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All Journal Elkawnie Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Al-Kimia Adi Widya : Jurnal Pengabdian Masyarakat JMM (Jurnal Masyarakat Mandiri) Pharmasipha Lex Librum: Jurnal Ilmu Hukum Jambura Journal of Chemistry Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) Journal of English Language and Education Indonesian Journal of Pharmaceutical Education Jurnal Kolaboratif Sains Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Journal of Business Management and Economic Development JAPB Parapemikir Jurnal Ilmiah Farmasi International Journal of Multilingual Education and Applied Linguistics Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Community and Clinical Pharmacy Journal of Pharmacology and Natural Products SIMPUL: Jurnal Ilmu Politik dan Hukum Lex Librum : Jurnal Ilmu Hukum
Muhammad Taupik
Jurusan Farmasi, Fakultas Olahraga Dan Kesehatan, Universitas Negeri Gorontalo
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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STUDI POLA FRAGMENATASI JAMU TERKONFIRMASI PARASETAMOL MENGGUNAKAN LIQUID CHROMATOGRAPHY MASS SPECTROSCOPY (LCMS) Muhammad Taupik; Endah Djuwarno; Muhamad Handoyo Sahumena
Pharmasipha: Pharmaceutical Journal of Islamic Pharmacy Vol 4, No 2 (2020): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (422.223 KB) | DOI: 10.21111/pharmasipha.v4i2.4558

Abstract

Salah satu bahan kimia obat yang sering ditambahkan pada jamu adalah parasetamol karena obat ini merupakan obat analgetik-antipiretik. Sampel terdiri atas 6 sampel jamu  dengan merek berbeda. Analisis kualitatif dengan metode KLT menggunakan fase gerak n-heksan:etil asetat (1:1) diperoleh tiga sampel yang positif mengandung parasetamol yakni sampel D, E, dan F. Ketiga sampel yang positif mengandung parasetamol dihitung kadarnya dengan metode LCMS. Analisis kuantitatif dengan LCMS menggunakan fase terbalik dengan fase gerak asetonitril:air (15%>:85%> v/v) pada laju alir 0.2 mL/menit dan volume injeksi 5 gL. Berdasarkan data kromatogram LCMS diperoleh waktu retensi (Rf) parasetamol 1,038 menit. Rata-rata waktu  retensi  sampel  jamu  mendekati   waktu  retensi parasetamol. Pendekatan selanjutnya berdasarkan pola fragmentasi dari Spektroskopi Massa. Berdasarkan data spektrum massa diperoleh fragmentasi dari parasetamol (152 m/z) membentuk  fragmen yakni p-aminofenol (109 m/z) dan asetalaldehid (44 m/z). Ion p-aminofenol,  menghasilkan subfragmen aldehyde (32 m/z) dan cyclopentadienylidene  (81 m/z). Berdasarkan hasil analisis menggunakan metode LCMS diperoleh empat sampel yang mengandung parasetamol, Sampel D. E dan F. Seharusnya ketiga sampel tersebut tidak diperbolehkan diperjualbelikan dan dikonsumsi karena  berdasarkan Peraturan  Menteri  Kesehatan  No. 006 Tahun 2012 pasal 33 dan pasal 37 tentang industri dan usaha obat tradisional bahwa obat tradisional dilarang mengandung bahan kimia hasil isolasi atau sintetik yang berkhasiat obat. Meski kandungan parasetamol dalam tergolong sedikit, tetapi menurut Permenkes RINo. 007 tahun 2012 bahwa bahan kimia obat mutlak tidak diperbolehkan terdapat dalam obat tradisional.
STUDI HEPATOPROTEKTOR GULMA SIAM (Chromolaena odorata) PADA TIKUS YANG DIINDUKSI PARASETAMOL Endah Nurrohwinta Djuwarno; Widysusanti Abdulkadir; Muhammad Taupik
Pharmasipha: Pharmaceutical Journal of Islamic Pharmacy Vol 4, No 2 (2020): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v4i2.4559

