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A Study on Lung Cancer Chemotherapy Regimen Administration at Universitas Gadjah Mada Academic Hospital Oktariyanto, Efel Erlambang; Yasin, Nanang Munif; Puspitasari, Ika
Academic Hospital Journal Vol 6, No 2 (2024)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v6i2.99663

Abstract

Background: One of the main ways to treat lung cancer is through chemotherapy regimens. Due to the complexity of lung cancer pathophysiology, the variability of chemotherapy given tends to cause drug interactions and toxicity in patients.Objective: Based on this, this study aims to determine the characteristics of lung cancer patients and identify chemotherapy administration patterns based on the NCCN therapy guidelines, identify interactions and side effects of chemotherapy that occur in patients diagnosed with lung cancer who are undergoing outpatient therapy at the Universitas Gadjah Mada Academic Hospital.Method: This research was carried out with a case-series design, namely by conducting a study using descriptive methods that provide an overview of patient characteristics, chemotherapy regimen patterns and their conformity to NCCN guidelines, potential drug-drug interactions (DDIs), and the incidence of side effects experienced by patients. Data was collected retrospectively through medical records of lung cancer patients undergoing outpatient treatment in the period April 2022 – April 2023 who met the inclusion and exclusion criteria.Result: There were a total of 27 patients in this study with patient characteristics predominantly in the elderly age range (> 60 years), 18 patients (66.7%), with exon 19 mutation NSCLC lung cancer type (n = 13; 92.6%), stage IV (n = 25 ; 92.6%), as well as non-smoking patients (n = 15 ; 55.6%). Chemotherapy regimen patterns at Gadjah Mada University Academic Hospital for lung cancer patients included afatinib (n = 14; 51.9%), gefitinib (n = 12; 44.4%), and cisplatin pemetrexed (n = 1; 3.7 %) with conformity reaching 100% in the accuracy of indications, dosage and usage information. In this study, it was identified that there were 2 Potential DDIs that occurred in 1 patient (3.7%) with respective risks, namely C and B which included cisplatin-furosemide and cisplatin-ondansetron interactions. Side effects were known to occur in almost all patients (n = 23; 85.2%) where side effects in the form of skin toxicity and diarrhoea were the two most frequently identified types of side effects with a percentage of 59.3% (n = 16). and 40.7% (n = 11).Conclusion: More than 90% of NSCLC showed exon 19 mutation. The most chemotherapy given to the patients was afatinib. There were a potential interaction between cisplatin and either furosemide or ondansetron.
Comparison of effectiveness and safety between ceftriaxone/azithromycin and levofloxacin in hospitalized CAP patients: a review Hikmah, Nurul; Andayani, Tri Murti; Puspitasari, Ika
Majalah Farmaseutik Vol 20, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i3.94147

Abstract

Community-acquired pneumonia (CAP) is a major health issue as it is a highly prevalent disease with significant morbidity and mortality worldwide. Current IDSA guidelines recommend ceftriaxone/azithromycin combination or levofloxacin monotheraphy as one of the empirical antibiotic options in non-ICU hospitalized CAP patients. This literature review aims to evaluate the comparative effectiveness and safety of ceftriaxone/azithromycin combination therapy and levofloxacin monotherapy in non-ICU hospitalized CAP patients. Four databases (PubMed, Scopus, DOAJ, and Cochrane Library) were used for article search with Boolean approach. Publication years were limited to 2013-2023 and without study design restrictions. Five articles which met the inclusion and exclusion criteria were evaluated. Two RCTs compared the effectiveness and safety of ceftriaxone/azithromycin combination and levofloxacin monotherapy, while the other 3 studies did not compare the safety of both antibiotic regimens due to the limitations of retrospective study design. The five studies analyzed the effectiveness of both regimens on various outcomes such as clinical improvement, mortality, and length of stay (LOS). The results of this literature review demonstrated that levofloxacin monotherapy had better clinical improvement, lower mortality, and reduced length of stay in non-ICU hospitalized CAP patients compared to ceftriaxone/azithromycin combination. However, the safety of both treatment regimens is still uncertain due to the limited number of studies evaluating the incidence of adverse events.
Modifikasi Metode Pemberian Infus Vankomisin dan Amiodaron Melalui Vena Perifer : Kajian Literatur Hafizah, Ilmi Nur; Puspitasari, Ika; Andayani, Tri Murti
Majalah Farmaseutik Vol 21, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i1.94376

