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All Journal Jurnal Ilmiah Farmasi The Journal of Experimental Life Sciences (JELS) Journal of Indonesian Tourism and Development Studies Biotropika Pelita Perkebunan Jurnal Pembangunan dan Alam Lestari Jurnal Farmasi Klinik Indonesia Majalah Kulit, Karet, dan Plastik Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmacon Journal of Tropical Biodiversity and Biotechnology INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Jurnal Biodjati Journal of Islamic Medicine JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Manuju : Malahayati Nursing Journal JFIOnline J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Jurnal Farmasi Higea Pharmacoscript An-Nadaa: Jurnal Kesehatan Masyarakat Pharma Xplore : Jurnal Sains dan Ilmu Farmasi ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Layanan Masyarakat (Journal of Public Service) Journal of Community Development Berkala Penelitian Hayati Jurnal Ilmiah Kesehatan (JIKA) Pharmaceutical Sciences and Research (PSR) Borneo Journal of Pharmacy Agrimas : Jurnal Pengabdian Masyarakat Bidang Pertanian Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Folia Medica Indonesiana Journal of Pharmascience
Suharjono, Suharjono
Faculty Of Pharmacy, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Isolation and Identification of Indigenous Cellulolytic Bacteria from Sago Pith Waste at Palopo, South Sulawesi, Indonesia Faizah, Mamluatul; Ardyati, Tri; Suharjono, Suharjono
The Journal of Experimental Life Science Vol. 10 No. 2 (2020)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2020.010.02.09

Abstract

Palopo, South Sulawesi, is one of the traditional industrial centers of sago processing. The accumulation of sago pith waste around industrial sites can pollute the environment. Some microorganisms can degrade the cellulose in sago pith waste. This study was aimed to evaluate the indigenous cellulolytic bacteria from sago pith waste as a biodegradation agent. Bacteria were isolated from sago pith waste and grown on a 1% Carboxyl methyl cellulose (CMC) agar medium. The cellulolytic activity was analyzed semiquantitatively using 1% Congo red and quantitatively using the 3,5-Dinitrosalicylic Acid (DNS) method at pH variations of 4, 5, and 6. The potential isolate was identified based on 16S rDNA sequence similarity. This study obtained 21 bacterial isolates where six isolates were A1D, A1E, A1I, A1K, A2A, and B1A had the highest cellulolytic index at 0.82 - 1.13. Among those six isolates, the A1E isolate had the highest cellulolytic activity, 0.54 U.mL-1 at pH 6. The isolate A1E was identified as Burkholderia cepacia JCM 2799 with 99.73% similarity of 16S rDNA sequence. Keywords: Burkholderia cepacia, cellulolytic bacteria, cellulase enzyme, sago waste.
Optimization of ADMET Properties Prediction for Remdesivir, Favipiravir, and their Metabolites Elimination Profiles Purnamayanti, Anita; Suharjono, Suharjono; Rahmadi, Mahardian
Borneo Journal of Pharmacy Vol. 9 No. 1 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i1.8464

Abstract

In silico methods have become crucial for the rapid preliminary assessment of drug compound absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties, particularly for vital antivirals such as remdesivir and favipiravir, early in the drug development process. This study aimed to predict the pharmacokinetic profiles of remdesivir, favipiravir, and their respective metabolites, explicitly focusing on their interactions within the unique anatomy and physiology of human elimination organs. Compound summaries from PubChem were computationally analyzed using the pkCSM, ProTox-II, and ADMETLab 3.0 platforms. These predictions were then critically evaluated in the context of established hepatic and renal elimination mechanisms. Favipiravir and its metabolites generally exhibited a favorable ADMET profile, characterized by good oral absorption, wide distribution, efficient metabolism, and rapid excretion, albeit with a slight potential for blood-brain barrier penetration. In contrast, remdesivir, its nucleotide metabolite, and favipiravir showed the highest predicted likelihood of inducing hepatotoxicity. Concerning renal toxicity, remdesivir, remdesivir monophosphate, and the active triphosphate forms of both remdesivir and favipiravir presented a notable risk. This elevated renal risk was primarily attributed to their predicted low renal clearances, potentially resulting from insufficient penetration across the negatively charged glomerular filtration barrier. In conclusion, favipiravir and its metabolites demonstrated a more desirable ADMET profile than remdesivir. These preliminary findings suggest a differential safety and pharmacokinetic landscape between the two antiviral agents. Future research should prioritize leveraging advanced AI-based ADMET platforms to simulate complex human organ functions more accurately, refining these predictive models, and guiding subsequent in vivo investigations.
Analysis of Antibiotics on Patients Surgery, before and after Used Guidelines for Antibiotics (PPAB) Lisa Narulita; Riefkah Bilal; Mohammad Akram; Suharjono Suharjono
Journal of Pharmascience Vol. 7 No. 1 (2020): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8074

