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All Journal Jurnal Ilmiah Farmasi The Journal of Experimental Life Sciences (JELS) Journal of Indonesian Tourism and Development Studies Biotropika Pelita Perkebunan Jurnal Pembangunan dan Alam Lestari Jurnal Farmasi Klinik Indonesia Majalah Kulit, Karet, dan Plastik Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmacon Journal of Tropical Biodiversity and Biotechnology INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Jurnal Biodjati Journal of Islamic Medicine JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Manuju : Malahayati Nursing Journal JFIOnline J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Jurnal Farmasi Higea Pharmacoscript An-Nadaa: Jurnal Kesehatan Masyarakat Pharma Xplore : Jurnal Sains dan Ilmu Farmasi ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Layanan Masyarakat (Journal of Public Service) Journal of Community Development Berkala Penelitian Hayati Jurnal Ilmiah Kesehatan (JIKA) Pharmaceutical Sciences and Research (PSR) Borneo Journal of Pharmacy Agrimas : Jurnal Pengabdian Masyarakat Bidang Pertanian Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Folia Medica Indonesiana Journal of Pharmascience
Suharjono, Suharjono
Faculty Of Pharmacy, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Peran Fomepizole dalam Penanganan Toksisitas Etilen Glikol dan Dietilen Glikol Simorangkir, Lewi Tigor; Suharjono, Suharjono
Journal of Islamic Pharmacy Vol 8, No 1 (2023): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v8i1.20790

Abstract

Etilen glikol dan Dietilen glikol merupakan alkohol yang bersifat toksik yang dapat meningkatkan mortalitas dan morbiditas. Pada tahun 1997 FDA menyetujui penggunaan fomepizole (4-methylpyrazole) sebagai tatalaksana toksisitas etilen glikol yang dapat di kombinasi dengan terapi hemodialisa. Fomepizole adalah inhibitor kompetitif alcohol dehydrogenase sama seperti etanol sehingga dapat menghambat pembentukan metabolit toksik dari etilen glikol. Fomepizole memiliki afinitas 8.000 kali lebih besar terhadap alcohol dehydrogenase dibandingkan etanol serta  farmakokinetik fomepizole dapat di prediksi dan efek samping lebih ringan. Pedoman saat ini dari beberapa literatur menyarankan terapi hemodialisa pada toksisitas etilen glikol jika konsentrasi serum etilen glikol dalam darah 50 mg/dL, asidosis berat, gagal ginjal, dan kadar asam glikolat 10 mmol/L. Sedangkan fomepizole dapat indikasikan jika konsentrasi plasma Etilen Glikol 20 mg/dL, riwayat penggunaan penggunaan etilen glikol dan dietilen glikol dengan osmolal GAP 10 mOsm/L atau kecurigaan penggunaan etilen glikol dan dietilen glikol dengan PH arteri 7,3, CO2 20 mmol/L dan osmolar GAP 10 mOsm/L 
Pemanfaatan Keong Mas Untuk Pupuk Organik Cair di Kelompok Tani Podo Tentrem Kecamatan Wuluhan Jember Suharjono, Suharjono; Asmono, Sepdian Luri; Wardana, Rudi
Journal of Community Development Vol. 3 No. 3 (2023): April
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v3i3.108

Abstract

The golden snail is one of the pests that damage rice plants, this pest has the ability to reproduce quickly, causing the golden snail to become one of the main pests in lowland rice. But the golden snail can be used as a basic material for liquid organic fertilizer (LOF) because it contains protein, Azotobacter, Azospirillum, phosphate solubilizing microbes, Pseudomonas, Staphylococcus, enzymes and the hormone auxin. The effectiveness of the golden snail LOF has been tested on several agricultural crops, one of which is rice. In the Podo Tentrem Farmers Group, these pests are simply thrown away and have not been utilized properly. Whereas the potential of this golden snail can be very high if it is processed into organic fertilizer. Therefore, with this community service activity, it is hoped that it can improve competence, skills and increase the production output of the Podo Tentrem farmer group. This can be measured by the enthusiasm of the participants who were attended by 100% of the invitees, besides that the participants also knew the stages of work and succeeded in making Keong Mas LOF well. In addition, other assessment indicators are using quantitative data on pre-test and post-test scores. Before the counseling was carried out, the pretest value was 50 and after the knowledge training, it increased with an average post-test score of 76. These results can indicate that in theory and practice, on average, participants understand and can make golden snail LOF.
REVIEW ARTIKEL: EFIKASI, KEAMANAN, DAN DURASI PENGGUNAAN ANTIPLATELET GOLONGAN P2Y12 INHIBITOR PADA PASIEN SINDROM KORONER AKUT Yustiana, Yustiana; Suharjono, Suharjono; Dwiyatna, Surya; Atmajani, Wanudya
Jurnal Farmasi Higea Vol 16, No 1 (2024)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v16i1.590