Abstract

Amiodaron dan vankomisin merupakan obat yang sering digunakan pada populasi bedah jantung dengan saran pemberiannya melaui vena sentral. Akan tetapi, pemasangan vena sentral menimbulkan berbagai komplikasi yang dapat memperburuk kondisi pasien, serta penggunaannya secara teknis susah untuk diterapkan pada kondisi darurat. Sehingga diperlukan cara/metode pemberian infus melalui vena perifer dengan memperhatikan reaksi yang ditimbulkan seperti infiltrasi, ekstravasasi, plebitis bahkan infeksi. Kajian ini bertujuan untuk mengetahui apakah modifikasi metode atau pedoman praktek klinik pemberian infus amiodaron atau vankomisin melalui perifer aman dan dapat menurunkan komplikasi. Pencarian literatur dilakukan menggunakan database Pubmed dan Cochrane yang diterbitkan 10 tahun terakhir yang berupa penelitian observasional maupun experimental dengan desain penelitian cohort, crossectional, deskriptif, randomized control trial dan quasi experimental. Dari 26 artikel yang ditemukan terdapat 4 artikel yang memenuhi kriteria peneliti. Kesimpulan dari hasil penelusuran yang didapat yaitu pemberian infus vankomisin dalam jangka waktu pendek aman diberikan melalui vena perifer khususnya menggunakan kateter midline dan penggunaan konsentrasi vankomisin yang rendah mampu menurunkan kejadian plebitis. Sedangkan Pemberian amiodaron konsentrasi tinggi disarankan menggunakan vena sentral disertai penggunaan in-line filter.
Amikasin: Profil Penggunaan pada Pasien Dewasa Rawat Inap di RSUP Dr.Sardjito Yogyakarta berdasarkan Fungsi Ginjal Utami, Esti Dyah; Puspitasari, Ika; Asdie, Rizka Humardewayanti; Lukitaningsih, Endang; Dahesihdewi, Andaru
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.829 KB) | DOI: 10.35617/jfionline.v13i1.9

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Amikacin is used for serious infection treatment, with a nephrotoxicity incidence of 3-13%. More than 90% of amikacin is excreted through the renal in unchanged form, thus accumulation may occur in renal dysfunction. This research is aimed to determine the amikacin usage profiles based on the patient’s renal function and evaluate the association between a renal function with hospital discharge conditions and length of stay (LOS). This research was conducted by collecting the medical record data of adult inpatients at Dr. Sardjito Hospital treated with amikacin in 2020. A Chi-Square test was used to determine the proportion differences between 2 groups of patients with different renal functions, and the relationship of renal function with discharge condition and LOS. The majority of 78 subjects had normal renal function, with a diagnosis of mixed infection. Amikacin was used as definitive therapy, as an antibiotic combination, with a median dosage of 14.3mg/kgBW/day, 12 hours interval, and 5 days duration. Results showed that the CrCl, infection type, comorbid, amikacin intervals and duration had significantly different proportions (p<0.05) between patients with normal renal function and those with renal dysfunction. Renal function was positively associated with the patient’s discharge condition, but not with LOS.
IMPLEMENTASI STBM PILAR 4 (PENGELOLAAN SAMPAH RUMAH TANGGA) DI KABUPATEN PROBOLINGGO Fatiha, Muvina Rizkia; Mulyanto, Heri; Puspitasari, Ika; Kurniawaty, Yenni Dwi; Rahmah, Naurah Alifah
Jurnal Kesehatan Tambusai Vol. 6 No. 1 (2025): MARET 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i1.42645

