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All Journal Jurnal Ilmiah Farmasi The Journal of Experimental Life Sciences (JELS) Biotropika Pelita Perkebunan Folia Medica Indonesiana Jurnal Farmasi Klinik Indonesia Majalah Kulit, Karet, dan Plastik Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmacon Journal of Tropical Biodiversity and Biotechnology INDONESIAN JOURNAL OF PHARMACY Pharmascience Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Journal of Islamic Medicine JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Manuju : Malahayati Nursing Journal JFIOnline J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Jurnal Farmasi Higea Pharmacoscript An-Nadaa: Jurnal Kesehatan Masyarakat Pharma Xplore : Jurnal Sains dan Ilmu Farmasi ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Layanan Masyarakat (Journal of Public Service) Journal of Community Development Berkala Penelitian Hayati Pharmaceutical Sciences and Research (PSR) Agrimas : Jurnal Pengabdian Masyarakat Bidang Pertanian Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

Suharjono, Suharjono

Faculty Of Pharmacy, Universitas Airlangga

Author-ID : 389234

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Bioanalisis Metabolit Gliklazida Dalam Mikrosom Hati Manusia Dengan Metode HPLC Suharjono, Suharjono
Majalah Ilmu Kefarmasian Vol. 5, No. 3
Publisher : UI Scholars Hub

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Gliclazide (GZ) is oral sulphonylurea-2 generation used for treatment of diabetes mellitus type-2. Gliclazide is metabolized in the smooth endoplasmic reticulum of liver, which can be made in preparation of human liver microsomes. These microsomes rich in cytochrome P450 (CYP450). Major metabolite of GZ in the microsomes are, 7β-OH-GZ, 6α-OHGz, 6β-OH-GZ, and Me-OH-GZ. HPLC method for GZ me-tabolites was done without extraction by organic solvents, but with direct precipita-tion GZ incubation results in the human liver microsomes using perchloric acid. The aim of the study is to determine the level of four GZ metabolites in human liver microsomes by HPLC method. Gliclazide 400 µM were incubated in human liver microsomes using regenerating reagent at 370C for 90 minutes. The reaction were terminated by cooling the incubation tubes at 40C and the addition of 10 µl perchloric acid 70%, then were added 20 µl solution of internal standard of chlopropamide 200 µM, were centrifuged 14,000 rpm for 10 minutes, supernatan taken. Then 200 µl supernatan were added 5 µl of 2 M NaOH, were mixed and centrifuged again at 14,000 rpm for 5 minutes. Then 65 µl supernatant were injected into HPLC column (Beckman), column Ultrasphere ODS 5 µM 4.6 mm x 25 cm, UV detector at 235 nm. HPLC eluent solution was 5mM acetate buffer (pH 4.3)-Acetonitrile (70: 30), with a flow rate of 1.5 ml / min. The retention times of 7β-OH-GZ, 6α-OHGz, 6β-OH-GZ, Me-OH-GZ, chlorpropamide (IS) and Gliclazide were 4.40; 4.58; 5.55; 7.3; 12.30 and 36 minutes (without microsomes) and that with microsomes only 3 metabolites GZ were measured, except metabolite of 6α-OHGz. Linearity, recovery, reproducibility, precision were very good for determining metabolites GZ in human liver microsomes. Bioanalysis by HPLC method for the main metabolites of 7β-OH-GZ, 6β-OH-GZ and Me-OH-GZ were appropriate, because the method were selected, cheap, easy, fast and good validity.

Studi Penggunaan Antibiotika Pada Penderita Rawat Inap Pneumonia (Penelitian Di Sub Departemen Anak Rumkital Dr. Ramelan Surabaya) Suharjono, Suharjono; T, Yuniati; Sumarno, Sumarno; SJ, Semedi
Majalah Ilmu Kefarmasian Vol. 6, No. 3
Publisher : UI Scholars Hub