Abstract

ABSTRAK Sejak    tahun    2011    World   Health    Organisasi   (WHO)   dan    Komite Pengedalian Resisten Antimikroba  (KPRA) sejak 2015, untuk  menetapkan kebijakan penggunaan antibiotik  dengan menyusun formularium dan  Pedoman Penggunaan Antibiotik (PPAB). Penggunaan antibiotik  berlebihan berkontribusi pada resistensi maka  penelitian ini bertujuan, menganalisis besarnya perbedaan penggunaan antibiotik  pada pasien rawat  inap bedah sebelum digunakan PPAB (Periode  Mei 2018)  dan  setelah  digunakan  PPAB (Periode  Mei 2019)  dengan ATC  / DDD (Defined   Daily  Dose).  Jenis  dan   rancangan  penelitian  adalah deskriptif cross-sectional dengan data retrospektif. Data  yang  diambil  meliputi peresepan antibiotik  di ruang  bedah. Data dianalisis dengan uji tanda (sign test) dan  uji wilcoxon  dengan hasil sign test yang  bertanda negatif sebanyak 9 dan bertanda positif sebanyak 2 dan  uji wilcoxon  menyatakan Sig.(2-tailed 0,062) (α=0,05) artinya   penggunaan  antibiotik   sebelum  dan setelah digunakan PPAB tidak berbeda atau  sama berdasarkan statistik. Tetapi dari  persentasi  penggunaan  antibiotik   terdapat 9  antibiotik   yang penggunaannya  menurun setelah digunakan PPAB  seperti sefoperason 50%, seftriaxon  52%,  sefuroxime  87%,  sepirom  90%,  siproflosasin  17%,  gentamisin 99%, levofloxasin 60%, metronidazol 79% dan  moxifloksasin 86%. Disimpulkan PPAB  perlu ditingkatkan dalam penggunaan antibiotik  di RSUD dr.H.Slamet Martodirdjo dan  penggunaa seftriakson  dapat meningkatkan  multi drug resistant. Dengan  demikian perlu  adanya evaluasi dan  monitoring dalam menerapkan PPAB. Kata kunci: ATC/DDD; Pasien Bedah; PPAB  ABSTRACT Since  2011  the  World Health  Organization (WHO) and  the  National Antimicrobial  Resistant Control  Committee (KPRA) in indonesia since 2015, to establish antibiotic use policies by developing formularies and  Antibiotic  Use Guidelines (PPAB). Excessive use of antibiotics contributing to resistance, this study aims, analyzing the  magnitude of  differences in antibiotic use patients surgery before PPAB (May 2018  period)  and after  PPAB (May 2019  period)  with ATC / DDD (Defined  Daily Dose). Type and  design  of the  study is  descriptive cross-sectional with retrospective. Data  taken  included prescribing antibiotics. Data  were  analyzed by sign test and  Wilcoxon test with 9 negative sign and  2 positive sign results and  Wilcoxon  test stated Sig. (2-tailed 0.062)>  (α = 0.05), meaning that  use of antibiotics before and  after  PPAB is not different or the same based on statistics. But from the percentage of antibiotic 9   decreased  after    PPAB,   such  as   cefoperazone  50%,   cefriaxone   52%, cefuroxime  87%,  cefpirome  90%,  ciprofloxacin  17%,  gentamicin  99%, levofloxacin 60%, metronidazole 79% and  moxifloxacin 86%.  Concluded that PPAB needs to be improved in the use of antibiotics in RSUD dr.H. Islamet Martodirdjo and the use of ceftriaxone can increase multi drug resistant. Thus the need for evaluation and monitoring in implementing PPAB. Keywords:  ATC/DDD; Surgical Patients; PPAB
