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Profil Urinalisa Pasien Diabetes Tipe-2 dengan Terapi Antidiabetik Oral Sebagai Skrining Disfungsi Ginjal di RSUD Bahteramas Sulawesi Tenggara Muhammad Ilyas Y.; Darmayanita Wenty; Kemal Idris Balaka; Aprianto; Immel Putri Qaila; Adriatman Rasak; Halik; Nurhikma
Jurnal Informatika dan Kesehatan Vol. 3 No. 2 (2026): IKN : Jurnal Informatika dan Kesehatan
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ikn.v3i2.5177

Abstract

Type-2 diabetes mellitus (DM) is a chronic metabolic disease with a high risk of microvascular complications, one of which is diabetic nephropathy. Oral antidiabetic medications are the primary choice for type-2 DM patients to control blood sugar; however, they must be used appropriately, safely, and effectively, as improper use may lead to side effects such as impaired kidney function. Therefore, urinalysis serves as a simple initial screening method to detect impaired kidney function. However, data regarding urinalysis profiles in type-2 DM patients receiving oral antidiabetic therapy at Bahteramas General Hospital remain limited. This study aims to determine the urinalysis profile in patients with type-2 diabetes undergoing oral antidiabetic therapy as an early detection method for kidney dysfunction. This study uses a descriptive design with a cross-sectional approach. The sample consisted of 40 patients with type-2 diabetes undergoing oral antidiabetic therapy who met the inclusion criteria. Urinalysis was performed qualitatively via urine macroscopy, semi-quantitatively using dipsticks, and through microscopic analysis of urine sediment. Of the 40 samples analyzed, the chemical test results showed glucose at 52.5%, protein at 62.5%, erythrocytes at 67.5%, and leukocytes at 40%. Microscopic examination revealed the following results: 50% leukocytes, 100% erythrocytes, 52.5% epithelial cells, 12.5% crystals, and 25% bacteria. These findings indicate a possible impairment of kidney function in some patients on oral antidiabetic therapy. It is recommended to routinely perform follow-up blood tests for creatinine and urea/BUN as an initial screening to detect complications of renal dysfunction in diabetic patients.   ABSTRAK Diabetes melitus (DM) tipe-2 merupakan penyakit metabolik kronik yang berisiko tinggi menimbulkan komplikasi mikrovaskular, salah satunya adalah nefropati diabetik. Penggunaan obat antidiabetik oral merupakan pilihan utama pada pasien DM tipe-2 untuk mengontrol gula darah, namun harus disertai dengan penggunaan yang tepat, aman dan efisien dimana, penggunaan yang kurang tepat dapat beresiko pada efek samping gangguan fungsi ginjal. Oleh karena itu, pemeriksaan urinalisa menjadi metode skrining awal yang sederhana untuk mendeteksi gangguan fungsi ginjal. Namun, data mengenai profil urinalisa pada pasien DM tipe-2 dengan terapi antidiabetik oral di RSUD Bahteramas masih terbatas. Penelitian ini bertujuan untuk mengetahui profil urinalisa pada pasien DM tipe-2 yang menjalani terapi antidiabetik oral sebagai deteksi dini terhadap disfungsi ginjal. Penelitian ini menggunakan desain deskriptif dengan pendekatan cross-sectional. Sampel terdiri dari 40 pasien DM tipe-2 yang menjalani terapi antidiabetik oral dan memenuhi kriteria inklusi. Pemeriksaan urinalisa dilakukan secara kualitatif dengan makroskopis urine, semi-kuantitatif menggunakan dipstick dan analisis mikroskopis sedimen urin. Dari 40 sampel yang dianalisis ditemukan hasil pemeriksaan kimia glukosa sebesar 52,5%, protein 62,5%, eritrosit 67,5%, leukosit 40%. Sedangkan pada pemeriksaan mikroskopis ditemukan hasil leukosit sebanyak 50%, eritrosit 100%, sel epitel 52,5%, kristal 12,5%, dan bakteri 25% .Temuan ini mengindikasikan kemungkinan adanya gangguan fungsi ginjal pada sebagian pasien menjalani terapi antidiabetik oral. Disarankan untuk melakukan pemeriksaan lanjutan kreatinin dan Ureum/BUN darah secara rutin sebagai skrining awal mendeteksi komplikasi disfungsi ginjal pada pasien diabetes.  
Immunomodulatory potential of galing (Cayratia trifolia L. Domin) plant on IgM antibody and monocytes in Salmonella typhi-infected rats Muhammad Ilyas Y.; Nirwati Rusli; Wahyuni; Asriullah Jabbar; Asniar Pascayantri; Lukman La Basy
Current Research on Biosciences and Biotechnology Vol. 8 No. 1 (2026)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2026.8.1/VIGAR0LA