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Pneumonia is an infectious disease that was caused inflammation of acute parenchy-mal compression of the lungs and bacterial exudate from lung tissue on the main from Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Klebsiella pneumonia, Mycobacterium tuberculosis. Selection of appropriate antibiotic therapy and rational will determine the treatment to avoid the occurrence of bacterial resistance. In addition it is also possible the use of other drugs that can increase the chances of Drug Related Problems (DRP). Pattern of antibiotic use in Rumkital Dr. Ramelan Surabaya has never been done. Studying the pattern use of antibiotics in hospitalized patients with pneumonia in the Sub Department of Pedi-atric Rumkital Dr. Ramelan and related the dose, other therapies, as well as identify the DRP. This research is a method descriptive survey research in the form of a retrospective and descriptive study. Materials research is the Medical Records pa-tients hospitalized with the final diagnosis of pneumonia, starting January 1, 2004 until April 30, 2006 that meet inclusion criteria. Of the study population who account for 50 found 41 patients who fulfilled the inclusion criteria. Antibiotics single most widely accepted patients without comorbidities were ampicillin iv 26.92% (14 patients) and iv sefotaksim 21.15% (11 patients), while the antibiotic combina-tion widely accepted patients is ampicillin iv / po + kloksasilin iv / po 13.46% (7 patients) and kloksasilin iv + ceftriaxone iv 5.77% (3 patients) and the rest other antibiotic combinations. DRP study found 56.9% patients received appropriate anti-biotic dose literature and 43.1% patients receiving doses underdose. Use of antibiotics above is already in ccordance with reference and other therapies. Single antibiotic or combination of 2 antibiotics penicillin and cephalosporin classes often used to treat pneumonia.

Remdesivir: Mechanism and Effectiveness for Coronavirus Disease 2019 (COVID-19) Neldi, Vina; Suharjono, Suharjono
Pharmaceutical Sciences and Research Vol. 7, No. 4
Publisher : UI Scholars Hub

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Currently, coronavirus disease 2019 (COVID-19) is a very serious health problem. The World Health Organization (WHO) has characterized this disease as a pandemic. Recommendations related to vaccines and drugs are not available yet because they are still in the clinical trial phase, and one of the superior drugs is remdesivir which has an antiviral activity. Several clinical trials of this drug are being carried out with the aim of evaluating its safety and efficacy in COVID-19 patients. There are two clinical trials with completed recruitment status, which are NCT04257656 and NCT04280705. NCT04257656 showed that remdesivir had faster time for clinical improvement in severe COVID-19 patients compared to placebo although it was not found to be statistically significant. Moreover, NCT04280705 showed that remdesivir was superior compared to placebo in shortening the recovery time in hospitalized adults with COVID-19. Gilead Sciences is also conducting clinical trials on this drug, and WHO has also conducted a solidarity trial and INSERM DisCoVery trials on remdesivir. Based on two clinical trials completed, satisfactory results are shown in patients with remdesivir therapy compared with patients who received placebo, although it is very important to wait for the results of other ongoing clinical trials to strengthen the evidence of the safety and efficacy of this drug.

PENGEMBANGAN MODEL HEWAN PERCOBAAN TIKUS DIABETES MELLITUS TIPE 2 KARENA RESISTENSI INSULIN YANG DIINDUKSI DENGAN HUMAN INSULIN JANGKA PANJANG Yance Anas; Ria Rositasati; Meita Rafika Fitriani; Suharjono Suharjono
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Hyperinsulinemia may precede insulin resistance in patients with Type 2 diabetes. In this study, we tried to reveal an influence of long-term treatment of human insulin to hyperglycemic and insulin resistance in male Wistar rats. Before the experiment, blood-glucose levels measured two hours after 2 g/Kg glucose imposition. Rats receive human insulin (0.45-1.80) IU/KgBW/day subcutaneously every day for 14 days. Furthermore, human insulin 1.8 IU/KgBW/day also provide a period of7,14and 21days. At theend of the experiment,we mademeasurements ofblood-glucoselevelstwo hoursafterthe imposition glucose.There are, the influence oflong-termtreatment of human insulin determined bycomparing the blood-glucoselevelsbeforeandafter insulin treatment. Insulin resistance isdeterminedby comparing thehypoglycemiceffect of glibenclamide 10 mg/Kg BW to the control group. The results concluded that the humaninsulin1.80 IU/KgBW/day treatment for 14dayscan improveblood-glucoselevel'sWistarmale ratsup to126.369mg/dL(p<0.05)withpatternsdoes notdepend onthe length of timeof administration.The averageof % hypoglycemiceffect of glibenclamide10mg/kgBW in ratswhoreceived treatment with human insulin 1.80IU/kg BW/dayswereat 18,31%,smaller thancontrols (62.20%) (p<0.05). Decrease in hypoglycemic effects of glibenclamide 10 mg/kg BW caused by mice has insulin resistance might be due to a result of long-term insulin administration. Keywords : Human insulin, insulin resistance, Type 2 diabetes animal models

