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All Journal Jurnal Ilmiah Farmasi The Journal of Experimental Life Sciences (JELS) Journal of Indonesian Tourism and Development Studies Biotropika Pelita Perkebunan Jurnal Pembangunan dan Alam Lestari Jurnal Farmasi Klinik Indonesia Majalah Kulit, Karet, dan Plastik Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmacon Journal of Tropical Biodiversity and Biotechnology INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Journal of Islamic Medicine JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Manuju : Malahayati Nursing Journal JFIOnline J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Jurnal Farmasi Higea Pharmacoscript Jurnal Ners An-Nadaa: Jurnal Kesehatan Masyarakat Pharma Xplore : Jurnal Sains dan Ilmu Farmasi ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Layanan Masyarakat (Journal of Public Service) Berkala Penelitian Hayati Jurnal Ilmiah Kesehatan (JIKA) Pharmaceutical Sciences and Research (PSR) Journal of Public Health and Pharmacy Borneo Journal of Pharmacy Agrimas : Jurnal Pengabdian Masyarakat Bidang Pertanian Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Folia Medica Indonesiana Journal of Pharmascience
Suharjono
Departemen Farmasi Klinik, Fakultas Farmasi, Universitas Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Control & Systems Engineering Decision Sciences, Operations Research & Management Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Analisis Penggunaan Antibiotik Pada Pasien Bedah Umum dengan Metode ATC/DDD di RSAU Efram Harsana Lanud Iswahyudi Maospati Dara Demi Sahayuna; Sulih Probo Sindy; Imron Solihin; Suharjono Suharjono
Journal of Pharmascience Vol. 11 No. 1 (2024): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i1.8914

Abstract

Penggunaan antimikoba pada pasien bedah umum pasca operasi digunakan untuk mencegah terjadinya infeksi luka operasi. Namun pada penggunaan antimikroba yang tidak bijak dapat menyebabkan terjadinya resistensi antibiotik. Jika sudah terjadi resistensi antibiotik hal tersebut dapat menyulitkan terapi. Oleh karena itu, perlu dilakukannya pengendalian penggunaan antibiotik dengan cara penggunaan yang rasional / bijak. Pencegahan terjadinya resistensi antimikroba dapat dilakukan dengan menyesuaikan pemberian antibiotik pada pedoman terapi serta dapat dilakukan evaluasi secara kuantitatif maupun kualitatif secara berkala. Tujuan penelitian ini adalah untuk mengetahui nilai DDD dari antibiotik di RSAU Efram Harsana Lanud Iswahyudi. Penelitian ini merupakan penelitian deskriptif-analitik dengan desain cross sectional dengan pengambilan data secara retrospektif pada pasien bedah umum RSAU Efram Harsana Iswahjudi selama peridoe Juli-September 2019. Dari laporan rekam medis peresepan antibiotik sebanyak 401 dari 339 rekam medis diperoleh hasil dengan pemakaian jenis antimikroba tertinggi  golongan sefalosporin ceftriaxon 15,909/100 pasien-hari dan pemakaian jenis antimikroba terendah yaitu ceftazidim 0,098/100 pasien-hari.  Kata Kunci: Pasien Bedah Umum, Antibiotik, ATC/DDD, Resistensi Antimikroba, DDD/100. The use of antimicrobials in postoperative general surgery patients is used to prevent wound infection. However, the use of antimicrobials that are not wise can cause antibiotic resistance. If antibiotic resistance has occurred this can complicate therapy. Therefore, it is necessary to control the use of antibiotics by means of rational use. Prevention of antimicrobial resistance can be done by adjusting the administration of antibiotics in the therapeutic guidelines and periodic quantitative and qualitative evaluations can be done. This study aims to determine the DDD value of antibiotics in general surgery patients at Efram Harsana Hospital Iswahjudi Lanud. This research is a type of descriptive study with a retrospective cross sectional design using ATC / DDD analysis. Data obtained from the medical records of general inpatients in Efram Harsana Hospital peridoe July-September 2019. From the medical record report prescribing antibiotics as many as 401 out of 339 medical records obtained results with the use of the highest type of antimicrobial cephalosporin ceftriaxon 15,909 DDD / 100 days of treatment and 100 days of treatment and obtained the results of the use of the highest antimicrobial type cephalosporin ceftriaxon 15,909 DDD / 100 days of hospitalization and The lowest use of antimicrobial types was ceftazidim 0.098 DDD / 100 days of hospitalization.
Kajian Literatur: Terapi Cairan Pada Sepsis Diyna Rusayliya Purwanto; Suharjono Suharjono; Nurmainah Nurmainah
Journal of Pharmascience Vol. 12 No. 1 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i1.20168