Abstract

Gulma siam (Kopasanda) merupakan jenis tumbuhan gulma dari famili Asteraceae yang dikenal memiliki aktivitas antioksidan yang disebabkan oleh kandungan tinggi akan flavonoid dan adanya alkaloid, saponin, glikosida sianogenik, tanin dan asam fitat. Hati merupakan organ terbesar dan merupakan situs utama untuk metabolisme dan pengeluaran. Kerusakan hati dapat disebabkan paparan zat toksik (hepatotoksik) salah satunya parasetamol. Tujuan penelitian ini adalah untuk mengetahui efektivitas ekstrak etanol Chromolaena odorata terhadap penurunan enzim ALT dan AST pada mencit jantan yang diinduksi parasetamol serta konsentrasi optimalnya sebagai hepatoprotektor. Penelitian ini menggunakan desain eksperimental laboratorium, hewan coba mencit jantan dikelompokkan menjadi 5 kelompok dengan jumlah 3 ekor setiap kelompok yang diinduksi ekstrak selama 7 hari, dan diberi parasetamol dosis toksik pada hari ke-8. Hari ke 1-7 kontrol positif diberi Curcuma Z dosis 1 mg, kontrol negatif diberi Na.Cmc 1%, dan setiap kelompok dosis 1,05, 1,47 dan 1,89 mg untuk mencit 30g. Mencit diambil darah selama 3 kali, sebelum pemberian ekstrak, hari ke-8 dan setelah pemberian pct untuk diukur kadar ALT dan AST. Uji statistik menggunakan One way Annova dengan pengujian LSD. Hasil uji menunjukkan ekstrak gulma siam dosis 35 mg, 49 mg dan 63 mg memiliki kadar rata-rata ALT 34,3 µL, 36 µL, 28,3 µL dan AST 73 µL, 76,67 µL, 55 µL. Kesimpulannya ekstrak etanol 70% Chromolaena odorata memiliki hepatoprotektor dengan konsentrasi paling efektif yaitu pada 1,89 mg dengan rerata ALT 28,3 µL dan AST 55 µL.
ISOLASI SENYAWA ALKALOID DARI TUMBUHAN MAHONI (Switenia mahagoni Jacq) Muhammad Taupik; Endah Nurrohwinta Djuwarno; Moh Adam Mustapa
Pharmasipha: Pharmaceutical Journal of Islamic Pharmacy Vol 5, No 2 (2021): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v5i2.6663

Abstract

Penelitian ini bertujuan untuk mengidentifikasi senyawa Alkaloid yang terkandung didalam biji buah mahoni (Switenia mahagoni Jacq). Senyawa target hasil isolasi diidentifikasi menggunakan spektrofotometri UV-Vis. Proses pengambilan senyawa menggunakan metode refluks hingga diperoleh ekstrak kental berwarna hijau gelap sebanyak 27 gram. Identifikasi awal dilakukan dengan skrining fitokimia pada ekstrak kental methanol, meliputi skrining senyawa alakaloid, flavonoid, dan saponin. Proses fraksinasi dilakukan dengan sistem partisis cair-cair menggunakan n-heksanaa dan metanol dan selanjutnya hasil partisi dipekatkan dengan rotary evaporator. Fraksi metanol dielusi pada plat KLT (Kromatografi Lapis Tipis) guna mendapatkan formulasi eluen terbaik untuk dilanjutkan pada Kromatografi Cair Vakum (KCV) dan diperoleh formula eluen terbaik n-heksanaa:metanol (4:1). Proses pemisahan menggunakan KCV dengan silica gel 60 PF254, dengan system eluen n-heksana:metanol bergradien. Isolat dievaluasi kemurniannya menggunakan KLT. Isolat diidentifikasi menggunakan Spektrofotometri UV-Vis dan serapan diperoleh pada panjang gelombang gelombang 208, 240, 286 nm. Nilai absorbansi berturutturut 0,318; 0,852; dan 0,443 A. Hasil interpretasi data mengkonfirmasi bahwa terdapat ikatan rangkap terkonjugasi dikarenakan serapan terbentuk pada panjang gelombang 250-800 nm. Diduga terjadi transisi nπ* yang mengindikasikan gugus N-H dengan abrosbansi pada rentang ultraviolet kuarsa (200-400 nm).
Formulasi Sampo Kombinasi Ekstrak Seledri (Apium graveolens) dan Ekstrak Kayu Manis (Cinnamomum burmanii) Serta Uji Aktivitasnya pada Jamur AM. Andy Suryadi; Muhammad Taupik; Mahdalena SY. Pakaya; Endah Nurrohwinta Djuwarno; Juliyanty Akuba
Jambura Journal of Chemistry Vol 3, No 2 (2021): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v3i2.11199