POTENSI HIPOGLIKEMIK EKSTRAK ETANOLIK DAUN SRIKAYA Yance Anas; Kenyo Alexandra Oktaviani; Suharjono Suharjono
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 7 NO. 2 DESEMBER 2010
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Active compounds in the leaves of sugar apple is believed to lower blood sugar levels, so it can be used as an oral hypoglycemic agent in the treatment of diabetes. The purpose of this research is to prove the hypoglycemic effect of ethanol extract of sugar apple leaves in Wistar male rats. The research was conducted by using oral glucose test in the group of rats who received treatment doses of sugar apple leaves etanolik extract (75.6, 151.2 and 302.4) mg / KgBW and control groups. Test materials were given 30 minutes before loading 2g/KgBB glucose orally. Research data is the blood glucose level every time which is converted into data AUC0-300 and % hypoglycemic effect. Potential hypoglycemic effects (ED50) were measured using probit analysis. Statistical analysis performed using Kruskal-Wallis test followed by Mann-Whitney test at the level of 95%. In addition, also identified the active compound flavonoid with qualitative chemical analysis method. The results showed that ethanol extract of leaves of sugar apple dose (75.6, 151.2 and 302.4) mg / kg has a hypoglycemic effect on male wistar rats subjected to glucose (P <0.05), with the percentage hipogllikemik effect amounts to (11.05, 23, 01 and 42.793)%. Potency (ED50) etanolik extract sugar apple leaves as hypoglycemic agents amounted to 339 mg / KgBW. In this study, ethanol extract of sugar apple leaves positive active compounds containing flavonoid. Key words: hypoglycemic, sugar apple

AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN RANDU (Ceiba petandra L. Gaern.) PADA MENCIT JANTAN GALUR Balb/C yance yance; risha fillah fithria; Yulia Ayu Purnamasari; Kusuma Arum Ningsih; Andri Geger Noviantoro; Suharjono Suharjono
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTTraditionally, cottonwood's leaves have been used to treat diarrhea. The objective of the study was to investigate antidiarrheal properties of cottonwood’s leaves ethanol extract (EEDR). In addition, this study also wants to reveal the action mechanism of EEDR as antidiarrheal through its activities as antisecretory and antimotility in Balb/C strain male mice. An experimental study performed with randomized matched two-group post test only design approach. EEDR (200-800) mg/kg BW was administered orally to three groups of mice to evaluate the activity of extract as antidiarrheal and antisecretory on castor oil induced diarrhea model in mice. To evaluate the extract as antimotility, EEDR (1.0, 2.0 and 4.0) g/kg BW was provided orally to Balb/C strain male mice. Two other groups received NaCl 0.9 % 20 mL/Kg BW and Loperamide HCl 50 mg/Kg BW. The results showed the EEDR have pharmacological effects as antidiarrhea on Balb/C strain male mice with a mechanism of action as antisecretory and antimotility. The results of this study have been successfully providing the scientific basis of the use of cottonwood’s leaves as antidiarrhea by Indonesian people.Key words : cottonwood’s leaves ethanol extract, castor oil, antidiarrhea, antisecretory

POTENSI FRAKSI n-HEKSAN EKSTRAK ETANOL RIMPANG LENGKUAS [Alpinia galanga (L.) Swartz.] DALAM MENINGKATKAN KUALITAS SPERMA DAN SPERMATOGENESIS Yance Anas; Imam Faozi; Suharjono Suharjono
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Flavonoids and steroid's compounds have been identifying in the galangal rhizome [Alpinia galanga (L.) Swartz.]. This compound has hormonal and antioxidant effects and can improve the spermatogenesis and quality of spermatozoa. The purpose of this study is to find out the effects of the n-hexane fractions from galangal rhizome ethanol extract (HFGREE) on male Swiss mice spermatogenesis and quality of spermatozoa. This research is a laboratory experimental with randomized matched post test only controls group design. Twenty-four male Swiss mice (8-weeks old) divided among four groups: control groups (mice treated with CMC 1.0% 10 mL.kg-1.day-1), and three groups of mice treated with HFGREE (1.29; 2.58 and 5.16) mg.kg-1.day-1 for 30 days. All mice sacrificed at day 31. Furthermore, testicular tissue sections are used to calculate the score of spermatogenesis. Spermatozoa in the epididymis were used to assess the quality of spermatozoa. The results showed the HFRGEE (2.58 and 5.16) mg.kg-1.day-1 for 30 days, significantly elevate spermatogenesis score, and improve the spermatozoa count, spermatozoa motility, healthy and normal spermatozoa of male Swiss mice (p<0.05). Further studies can focus on the identification of active compounds in HFGREE that play a role in improving spermatogenesis and quality of spermatozoa. Key words: n-hexane fraction, galangal rhizome ethanol extract, spermatogenesis, quality of spermatozoa