Abstract

Typhoid fever remains a health problem that requires support from both humoral and cellular immune responses. Therefore, the search for natural immunomodulators is important. Galing plant (Cayratia trifolia L. Domin) contains bioactive compounds such as flavonoids, alkaloids, and saponins, which are thought to have the potential to enhance immune responses. This study aimed to evaluate the immunomodulatory effects of ethanol extracts of galing leaves and stems on immunoglobulin M (IgM) levels and monocyte counts in male white rats induced with Salmonella typhi. The research hypothesis was that ethanol extract of galing plant could increase IgM levels and monocyte counts. This study used a randomized posttest-only control group design with seven treatment groups: normal control, negative control, positive control, leaf extract at doses of 400 and 500 mg/kg BW, and stem extract at doses of 400 and 500 mg/kg BW. IgM levels were measured using the ELISA method, while monocyte counts were analyzed using a hematology analyzer. The results showed that administration of ethanol extract of galing plant significantly increased IgM levels and monocyte counts compared with the negative control (p<0.05). The leaf extract group at a dose of 500 mg/kg BW showed the highest IgM level of 22.94 ± 2.00 ng/mL and the highest monocyte count of 8.44 ± 0.11%. A positive correlation was found between IgM levels and monocyte counts (p<0.05). Ethanol extract of galing plant has the potential to be developed as a natural immunomodulator to enhance immune responses against infection.
UJI DAYA HAMBAT EKSTRAK BUNGA TANAMAN BOROCO (Celosia argentea L.) TERHADAP Candida albicans PENYEBAB KEPUTIHAN Randa Wulaisfan; Yulianti Fauziah; Esti Badia; Muh. Asdar Setiawan; Muhammad Ilyas Y
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 3 No. 3 (2026): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, September 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v3i3.2745

Abstract

Boroco flower (Celosia argentea L.) is one of the plants that can be used as a traditional medicine because it contains alkaloid compounds, saponins and flavonoids which are antifungal so it is believed to be used in treating diseases such as vaginal discharge caused by the fungus Candida albicans. The antimicrobial activity test method used is the agar well method and the media used is Saboraud Dextrose Agar (SDA) media. The test samples in this study were made in 3 replications with concentrations of 10%, 20% and 30% and 2 controls namely positive and negative controls. This study aims to determine the extract of boroco plant flowers (Celosia argentea L.) in inhibiting the growth of Candida albicans. The results showed that a concentration of 10% had an average inhibitory power of 3.4 mm with a moderate inhibitory category, at a concentration of 20% had an average inhibitory power of 4.5 mm with a moderate inhibitory category, at a concentration of 30% had an average inhibitory power of 4.8 mm with a moderate inhibitory category. From the research results, it can be concluded that boroco flower extract is able to inhibit the growth of Candida albicans fungus.
Aktivitas Antioksidan dan Antidiabetes Fraksi Daun Galing (Cayratia trifolia L.Domin.) Secara In Vitro Muhammad Ilyas Y.; Nirwati Rusli; Nia Repliana; Fitriani W. Alani; Lukman La Basy
Jurnal Pharmacia Mandala Waluya Vol. 5 No. 5 (2026): Jurnal Pharmacia Mandala Waluya
Publisher : Prodi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54883/jpmw.v5i5.791