Abstract

Sindroma koroner akut (SKA), termasuk unstable angina (UA) dan infark miokard (IM) merupakan manifestasi penyakit jantung koroner. Penyakit jantung koroner merupakan penyebab kematian terbesar pada kasus kardiovaskular sehingga diperlukan penanganan dan terapi yang adekuat. Terapi antiplatelet merupakan terapi utama dalam manajemen penanganan sindroma koroner akut. Dual antiplatelet therapy (DAPT) adalah standar terapi da SKA. Antiplatelet golongan P2Y12 inhibitor merupakan salah satu komponen penting dalam DAPT. Adanya risiko perdarahan dan kejadian iskemia yang dapat terjadi selama terapi dengan P2Y12 inhibitor membuat pemilihan P2Y12 inhibitor menjadi suatu yang krusial. Pemilihan jenis obat dan durasi antiplatelet P2Y12 inhibitor tidak hanya mempertimbangkan efikasi, seperti MACE, tetapi juga perlu mempertimbangkan keamanan pasien, seperti kejadian, major bleeding, dan kejadian iskemia. Review artikel ini akan membahas terkait efikasi, keamanan, serta durasi dari penggunaan P2Y12 inhibitor pada pasien SKA berdasarkan bukti-bukti klinis.
Comparison of Soil Arthropod Diversity and Community Structure in Various Types of Land Cover in Malang Region, East Java, Indonesia Yanuwiadi, Bagyo; Suharjono, Suharjono; Kurniawan, Nia; Fathoni, Muhammad; Nurrofik, Agus; Assiddiqy, Miftah Farid; Shahroni, Abdul Mutholib
Journal of Tropical Biodiversity and Biotechnology Vol 8, No 3 (2023): December
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jtbb.79496

Abstract

Land cover heterogeneity can affect the structure of biodiversity in the supplied niche, so it is necessary to know the taxa community. This study aimed to understand the effect of land cover variation on the diversity and community structure of soil arthropods. The types of habitats used include urban areas, agroforestry, gardens, and natural forests which are determined in the Malang Region, East Java, Indonesia. Hand sorting and hay bait traps were applied in this study to obtain a variety of arthropod soils and the Berlese-Tullgren funnel was used to extract them. As a result, there are 25 families from 15 orders collected based on their ecological roles. The abundance of Philoscidae in sites S1 and S2 (urban green space), Talitridae in site S6 (agroforestry), and Isotomidae in sites S3, S4, and S5 (highland mixed forest) was highest and dominant. Site S7 has the highest diversity (H' = 2.56; 1-D = 0.90; J' = 0.76) even though its family richness is lower. The site S3 counter-site had relatively high taxa richness (TR = 13), but low diversity (H' = 1.02; 1-D = 0.39; J' = 0.16). Based on clustering analysis and NMDS ordination, 3 classifications of habitat types were obtained, namely I (S6 & S7), II (S3, S4 & S5), and III (S1 & S2). Mixed forest habitats contain a more complex diversity of soil arthropods, which can serve as a model for improving the fertility of disturbed ecosystems. 
Profil Pengetahuan Penyakit Kanker Dan Dampak Bahan Berbahaya Di Lingkungan Masyarakat Pengrajin Sandal Mahardian R, Mahardian R; Ratri, Dinda Monika Nusantara; Yusfar, Yunarti; Samirah, Samirah; Chrismawan A, Chrismawan A; Suharjono, Suharjono
An-Nadaa: Jurnal Kesehatan Masyarakat (e-Journal) Vol 10, No 2 (2023): AN-NADAA JURNAL KESEHATAN MASYARAKAT (DESEMBER)
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/ann.v10i2.9801

Abstract

Penelitian ini menunjukkan pemahaman dan sikap peserta sudah baik mengenai penyakit kanker, pencegahan kanker dan dampak cemaran bahan berbahaya yang mempengaruhi kesehatan. Namun, masih terdapat masyarakat yang menunjukkan  dari peserta perlu meningkatkan pengetahuan mereka tentang pola hidup sehat, pola hidup sehat untuk mencegah kanker dan dampak cemaran serta bahan – bahan yang mencemari lingkungan
Peran Vitamin D Terhadap Kanker: Sebuah Tinjauan Literatur Umami, Zahra; Suharjono, Suharjono
Journal of Islamic Medicine Vol 8, No 2 (2024): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2024
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v8i2.26058

