Garuda - Garba Rujukan Digital

p-Index From 2021 - 2026

4.269

P-Index

This Author published in this journals

All Journal Jurnal Ilmiah Farmasi The Journal of Experimental Life Sciences (JELS) Biotropika Pelita Perkebunan Folia Medica Indonesiana Jurnal Farmasi Klinik Indonesia Majalah Kulit, Karet, dan Plastik Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmacon Journal of Tropical Biodiversity and Biotechnology INDONESIAN JOURNAL OF PHARMACY Pharmascience Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Journal of Islamic Medicine JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Manuju : Malahayati Nursing Journal JFIOnline J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Jurnal Farmasi Higea Pharmacoscript An-Nadaa: Jurnal Kesehatan Masyarakat Pharma Xplore : Jurnal Sains dan Ilmu Farmasi ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Layanan Masyarakat (Journal of Public Service) Journal of Community Development Berkala Penelitian Hayati Pharmaceutical Sciences and Research (PSR) Agrimas : Jurnal Pengabdian Masyarakat Bidang Pertanian Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

Suharjono, Suharjono

Faculty Of Pharmacy, Universitas Airlangga

Author-ID : 389234

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

Published : 66 Documents Claim Missing Document

Claim Missing Document

Articles

1 2 3 4 5

IN VITRO ANTIBACTERIAL ACTIVITY OF CEFADROXIL CAPSULES CONSUMED BY PATIENTS IN THE HOSPITAL Mahfudz Mahfudz; Suharjono Suharjono; Isnaeni Isnaeni; Primadi Avianto
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 18, No 2 (2021)
Publisher : Sanata Dharma University

Clinical use of cefadroxil, particularly in Bangka Tengah Hospital, is proven beneficial to overcome mild to moderate infections which especially occur in soft tissues such as skin, upper respiratory tract, pharyngitis, tonsillitis and urinary tract. For this reason, it is necessary to procure cefadroxil to be available enough for the treatment of cases of these diseases. The cefadroxil used by the Central Bangka Hospital was obtained from several pharmaceutical industries with different prices and distributions, due to the possibility that the active raw materials and ingredients had different origins, so there was concern that the microbiological quality would be different. Drug procurement is carried out using the e-catalog or non-e catalog method. This study aimed to examine the microbiological quality of six preparations (A, B, C, D, E, and F) in terms of their inhibitory activities against Gram-positive and Gram-negative bacteria. The bioassay was carried out by diffusion agar method using Escherichia coli ATCC 29522 and Staphylococcus aureus ATCC 29523 as the bacterial test, and nutrient agar as the test medium. The inhibitory activities were compared to cefadroxil standard for measuring the ratio potency. The results showed that all samples fulfilled USP 41 requirements with potential ratio of 90% to 120% and minimum inhibitory concentration of ≤ 8 ppm and ≤ 2 ppm against Escherichia coli and Staphylococcus aureus respectively. The potency ratios to cefadroxil standard were 95.9%, 99.1%, 100.0%, 96.7%, 96.2% and 98.2% against Staphylococcus aureus while the potency ratios of 95.6%, 99.3%, 103.8%, 97.1%, 95.7% and 100.4% were achieved against Escherichia coli for A, B, C, D, E, and F samples, respectively.

HERBS USED AS ANALGESIC BY DAYAK TRIBE IN NORTH KALIMANTAN INDONESIA Irma Novrianti; Faizal Mustamin; Suharjono Suharjono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

Traditional medicines produced from medicinal plants have played an important role in disease treatment in Dayak Tribe, North Kalimantan. Northern Kalimantan belongs to a remote area where health facilities like healthcare center (puskesmas pusat kesehatan masyarakat) and hospital are not easily accessible. This research aims to investigate herbs used by Dayak tribe in North Kalimantan for treating pain. It is a descriptive research applying two research methods i.e. observation and interview. We directly observed the research object and proposed questions to respondents that were traditional healers from each village. The research was conducted in nine villages within three regencies in North Kalimantan. Meanwhile, 38 herbs collected in this research were from 26 families and 34 species. Four species were still locally named. The highest proportion of the herb family used was Asteraceae. The most frequently used part of the herb for medicine was the leaf (60.53%). The main serving methods were by boiling the herb and drinking it (63.15%). Bone pain and stomachache were two main illnesses mostly treated by local herb therapy involving 11 herbs. In conclusion, Dayak tribe in North Kalimantan still used herbs to treat their pain.