Abstract

Tumbuhan Galing (Cayratia trifolia L. Domin) salah satu tumbuhan endemik di Sulawesi Tenggara yang memiliki berbagai aktivitas farmakologi, d i antaranya sebagai antioksidan dan antidiabetes. Hal ini didukung oleh kandungan metabolit sekunder yang terdapat dalam tumbuhan galing, seperti flavonoid, fenolik, tanin, dan saponin yang telah dilaporkan memiliki berbagai aktivitas farmakologi. Namun, laporan ilmiah mengenai aktivitas antioksidan dan antidiabetes fraksi daun galing masih terbatas sehingga perlu dilakukan penelitian lebih lanjut secara in vitro. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dan antidiabetes fraksi daun galing. Jenis penelitian yang digunakan adalah penelitian analitik eksperimental dengan desain penelitian laboratorium secara in vitro.Sampel penelitian berupa ekstrak etanol dan fraksi daun galing yang terdiri atas fraksi etanol, etil asetat, dan n-heksan. Pengujian aktivitas antioksidan dengan metode DPPH pada panjang gelombang 517 nm dan metode ABTS pada panjang gelombang 735 nm serta pengujian antidiabetes melalui penghambatan enzim α-glukosidase pada panjang gelombang 400 nm menggunakan spektrofotometer UV-Vis. Hasil penelitian menunjukkan seluruh sampel memiliki aktivitas antioksidan kategori sangat kuat dengan nilai IC₅₀<50 μg/mL. Fraksi etanol menunjukkan aktivitas antioksidan dengan nilai IC₅₀ tertinggi pada metode DPPH dan ABTS masing-masing 1,32 μg/mL dan 0,123 μg/mL. Pada pengujian antidiabetes, fraksi etil asetat menunjukkan aktivitas penghambatan α-glukosidase terbaik dengan nilai IC₅₀ sebesar 43,401 μg/mL dengan kategori sangat kuat . Berdasarkan hasil tersebut, daun galing berpotensi dikembangkan sebagai sumber antioksidan dan antidiabetes alami.Penelitian selanjutnya diharapkan dapat melakukan identifikasi senyawa aktif dan pengujian in vivo untuk mendukung pengembangan daun galing sebagai kandidat obat herbal
Co-Authors ,, Suryani ., HALIK Abd. Arif Rachmat Halim Adriatman Rasak Adryan Fristiohady Adryan Fristiohady Agung Wibawa Mahatva Yodha Aisyah Asman Ajeng Diantini, Ajeng Al Indra Jaya Tamsa Alma Dita Harun Amaliah Amaliah Anastasyah Putri Andriani, Rina Angriani Fusvita Ani Umar Aprianto Apriyanto Apriyanto Arba, Muhammad Arfan Arfan Ari Putra Utama Ari Sartinah Ari Sartinah Asbath Said Asniar Pascayantri Asnita Hafsani Aspadiah, Vica Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asrumin Asrumin Astrid Indalifiany Aulia Amala Badia, Esti Bafadal, Mentarry Bai Athur Ridwan Balaka, Kemal Idris Baru Sadarun Bonni Rubak Chelvin Trio Saputra Darmayanita Wenty Daud, Nur Saadah Dayatriana Muthalib Derianti Derianti Dewiyanti Madu Dian Munasari Dian Munasari Solo Dian Munasari Solo Dini Putri Sari Dwi Arini Jufri Eka Safitri Elma Winarti Elvi Rahmayani