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Uji Toksisitas Akut Sediaan SNEDDS Pentagamavunon-0 pada Mencit Betina BALB/c Perdana, Ilham; Yuniarti, Nunung; Puspitasari, Ika
Majalah Farmaseutik Vol 21, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i2.98572

Abstract

Pentagamavunon-0 (PGV-0) merupakan senyawa turunan kurkumin yang dikembangkan dalam bentuk sediaan Self-Nanoemulsifying Drug Delivery System (SNEDDS) dan memiliki aktivitas farmakologi terhadap brain disorder yang hingga saat ini belum terdapat data ilmiah mengenai tingkat keamanannya. Penelitian ini bertujuan untuk mengetahui klasifikasi toksisitas SNEDDS PGV-0 berdasarkan parameter gejala toksisitas, perubahan berat badan dan nilai LD50. Penelitian dilakukan menggunakan prosedur uji sesuai OECD Test Guidelines 420 Fix-dose Procedure. Hewan uji yang digunakan pada penelitian ini adalah 10 mencit betina BALB/c dengan masing-masing kelompok terdiri dari 5 ekor mencit. Kelompok kontrol diberi perlakuan senyawa pembawa SNEDDS dan kelompok perlakuan menggunakan SNEDDS PGV-0.  Dosis awal SNEDDS PGV-0 digunakan sebesar 300 mg/kgBB dan dilanjutkan untuk uji utama. Hasil penelitian menunjukkan adanya gejala toksisitas yang muncul pada pemberian SNEDDS PGV-0 berupa gatal, percepatan nafas, mengantuk hingga kematian. Terjadi kenaikan berat badan pada hewan uji, tetapi bukan perubahan berat badan yang bermakna (p>0,05). Penentuan nilai LD50 cut off sebesar 300 mg/kgBB dengan kategori toksisitas 4.
Nursing Care for Post Op Orif Femur Fracture Patients with Ambulation Support Interventions in the Special Surgery Room Rsud Jenderal Ahmad Yani Metro Year 2024 Puspitasari, Ika; Sugiarto, Sugiarto; Wardoyo, Eko
INDOGENIUS Vol 4 No 2 (2025): INDOGENIUS
Publisher : Department of Publication of Inspirasi Elburhani Foundation Desa. Pamokolan, Kecamatan Cihaurbeuti, Kabupaten Ciamis, Provinsi Jawa Barat, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/igj.v4i2.494

Abstract

Background and Objectives: Femur fractures are one of the leading causes of complications and death that require proper management to prevent morbidity, complications, and accelerate patient recovery. The management of femur fractures includes pharmacological and non-pharmacological approaches, one of which is ambulation support. The purpose of this scientific work is to describe nursing care in postoperative patients with femur fractures through innovative ambulation support interventions. Methods: This research design uses a case study on a postoperative patient with a femur fracture, with early ambulation interventions carried out every day for 3 days of care. Results: The results showed increased left limb mobility, decreased edema, and tingling, and decreased pain intensity from scale 5 to scale 3 after 3 days of treatment. Conclusion:  Early ambulation as part of postoperative management of femur fracture is effective in reducing pain, improving mobility, and accelerating patient recovery. This approach can be adopted in nursing practice to improve the postoperative rehabilitation process.
Teachers' Perceptions of the Use of Canva in Developing Islamic Religious Education Learning at MTS Muhammadiyah 7 Panceng Al-Muzzaki, Rizqi Hariyono; Bakhruddin, Muhammad; Puspitasari, Ika
Al Qalam: Jurnal Ilmiah Keagamaan dan Kemasyarakatan Vol. 19, No. 4 : Al Qalam (Juli 2025)
Publisher : Sekolah Tinggi Ilmu Al-Qur'an (STIQ) Amuntai Kalimantan Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35931/aq.v19i4.5258