Abstract

Vitamin D is a potent steroid hormone precursor that regulates a broad spectrum of physiological processes in the body. Besides its general role in bone metabolism, vitamin D plays an important role in the prevention and treatment of many diseases such as cancer. The aim of this literature review is to examine in more depth the role of vitamin D as an anticancer. There are studies that reveal biological mechanisms mediated by vitamin D in regulating cancer cells, such as cell renewal, cell proliferation, cell differentiation, cell transformation, and cell death. Other studies have also revealed a link between the immune system and the anti-neoplastic effects of vitamin D. Research shows that low levels of vitamin D in circulation are associated with an increased risk of cancer. The use of supplementation alone or in combination with immunotherapy or other chemotherapy may promote better clinical outcomes. These promising results still require further development and research through novel approaches targeting vitamin D signaling and metabolic systems to improve cancer therapeutic outcomes.
Analisis Penggunaan Antibiotika pada Pasien Penyakit Dalam di RSUD Dr. H. Slamet Martodirdjo Pamekasan dengan Metode ATC/DDD Ridwan, Achmad; Narulita, Lisa; Widyadi, Elvan Dwi; Suharjono, Suharjono
JSFK (Jurnal Sains Farmasi & Klinis) Vol 6 No 3 (2019): J Sains Farm Klin 6(3), Desember 2019
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.6.3.237-242.2019

Abstract

Resistensi antimikroba (AMR) merupakan masalah kesehatan yang mendunia. Resistensi tidak dapat dihilangkan namun dapat diperlambat dengan cara menggunakan antibiotika secara bijak. Salah satu cara yang dapat dilakukan untuk menanggulangi resistensi antimikroba dengan melakukan evaluasi penggunaan antibiotika baik secara kuantitatif maupun kualitatif. Tujuan penelitian ini adalah untuk mengetahui pola penggunaan antibiotika pada pasien ilmu  penyakit dalam RSUD Dr. H. Slamet Martodirdjo Pamekasan selama periode Januari-Maret 2019. Penelitian ini merupakan penelitian deskriptif-analitik (cross-sectional) dengan pengambilan data secara retrospektif serta jumlah sampel 482 pasien yang selanjutnya dianalisis menggunakan metode ATC dan DDD. Hasil penelitian menunjukkan nilai total DDD pemakaian antibiotika adalah 76,03/100 patient-days dengan total LOS pasien adalah 2270 hari. Penggunaan antibiotika tertinggi adalah ceftriaxone 37,56/100 patient-days, ciprofloxacin 25,78/100 patient-days, dan levofloxacin 6,05/100 patient-days. Golongan antibiotika yang masuk ke dalam segmen DU 90% yaitu ceftriaxone, ciprofloxacin, dan levofloxacin, sehingga harus dipantau penggunaannya karena berpotensi pada risiko resistensi. Kedepan perlu dilakukan penelitian lanjutan terkait evaluasi kualitas penggunaan antibiotika, serta dilakukan intervensi yang tepat untuk meningkatkan penggunaan antibiotika secara bijak dengan harapan dapat menekan angka resistensi antibiotika.
Review: Perbandingan antara Standard Half-Life (SHL) dan Extended Half-Life (EHL) Replacement Therapy berbasis Real-World Evidence (RWE) Sudirman, Agriawan; Suharjono, Suharjono; Nasir, Ahmad; Safarudin, Rudi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 No 3 (2022): J Sains Farm Klin 9(3), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.3.221-226.2022