Analysis of Antiemetic Premedication Administration Timing on Nausea and Vomiting Incidence among Breast Cancer Patients Receiving Chemotherapy Mahardian Rahmadi; Indira D. Kharismawati; Heru Purwanto; Irvina Harini; Suharjono Suharjono; Chris Alderman
Indonesian Journal of Clinical Pharmacy Vol 9, No 4 (2020)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2020.9.4.298

The risk factors affecting chemotherapy-induced nausea and vomiting (CINV) includes antiemetic premedication time pattern, and this study investigates the capability of enhancing this in breast cancer patients receiving high emetogenic chemotherapy (HEC). Furthermore, this observational research was implemented at the oncology unit of Dr. Soetomo General Hospital Surabaya over a three-month period involving 69 female patients. The results showed unspecific antiemetic premedication timing in comparison to those with recommended timeframes, was connected with greater occurrence of both acute nausea in all cycles of chemotherapy (p<0.05), and acute vomiting in second and third cycles (p<0.05) but not in the first cycle (p=0.49). However, specific time administration of antiemetic treatment was linked with lower incidence of delayed nausea in all cycles (p<0.05), and less delayed vomiting in second and third cycles (p<0.05) but not in first cycle (p=0.10). These findings indicate specific time administration of antiemetic drugs causes significant advantages in mitigating CINV among breast cancer patients treated with emetogenic chemotherapy, and significantly lessened the occurrence of acute and delayed nausea and vomiting.Keywords: Antiemetic premedication timing, breast cancer, CINV, nausea and vomiting Analisis Waktu Pemberian Premedikasi Antiemetik terhadap Kejadian Mual Muntah pada Pasien Kanker Payudara yang Mendapatkan Kemoterapi AbstrakKemoterapi dapat menginduksi mual muntah (chemotherapy-induced nausea and vomiting, CINV) yang dipengaruhi oleh beberapa faktor. Salah satu faktornya adalah waktu pemberian premedikasi antiemetik yang dapat meningkatkan kejadian CINV pada pasien kanker payudara yang menerima kemoterapi. Studi ini menganalisis waktu pemberian premedikasi antiemetik terhadap kejadian mual dan muntah yang terjadi pada pasien kanker payudara yang mendapatkan kemoterapi dengan tingkat emetogenik yang tinggi. Penelitian ini merupakan penelitian observasional prospektif dilakukan di Poli Onkologi Satu Atap RSUD Dr. Soetomo Surabaya selama periode pengambilan data tiga bulan dan melibatkan 69 wanita kanker payudara yang mendapat kemoterapi dengan tingkat emetogenik yang tinggi. Pemberian premedikasi antiemetik dengan waktu yang tidak spesifik, meningkatkan kejadian mual akut pada semua siklus dengan p<0,05 dan pada kejadian muntah akut pada siklus kedua dan ketiga (p<0,05), namun tidak pada siklus pertama kemoterapi (p=0,49). Pemberian premedikasi antiemetik dengan waktu spesifik dapat menurunkan kejadian mual tertunda di siklus pertama hingga ketiga (p<0,05) dan pada kejadian muntah tertunda pada siklus kedua dan ketiga (p<0,05), namun tidak pada siklus pertama (p=0,10). Penelitian ini memberikan bukti bahwa premedikasi antiemetik yang diberikan dengan waktu spesifik memberikan manfaat dalam mengurangi kejadian CINV yang berpotensi pada pasien kanker payudara yang mendapatkan kemoterapi dengan tingkat emetogenik tinggi. Kata kunci: CINV, kanker payudara, mual dan muntah, waktu pemberian premedikasi antiemetik