Abstract

This research aims to analyze teachers' perceptions of the use of Canva in PAI learning development at MTS Muhammadiyah 7 Panceng. The research method used is a qualitative approach with data collection techniques through interviews, observations, and observations. The research subjects included students and PAI teachers at MTS Muhammadiyah 7 Panceng. The results showed that PAI teachers at MTS Muhammadiyah 7 Panceng school considered Canva as an effective learning tool in improving the quality of PAI learning materials, because of the various templates and interesting features provided by Canva from free to paid. The use of Canva helps teachers in creating interactive and interesting learning materials, thus increasing students' interest and motivation to learn. However, some teachers experience technical difficulties and need optimal training in using Canva. This research contributes to the development of innovative and effective PAI learning strategies. The results of this study can be used as a reference for PAI teachers in developing quality learning materials.
Integration of Theory of Planned Behavior and Value-Attitude-Behavior as a Basis for Decision Making in Selecting Event Organizer Services Puspitasari, Ika; Roostika, Raden Roro Ratna
JPEK: Jurnal Pendidikan Ekonomi dan Kewirausahaan Vol 9 No 2 (2025): JPEK (Jurnal Pendidikan Ekonomi dan Kewirausahaan)
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/jpek.v9i2.30028

Abstract

The post-Covid-19 pandemic Event Organizer (EO) business has shown rapid recovery and growth as part of the MICE sector. Amid the increasingly fierce competition in the EO business, understanding the factors that influence client loyalty is crucial for business continuity, but research integrating TPB and VAB in this context is still very limited. This study aims to analyze the influence of subjective norms, attitudes, and quality on client loyalty in the decision to choose event organizer services. The research method uses a quantitative approach with data collection techniques through online questionnaires. The sampling technique used purposive sampling on EO service client respondents in Jayapura City and surrounding areas, and the data were analyzed using SPSS software. The results showed that subjective norms have a significant effect on loyalty, attitudes have a significant effect on loyalty, and quality has a significant effect on loyalty. These findings confirm the relevance of TPB and VAB in the context of the MICE industry, and provide practical implications for EO business people in developing effective marketing strategies to increase client loyalty.
THE RELATIONSHIP FREQUENCY OF DRINK COFFEE WITH BLOOD PRESSURE IN HYPERTENSION PATIENTS IN CANGKRING VILLAGE, SIDOKARE DISTRICT, SIDOARJO DISTRICT, SIDOARJO DISTRICT: THE RELATIONSHIP FREQUENCY OF DRINK COFFEE WITH BLOOD PRESSURE IN HYPERTENSION PATIENTS IN CANGKRING VILLAGE, SIDOKARE DISTRICT, SIDOARJO DISTRICT, SIDOARJO DISTRICT Ilmi, Miftakhun Nafidatul; Roni, Faishol; Puspitasari, Ika
WELL BEING Vol 5 No 1 (2020): Well Being
Publisher : LPPM STIKes Bahrul Ulum Jombang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51898/wb.v5i1.56

Abstract

Hypertension often does not cause symptoms, while persistently high blood pressure in the long term can cause complications, namely, damage to the kidneys, heart, and brain. Consumption of caffeinated coffee can increase the risk of pressure. blood namely hypertension. The aim is to determine the relationship between coffee drinking frequency and blood pressure in patients with hypertension in the Cangkring sub-village of Sidokare, Sidoarjo Sub-district, Sidoarjo Regency. The study design uses cross-sectional. The population was 40 and samples were taken by 36 respondents with total sampling techniques. This research instrument uses checklist sheets and observation sheets. Based on the research results of Coffee Drinking Frequency found in Cangkring Hamlet, Sidokare Subdistrict, Sidoarjo Subdistrict, Sidoarjo Regency, most rarely 29 respondents (80.6%) Hypertension was found in Cangkring Hamlet, Sidokare Subdistrict, Sidoarjo Subdistrict, Sidoarjo Regency, most of Stage 1 hypertension was 23 respondents (63, 63 9%). Data analysis using the Spearman Rank Test with p-value is 0.139 because the p-value is 0.005 then H1 is rejected, which means there is no relationship between coffee drinking frequency and blood pressure in hypertension sufferers.
Evaluation of Adverse Drug Reaction Reporting on the Badan POM Website in Yogyakarta Special Region Ernawati, Hafifah; Ikawati, Zullies; Puspitasari, Ika; Abdoellah, Siti Asfijah; Kurniawati, Fivy
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 15, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.105134