Abstract

Sepsis merupakan kondisi yang mengancam jiwa dan perlu penanganan tepat waktu untuk mengurangi angka kematian. Terapi cairan merupakan salah satu landasan manajemen sepsis. Terapi cairan atau resusitasi bertujuan untuk memperbaiki kekurangan volume darah untuk memastikan curah jantung dan perfusi darah organ normal serta untuk melindungi fungsi organ. Namun, panduan terapi cairan yang benar dan optimal pada pasien dengan sepsis masih menjadi masalah yang sulit karena tanda-tanda klinis dari respon cairan yang sulit, terutama pada pasien anak. Tinjauan naratif ini bertujuan untuk memberikan gambaran mengenai pemilihan jenis terapi cairan pada pasien sepsis. Jenis terapi cairan yang sering digunakan pada pasien sepsis adalah kristaloid dan koloid. Balanced kristaloid direkomendasikan sebagai cairan resusitasi lini pertama pada pasien dengan sepsis karena murah, tersedia secara luas, dan menyebabkan lebih sedikit efek samping serius. Namun, pertimbangan dalam memilih jenis terapi cairan pada sepsis lebih disarankan agar dilakukan pendekatan secara individu, menyesuaikan dengan kondisi klinis pasien sepsis.
Optimization of ADMET Properties Prediction for Remdesivir, Favipiravir, and their Metabolites Elimination Profiles Anita Purnamayanti; Suharjono Suharjono; Mahardian Rahmadi
Borneo Journal of Pharmacy Vol. 9 No. 1 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i1.8464

Abstract

In silico methods have become crucial for the rapid preliminary assessment of drug compound absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties, particularly for vital antivirals such as remdesivir and favipiravir, early in the drug development process. This study aimed to predict the pharmacokinetic profiles of remdesivir, favipiravir, and their respective metabolites, explicitly focusing on their interactions within the unique anatomy and physiology of human elimination organs. Compound summaries from PubChem were computationally analyzed using the pkCSM, ProTox-II, and ADMETLab 3.0 platforms. These predictions were then critically evaluated in the context of established hepatic and renal elimination mechanisms. Favipiravir and its metabolites generally exhibited a favorable ADMET profile, characterized by good oral absorption, wide distribution, efficient metabolism, and rapid excretion, albeit with a slight potential for blood-brain barrier penetration. In contrast, remdesivir, its nucleotide metabolite, and favipiravir showed the highest predicted likelihood of inducing hepatotoxicity. Concerning renal toxicity, remdesivir, remdesivir monophosphate, and the active triphosphate forms of both remdesivir and favipiravir presented a notable risk. This elevated renal risk was primarily attributed to their predicted low renal clearances, potentially resulting from insufficient penetration across the negatively charged glomerular filtration barrier. In conclusion, favipiravir and its metabolites demonstrated a more desirable ADMET profile than remdesivir. These preliminary findings suggest a differential safety and pharmacokinetic landscape between the two antiviral agents. Future research should prioritize leveraging advanced AI-based ADMET platforms to simulate complex human organ functions more accurately, refining these predictive models, and guiding subsequent in vivo investigations.
Knowledge, Attitudes, and Practices: Preventing Delayed CINV with Antiemetics Ratih Pratiwi Sari; Muhammad Darwin Prenggono; Aditya Maulana Perdana Putra; Mahardian Rahmadi; Suharjono Suharjono
Journal of Public Health and Pharmacy Vol. 6 No. 2 (2026)
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v6i2.7527

