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Nusdianto Triakoso
Division Of Veterinary Clinic, Faculty Of Veterinary Medicine, Universitas Airlangga, Surabaya-Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Journal : Journal of Applied Veterinary Science and Technology

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The Influence of Oral Administration of Red Dragon Fruit Peels Extract (Hylocereus polyrhizus) on Increasing High Density Lipoprotein in Male White Rats (Rattus norvegicus) Hypercholesterolemia Ahmad Thoriqul Firdaus; Gandul Atik Yuliani; Tri Wahyu Suprayogi; Nusdianto Triakoso; Eduardus Bimo Aksono Herupradoto; Nanik Hidayatik
Journal of Applied Veterinary Science And Technology Vol. 4 No. 1 (2023): April 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/javest.V4.I1.2023.1-4

Abstract

Background: Hypercholesterolemia is one of the most common diseases in the world, with cholesterol levels exceeding normal levels. Hypercholesterolemia can cause various systemic disorders in the body. One of the signs is by decreasing HDL (High-Density Lipoprotein) cholesterol levels. Dragon fruit peel contains many ingredients, such as vitamin B3 (niacin), vitamin C, flavonoids, anthocyanins, and other minerals that can affect the increase in HDL production and reduce total cholesterol levels. Purpose: To know the effect of red dragon fruit peel extract (Hylocereus polyrhizus)on increasing levels of High-Density Lipoprotein (HDL) in male rats (Rattus norvegicus) hypercholesterolemia. Methods: Male rats were made hypercholesterolemic using a mixture of lard (3 ml) and egg yolk (1 g) for 14 days orally. 20 hypercholesterolemic male rats were further divided into 5 treatment groups and given dragon fruit peel extract therapy with different treatments, namely T0 negative control (CMC-Na 1% + aquadest), T1 positive control (Simvastatin 0.0013 mg/200 g BW), T2, T3 and T4 (each 100, 150, 200 mg/kg BW red dragon fruit peel extract) for 14 days orally.  Blood serum was taken on day 36 and tested in the laboratory using a chemical analyzer machine; then the data were analyzed using the univariant multiple way one-way ANOVA statistical test with a significant difference (p>0.05). Results: The P4 treatment group has an effective dose (200 mg/kg BW) to increase high-density lipoprotein (HDL) levels, while the P3 treatment group (dose 150 mg/kg BW) is less effective but can still have an effect. Conclusion: This research showed that red dragon fruit peel extract could increase HDL (High-Density Lipoprotein) cholesterol levels with an effective 200 mg/kg BW dose.
Co-Authors Agustono, Bodhi Ahmad Thoriqul Firdaus Aksono HP., Eduardus Bimo Al arif, Mohammad Anam Al-Arif, Moh. Anam Annise Proboningrat Ardianto Ardianto Ardiyansyah, Septiana Alafia Yusi Arimbi Arimbi Aulia Rakhman, Muhammad Andika Bambang Sektiari Lukiswanto Billa, Lutfiah Annisa Boedi Setiawan Budiarto Budiarto Burhanudin Cahya, Rizka Wulan Chairul Anwar Diba, Lucky Dini, Sayyida Kamila Djoko Galijono DWI WIJAYANTI Erma Safitri Estoepangestie, Agnes Theresia Soelih Faisal Fikri Fedik Abdul Rantam Fransiska, Eunike Melanda Gandul Atik Yuliani Hani Plumeriastuti Hasibuan, Sandi Aziz Herry Agoes Hermadi Hidajati , Nove Hidayatik, Nanik Hisyam, Mirza Atikah Madarina IMAM MUSTOFA Ira Sari Yudaniayanti Ismudiono Ismudiono Ivanalee, Angela Swasti Iwan Sahrial Hamid Iwan Sahrial Hamid Kadek Rachmawati Kadek Rachmawati Kuncorojakti, Suryo Legowo, Djoko Lilik Maslachah LINA SUSANTI Lucia Tri Suwanti, Lucia Tri Luthfiyyah Nur Afifah Siswandi Ma'ruf, Anwar Mahdi, Daffa Amanul Maudika Pamela Fiorenza Mirni Lamid Mochamad Lazuardi Mufasirin Muhandis, Putri Jauza Aulia Mustofa Helmi Effendi Niken Hastuti, Apriliwiyani Nunuk Dyah Retno Lastuti Poedji Hastoetik Poedji Hastutiek Praja, Ratih Novita Prastiya, Ragil Angga Primarizky, Hardany Pujiyanto, Mahendra Putrianirma, Rizki Raharjo, Dadik Rahmadhani, Nurmitasari Rahmahani, Jola Rahmawati, Rr Indah Nur Rao, Sherbrina Bai Seenivasa Rosyta, Pegy Saputro, Amung Logam Sardjana, I Komang Wiarsa Soeharsono Sri Agus Sudjarwo Srimaryanto, Leonardo Reza Sudjono, Budi Santoso Suherni Susilowati Sunarso, Agus Suzanita Utama Taufan Ary Handoko Tjuk Imam Restiadi Tri Wahyu Suprayogi Veena Vasheene Vijaya Kumar Vensko Zico Dandi Wahyu Pratama Warsito, Sunaryo Hadi Wibawati, Prima Ayu Widjiati Widjiati, Widjiati Widodo, Oky Setyo Widya Paramita Lokapirnasari Wiwik Misaco Yuniarti Wiwik Misaco Yuniarti Wiwik Misaco Yuniarti Yudhana, Aditya Yulianti Mauludy Utami Yulianto, Rangga Yunita, Maya Nurwartanti Zahro, Vida Seanita