Abstract

Background: Adverse Drug Reaction (ADR) is defined as a harmful and unintended response to a drug, as a part of the pharmacovigilance system to identify drug safety-related issues. As a regulatory, the Indonesian Food and Drug Authority (BPOM) has facilitated an online reporting platform for healthcare professionals via the website www.e-meso.pom.go.id.Objectives: The objective of this study is to characterize Adverse Drug Reaction (ADR) reporting within the Special Region of Yogyakarta, serving as an early detection mechanism for potential drug safety hazards.Methods: This observational cross-sectional survey study utilized ADR reporting data obtained from the MESO website of the Indonesian Food and Drug Authority in the Special Region of Yogyakarta (DIY). The collected data were subjected to descriptive analysis. A total of 169 reports were analyzed, encompassing 255 suspected drugs and 255 ADR events.Results: The report identifies three predominant groups of patient disease characteristics: diseases of the circulatory system (15.38%), certain infectious and parasitic diseases (11.24%), and diseases of the respiratory system (9.47%). Regarding the type of ADR based on its Sub Organ Class (SOC), Skin and subcutaneous tissue disorders is most frequently involved (21.57%). The antibiotic group is the most commonly suspected type of drug (34.90%), with Levofloxacin and Ceftriaxone being the most implicated in causing ADR (11.24%). Oral administration is the most common route associated with ADR, followed by intravenous administration.Conclusion: In 2023, the monitoring of ADR in the Special Region of Yogyakarta revealed that antibiotics were the most frequently suspected drug class in relation to ADR. The dermatological organ system was also identified as the predominant organ affected by these reactions.
Tunneled Epidural Analgesia for Refractory Scrotal Cancer Pain: A Case-Based Evaluation of Therapeutic Efficacy Nur Azza, Kamala Kan; Tomo, Wahyu Kartiko; Darwito, Darwito; Puspitasari, Ika; Mahmud, Mahmud; Widyastuti, Yunita
Academic Hospital Journal Vol 7, No 2 (2025)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v7i2.109434

Abstract

Background: Scrotal Squamous Cell Carcinoma (SCC) is a rare malignancy. Although SCC typically demonstrates slow progression, in advanced stages with significant size, it can cause considerable pain due to mass effect and local tissue invasion. The management of cancer-related pain encompasses a wide spectrum of approaches, ranging from pharmacologic to surgical interventions. In cases where patients become intolerant to the side effects of pharmacologic therapies and adequate pain relief cannot be achieved, while surgical options are either not feasible, interventional pain management may offer an effective alternative. Tunneled Epidural Analgesia represents one such interventional technique that can be considered for refractory pain. This case report aims to evaluate the efficacy of tunneled epidural analgesia administration in managing intractable pain associated with advanced scrotal SCC.Materials and methods: This case report is structured according to the CARE (Case Report) guideline. The study was conducted at UGM Academic Hospital, where the patient received evaluation and treatment.Case: A 65-year-old male diagnosed with SCC presented experiencing refractory cancer pain. Despite receiving conventional analgesic therapy, he experienced no significant pain relief and developed adverse effects. Pain management was subsequently escalated to an interventional approach using a bupivacaine 0.125% and fentanyl 25 mcg administered via a tunneled epidural drug delivery system. This intervention resulted in effective pain control, enabling him to do daily activities. With this modality, the pain remained well managed, although occasional breakthrough pain occurred, which was successfully managed with 1% lidocaine as a rescue analgesic.Conclusion: Tunneled epidural analgesia using a combination of opioid and bupivacaine has demonstrated effectiveness in the management of refractory scrotal cancer pain.
Effect of Soaking Tawes Fish Eggs (Barbonymus gonionotus) in Tea Solution (Camellia sinensis) on the Hatchability and Survival of Larvae Puspitasari, Ika; Hastuti, Sri; Sarjito, Sarjito; Nurlatifah, Annisa Oktafianti
Sains Akuakultur Tropis : Indonesian Journal of Tropical Aquaculture Vol 9, No 2 (2025): SAT edisi September
Publisher : Departemen Akuakultur FPIK UNDIP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/sat.v9i2.29360