Abstract

Rambut merupakan salah satu bagian vital pada tubuh yang berasal dari ektoderm di kulit dan juga sebagai pelengkap pelindung pada tubuh (aksesoris). Masalah pada rambut dan kulit kepala yang sering terjadi adalah ketombe. Gejala umum yang sering terjadi yaitu mulai timbulnya sisik-sisik putih pada kulit kepala, gatal, dan juga bisa juga disertai dengan kerontokan rambut. Hal ini disebabkan karena adanya beberapa mikroorganisme yang terdapat pada ketombe seperti Malassezia furfur dan Candida albicans. Tanaman yang kaya senyawa flavonoid diketahui memiliki aktivitas sebagai anti bakteri dan anti jamur. Penggunaan formulasi herbal dapat dijadikan sebagai alternatif yang baik untuk terapi dalam mengatasi mikroorganisme yang terdapat pada ketombe. Di Indonesia, seledri dan kayu manis secara tradisional dapat digunakan untuk mengatasi pertumbuhan jamur. Pada penelitian ini memformulasikan sampo kombinasi antara ekstrak seledri dan ekstrak kayu manis sebagai anti jamur dalam bentuk sedian gel. Hasil evaluasi fisik menunjukkan formula gel memiliki stabilitas yang baik. Aktivitas anti jamur dari kombinasi ekstrak seledri dan ektrak kayu manis mempunyai daya hambat paling besar dengan pengulangan berturut-turut pada jamur Mallasezia furfur (35mm; 34mm; 35mm) dan pada jamur Candida albicanus (30mm; 31mm; 30mm) dengan konsentrasi (20%; 20%).
AKTIVITAS DIURESIS Leucaena leucocephala.L PADA MENCIT JANTAN (Mus musculus) Muhammad Ricky Ramadhian; Khairil Pahmi; Muhammad Taupik
Journal Syifa Sciences and Clinical Research Vol 3, No 1 (2021): Volume 3 Edisi 1 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i1.9894

Abstract

Diuretics are compounds or drugs that can increase urine volume. This study focused on exploring the activity and concentration of ethanol extract of lamtoro leaves (Leucaenaleucocephala L.) as a diuretic in male house mice (Musmusculus) using experimental research. The method used was to observe the physical activity of urine produced for 120 minutes. Lamtoro leaves extraction was done by maceration using solvent ethanol, then phytochemical screening tests. The screening results stated positively contained alkaloids, flavonoids, terpenoids, and tannins. The animals used were 25 house mice, divided into 5 groups. Group 1 was given Na-CMC 1% w/v suspension, group 2 with furosemide suspension 0.0041% w/v, group 3 with 25% w/v lamtoro leaf ethanol extract, group 4, ethanol extract 50% w/l lamtoro leaf , and group 5 was ethanol extract 75% w/v of lamtoro leaves. Urine volume of the house mice was measured at 15, 30, 45, 60, 75, 90, 105, and 120 minutes.
FORMULASI EMULGEL DARI EKSTRAK DAUN KELOR (Moringa oleifera LAM) SERTA EVALUASI AKTIVITAS ANTIOKSIDAN DENGAN METODE DPPH Nurul Istiqomah; Juliyanti Akuba; Muhammad Taupik
Journal Syifa Sciences and Clinical Research Vol 3, No 1 (2021): Volume 3 Edisi 1 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i1.9874

Abstract

Moringa (Moringa oleifera Lam) is one of the plants that has high antioxidant activity, especially in the leaves. Emulgel is one of the topical dosage which dermatologically has several beneficial properties, namely thixotropic, not oily, easy to spread, easy to clean, soft, easy to wash, long lasting, transparent and comfortable when used. The purpose of this research was to formulate moringa (Moringa oleifera Lam) leaves extract into emulgel dosage forms and determine the antioxidant activity of the dosage using DPPH method.The research began with extraction of moringa leaves and optimization of the base by varying the concentration of carbopol 940 as gelling consisting of F1 0.5%, F2 1%, F3 1.5% and F4 2%. The base that met the requirements of good physical stability was F2.  The F2 base was then made into emulgel dosage with 3 concentration variations of the extract, namely F2a 4%, F2b 5% and F2c 6%. The physical stability test result of each formula met the organoleptic test,the pH test, the dispersion test, the adhesion test, the viscosity test, and the freeze-thaw test. The One way ANOVA statistical test result showed that the p value was greater than 0.05, which meant that the emulgel dosage had good physical stability. The IC50values of each antioxidant activity result were F2a (t0 = 120.464 g/mL; t28 = 144.887 g/mL), F2b (t0 = 113.642 g/mL; t28 = 128.407g/mL), F2c (t0 = 74.745 g/mL; t28 = 90.618 g/mL). The statistical results of the t-test showed thep value = 0,027, (0.05), This indicated that there were significant difference results of the antioxidant activity test between the three formulas on the first day (t0) and on the 28th day (t28).
Efek Antelmintik Ekstrak Metanol Kulit Batang Nangka (Artocarpus heterophyllus) terhadap Cacing Ascaris lumbricoides Hamsidar Hasan; Nur Ain Thomas; Muhammad Taupik; Gita Potabuga
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.14217