Abstract

Hemophilia is a common hereditary coagulation blood disorder due to the deficiency activity of clotting factors. Hemophilia is divided into two, namely hemophilia A and hemophilia B. Among all treatments, standard half-life (SHL) and extended half-life (EHL) factor replacement products are the most commonly used. This study aimed to review real-world evidence on the comparison of SHL and EHL. A literature search was conducted in PubMed and google scholar published from 2017 to 2021. There were 10 articles that met the criteria. Based on the synthesis results, the total proportion of patients using EHL factor concentrates for both on‐demand and prophylactic factor replacement therapy increased. Recent evidence reveals that EHL may reduce the number of infusions, increase factor trough levels, and substantially decrease the annual bleeding rate. Efficacy-wise, EHLs unquestionably have better performances than SHLs; however, the EHL products seem to be too expensive to be utilized as the primary standard of care for hemophilia. However, the economic aspect of the replacement factor switching still required more in-depth studies.
Peningkatan Pemahaman Guru Biologi SMA Kota Malang tentang Evolusi Mikroba melalui Teknologi CRISPR dan Mekanisme Resistensi Antibiotik Jatmiko, Yoga Dwi; Suharjono, Suharjono; Ardyati, Tri; Mustafa, Irfan
J-Dinamika : Jurnal Pengabdian Masyarakat Vol 10 No 1 (2025): April
Publisher : Politeknik Negeri Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The implementation of Merdeka Curriculum in high school requires Biology teachers to face new challenges in teaching, especially the topic of microbial evolution. Microbes play an important role as a model in understanding the evolutionary process, including through CRISPR technology (genome editing). In addition, the mechanism of antibiotic resistance is also a clear example of evolution through genetic changes. However, limited access to information and facilities is an obstacle for teachers in developing appropriate learning modules. This service activity aims to improve the insight and competence of Biology teachers related to microbial evolution, through the introduction of CRISPR technology and antibiotic resistance, both in theory and practice. The training began with a pre-training survey on antibiotic use, material delivery and continued with antibiotic sensitivity test practice. Evaluation in the form of pretest and posttest was also given to participants who were categorized on a scale of understanding: very low, low, medium, high, and very high. The training participants had sufficient experience in the use of antibiotics before the training, but their understanding of antibiotics still varied. The pretest results obtained an understanding of 8.3% very low, 20.8% low, 33.3% medium, 33.3% high, and 4.2% very high. The posttest results showed a significant difference, with only two categories, 38.1% high and 61.9% very high. This result shows that the participants' understanding has increased by 28.4% with an average pretest score of 62 and posttest score of 87. In addition, participants were also able to conduct antibiotic sensitivity tests and how to interpret the data. The participants' response was very positive, with a satisfaction index score between 94-97 which is classified as very good. The theory and practice obtained are expected to increase teacher innovation in learning for students to understand microbial evolution.
Isolation and Identification of Rhizosphere Bacteria Associated with Taro (Colocasia esculenta L. Schott) as Plant Growth Promoting Rhizobacteria Makitalentu, Feybe; Mustafa, Irfan; Suharjono, Suharjono
The Journal of Experimental Life Science Vol. 12 No. 2 (2022)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2022.012.02.01