Clinical Pharmacist’s Role in Optimizing Therapy through Drug-Related Problems Identification Liana Debora; Eni Susanti; Suharjono Suharjono
Indonesian Journal of Clinical Pharmacy Vol 10, No 4 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.4.303

Clinical pharmacists play an important role in a clinical setting as part of a team. Drug-related problem (DRP) is the main part pharmacist should focus on to achieve the optimal therapy for patients. Therefore, this study aimed to investigate the role of clinical pharmacy in a private hospital of West Java, Indonesia, and describe the prevalence of DRPs and several factors associated with the risk of DRPs. The clinical pharmacist's monthly report was obtained from June to August 2020. Furthermore, problems, causes, and types of DRP were identified using PCNE Classification V9.1. Drug classes and other factors related to DRP were also investigated. This was a descriptive study with a retrospective approach to medical records, where 240 DRPs were identified in 157 patients. Approximately 4.45% experienced DRP, especially in ICU at 45.83% and Stroke Unit or SU-IC at 25.42%. The most common DRPs were incomplete drug treatment, drug interaction, and dose adjustment. Antimicrobial, cardiovascular agents, and PPI were the most commonly involved. In the linear regression analysis, length of stay and number of therapy significantly affect DRP. In this study, pharmacists intervented each DRP, with 57% accepted as fully and partially implemented by the physicians. A total of 22% of interventions ended with unknown status due to limited follow-up time. Meanwhile, reviews on medication by clinical pharmacists lead to improvement in drug treatment. The implementation of clinical pharmacy services shows many DRPs to be prevented and increases therapy optimization.Keywords: Clinical pharmacist, drug-related problems, drugs, hospital, intervention Peran Farmasis Klinis dalam Optimalisasi Pengobatan melalui Identifikasi Permasalahan Obat AbstrakFarmasis klinik memiliki peran penting dalam tim di RS terutama dalam mencapai terapi optimal bagi pasien melalui penanganan drug related problems (DRP). Tujuan penelitian ini adalah untuk mengetahui peran farmasis klinik di salah satu RS swasta di Jawa Barat dan faktor risiko terjadinya DRP. Data dari laporan farmasi klinik diambil pada bulan Juni–Agustus 2020. Identifikasi permasalahan, penyebab, jenis DRP dilakukan berdasarkan PCNE Classification V9.1. Golongan obat dan faktor lain yang menyebabkan DRP juga dikaji. Studi ini berupa penelitian deskripsi dengan pendekatan retrospektif berdasarkan rekam medik pasien. Farmasis mengidentifikasi 240 DRP pada 157 pasien rawat inap. Sekitar 4,45% pasien di RS berpotensi mengalami DRP, terutama yang dirawat di ruang perawatan intensif (45,83%) dan unit strok (25,42%). DRP yang paling sering terjadi adalah terapi obat kurang tepat, interaksi obat, dan perlunya penyesuaian dosis. Antimikroba, obat kardiovaskular, dan PPI merupakan obat yang paling sering menyebabkan DRP. Pada analisis statistik menggunakan regresi linier, lama perawatan dan jumlah jenis obat signifikan menyebabkan DRP. Farmasis menyampaikan usulan kepada dokter (>70% kasus). Sebanyak 22% usul berakhir dengan status yang tidak diketahui karena kurangnya waktu untuk follow up usul kepada dokter. Tingkat penerimaan usul yaitu 57%, baik yang diterima sepenuhnya maupun diterima sebagian. Pengkajian pengobatan pasien mendorong beberapa perbaikan terapi obat. Penerapan layanan farmasi klinis dapat mendeteksi dan mencegah DRP sehingga mengoptimalkan pengobatan pasien. Kata kunci: Drug-related problems, farmasis klinik, intervensi, obat, rumah sakit