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Menurut SIPSN KemenLHK (2024), Pada tahun 2024, Provinsi Jawa Timur memiliki total timbulan sampah sebesar 3,212,635.23 ton/tahun dengan sumber sampah sebesar 63% berasal dari Rumah tangga. Implementasi STBM pilar ke 4 merupakan salah satu solusi dalam mengatasi permasalahan sampah domestik dengan melibatkan partisipasi aktif masyarakat. Penulisan artikel ini bertujuan untuk mengetahui tingkat implementasi terhadap STBM pilar 4 mengenai pengelolaan sampah rumah tangga di Kabupaten Probolinggo. Desain penelitian yang digunakan adalah kuantitatif deskriptif dengan metode pengumpulan data verifikasi STBM. Adapun yang menjadi populasi adalah Seluruh KK di Kabupaten probolinggo yang tersebar di 24 Kecamatan. Sedangkan pengambilan sampel dilakukan pada 8 Kecamatan, dengan 16 desa/kelurahan. sampel yang diambil berjumlah 400 KK. Hasil verifikasi STBM Pilar ke 4 di Kabupaten Probolinggo menunjukkan, Sebesar 74,50% KK belum melakukan pengelolaan sampah KK. Sedangkan KK yang telah melakukan pengelolaan sampah hanya sebesar 24,50%. Sementara itu, 77,25%  KK di Kabupaten Probolinggo menjaga kebersihan lingkungan rumah mereka dengan tidak membiarkan sampah berserakan. Namun, hanya 54,25% KK yang memiliki tempat sampah yang memenuhi persyaratan. Selain itu, 45,75% KK telah menerapkan perlakuan aman terhadap sampah. Sementara itu, tingkat pemilahan sampah juga telah diterapkan oleh 51,75% KK. Sebagian besar KK di Kabupaten Probolinggo masih belum melakukan pengelolaan sampah rumah tangga, oleh karena itu diperlukan pendekatan yang lebih komprehensif melalui pengetahuan berkelanjutan, peningkatan infrastruktur pengelolaan sampah, dan peraturan yang lebih ketat diperlukan untuk mendorong praktik pengelolaan sampah yang lebih efektif dan berkelanjutan di  Probolinggo.
IMPLEMENTASI STBM PILAR 3 (PENGELOLAAN AIR MINUM DAN MAKANAN RUMAH TANGGA) DI KABUPATEN PROBOLINGGO Naurah Alifah Rahmah; Mulyanto, Heri; Puspitasari, Ika; Kurniawaty, Yenni Dwi; Fatiha, Muvina Rizkia
Jurnal Kesehatan Tambusai Vol. 6 No. 1 (2025): MARET 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i1.42646

Abstract

Pengelolaan air minum yang tidak sesuai standar dapat menyebabkan penyakit dan salah satu penyakit yang dapat terjadi adalah diare. Pengolahan makanan yang tidak tepat maupun cara penyajian makanan yang tidak sesuai standar memiliki dampak yang buruk terhadap kesehatan dan dapat menjadi faktor risiko terjadinya penyakit berbasis lingkungan. (Julia et al., 2024). Implementasi dari STBM Pilar 3 dapat meningkatkan partisipasi masyarakat dalam pengelolaan air minum dan makanan skala rumah tangga. Penulisan artikel ini bertujuan untuk menggambarkan bagaimana implementasi STBM Pilar 3 di Kabupaten Probolinggo. Desain penelitian yang digunakan adalah deskriptif kuantitatif  dengan metode pengumpulan data hasil verifikasi STBM. Populasi dari penelitian adalah seluruh KK di Kabupaten Probolinggo yang tersebar di total 24 Kecamatan. Pengambilan sampel menggunakan metode Stratified Random Sampling dan didapatkan 8 Kecamatan, 16 desa/kelurahan, dan total sampel berjumlah 400 KK. Hasil verifikasi STBM Pilar 3 menunjukkan bahwa sebagian besar masyarakat di Kabupaten Probolinggo telah melakukan PAMM-RT dengan capaian sebesar 62,50% atau sebanyak 250 KK dari total 400 KK yang menjadi sampel. Beberapa KK di Desa Alas Nyiur Kecamatan Besuk memiliki sumur yang menjadi sumber air bersih hanya berjarak < 10 meter ke cubluk dan kamar mandi. Capaian PAMM-RT yang masih di angka 62,5% menunjukkan bahwa masih ada tantangan dalam meningkatkan kesadaran dan praktik masyarakat terkait keamanan pangan dan air minum. Untuk mengatasi permasalahan ini, diperlukan peningkatan infrastruktur air bersih dan sosialisasi untuk mendorong masyarakat supaya dapat meningkatkan kesadaran dan praktik pengelolaan air minum dan pangan dan mencapai derajat kesehatan seoptimal mungkin.
Upaya guru pendidikan agama Islam dalam penanganan kasus verbal harassment untuk menjaga kesehatan mental siswa Mufida, Arizzatul Aulia; Hidayat, Moch. Charis; Puspitasari, Ika
Al-Liqo: Jurnal Pendidikan Islam Vol. 10 No. 1 (2025): Al-Liqo: Jurnal Pendidikan Islam
Publisher : Program Studi Pendidikan Agama Islam STAI Auliaurrasyidin Tembilahan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46963/alliqo.v10i1.2592

