang gede purnama Sewoyo, Palagan Senopati Siti Maryam Soetjiningsih - Soetjiningsih . Sri Kayati Widyastuti Sri Wahjuni SUMARNO Suryadi, Nyoman Tigeh Sutjahjo Suherman, Sutjahjo Suwarno - T. Sari Nindia Tjok Gede Oka Pemayun, Tjok Gede Oka Tjokorda Gde Agung Suwardewa Wayan Tunas Artama Wimpie I Pangkahila Yasunobu Matsumoto Yosevangelika Hutabarat Yoshihiro Hayashi