Effect of Attapulgite on the Oral Bioavailability of Ciprofloxacin Zamrotul Izzah; Veronica Gratia; Toetik Aryani; Suharjono Suharjono
Indonesian Journal of Clinical Pharmacy Vol 2, No 2 (2013)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.014 KB)

As a result, this drug-drug interaction may reduce ciprofloxacin bioavailability. This study was aimed to determine the effect of attapulgite on the bioavailability of a single orally-administered ciprofloxacin. Six New Zealand white rabbits received each of the following treatments in a randomized, three-way crossover sequence, separated by a 7-day washout period: (i) ciprofloxacin (23 mg/kgBW) alone; (ii) ciprofloxacin (23 mg/kgBW) given simultaneously with attapulgite (28 mg/kgBW); (iii) ciprofloxacin(23 mg/kgBW) given 2 hours after attapulgite (28 mg/kgBW). Blood samples (1 mL) were collected from the marginal ear vein up to 240 minutes postdose. The plasma concentrations of ciprofloxacin were determined by a validated high-performance liquid chromatography method. The maximum concentration and oral bioavailability (AUC0-240 min) of ciprofloxacin were significantly decreased by 49% and 32% when administered concomitantly with attapulgite (p<0.001). Attapulgite appeared to have no significant effect on the bioavailability of ciprofloxacin when administered 2 hours before ciprofloxacin. In conclusion, the oral bioavailability of ciprofloxacin is markedly reduced when administered concomitantly with attapulgite. This drug-drug interaction may decrease clinical efficacy and promote microbial resistance to ciprofloxacin. However, the interaction could be minimized by separating the adminsitration of these drugs at least 2 hours.Key words: Attapulgite, bioavailability, ciprofloxacin, drug-drug interactionPengaruh Atapulgit pada Ketersediaan Hayati Siprofloksasin OralKemampuan absorpsi atapulgit dapat menghambat absorpsi siprofloksasin pada pemberian per oral. Sebagai hasilnya, interaksi obat-obat ini dapat menurunkan ketersediaan hayati siprofloksasin. Penelitian ini bertujuan untuk mendeterminasi efek atapulgit pada ketersediaan hayati obat siprofloksasin yang diberikan secara oral. Sebanyak 7 kelinci putih Selandia Baru menerima perlakuan secara random dengan desain three-way crossover sequence, yang dipisahkan dengan periode washout 7 hari. (i) siprofloksasin (23 mg/kgBB); (ii) siprofloksasin (23 mg/kgBB) diberikan secara simultan dengan atapulgit (28 mg/kgBB); (iii) siprofloksasin (23 mg/kgBB) diberikan 2 jam setelah pemberian atapulgit (28 mg/kgBB. Sampel darah (1 mL) dikumpulkan pada marginal ear vein setelah 240 menit pemberian obat. Konsentrasi siprofloksasin plasma dihitung dengan metode kromatografi cair kinerja tinggi tervalidasi. Konsentrasi maksimum dan ketersediaan hayati oral (AUC0-240 min) siprofloksasin secara signifikan berkurang 49% dan 32% ketika dikombinasikan bersamaan dengan atapulgit (p< 0,001). Atapulgit tidak memiliki pengaruh signifikan pada ketersediaan hayati ketika diberikan 2 jam sebelum siprofloksasin. Ketersediaan hayati siprofloksasin berkurang secara signifikan ketika diberikan bersamaan dengan pemberian atapulgit. Interaksi obat dengan obat ini dapat mengurangi efikasi obat dan meningkatkan resistensi mikrob terhadap siprofloksasin. Namun, interaksi dapat dikurangi dengan pemberian obat pada jarak waktu minimal 2 jam.Kata kunci: Atapulgit, interaksi obat dengan obat, ketersediaan hayati, siprofloksasin