Abstract

Islamic Religious Education (PAI) teachers hold a strategic role in maintaining students’ mental health by preventing verbal harassment in schools. This study aims to analyze the strategies employed by PAI teachers in addressing verbal harassment at SMP Maryam Surabaya. Using a descriptive qualitative approach, data were collected through in-depth observation and interviews. The findings reveal that PAI teachers implement dialogic and narrative approaches to help students understand the negative impacts of verbal harassment. These approaches are reinforced by academic evaluations that include moral assessments as a preventive measure. In addition, religious values are integrated into the learning process to foster students’ social awareness. Despite various efforts, challenges such as student resistance remain. The study concludes that PAI teachers play a crucial role in creating a safe, inclusive school environment that supports students' mental well-being.
Effectiveness of Tikrar Method to Support Quran Memorization Ability of Students of Elementary School Muhammadiyah 04 Surabaya Fauziyah, Jihan; Hidayat, Moch Charis; Puspitasari, Ika
Al Qalam: Jurnal Ilmiah Keagamaan dan Kemasyarakatan Vol. 19, No. 4 : Al Qalam (Juli 2025)
Publisher : Sekolah Tinggi Ilmu Al-Qur'an (STIQ) Amuntai Kalimantan Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35931/aq.v19i4.5290

Abstract

This research aims to describe the effectiveness of applying the Tikrar method in improving the ability to memorize the Al-Qur'an in grade 5 students at SD Muhammadiyah 04 Surabaya. The Tikrar method, which prioritizes repetition of verses from the Koran, has proven effective in speeding up and strengthening students' memory process. The research used a qualitative approach with case studies, involving interviews with school principals, tahfidz teachers, and direct observation of the student learning process. The research results showed that almost 90% of class 5A students succeeded in memorizing Juz 30 after applying the Tikrar method, which was supported by a conducive learning environment, such as a comfortable classroom atmosphere and intensive guidance from the tahfidz teacher. The main supporting factors for the success of this method are student motivation and the role of parents, although there are challenges in supporting at home. The Tikrar method has been proven to be more effective than the previously used talaqqi method, especially in terms of time efficiency and memorization quality. This research suggests integrating social media or digital-based learning applications to support rote repetition outside school hours.
Habit of Applying Magic Words (Excuse Me, Please, Sorry and Thank You) in Supporting the Character of Early Childhood in Little Star Kindergarten Nisa, Solikhatun; Puspitasari, Ika; Arifin, Shokhibul
Al Qalam: Jurnal Ilmiah Keagamaan dan Kemasyarakatan Vol. 19, No. 3 : Al Qalam (Mei 2025)
Publisher : Sekolah Tinggi Ilmu Al-Qur'an (STIQ) Amuntai Kalimantan Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35931/aq.v19i3.4471

Abstract

Character education in early childhood has an important role in building an independent and confident personality. This study aims to determine how the habit of applying the magic words excuse me, please, sorry and thank you in supporting the character of early childhood in TKIT Little Star Surabaya. This study uses a qualitative descriptive approach. The description is compiled based on data obtained from the field, precisely at TKIT Little Star. This study uses observation and interview techniques as data collection and the subjects of this study include class teachers and A1 students who are the application of the habit of the magic words excuse me, please, sorry and thank you. In the implementation of this habit does not always run smoothly there are challenges in the implementation but with the example and real examples from the teacher makes students see and do the habit of the magic words so that ethical manners in students are formed and support character education and cooperation of parents at home is also one of the supporters. Character when it has been formed from an early age will be carried over into adulthood.
Pemberdayaan Masyarakat Padang Tarok Kecamatan Baso Melalui Workshop Tumbuh Kembang dan Penanganan Anak Berkebutuhan Khusus Triswandari, Retno; Mulyani, Lili; Saputra, Indra; Lestari, Ayu Eka; PuspitasarI, Ika
Sentra Cendekia Vol 6 No 2 (2025): Juni
Publisher : Universitas Ivet