Abstract

Introduction: Chemotherapy-induced nausea and vomiting (CINV) is the most feared side effect by cancer patients. To prevent and minimize the occurrence of delayed CINV, patients are given post-chemotherapy antiemetics. Adequate patient knowledge is essential for promoting awareness of CINV and the appropriate use of post-chemotherapy antiemetics. This study examines the knowledge, attitudes, and practice of cancer patients towards the occurrence of delayed CINV and the use of post-chemotherapy antiemetics. Methods: Descriptive cross-sectional study conducted in the chemotherapy room at Hospital X, South Kalimantan, Indonesia. The study was conducted in September-November 2024. Face-to-face interviews guided by a structured questionnaire were conducted on 114 cancer patients. Results: The study revealed that patient knowledge regarding the side effects of CINV and the use of post-chemotherapy antiemetics was generally limited. Specifically, 49 respondents (43%) demonstrated a basic level of knowledge, 35 respondents (30.7%) showed sufficient knowledge, and 30 respondents (26.3%) exhibited good knowledge. Patients with higher education levels demonstrated significantly higher scores in both the attitude domain (3.31 ± 1.277) and the practice domain (3.75 ± 1.223). Conclusion: Healthcare professionals play a crucial role in educating patients on the appropriate use of antiemetic medications. Effective education aims to enhance chemotherapy patients' knowledge, attitudes, and practices regarding the use of post-chemotherapy antiemetics.
Drug–Drug Interactions and Phenytoin Therapeutic Response: A Systematic Literature Review Suharjono Suharjono; Imamatus Shaleha; Findari Megantari; Lenny Octaviana; Putra Adi Purnama
Jurnal Ners Vol. 10 No. 3 (2026): JULI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i3.59845