Effects of Probiotics and Vitamin B Supplementation on IFN-γ and IL-12 Levels During Intensive Phase Treatment of Tuberculosis Budi Suprapti; Suharjono Suharjono; Rahmawati Raising; Yulistiani Yulistiani; Zamrotul Izzah; Wenny Putri Nilamsari; Prastuti Asta Wulaningrum; Arief Bachtiar
Indonesian Journal of Pharmacy Vol 29 No 2, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Tuberculosis is an acute infectious disease that primarily affects the lungs. Probiotics supplementation can increase the number and activity of NK cell in peripheral blood by modulation of IL-12, thus increasing IFN-γ production by Th1 response. Vitamin B1 acts on macrophages and affects neutrophil motility. Vitamin B6 is associated with the release of cytokines and the responsiveness of NK cells, while vitamin B12 affects to lymphocytes, Tcell proliferation, CD4+ ratios, and NK cell activity. To analyze the effects of probiotics and vitamin B1, B6, B12 supplementation on IFN-γ and IL-12 levels during intensive phase of antituberculosis treatment. The study was pre-post test randomised control by time series. The control group was TB patients with standard therapy of antituberculosis and vitamin B6, while the intervention group was TB patients receiving therapy plus once daily probiotics and vitamin B1, B6, B12supplementation during the intensive phase. Blood samples were withdrawn at baseline, one month, and two months after therapy to measure plasma IFN-γ and IL-12 levels using the ELISA method. Twenty two patients were divided equally into two groups. There was a tendency to greater increase of IFN-γ in the first month of the intervention group, followed by a significant decline after two-month therapy (p < 0.05). In both groups there was a rise in IL-12 levels after one month followed by a decrease in the second month (p > 0.05). However, the percentage was higher in the supplementation group. Adding probiotics and vitamins B1, B6, B12 could improve immune response through IL-12 and IFN-γ modulation during intensive phase therapy.

Analysis of Antibiotics on Patients Surgery, before and after Used Guidelines for Antibiotics (PPAB) Lisa Narulita; Riefkah Bilal; Mohammad Akram; Suharjono Suharjono
Jurnal Pharmascience Vol 7, No 1 (2020): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8074

ABSTRAK Sejak tahun 2011 World Health Organisasi (WHO) dan Komite Pengedalian Resisten Antimikroba (KPRA) sejak 2015, untuk menetapkan kebijakan penggunaan antibiotik dengan menyusun formularium dan Pedoman Penggunaan Antibiotik (PPAB). Penggunaan antibiotik berlebihan berkontribusi pada resistensi maka penelitian ini bertujuan, menganalisis besarnya perbedaan penggunaan antibiotik pada pasien rawat inap bedah sebelum digunakan PPAB (Periode Mei 2018) dan setelah digunakan PPAB (Periode Mei 2019) dengan ATC / DDD (Defined Daily Dose). Jenis dan rancangan penelitian adalah deskriptif cross-sectional dengan data retrospektif. Data yang diambil meliputi peresepan antibiotik di ruang bedah. Data dianalisis dengan uji tanda (sign test) dan uji wilcoxon dengan hasil sign test yang bertanda negatif sebanyak 9 dan bertanda positif sebanyak 2 dan uji wilcoxon menyatakan Sig.(2-tailed 0,062) (α=0,05) artinya penggunaan antibiotik sebelum dan setelah digunakan PPAB tidak berbeda atau sama berdasarkan statistik. Tetapi dari persentasi penggunaan antibiotik terdapat 9 antibiotik yang penggunaannya menurun setelah digunakan PPAB seperti sefoperason 50%, seftriaxon 52%, sefuroxime 87%, sepirom 90%, siproflosasin 17%, gentamisin 99%, levofloxasin 60%, metronidazol 79% dan moxifloksasin 86%. Disimpulkan PPAB perlu ditingkatkan dalam penggunaan antibiotik di RSUD dr.H.Slamet Martodirdjo dan penggunaa seftriakson dapat meningkatkan multi drug resistant. Dengan demikian perlu adanya evaluasi dan monitoring dalam menerapkan PPAB. Kata kunci: ATC/DDD; Pasien Bedah; PPAB ABSTRACT Since 2011 the World Health Organization (WHO) and the National Antimicrobial Resistant Control Committee (KPRA) in indonesia since 2015, to establish antibiotic use policies by developing formularies and Antibiotic Use Guidelines (PPAB). Excessive use of antibiotics contributing to resistance, this study aims, analyzing the magnitude of differences in antibiotic use patients surgery before PPAB (May 2018 period) and after PPAB (May 2019 period) with ATC / DDD (Defined Daily Dose). Type and design of the study is descriptive cross-sectional with retrospective. Data taken included prescribing antibiotics. Data were analyzed by sign test and Wilcoxon test with 9 negative sign and 2 positive sign results and Wilcoxon test stated Sig. (2-tailed 0.062)> (α = 0.05), meaning that use of antibiotics before and after PPAB is not different or the same based on statistics. But from the percentage of antibiotic 9 decreased after PPAB, such as cefoperazone 50%, cefriaxone 52%, cefuroxime 87%, cefpirome 90%, ciprofloxacin 17%, gentamicin 99%, levofloxacin 60%, metronidazole 79% and moxifloxacin 86%. Concluded that PPAB needs to be improved in the use of antibiotics in RSUD dr.H. Islamet Martodirdjo and the use of ceftriaxone can increase multi drug resistant. Thus the need for evaluation and monitoring in implementing PPAB. Keywords: ATC/DDD; Surgical Patients; PPAB