PENGARUH PEMBERIAN JUS KECAMBAH KACANG HIJAU (Vigna radiata (L.) R. Wilczek)TERHADAP KUALITAS SPERMATOZOA DAN SPERMATOGENESIS MENCIT JANTAN GALUR SWISS Yance Anas; Nur Chakim; Suharjono Suharjono
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No. 1 Juni 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Efficacy of mung bean sprouts as natural fertility enhancer for men was not widely investigated and published. The objective of this study is to investigate the effect of mung bean sprout’s juice on male Swiss mice spermatozoa quality and spermatogenesis. An experimental study performed with randomized matched two-group post test only design approach. Thirtymale mice were dividedinto fivegroups randomly, which consist of a control group (CMC25mL/kg BW/day); d-α-tocopherol group (556 IU/kg BW/day) and three mung beans sproutjuice groups (33, 66 and 132) mg/kg BW/day. Mice treated every dayfor 20days orally. Micewere sacrificed; testis and epididymis were collected and examined. The spermatozoa quality (count, progressive motility and normal morphology) and spermatogenesis observed. The results showedthatmung bean sproutsjuice treatment (33, 66 and 132) mg/Kg BW/day for 20 days did not enhance male Swiss strain mice fertility. Spermatogenesis score, count and normal morphology spermatozoa that receive treatment with mung bean sprout juice was not significantly different to the control group (p>0.05). Conversely; mung bean sprouts juice treatment lead to decrease male Swiss strain mice spermatozoa progressive motility (p<0,05). Keywords: Mung bean sprouts (Vigna radiata (L.) R.Wilczek) juice, spermatozoa quality, spermatogenesis.

Interferons and its use in children with COVID-19: A narrative review Chairunnisa Chairunnisa; Suharjono Suharjono
Jurnal Ilmiah Farmasi Vol. 18 No. 2 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss2.art18

Background: All ages, including children, are susceptible to the disease COVID-19. The severity of COVID-19 in children is mild than in adults. One of the recommended antiviral drugs for COVID-19 in children is interferon. Objective: To describe the efficacy and safety of using interferon in children with COVID-19 Method: The article is a narrative study. The main databases in the article search process in this literature review are PubMed and Google Scholar. Results: The articles could potentially be involved in this study were 28 articles. A total of 13 articles included the criteria, 9 articles discussed the use of interferon against respiratory syndrome, 4 articles on interferon in children, and one reference from a literature search. Conclusion: Interferon therapy in COVID-19 in children has a high cure rate but needs to be evaluated in a larger sample of pediatric patients.

Review: Perbandingan antara Standard Half-Life (SHL) dan Extended Half-Life (EHL) Replacement Therapy berbasis Real-World Evidence (RWE) Agriawan Sudirman; Suharjono Suharjono; Ahmad Nasir; Rudi Safarudin
Jurnal Sains Farmasi & Klinis Vol 9, No 3 (2022): J Sains Farm Klin 9(3), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.3.221-226.2022

Hemophilia is a common hereditary coagulation blood disorder due to the deficiency activity of clotting factors. Hemophilia is divided into two, namely hemophilia A and hemophilia B. Among all treatments, standard half-life (SHL) and extended half-life (EHL) factor replacement products are the most commonly used. This study aimed to review real-world evidence on the comparison of SHL and EHL. A literature search was conducted in PubMed and google scholar published from 2017 to 2021. There were 10 articles that met the criteria. Based on the synthesis results, the total proportion of patients using EHL factor concentrates for both on‐demand and prophylactic factor replacement therapy increased. Recent evidence reveals that EHL may reduce the number of infusions, increase factor trough levels, and substantially decrease the annual bleeding rate. Efficacy-wise, EHLs unquestionably have better performances than SHLs; however, the EHL products seem to be too expensive to be utilized as the primary standard of care for hemophilia. However, the economic aspect of the replacement factor switching still required more in-depth studies.