Co-Authors A.A. Ketut Agung Cahyawan W Achmad Ridwan Achmad Ridwan, Achmad Agriawan Sudirman Ahmad Nasir ahmad, abraham Aliviyanti, Dian Andri Geger Noviantoro Anita Purnamayanti Aprillia Wijaya, Stefani Arfani, Nurfitri Ari Wibowo Arief Bachtiar Arina Dery Puspitasari Assiddiqy, Miftah Farid Bagiyo, Harry Bagiyo, Harry Bagyo Yanuwiadi Bambang Eko Wahyono Bambang Sidharta Bambang Sudarmanto Budi Suprapti Budiatin, Aniek Setya Budiatin, Aniek Setya Catur Retnaningdyah Chairunnisa Chairunnisa Chris Alderman Chrismawan A, Chrismawan A Chrismawan Ardianto Dea Ayu Nabilah Debora Shinta Liana Dewi Wara Shinta Didik Hasmono Dinda Monika Nusantara Ratri Diniah, Melisa Nur Djafar, Zaenab Dliyauddin, Moh Dwiyatna, Surya Ekanita Desiani Elvan Dwi Widyadi Emiliana Kasmudjiastuti Emy Sulistyo Astuti Endang Arisoesilaningsih Endang Retnowati Eni Susanti Faizah, Mamluatul Faizal Mustamin Fandyka Yufriza Ali Fasich Fasich Fransiska Maria Christianty Gratia, Veronica Hari Prasetyo Hasria Alang Heru Purwanto Hubby, Hubby I Gede Edy Sagitha I Ketut Mandikin Ilham Rizqy Isnain Imam Faozi Imam Susilo Indira D. Kharismawati Irfan Mustafa Irma Novrianti Irma Novrianti Irvina Harini Isnaeni Jaka Susila Jikrona, Rafi Joni Kusnadi Joni Wahyuhadi, Joni Jufri Ubrusun Junaidi Khotib Kenyo Alexandra Oktaviani Khaerani Khaerani Khusnul Fitri Hamidah Kusuma Arum Ningsih Kuwatno Kuwatno Lestiono, . Lestiono, . Lewi Tigor Simorangkir Lisa Narulita Lisa Narulita Liziyyannida Liziyyannida M. Yusuf Assegaf Mahardian R, Mahardian R Mahardian Rahmadi Mahfudz Mahfudz Makitalentu, Feybe Marcha Debby Saraswati Mareta Rindang Andarsari Masyrobatin, Masyrobatin Medina, Farah Meita Rafika Fitriani Melasari, Wulan Panduwi Mohammad Akram Muhammad Aminuddin, Muhammad Muhammad Fathoni, Muhammad Mulja Hadi Santosa Narulita, Lisa Nasir, Ahmad Neldi, Vina Nia Kurniawan Nur Afni NUR CHAKIM Nur ‘Azah Nurmainah Nurmainah Nurrofik, Agus Octaviany, Evi Paramita, Angggun Putri Paulus Sugianto Prasetyanti, Intan Kris Prastuti Asta Wulaningrum Pratita, Dian Galuh Pratiwi, Esti Rizkiana Primadi Avianto Purwanto, Diyna Rusayliya Rahman, Gilang Mauladi Rahmawati Raising Ria Rositasati Riefkah Bilal risha fillah fithria Risthanti, Reine Risa Rodiyati Azrianingsih Rosdiana, Eva Rudi Safarudin Rudi Wardana Rusdiana, Silvia Rusdiana, Silvia Safarudin, Rudi Sahayuna, Dara Demi Samirah Samirah Samirah Samirah, Samirah Samsulhadi, Wiwid Sanita Suriani Sari, Erni A Semedi S J Shafira Muti Ardiana Shahroni, Abdul Mutholib Shofia Ummu, Lathifa Simorangkir, Lewi Tigor Sindy, Sulih Probo Sinuraya, Sabarita SJ, Semedi Soemarno Soemarno Solihin, Imron Sudirman, Agriawan Sukardiman Sumarno . Sumarno Sumarno Suryadi Suryadi Susilo, Dwi Hari Sutrisnaningsih, Evy Sari Suwardi Suwardi Toetik Aryani Tri Ardyati Umami, Zahra Veronica Gratia Wanudya Atmajani WENNY PUTRI NILAMSARI Widhiati Widhiati Widyadi, Elvan Dwi Wiwid Samsulhadi Wulan Panduwi Melasari Yance Anas yance yance Yen Yen Ari Indrawijaya YOGA DWI JATMIKO Yogiarto Yogiarto Yulia Ayu Purnamasari Yulistiani Yulistiani Yulistiani Yulistiani, Yulistiani Yulistiani, . Yuniati T Yuniati T Yuniati T, Yuniati Yusfar, Yunarti Yustiana Yustiana, Yustiana Zamrotul Izzah Zulfiana, Risa