Abstract

Tawes fish (Barbonymus gonionotus) is one of the fish with high production demand, but seed production is still low. One of the obstacles is fungal attacks. An alternative to overcome fungal attacks in the hatching phase of fish eggs is to use one of the plants that is anti-fungal. One alternative ingredient that is safe and can be used in controlling fungi is using tea. The active compounds of flavonoids, tannins, saponins found in tea are expected to be natural alternative ingredients for anti-fungals. This study aims to determine the effect and optimum concentration of tea solution (C. sinensis) on the hatching power and survival rate of tawes fish larvae (B. gonionotus). This study was conducted in April 2023 at the UPT Balai Benih Ikan Pandak Banyumas, Central Java. The method used was an experiment with a Completely Randomized Design (CRD) with 4 replications and 5 replications each. The hatching media was added with tea solution (C. sinensis) with concentrations A (0 g/l), B (3 g/l), C (6 g/l), and D (9 g/l). The data observed included the length of egg hatching time, yolk absorption time, egg hatchability (HR), survival rate (SR), and water quality. The results showed that soaking eggs in tea solution affected the hatching power of eggs and the survival of tawes fish larvae. The results of the hatching rate values in succession from treatments A to D were 64.00 ± 4.18a%, 81.00 ± 4.18c%, 85.00 ± 3.54c% and 71.00 ± 4.18b%, while the results of the survival rate values in succession from treatments A to D were 62.47 ± 3.15a%, 75.41 ± 9.46bc%, 79.90 ± 3.86c%, and 67.56 ± 6.33d). The optimum dose of soaking tawes fish eggs in tea leaf solution for the hatching power of eggs and the survival of tawes fish larvae was 4.96 - 4.98 g / l.
Penerapan Metakognitif Dalam Media Pembelajaran Puspitasari, Ika
TADARUS Vol 8 No 1 (2019)
Publisher : Prodi Pendidikan Agama Islam - Fakultas Agama Islam ( FAI )

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/td.v8i1.3045

Abstract

AbstrakDalam arti yang lebih substansial, proses pembelajaran diharapkan mampu memperluas keterampilan siswa dalam memecahkan masalah danmengintensifkan kemampuan metakognitifnya. Pertanyaan yang muncul untukdikaji adalah 1) bagaimana penerapan metakognitif dalam pembelajaran. 2)bagaimana peran media pembelajaran, 3) bagaimana penerapan metakognitifdalam media pembelajaran. Pentingnya penerapan metakognisi dalampembelajaran telah dilaporkan oleh beberapa peneliti, salah satunya menurutLivingston  (1997) metakognisi memiliki peranan penting dalam keberhasilanbelajar, oleh karena itu penting mempelajari aktivitas dan pengembanganmetakognisi untuk menentukan bagaimana siswa dapat diajar sehingga merekadapat menerapkan sumber-sumber pengetahuan dengan lebih baik melaluipengontrolan metakognisinya. Pengembangan kecakapan metakognisi pada siswamerupakan suatu tujuan pendidikan yang sangat berharga, karena kecakapan itudapat membantu mereka menjadi pelajar yang dapat mengatur diri sendiri danbertanggung jawab terhadap kemajuan belajar diri sendiri serta beradaptasiterhadap strategi belajar untuk mencapai tuntutan tugas. Langkah pelaksanaanmetakognitif dalam pembelajaran berdasarkan John Flavell adalah 1) aktivitasmerencanakan, 2) menyusun tujuan, 3) evaluasi dan monitoring proses ( refleksi ),4) menyusun strategi. Media adalah segala sesuatu yang dapat digunakan untuk menyalurkan pesan dari pengirim ke penerima pesan, sehingga dapat merangsang pikiran,perasaan, perhatian peserta didik sehingga proses belajar peserta didik terjadi dandapat mendorong peserta didik belajar lebih baik pada dirinya. Pemanfaatanmedia pembelajaran seharusnya bagian yang harus mendapatkan perhatian gurusebagai fasilitator dalam setiap kegiatan pembelajaran, oleh karena itu pendidikperlu mempelajari bagaimana menetapkan media pembelajaran agar dapatmengefektifkan pencapaian tujuan pembelajaran dalam proses belajar mengajar.  Kata Kunci: Metakognitif, Media Pembelajaran
Pembelajaran Ict Menggunakan Program “Vectorian Giotto” Puspitasari, Ika
TADARUS Vol 8 No 2 (2019)
Publisher : Prodi Pendidikan Agama Islam - Fakultas Agama Islam ( FAI )