Abstract

Taro is one of the food crops that has the potential to maintain food security. It has a high carbohydrate content and nutrients with a low glycemic index value. Taro is widely cultivated with intercropping techniques, especially in Kedungkandang District, Malang City. However, this technique caused a decrease in talas tubers production with only 7-10 tons ha-1. This number was lower than the total optimal production with 20.7 tons ha-1 of taro tubers. Plant Growth Promoting Rhizobacteria (PGPR), one of the most potential biofertilizers, can solve this problem with abilities such as phosphate-solubilizing, production of IAA, and nitrogen fixation. This research aimed to analyze the potency and identify the species of taro rhizosphere bacteria that had the best ability as PGPR agents. Taro rhizosphere bacteria were isolated using Pikovskaya medium and TSA (Tryptic Soy Agar) respectively. The PGPR abilities were evaluated on the phosphate-solubilizing, production of IAA, and nitrogen fixation. A total of 12 isolates for phosphate-solubilizing bacteria and ten isolates of IAA-producing bacteria. The highest concentration of phosphate solubilization was P1 isolate, with the concentration of 6.8 μg.mL-1; while I4 isolate had the highest potency for IAA production with the concentration of 23.11 μg.mL-1. Isolates P1 and I4 were selected for the nitrogen fixation ability test. P1 isolate shows the highest ammonia concentration of 2.52 μg.mL-1, and it was identified as Stenotrophomonas rhizophila with a similarity of 99.91% with Stenotrophomonas rhizophila R2A2 67. The potential isolates can be used as PGPR agents or biofertilizers to increase the production of taro plants.      Keywords: Colocasia esculenta, IAA, Nitrogen, PGPR, Phosphate.
Co-Authors A.A. Ketut Agung Cahyawan W Achmad Ridwan Achmad Ridwan, Achmad Agriawan Sudirman Ahmad Nasir ahmad, abraham Aliviyanti, Dian Andri Geger Noviantoro Anita Purnamayanti Aprillia Wijaya, Stefani Arfani, Nurfitri Ari Wibowo Arief Bachtiar Arina Dery Puspitasari Assiddiqy, Miftah Farid Bagiyo, Harry Bagiyo, Harry Bagyo Yanuwiadi Bambang Eko Wahyono Bambang Sidharta Bambang Sudarmanto Budi Suprapti Budiatin, Aniek Setya Budiatin, Aniek Setya Catur Retnaningdyah Chairunnisa Chairunnisa Chris Alderman Chrismawan A, Chrismawan A Chrismawan Ardianto Dea Ayu Nabilah Debora Shinta Liana Dewi Wara Shinta Didik Hasmono Dinda Monika Nusantara Ratri Diniah, Melisa Nur Djafar, Zaenab Dliyauddin, Moh Dwiyatna, Surya Ekanita Desiani Elvan Dwi Widyadi Emiliana Kasmudjiastuti Emy Sulistyo Astuti Endang Arisoesilaningsih Endang Retnowati Eni Susanti Faizah, Mamluatul Faizal Mustamin Fandyka Yufriza Ali Fasich Fasich Fransiska Maria Christianty Gratia, Veronica Hari Prasetyo Hasria Alang Heru Purwanto Hubby, Hubby I Gede Edy Sagitha I Ketut Mandikin Ilham Rizqy Isnain Imam Faozi Imam Susilo Indira D. Kharismawati Irfan Mustafa Irma Novrianti Irma Novrianti Irvina Harini Isnaeni Jaka Susila Jikrona, Rafi Joni Kusnadi Joni Wahyuhadi, Joni Jufri Ubrusun Junaidi Khotib Kenyo Alexandra Oktaviani Khaerani Khaerani Khusnul Fitri Hamidah Kusuma Arum Ningsih Kuwatno Kuwatno Lestiono, . Lestiono, . Lewi Tigor Simorangkir Lisa Narulita Lisa Narulita Liziyyannida Liziyyannida M. Yusuf Assegaf Mahardian R, Mahardian R Mahardian Rahmadi Mahfudz Mahfudz Makitalentu, Feybe Marcha Debby Saraswati Mareta Rindang Andarsari Masyrobatin, Masyrobatin Medina, Farah Meita Rafika Fitriani Melasari, Wulan Panduwi Mohammad Akram Muhammad Aminuddin, Muhammad Muhammad Fathoni, Muhammad Mulja Hadi Santosa Narulita, Lisa Nasir, Ahmad Neldi, Vina Nia Kurniawan Nur Afni NUR CHAKIM Nur ‘Azah Nurmainah Nurmainah Nurrofik, Agus Octaviany, Evi Paramita, Angggun Putri Paulus Sugianto Prasetyanti, Intan Kris Prastuti Asta Wulaningrum Pratita, Dian Galuh Pratiwi, Esti Rizkiana Primadi Avianto Purwanto, Diyna Rusayliya Rahman, Gilang Mauladi Rahmawati Raising Ria Rositasati Riefkah Bilal risha fillah fithria Risthanti, Reine Risa Rodiyati Azrianingsih Rosdiana, Eva Rudi Safarudin Rudi Wardana Rusdiana, Silvia Rusdiana, Silvia Safarudin, Rudi Sahayuna, Dara Demi Samirah Samirah Samirah Samirah, Samirah Samsulhadi, Wiwid Sanita Suriani Sari, Erni A Semedi S J Shafira Muti Ardiana Shahroni, Abdul Mutholib Shofia Ummu, Lathifa Simorangkir, Lewi Tigor Sindy, Sulih Probo Sinuraya, Sabarita SJ, Semedi Soemarno Soemarno Solihin, Imron Sudirman, Agriawan Sukardiman Sumarno . Sumarno Sumarno Suryadi Suryadi Susilo, Dwi Hari Sutrisnaningsih, Evy Sari Suwardi Suwardi Toetik Aryani Tri Ardyati Umami, Zahra Veronica Gratia Wanudya Atmajani WENNY PUTRI NILAMSARI Widhiati Widhiati Widyadi, Elvan Dwi Wiwid Samsulhadi Wulan Panduwi Melasari Yance Anas yance yance Yen Yen Ari Indrawijaya YOGA DWI JATMIKO Yogiarto Yogiarto Yulia Ayu Purnamasari Yulistiani Yulistiani Yulistiani Yulistiani, Yulistiani Yulistiani, . Yuniati T Yuniati T Yuniati T, Yuniati Yusfar, Yunarti Yustiana Yustiana, Yustiana Zamrotul Izzah Zulfiana, Risa