Abstract

Jackfruit (Artocarpus heterophyllus) is a type of plant that grows in Indonesia which functions as a food ingredient and as traditional medicine. Generally, this genus contains prenylated flavonoid compounds. This study aimed to determine the anthelmintic effect of jackfruit bark extract against Ascaris lumbricoides worms by utilizing total maceration with methanol solvent as the extraction method, which yielded 6.61%. Roundworm Ascaris lumbricoides are found in pig intestines. The samples were divided into 5 groups, including positive control of 250 mg combantrin solution, negative control of NaCMC and a treatment group of jackfruit bark extract with a concentration of 1%, 3%, and 5%. Each group consisted of three worms, incubated at 37oC for 24 hours with a 6 hours interval. The results showed that at a concentration of 5%, a jackfruit bark extract was efficient as an anthelmintic caused two worms to lyse at 6 hours and  one at 12 hours.
Evaluasi Kemampuan Tabir Surya Ekstrak Biji Jagung (Zea mays L.) Secara In Vitro Menggunakan Metode Spektrofotometri UV-Vis Muhammad Taupik; Wiwin R. kunusa; Jafar La Kilo; A. Mu’thi Andy Suryadi; Zul Fikar Ahmad
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.14314

Abstract

Corn kernels (Zea mays L.) are plants serving as a natural sunscreen due to the presence of phenol and flavonoid compounds. The sunscreen compounds are able to protect skin from the effect of ultraviolet ray emitted by the sun. The purpose of this study was to determine the activity of corn kernels (Zea mays L.) as a in vitro sunscreen by the UV-Vis spectrophotometry method. The study was started by maceration of extracted seed samples using three various solvents, i.e., hexane, ethyl acetate and ethanol 70%. In the preliminary test, it was found that 70% positive ethyl acetate and ethanol extract contained phenol and flavonoid compounds, so that the step proceeded to the sunscreen activity test. The sunscreen activity test was determined based on the value of sun protecting factory value tested at wavelengths from 290 to 320 nm, the percentage of erythema transmission (% Te), and the percentage of pigmentation transmission (%Tp) values tested at wavelengths of 292.5-372.5 nm at 5 nm intervals. From these tests, the results revealed that the best activity was indicated by a concentration of 600 ppm for ethyl acetate extract and 70% ethanol with an average SPF value of 24.1724.18 ± 0.0852 (ultra protection) and 10.23 ± 0.021 (maximum protection). Te% of ethyl acetate and ethanol extract 70% were 3.92 ± 0.015 (extra protection) and .62 ± 0.026 (regular syringe), respectively. % Tp in 70% ethyl acetate and ethanol extract gets 19.61 ± 0.527 (total block) and 32.66 ± 2,594 (total block), respectively. The statistical analysis revealed that the normality and homogeneity test of significance value 0.05, meaning that the data distribution was not normal and homogeneous. By that, the step continued to the Kruskal-Wallis test. Based on the Kruskal-Wallis test, the significance value 0.05 showed that the significant differences in the ethanol and ethyl acetate samples per concentration with the SPF,% Te and% Tp values obtained was significant.
WASTE PROCESSING TRAINING AS AN ALTERNATIVE MATERIAL FOR CANDLES Nuri Suryani; Nana Krisdianti; Riski Pradana; Muhammad Taupik; Singgih Subiyantoro
Adi Widya : Jurnal Pengabdian Masyarakat Vol 4 No 2 (2020): ADIWIDYA
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33061/awpm.v4i2.4403

Abstract

In their life, the people of Siwal Village cannot be separated from the use of oil. Moreover, the majority of Siwal Village residents work as food or fried food sellers on the roadside. Repeated use of cooking oil can have harmful effects on health. In addition, used cooking oil that can no longer be used is usually dumped in careless places and causes environmental pollution. Another problem in Siwal Village is the lack of skills of children due to the influence of gadgets. With these things in mind, training on how to process used cooking oil into an alternative material for making used used wax is one of the right solutions. Activities consist of a location survey, implementation, results and discussion. Implementation includes; 1) preparation 2) counseling 3) training 4) mentoring 5) evaluation 6) advanced stage training. All activities carried out online are able to improve children's skills and reduce environmental pollution due to used waste. Keywords: oil, used cooking, wax
Analisis Kadar Bahan Kimia Obat Dexametason Pada Jamu Reumatik Menggunakan Spektrofotometri Uv-Vis Muhammad Taupik; A. Mu’thi Andy Suryadi; Endah Nurrohwinta Djuwarno; Faramita Hiola
Jambura Journal of Chemistry Vol 4, No 1 (2022): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v4i1.11233