Drug Utilization Study of Antibiotics in Bacterial Meningitis (A Retrospective Study in Dr. Soetomo General Hospital, Surabaya, Indonesia) Mareta Rindang Andarsari; Didik Hasmono; Samirah Samirah; Suharjono Suharjono; Dea Ayu Nabilah; Paulus Sugianto
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 4 No. 2 (2017): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Background: Meningitis defined as an inflammation of the meninges, a membrane that surrounds the brain. The inflammation is a result from bacterial infection. Central nervous system infection is a medical emergency because of the progressivity and potentially life-threatening. Antibiotics usage become crucial to reduce morbidity and mortality. Objective: This study was aimed to assess the use of antibiotics, prescribed for patients with bacterial meningitis in Neurology Department of Dr. Soetomo General Hospital Surabaya from January 2010 until June 2015. Methods: Retrospective study using medical record of inpatients obtained from January 1st 2010 until June 30th 2015. The inclusion criteria were inpatients with bacterial meningitis (diagnosed by physician using CT scan data, lumbal puncture and clinical signs and symptoms) and prescribed with antibiotics. Patients with antibiotics therapy less than 3 days and infection other than bacterials were excluded. Results: From 85 patients, male to female ratio was 1.66. Meningitis appear to be mostly occured in productive age, 39 (45.88%) in 15 - 29 years old and 40 (47.06%) in 30 - 60 years old. Number of antibiotics prescribed were 130 prescriptions, as single and combination therapy. The most prescribed antibiotic was cephalosporins (97 prescriptions), dominated by 2 g twice daily ceftriaxone with 86 (66.15%) from overall prescriptions. Followed by metronidazole and fluoroquinolons,11 (8.46%) and 8 (6.15%) respectively. In addition, there were 26 prescriptions of combination therapy, mostly ceftriaxone and metronidazole. Conclusion: Bacterial meningitis are mostly treated using ceftriaxone which is an appropriate drug of choice.