Elvina Elvina Eny Nurhikma Ertin Ertin Fadhliyah Malik Fadhliyah Malik Fadhliyah Malik Fauziah, Yulianti Firasmi Sangadji Firdayanti Firdayanti Firman Oktivendra Fitrawan, La Ode Muhammad Fitriani W. Alani Frilia Atikah Fristiohady, Adryan Hafifah, Salsabillah Hajah Ermawati Hajir Mayana Halik HALIK . Hasbiullah Hasbiullah Hasnawati Hasnawati Hendra Febriansyah Heni Umar Henny Kasmawati Immel Putri Qaila Immel Putri Qaila Indra Saputra Liambo Indri Wulandari Irma Irma Irma Irnawati Irnawati Irnawati Irnawati Irnawati Irza Sezil Utami Jamal Qadar Junli Hong Kadek Ayu Meithasari Karmila Karmila Karmilah Kemal Idris Balaka Kemal Idris Balaka Khansa Rafida Triaqilah La Ode MJ Purnama La Ode Muhammad Agus Sapdiman La Ode Muhammad Julian Purnama Lidya Agriningsih Haruna Lukman La Basy Lukman La Basy Lukman La Basy MAHMUDAH, RIFA'ATUL Mayasari, Citra Mentarri Bafadal Mesi Leorita Milawati Milawati Mohammad Ghozali Mubarak Mubarak Mubarak Mubarak Mubarak Muhammad Arba Muhammad Arba Muhammad H Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Ilyas Y Muhammad Isrul Muhammad Kaisar Winalda Buutuni Muhammad Sultanul Aulya Muhammad Syaiful Saehu Musdalipah Nasrudin Nasrudin Nasrudin Nasrudin Nasrudin Nasrudin Nasrudin Neneng Risnawati Nia Repliana Nirwati Rusli Novita Sari Syukur Nur Aisyah Abdullah Nur Aviarahma Sihani Nur Hikmah Nur Illiyyin Akib Nur Illyin Nur Mardatillah Al Mubaidillah Nur Salma Nuralifah Nuralifah, Nuralifah Nurhikma Nurhikma Nurhikma Nurhikma Nurhikma Nurhikma Nurhikma Nurhikma Nurhikma Nurhikma Nurhikma Nurhikma Nurhikma Nurjeddah Fariane Nurlian Nurlian Nurmawaddah Nurmawaddah Nurramadhani A. Sida Nurul Afdhaliyah Nurdin Nurul Hikmah Suhafid Parawansah, P Pita Alfionita Rachma Malina Rahmat Mualiadi RAHMAT MULIADI, RAHMAT Rakhmad Barus Rani Rahmah Reymon, Reymon RH. Fitri Faradilla Rifa’atul Mahmudah Rifa’atul Mahmudah Rifcha Selviana Puput Rima Anglia Rina Andriani Rini Apriani Risnawati Risnawati Rohana Agusraeni Ruslin Ruslin Sabarudin Sabarudin Sahidin F. Sahidin Sahidin Salmawati Salmawati Sasmitha Nasruddin Selfyana Austin Tee Seprian Hilman Sernita Setiawan, Muhammad Azdar Silviana Hasanuddin Siti Hayati Siti Helmyati Siti Rahmawaty Tombalissa Sitti Raodah Nurul Jannah Sri Aprilianti Idris Sri Rasniawaty Sri Susanty Srimuliana Sulsiah Sulsiah Sulsiah Sulsiah Sumi Wally Susanti Susanti Susanti Susanti Syifa Ahda Valentina Rumalean Titin Syafiransyah Ufu Rindang Ulfa Ulfa Uswatun Khasanah Vica Aspadiah Wa Ambe Wa Ode Ifan Mustikawati Wa Ode Islami Nur Wa Ode Mulyana Wa Ode Nurfinti Wa Ode Nurfinti Wa Ode Nuryani Wa Ode Salma wahyu ningsih Wahyuni Wahyuni Wahyuni Wahyuni Winalda Maharani Wulaisfan, Randa Yuliatika, Kristiana Yulidyah Syaffanie Lilikay Yustian Okwani Yuyun Suria Zalzabila Ashari Amir