Abstract

Traditional medicines are ingredients in the form of plant ingredients, animal ingredients, mineral substances, galenic, or mixtures of these ingredients that have been used for treatment from generation to generation and can be applied in accordance with the prevailing norms in society. One type of traditional medicine that is currently consumed by many people is herbal medicine. Jamu (empirical based herbal medicine) is a traditional medicine that is provided traditionally which contains all the plant ingredients that make up the herbal medicine which is hygienic (free of contamination) and is used traditionally. The research objective was to determine the presence of the chemical ingredient of dexamethasone drug in jamu for rheumatic and also to quantitatively determine the dexamethasone level in jamu for rheumatic by using uv-vis spectrophotometry. The results showed that all five jamu for rheumatic samples contained the chemical ingredient of dexamethasone drug with levels of each sample, namely jamu A 99,83 mg, jamu B 34,71 mg, jamu C 363,13 mg, jamu D 9,979 mg, and jamu E 778,97 mg
Co-Authors A Admiral A. Mu'thi Andy Suryadi A. Mu’thi Andy Suryadi A. Mu’thi Andy Suryadi A. Mu’thi Andy Suryadi Abdi Dzul Ikram Hasanuddin Adam Mustapa, Moh Adam Mustapa, Muhammad Adinda Mutmainnah Putri Rumiki Adinda, Fadhel Arjuna Ahmad Farhani AM. Andy Suryadi Amin, Muhammad Nur Andi Suryadi, A. Mu’thi Andy Suryadi, A. Mu'thi Andy Suryadi, A. Mu’thi Anggai, Rifka Anggraini Antuli, Zikran Nazar Antuli Aprianto Paneo, Mohamad Ariani H. Hutuba Ariani H. Hutuba Banne, Pratiwi Zesika Beby Bestari Djuarno, Endah Nurrohwintah Dr. Apt. Hamsidar Hasan S.Si.,M.Si Endah Nurrohwinta Djuwarno Faramita Hiola Febriana, Afifah Jihan Friskawati Hanapi Gita Potabuga Hamzah, Rosyidi Harwanto, Yelisnawati Hayati, Rahmi Hiola, Faramita Hutuba, Ariani Ishak Isa Ismail, Rahmawati Jafar La Kilo Jamiah Jamiah, Jamiah Julianty Akuba Kaino, Ratni Kasim, Sesha Ramadhani Khairil Pahmi kopman, aldafarista Krisdianti, Nana La Ode Aman LATIF, MULTIANI S Liansyah Angga Saputra Madania . Madania, Madania Mahdalena Sy Pakaya mahdalena sy. pakaya Makkulawu, Andi Maku, Mohamad Aditya Manno, Mohamad Reski Moh Adam Mustapa Mohamad Adam Mustapa Mohamad Aprianto Paneo molote, kasibee molote Muh. Ihsan Muhamad Handoyo Sahumena Muhamad Handoyo Sahumena Muhammad Nur Amin Muhammad Ricky Ramadhian Muhammad Rizal Firmanda Aditya Mursyidah, Andi Nana Krisdianti Nur Ain Thomas Nur Oktaviana Nur Rasdianah Nuri Suryani Nurul Istiqomah Pakaya, Juniarista Jessica Panu, Karmila Papeo, Dizky Ramadani Putri Payuyu, Alifia Pradana, Riski Puluhulawa, Lisa Efriani Radjak, Fahmi As Rahmawati, Nuzu Ramadhan L, Aditya Rannu, Jumriani Riska Wahyuni, Nor Riski Pradana Robert Tungadi S. Latif, Multiani Selvi Marcellia Singgih Subiyantoro Siti Surya Indah Nurdin Sitti Gonibala, Sintia Suryadi, A Mu'thi Andy Suryadi, A. Mu'thi Andy Suryadi, A. Muthi Andi Suryani, Nuri Teti Surriyati Tuloli Teti Sutriyati Tuloli Teti Sutriyati Tuloli Widy Susanti Abdulkadir Widy Susanti Abdulkadir Wiwin Rewini Kunusa Wiwit Zuriati Uno Zulfikar Ahmad