Pengaruh Lama Pemberian Fondaparinux terhadap Activated Partial Thromboplastin Time (APTT) pada Pasien Sindroma Koroner Akut Arina Dery Puspitasari; Suharjono Suharjono; Yogiarto Yogiarto
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 5 No. 2 (2018): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Pendahuluan: Fondaparinux 2,5 mg sebagai terapi antikoagulan pada pasien Sindroma Koroner Akut (SKA) di RSUD Dr. Soetomo Surabaya diberikan selama 5 hari, sedangkan pustaka menyebutkan bahwa fondaparinux diberikan selama 3 - 7 hari. Kadar steady-state dapat dicapai setelah 3 - 4 hari dan efek antikoagulan dari fondaparinux dapat bertahan selama 2 - 4 hari setelah terapi dihentikan pada pasien dengan fungsi ginjal normal. Diperlukan penelitian untuk mengetahui pengaruh lama pemberian fondaparinux 2,5 mg subcutan sekali sehari pada hari ke-3, 4, dan 5 terhadap Activated Partial Thromboplastin Time (APTT). Tujuan: Penelitian ini bertujuan untuk mengetahui apakah ada perbedaan pemberian fondaparinux terhadap nilai APTT pada penderita SKA. Metode: Sampel penelitian ini adalah seluruh pasien yang didiagnosis SKA yang diberikan terapi fondaparinux di RSUD Dr. Soetomo Surabaya. Jenis penelitian ini adalah observasional dengan rancang bangun prospektif kohort. Teknik pengambilan sampel dengan purposive sampling. Instrumen yang digunakan adalah rekam medis pasien dan hasil rekam pengukuran nilai APTT. Data demografi pasien dan nilai APTT dianalisis secara deskriptif dan One Way Anova digunakan untuk mengetahui perbedaan antara masing-masing kelompok terhadap lama pemberian fondaparinux terhadap APTT. Hasil: Penggunaan fondaparinux meningkatkan nilai rata-rata APTT dan mencapai target (25 - 40 detik) pada 9 orang pasien selama 3 hari (39,39 ± 8,02 detik), 4 hari (39,98 ± 12,15 detik), dan 5 hari (40,06 ± 6,21 detik). Tidak ada perbedaan bermakna antara APTT dengan lama pemberian fondaparinux 2,5 mg subcutan sekali sehari selama 3, 4, dan 5 hari (p > 0,05). Kesimpulan: Lama pemberian fondaparinux pada hari ke-3, 4, dan 5 tidak berbeda bermakna dalam meningkatkan nilai APTT.

Molecular Docking of Mangostin and Sinensetin Derivatives on SUR1-Pancreatic KATP Channel Target as Antidiabetic Intan Kris Prasetyanti; Sukardiman Sukardiman; Suharjono Suharjono
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 8 No. 3 (2021): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v8i32021.271-276

Background: Diabetes Mellitus (DM) is a complex chronic disease characterized by increased blood glucose. The incidence of this disease is rising, especially type 2 diabetes which is caused by insulin resistance in the body. SUR1-Pancreatic KATP Channel is a receptor as an antidiabetic target because its inhibition process can increase insulin production so that it can reduce blood glucose in people with type 2 diabetes. Objective: This study aims to identify the in-silico activity of the SUR1-Pancreatic KATP Channel macromolecules. Methods: Identification of macromolecular binding sites using Protein Plus software, then carried out molecular docking using AutoDock software, where the formed molecular interactions are further identified using the BIOVIA Discovery Studio software. Results: After determining the macromolecular binding site, the RMSD value was 1.253, allowing for further molecular docking. Molecular docking showed that the Ligands of mangostin (α, β, Î³-mangostin) and sinensetin derivatives had a good affinity, namely α-mangostin -6,31 kcal/mol; β-mangostin -5.78 kcal/mol; Î³-mangostin -6.17 kcal/mol and sinensetin -4.75 kcal/mol. Conclusion: The affinity sequence in the docking process for the SUR1 KATP channel macromolecules is α-mangostin > Î³-mangostin > β-mangostin > sinensetin. The highest affinity for the docking process on the macromolecule SUR1 KATP channel was α-mangostin with a value of Î”G -6.31 kcal/mol Ki 23.65 Î¼M.

