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All Journal Jurnal Sain Veteriner Jurnal Medik Veteriner Vitek : Bidang Kedokteran Hewan Jurnal Layanan Masyarakat (Journal of Public Service) Journal of Parasite Science Ovozoa: Journal of Animal Reproduction Bioscientist : Jurnal Ilmiah Biologi Jurnal Agro Veteriner
Tjuk Imam Restiadi
Departemen Reproduksi Veteriner, Fakultas Kedokteran Hewan, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Environmental Science Immunology & microbiology Medicine & Pharmacology Social Sciences Veterinary Other

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Efek Kadar Urea Nitrogen Darah (BUN) pada Tikus Putih (Rattus norvegicus) Bunting Setelah Pemberian Monosodium Glutamat (MSG) Organik dan Sintetis Tias, Eriza Putri Ayu Ning; Restiadi, Tjuk Imam; Widjiati, Widjiati; Wicaksono, M Galih; Setyaningsih, Endang
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 2 (2025): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i2.15781

Abstract

This study aims to explores blood urea nitrogen (BUN) levels in Wistar rats exposed to synthetic and organic MSG to identify potential renoprotective effects. The study design involved a control group (K) that was fed a normal diet only, and six treatment groups (P1–P6) that received doses of organic or synthetic MSG at 60, 120, or 240 mg/kg BW for 19 days. Each group consisted of six rats. MSG was administered orally and BUN levels were measured using the colorimetric method. The results showed no significant difference in BUN levels between the control group and the treatment groups (p > 0.05). The highest BUN levels were found in the control group, while the lowest levels were found in the group that received the highest dose of synthetic MSG (240 mg/kg BW). Additionally, BUN levels were lower with organic MSG at 120 and 240 mg/kg BW than with the 60 mg/kg BW dose, suggesting that bioactive compounds in tempeh and pineapple bromelain may have renoprotective effects. While the lowest BUN levels were observed in the group receiving the highest dose of synthetic MSG (240 mg/kg BW), this may be due to reduced protein intake or other metabolic adaptations rather than safety factors. Synthetic MSG at a dose of 240 mg/kg BW produced the lowest BUN levels, which may indicate reduced protein intake or other metabolic adaptations, rather than safety factors.
Effect of Moringa oleifera Lam. Leaf Extract on Sperm Motility and Abnormality in White Rats (Rattus norvegicus) Exposed to Cigarette Smoke: An In Vivo Experimental Study Bachtiar, Harris Yudhanta; Mafruchati, Maslichah; Yudaniayanti, Ira Sari; Restiadi, Tjuk Imam; Utomo, Budi; Plumeriastuti, Hani
Jurnal Sain Veteriner Vol 43, No 3 (2025): Desember
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.106028

Abstract

Background: CSE has been shown to induce oxidative stress, negatively impacting sperm quality and morphology by decreasing motility and increasing abnormalities. Moringa oleifera Lam. leaves are rich in flavonoids and other antioxidants that may counteract the harmful effects of free radicals. Objectives: This study aimed to investigate the effect of Moringa oleifera leaf extract on sperm motility and abnormality in male white rats (Rattus norvegicus) exposed to cigarette smoke. Method: This true experimental study used a completely randomized design. Twenty-five male rats were divided into five groups: negative control (K−), positive control (K+), and three treatment groups (P1, P2, P3) receiving oral administration of Moringa leaf extract at graded doses (13, 26, and 52 mg/kg BW) for 14 days, along with daily exposure to cigarette smoke. Results: Results showed that group P3 (52 mg/kg BW) had significantly higher sperm motility compared to the positive control and was statistically comparable to the negative control (p<0.05). Furthermore, sperm abnormality in group P3 decreased significantly, approaching the normal range. Conclusion: In conclusion, the administration of Moringa oleifera leaf extract at a dose of 52 mg/kg BW effectively preserved sperm motility and reduced abnormality in white rats exposed to cigarette smoke. These findings support the potential of Moringa oleifera as a phytotherapeutic agent to protect reproductive health against oxidative stress.
Co-Authors Abdul Samik, Abdul Abdullah Abdullah Agus Wijaya Agustono, Bodhi Amrullah, Muhammad Fajar Ananda, Hanifah Muslimah Andriyanti, Silvia Rani Bachtiar, Harris Yudhanta Bambang Hermanto Belgania, Ristaqul Husna Bimo Aksono Boedi Setiawan Budi Utomo Chusniati, Sri Dadik Rahardjo, Dadik Damayanti, Tita Darsono, Roesno Dian Ayu Permatasari Diba, Lucky Dinul, Ahmad Rajul Djoko Legowo DWI WIJAYANTI Endang Setyaningsih Endang Suprihati Erma Safitri Faisal Fikri Haditanojo, Wiyanto Hana Eliyani Hani Plumeriastuti Hanifah, Novi Fitria Hariadi, Mas'ud Hermin Ratnani Herry Agoes Hermadi Hidajati, Nove IMAM MUSTOFA Indira Vania Carisya Ira Sari Yudaniayanti Ismudiono Ismudiono, Ismudiono Isti Annisa Ramahtia Iwan Sahrial Hamid Kabayo, Fierda Kusriningrum Rochiman Mafruchati, Maslichah Masruroh, Laili Salisa Mirni Lamid Mochamad Lazuardi Mohamad Safri Sauqi Mujahid Mujahid, Mujahid Mustofa Helmi Effendi Nove Hidajati Nunuk Dyah Retno Lastuti Nusdianto Triakoso Pahlevy, Jolly Rifqi Poedji Hastutiek Pramesti, Nugraheni Anggara Prastiya, Ragil Angga Prastyorini, Vina Ari Pudji Srianto Rahmawati, Mitha Ardila Rimayanti Rimayanti Rochmah Kurnijasanti Samuel Inioluwa Akeju Saputro, Amung Logam Setiawan Koesdarto Setyadi, Arda Wahyu Setyawan, Firman Shinta Putri Quraini Soeharsono Soeharsono Sri Mumpuni Sosiawati Sri Pantja Madyawati, Sri Pantja Suherni Susilowati Supranianondo, Koesnoto Suzanita Utama Tatik Hernawati Tehupuring, Benjamin Chr Tias, Eriza Putri Ayu Ning Tita Damayanti Lestari Tri Wahyu Suprayogi Trilas Sardjito Umama, Ayu Riza Ummaisyah, Winadya Reika Vladika, Maulinda Agchirilia Wahjuni, Retno Sri Warsito, Sunaryo Hadi Wibawati, Prima Ayu Wicaksono, M Galih Widiyatno, Thomas V. Widjiati Widjiati, Widjiati Widodo, Oky Setyo Widya Paramita Lokapirnasari Wiwik Misaco Yuniarti Wurlina, W Yohana, Nadia Yudhana, Aditya Yulianti Mauludy Utami