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31331/sencenivet.v6i2.3929

Abstract

Anak berkebutuhan khusus (ABK) memerlukan perhatian dan penanganan yang tepat untuk mengoptimalkan potensi tumbuh kembangnya. Masyarakat Padang Tarok, Kecamatan Baso masih memiliki keterbatasan pengetahuan dan keterampilan dalam menangani ABK. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pemahaman dan kemampuan masyarakat dalam mengidentifikasi, menangani, dan mendampingi anak berkebutuhan khusus. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan Participatory Action Research (PAR) melalui workshop dengan teknik ceramah, diskusi, dan simulasi praktik. Peserta terdiri dari orangtua, guru, kader kesehatan, dan tokoh masyarakat. Materi workshop meliputi deteksi dini tumbuh kembang anak, jenis-jenis kebutuhan khusus, teknik stimulasi, dan strategi penanganan. Hasil menunjukkan bahwa setelah dilakukan pemberdayaan melalui workshop maka masyarakat Padang Tarok mampu memahami tahapan tumbuh kembang anak dan cara penanganan ABK dengan baik melalui aplikasi deteksi tumbuh kembang anak. Kegiatan ini juga berhasil membentuk kelompok pendukung ABK di tingkat komunitas. Workshop ini terbukti efektif dalam memberdayakan masyarakat untuk lebih peduli dan mampu menangani anak berkebutuhan khusus secara optimal.
Co-Authors Abdoellah, Siti Asfijah Abdul Gofir Achmad, Bayu Fandi Agil Novianto, Agil Agung Endro Nugroho Akhmad Kharis Nugroho Al-Muzzaki, Rizqi Hariyono Alchusnah, Retno Hayati Alexxander Alexxander, Alexxander Ali Djamhuri Amalia, Dita Ambar Yunita Nugraheni Amboro, Wisnu Andaru Dahesihdewi Annisa Oktafianti Nurlatifah, Annisa Oktafianti Arief Budiyanto Arief Nurrochmad Arifin, Shokhibul Arifin, Shokibul Asrori, A Astuti, Rini Budi Bakhruddin, Muhammad Bambang Sigit Riyanto Chairani, Farahdina Chandra Wahyu Purnomo Chandra, Lukman Ade Chusna, Nurul Darwito, Darwito Dibtyanusa, Ajib Djoko Wahyono Endang Lukitaningsih Ernawati, Hafifah Esti Dyah Utami Estiningsih, Daru Farisa Luthfiana Fatiha, Muvina Rizkia Fauziyah, Jihan Firmansyah, Moch Fikry Hafizah, Ilmi Nur Haryono, Eko Anwar Hemi Sinorita Hera Nirwati Heri Mulyanto, Heri HIDAYAT, MOCH CHARIS I Dewa Putu Pramantara Ida Safitri Laksanawati Ilham Perdana Ilmi, Miftakhun Nafidatul Indra Saputra Ismail, Asrul Khairunnisa, Dini Kumara, Intan Fatah Kurniawati, Fivy Kurniawaty, Yenni Dwi Kusharwanti, AM Wara Kusmantoro Edy S Lestari, Ayu Eka M. Yogi Riyantama Isjoni Maftuhah, Rifa’atul Mahmud Mahmud Marsila, Ulfi Ana Mika Tri Kumala Swandari, Mika Tri Kumala Mufida, Arizzatul Aulia Mulyani, Lili Nadiya, Salsabila Putri Nanang Munif Yasin Nastiti, Nindita Sari Nathania, Caroline Evanthe Naurah Alifah Rahmah Niken Puspitasari Nisa, Solikhatun Nunuk Aries Nurulita Nunung Yuniarti Nur Azza, Kamala Kan Nurul Hikmah Oktariyanto, Efel Erlambang Pratama, Alief Indra Pratiwi, Restu Dwi Probosuseno Probosuseno, Probosuseno Putri, Mukarromah Dita Rahmah, Naurah Alifah Rahmantika, Fitri Rizaldy Pinzon Rizka Humardewayanti Asdie Rochman, Zakki Tifani Ibadu Roni, Faishol Roostika, Raden Roro Ratna Rukmono Siswishanto Sarastuti, Dewi Sari Dewiyani, Sari Sarjito - Solekah, Putri Nur Sri Watini Sudar, Hasdiana Sugiarto S Sugiyarto, Okky Puspitasari Sumarningsih, Pebriati Suryani, Aliyatul Ilmi Susatyo Yuwono Susi Ari Kristina Susianti, Noor Alia Sutono Sutono Suwito, Darwito Tambun, Sabrina Handayani Thulus Hidayat, Thulus Titik Nuryastuti Titik Rahayu Tomo, Wahyu Kartiko Tri Hartati, Tri Tri Murti Andayani Tri Yanto Triswandari, Retno Utami, Annafi' Nanda Rohmah Wahyuntari, Evi Wardoyo, Eko Yanuar, Wihda Yunita Widyastuti Yusmiyati, Yusmiyati