Abstract

Phenytoin is an antiepileptic drug with a narrow therapeutic window that is susceptible to drug interactions and other non-genetic factors, causing significant variability in therapeutic response among epilepsy patients. This systematic review aims to examine types of drug interactions affecting pharmacokinetics and pharmacodynamics of phenytoin, analyze their impact on therapeutic effectiveness and toxicity, and present the role of non-genetic factors in response variability as a basis for individualized therapy. Literature search was conducted using PRISMA framework across PubMed, Scopus, Web of Science, Science Direct, and Cochrane Library databases from 2015-2024, yielding 10 articles meeting inclusion criteria. Review findings indicated that 66 percent of patients experienced drug interactions with pharmacokinetic predominance reaching 81.4 percent, involving omeprazole, amlodipine, and aspirin as the most frequently interacting agents. Polytherapy doubled the risk of poor seizure control, while therapy duration exceeding one year correlated with executive function impairment. Interactions with herbal products such as noni reduced plasma levels to subtherapeutic ranges. Non-genetic factors, particularly drug interactions, contribute substantially to phenytoin response variability, making individualized therapy based on therapeutic drug monitoring and comprehensive evaluation of patient medication profiles essential for optimizing therapy safety and effectiveness
Co-Authors A.A. Ketut Agung Cahyawan W Achmad Ridwan Achmad Ridwan, Achmad Aditya Maulana Perdana Putra Agriawan Sudirman Agriawan Sudirman Ahmad Nasir ahmad, abraham Aliviyanti, Dian Andri Geger Noviantoro Anita Purnamayanti Aprillia Wijaya, Stefani Arfani, Nurfitri Ari Wibowo Arief Bachtiar Arina Dery Puspitasari Assiddiqy, Miftah Farid Bagiyo, Harry Bagiyo, Harry Bagyo Yanuwiadi Bambang Eko Wahyono Bambang Sidharta Bambang Sudarmanto Budi Suprapti Budiatin, Aniek Setya Budiatin, Aniek Setya Catur Retnaningdyah Chairunnisa Chairunnisa Chris Alderman Chrismawan A, Chrismawan A Chrismawan Ardianto Dara Demi Sahayuna Dea Ayu Nabilah Debora Shinta Liana Dewi Wara Shinta Didik Hasmono Dinda Monika Nusantara Ratri Diniah, Melisa Nur Diyna Rusayliya Purwanto Djafar, Zaenab Dliyauddin, Moh Dwiyatna, Surya Ekanita Desiani Elvan Dwi Widyadi Emiliana Kasmudjiastuti Emy Sulistyo Astuti Endang Arisoesilaningsih Endang Retnowati Eni Susanti Faizah, Mamluatul Faizal Mustamin Fandyka Yufriza Ali Fasich Fasich Findari Megantari Fransiska Maria Christianty Gratia, Veronica Hari Prasetyo Hasria Alang Heru Purwanto Hubby, Hubby I Gede Edy Sagitha I Ketut Mandikin Ilham Rizqy Isnain Imam Faozi Imam Susilo Imamatus Shaleha Imron Solihin Indira D. Kharismawati Irfan Mustafa Irma Novrianti Irma Novrianti Irvina Harini Isnaeni Jaka Susila Jikrona, Rafi Joni Kusnadi Joni Wahyuhadi, Joni Jufri Ubrusun Junaidi Khotib Kenyo Alexandra Oktaviani Khaerani Khaerani Khusnul Fitri Hamidah Kusuma Arum Ningsih Kuwatno Kuwatno Lenny Octaviana Lestiono, . Lestiono, . Lewi Tigor Simorangkir Lisa Narulita Lisa Narulita Liziyyannida Liziyyannida M. Yusuf Assegaf Mahardian R, Mahardian R Mahardian Rahmadi Mahfudz Mahfudz Makitalentu, Feybe Marcha Debby Saraswati Mareta Rindang Andarsari Masyrobatin, Masyrobatin Medina, Farah Meita Rafika Fitriani Melasari, Wulan Panduwi Mohammad Akram Muhammad Aminuddin, Muhammad Muhammad Darwin Prenggono Muhammad Fathoni, Muhammad Mulja Hadi Santosa Narulita, Lisa Nasir, Ahmad Neldi, Vina Nia Kurniawan Nur Afni NUR CHAKIM Nur ‘Azah Nurmainah Nurmainah Nurmainah Nurmainah Nurrofik, Agus Paramita, Angggun Putri Paulus Sugianto Prasetyanti, Intan Kris Prastuti Asta Wulaningrum Pratita, Dian Galuh Pratiwi, Esti Rizkiana Primadi Avianto Purwanto, Diyna Rusayliya Putra Adi Purnama Rahman, Gilang Mauladi Rahmawati Raising Ria Rositasati Riefkah Bilal risha fillah fithria Risthanti, Reine Risa Rodiyati Azrianingsih Rosdiana, Eva Rudi Safarudin Rusdiana, Silvia Rusdiana, Silvia Safarudin, Rudi Sahayuna, Dara Demi Samirah Samirah, Samirah Samsulhadi, Wiwid Sanita Suriani Sari, Erni A Sari, Ratih Pratiwi Semedi S J Shafira Muti Ardiana Shahroni, Abdul Mutholib Shofia Ummu, Lathifa Simorangkir, Lewi Tigor Sindy, Sulih Probo Sinuraya, Sabarita SJ, Semedi Soemarno Soemarno Solihin, Imron Sukardiman Sulih Probo Sindy Sumarno . Sumarno Sumarno Suryadi Suryadi Susilo, Dwi Hari Sutrisnaningsih, Evy Sari Suwardi Suwardi Toetik Aryani Tri Ardyati Umami, Zahra Veronica Gratia Wanudya Atmajani WENNY PUTRI NILAMSARI, WENNY PUTRI Widhiati Widhiati Widyadi, Elvan Dwi Wiwid Samsulhadi Wulan Panduwi Melasari Yance Anas yance yance Yen Yen Ari Indrawijaya YOGA DWI JATMIKO Yogiarto Yogiarto Yulia Ayu Purnamasari Yulistiani Yulistiani Yulistiani Yulistiani, Yulistiani Yulistiani, . Yuniati T Yuniati T Yuniati T, Yuniati Yusfar, Yunarti Yustiana Yustiana, Yustiana Zamrotul Izzah Zulfiana, Risa