Co-Authors A.A. Ketut Agung Cahyawan W Achmad Ridwan Achmad Ridwan, Achmad Agriawan Sudirman Ahmad Nasir ahmad, abraham Andri Geger Noviantoro Aprillia Wijaya, Stefani Ari Wibowo Arief Bachtiar Arina Dery Puspitasari Assiddiqy, Miftah Farid Atmajani, Wanudya Bagiyo, Harry Bagiyo, Harry Bagyo Yanuwiadi Bambang Eko Wahyono Bambang Sidharta Bambang Sudarmanto Budi Suprapti Budiatin, Aniek Setya Budiatin, Aniek Setya Chairunnisa Chairunnisa Chris Alderman Chrismawan A, Chrismawan A Chrismawan Ardianto Dea Ayu Nabilah Debora Shinta Liana Desiani, Ekanita Dewi Wara Shinta Didik Hasmono Dinda Monika Nusantara Ratri Diniah, Melisa Nur Djafar, Zaenab Dwiyatna, Surya Elvan Dwi Widyadi Emiliana Kasmudjiastuti Emy Sulistyo Astuti Endang Retnowati Eni Susanti Faizal Mustamin Fandyka Yufriza Ali Fasich Fasich Fransiska Maria Christianty Gratia, Veronica Hari Prasetyo Hasria Alang Heru Purwanto Hubby, Hubby I Gede Edy Sagitha I Ketut Mandikin Ilham Rizqy Isnain Imam Faozi Imam Susilo Indira D. Kharismawati Irfan Mustafa Irma Novrianti Irma Novrianti Irvina Harini Isnaeni Jaka Susila Jikrona, Rafi Joni Kusnadi Joni Wahyuhadi, Joni Jufri Ubrusun Junaidi Khotib Kenyo Alexandra Oktaviani Khaerani Khaerani Khusnul Fitri Hamidah Kusuma Arum Ningsih Kuwatno Kuwatno Lestiono, . Lestiono, . Lewi Tigor Simorangkir Lisa Narulita Lisa Narulita Liziyyannida Liziyyannida M. Yusuf Assegaf Mahardian R, Mahardian R Mahardian Rahmadi Mahfudz Mahfudz Makitalentu, Feybe Marcha Debby Saraswati Mareta Rindang Andarsari Medina, Farah Meita Rafika Fitriani Mohammad Akram Muhammad Aminuddin, Muhammad Muhammad Fathoni, Muhammad Mulja Hadi Santosa Narulita, Lisa Nasir, Ahmad Neldi, Vina Nia Kurniawan Nur Afni NUR CHAKIM Nurmainah Nurmainah Nurrofik, Agus Paulus Sugianto Prasetyanti, Intan Kris Prastuti Asta Wulaningrum Pratita, Dian Galuh Primadi Avianto Purwanto, Diyna Rusayliya Rahman, Gilang Mauladi Rahmawati Raising Ria Rositasati Riefkah Bilal risha fillah fithria Risthanti, Reine Risa Rosdiana, Eva Rudi Safarudin Rudi Wardana Rusdiana, Silvia Rusdiana, Silvia Safarudin, Rudi Sahayuna, Dara Demi Samirah Samirah Samirah Samirah, Samirah Sari, Erni A Semedi S J Shafira Muti Ardiana Shahroni, Abdul Mutholib Shofia Ummu, Lathifa Simorangkir, Lewi Tigor Sindy, Sulih Probo SJ, Semedi Solihin, Imron Sudirman, Agriawan Sukardiman Sumarno . Sumarno Sumarno Suryadi Suryadi Susilo, Dwi Hari Sutrisnaningsih, Evy Sari Suwardi Suwardi Toetik Aryani Tri Ardyati Umami, Zahra Veronica Gratia WENNY PUTRI NILAMSARI Widhiati Widhiati Widyadi, Elvan Dwi Wiwid Samsulhadi Wulan Panduwi Melasari Yance Anas yance yance Yen Yen Ari Indrawijaya YOGA DWI JATMIKO Yogiarto Yogiarto Yulia Ayu Purnamasari Yulistiani Yulistiani Yulistiani Yulistiani, Yulistiani Yulistiani, . Yuniati T Yuniati T Yuniati T, Yuniati Yusfar, Yunarti Yustiana Yustiana, Yustiana Zamrotul Izzah Zulfiana, Risa

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