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/td.v8i2.4289

Abstract

AbstractEducation in Indonesia grows in line with the development of Science and Technology. Problems that often arise are influenced by the increasing ability of students, thesituation and environmental conditions, the influence of information and culture, and thedevelopment of science and technology. Purpose of this research explained ICT (InformationCommunication and Technology)  learning by using the program of “vectorian giotto”. TheICT Learning  can be used to facilitate the cooperation between educators and students.Information and Communication Technology (ICT) can be used as learning media to conveyinformation or teaching materials. As a teacher, it is now required to be able to createinnovative, creative and fun learning media. The “vectorian giotto” program is a vector-basedanimation program whose making animation is based the timeline. It serves to provide theobject change points that are writing, images, videos, sounds, etc are from the first changepoint (keyframe) to the point of change next (second keyframe). In the ICT learning courseusing the “vectorian giotto”  program, the student is demanded to make innovative andcreative learning media. This program is complete enough to create an illustrative animationin making learning media, users can enter writing, images, videos, or sounds into thisprogram designed as an animation, so that many objects can be compiled through thisprogram used as learning animations.Keywords: ICT, Learning, Program of Vectorian Giotto”
Co-Authors Abdoellah, Siti Asfijah Abdul Gofir Achmad, Bayu Fandi Agil Novianto, Agil Agung Endro Nugroho Akhmad Kharis Nugroho Al-Muzzaki, Rizqi Hariyono Alchusnah, Retno Hayati Alexxander Alexxander, Alexxander Ali Djamhuri Amalia, Dita Ambar Yunita Nugraheni Amboro, Wisnu Andaru Dahesihdewi Annisa Oktafianti Nurlatifah, Annisa Oktafianti Arief Budiyanto Arief Nurrochmad Arifin, Shokhibul Arifin, Shokibul Asrori, A Astuti, Rini Budi Bakhruddin, Muhammad Bambang Sigit Riyanto Chairani, Farahdina Chandra Wahyu Purnomo Chandra, Lukman Ade Chusna, Nurul Darwito, Darwito Dibtyanusa, Ajib Djoko Wahyono Endang Lukitaningsih Ernawati, Hafifah Esti Dyah Utami Estiningsih, Daru Farisa Luthfiana Fatiha, Muvina Rizkia Fauziyah, Jihan Firmansyah, Moch Fikry Hafizah, Ilmi Nur Haryono, Eko Anwar Hemi Sinorita Hera Nirwati Heri Mulyanto, Heri HIDAYAT, MOCH CHARIS I Dewa Putu Pramantara Ida Safitri Laksanawati Ilham Perdana Ilmi, Miftakhun Nafidatul Indra Saputra Ismail, Asrul Khairunnisa, Dini Kumara, Intan Fatah Kurniawati, Fivy Kurniawaty, Yenni Dwi Kusharwanti, AM Wara Kusmantoro Edy S Lestari, Ayu Eka M. Yogi Riyantama Isjoni Maftuhah, Rifa’atul Mahmud Mahmud Marsila, Ulfi Ana Mika Tri Kumala Swandari, Mika Tri Kumala Mufida, Arizzatul Aulia Mulyani, Lili Nadiya, Salsabila Putri Nanang Munif Yasin Nastiti, Nindita Sari Nathania, Caroline Evanthe Naurah Alifah Rahmah Niken Puspitasari Nisa, Solikhatun Nunuk Aries Nurulita Nunung Yuniarti Nur Azza, Kamala Kan Nurul Hikmah Oktariyanto, Efel Erlambang Pratama, Alief Indra Pratiwi, Restu Dwi Probosuseno Probosuseno, Probosuseno Putri, Mukarromah Dita Rahmah, Naurah Alifah Rahmantika, Fitri Rizaldy Pinzon Rizka Humardewayanti Asdie Rochman, Zakki Tifani Ibadu Roni, Faishol Roostika, Raden Roro Ratna Rukmono Siswishanto Sarastuti, Dewi Sari Dewiyani, Sari Sarjito - Solekah, Putri Nur Sri Watini Sudar, Hasdiana Sugiarto S Sugiyarto, Okky Puspitasari Sumarningsih, Pebriati Suryani, Aliyatul Ilmi Susatyo Yuwono Susi Ari Kristina Susianti, Noor Alia Sutono Sutono Suwito, Darwito Tambun, Sabrina Handayani Thulus Hidayat, Thulus Titik Nuryastuti Titik Rahayu Tomo, Wahyu Kartiko Tri Hartati, Tri Tri Murti Andayani Tri Yanto Triswandari, Retno Utami, Annafi' Nanda Rohmah Wahyuntari, Evi Wardoyo, Eko Yanuar, Wihda Yunita Widyastuti Yusmiyati, Yusmiyati