Co-Authors A.A. Ketut Agung Cahyawan W Achmad Ridwan Achmad Ridwan, Achmad Agriawan Sudirman Ahmad Nasir ahmad, abraham Andri Geger Noviantoro Aprillia Wijaya, Stefani Ari Wibowo Arief Bachtiar Arina Dery Puspitasari Assiddiqy, Miftah Farid Atmajani, Wanudya Bagiyo, Harry Bagiyo, Harry Bagyo Yanuwiadi Bambang Eko Wahyono Bambang Sidharta Bambang Sudarmanto Budi Suprapti Budiatin, Aniek Setya Budiatin, Aniek Setya Chairunnisa Chairunnisa Chris Alderman Chrismawan A, Chrismawan A Chrismawan Ardianto Dea Ayu Nabilah Debora Shinta Liana Desiani, Ekanita Dewi Wara Shinta Didik Hasmono Dinda Monika Nusantara Ratri Diniah, Melisa Nur Djafar, Zaenab Dwiyatna, Surya Elvan Dwi Widyadi Emiliana Kasmudjiastuti Emy Sulistyo Astuti Endang Retnowati Eni Susanti Faizal Mustamin Fandyka Yufriza Ali Fasich Fasich Fransiska Maria Christianty Gratia, Veronica Hari Prasetyo Hasria Alang Heru Purwanto Hubby, Hubby I Gede Edy Sagitha I Ketut Mandikin Ilham Rizqy Isnain Imam Faozi Imam Susilo Indira D. Kharismawati Irfan Mustafa Irma Novrianti Irma Novrianti Irvina Harini Isnaeni Jaka Susila Jikrona, Rafi Joni Kusnadi Joni Wahyuhadi, Joni Jufri Ubrusun Junaidi Khotib Kenyo Alexandra Oktaviani Khaerani Khaerani Khusnul Fitri Hamidah Kusuma Arum Ningsih Kuwatno Kuwatno Lestiono, . Lestiono, . Lewi Tigor Simorangkir Lisa Narulita Lisa Narulita Liziyyannida Liziyyannida M. Yusuf Assegaf Mahardian R, Mahardian R Mahardian Rahmadi Mahfudz Mahfudz Makitalentu, Feybe Marcha Debby Saraswati Mareta Rindang Andarsari Medina, Farah Meita Rafika Fitriani Mohammad Akram Muhammad Aminuddin, Muhammad Muhammad Fathoni, Muhammad Mulja Hadi Santosa Narulita, Lisa Nasir, Ahmad Neldi, Vina Nia Kurniawan Nur Afni NUR CHAKIM Nurmainah Nurmainah Nurrofik, Agus Paulus Sugianto Prasetyanti, Intan Kris Prastuti Asta Wulaningrum Pratita, Dian Galuh Primadi Avianto Purwanto, Diyna Rusayliya Rahman, Gilang Mauladi Rahmawati Raising Ria Rositasati Riefkah Bilal risha fillah fithria Risthanti, Reine Risa Rosdiana, Eva Rudi Safarudin Rudi Wardana Rusdiana, Silvia Rusdiana, Silvia Safarudin, Rudi Sahayuna, Dara Demi Samirah Samirah Samirah Samirah, Samirah Sari, Erni A Semedi S J Shafira Muti Ardiana Shahroni, Abdul Mutholib Shofia Ummu, Lathifa Simorangkir, Lewi Tigor Sindy, Sulih Probo SJ, Semedi Solihin, Imron Sudirman, Agriawan Sukardiman Sumarno . Sumarno Sumarno Suryadi Suryadi Susilo, Dwi Hari Sutrisnaningsih, Evy Sari Suwardi Suwardi Toetik Aryani Tri Ardyati Umami, Zahra Veronica Gratia WENNY PUTRI NILAMSARI Widhiati Widhiati Widyadi, Elvan Dwi Wiwid Samsulhadi Wulan Panduwi Melasari Yance Anas yance yance Yen Yen Ari Indrawijaya YOGA DWI JATMIKO Yogiarto Yogiarto Yulia Ayu Purnamasari Yulistiani Yulistiani Yulistiani Yulistiani, Yulistiani Yulistiani, . Yuniati T Yuniati T Yuniati T, Yuniati Yusfar, Yunarti Yustiana Yustiana, Yustiana Zamrotul Izzah Zulfiana, Risa

Title

Found 66 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 66 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 66 Documents
Search