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Remdesivir: Mechanism and Effectiveness for Coronavirus Disease 2019 (COVID-19) Neldi, Vina; Suharjono, Suharjono
Pharmaceutical Sciences and Research Vol. 7, No. 4
Publisher : UI Scholars Hub

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Abstract

Currently, coronavirus disease 2019 (COVID-19) is a very serious health problem. The World Health Organization (WHO) has characterized this disease as a pandemic. Recommendations related to vaccines and drugs are not available yet because they are still in the clinical trial phase, and one of the superior drugs is remdesivir which has an antiviral activity. Several clinical trials of this drug are being carried out with the aim of evaluating its safety and efficacy in COVID-19 patients. There are two clinical trials with completed recruitment status, which are NCT04257656 and NCT04280705. NCT04257656 showed that remdesivir had faster time for clinical improvement in severe COVID-19 patients compared to placebo although it was not found to be statistically significant. Moreover, NCT04280705 showed that remdesivir was superior compared to placebo in shortening the recovery time in hospitalized adults with COVID-19. Gilead Sciences is also conducting clinical trials on this drug, and WHO has also conducted a solidarity trial and INSERM DisCoVery trials on remdesivir. Based on two clinical trials completed, satisfactory results are shown in patients with remdesivir therapy compared with patients who received placebo, although it is very important to wait for the results of other ongoing clinical trials to strengthen the evidence of the safety and efficacy of this drug.
PENGEMBANGAN MODEL HEWAN PERCOBAAN TIKUS DIABETES MELLITUS TIPE 2 KARENA RESISTENSI INSULIN YANG DIINDUKSI DENGAN HUMAN INSULIN JANGKA PANJANG Yance Anas; Ria Rositasati; Meita Rafika Fitriani; Suharjono Suharjono
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (568.535 KB) | DOI: 10.31942/jiffk.v12i2.1408

Abstract

ABSTRACT Hyperinsulinemia may precede insulin resistance in patients with Type 2 diabetes.  In this study, we tried to reveal an influence of long-term treatment of human  insulin to hyperglycemic and insulin resistance in male Wistar rats.  Before the experiment, blood-glucose  levels measured two hours after 2 g/Kg glucose imposition.  Rats receive human insulin (0.45-1.80) IU/KgBW/day subcutaneously every day for 14 days.   Furthermore, human insulin 1.8 IU/KgBW/day also provide a period of7,14and 21days. At theend of the experiment,we mademeasurements ofblood-glucoselevelstwo hoursafterthe imposition  glucose.There are, the influence oflong-termtreatment of human insulin determined bycomparing the blood-glucoselevelsbeforeandafter  insulin treatment.  Insulin resistance isdeterminedby comparing thehypoglycemiceffect of glibenclamide 10 mg/Kg  BW  to the control group.  The results concluded that the  humaninsulin1.80 IU/KgBW/day  treatment  for 14dayscan improveblood-glucoselevel'sWistarmale ratsup to126.369mg/dL(p<0.05)withpatternsdoes notdepend onthe length of timeof administration.The averageof % hypoglycemiceffect of glibenclamide10mg/kgBW  in ratswhoreceived treatment with human  insulin 1.80IU/kg BW/dayswereat 18,31%,smaller thancontrols (62.20%) (p<0.05). Decrease in hypoglycemic effects of glibenclamide 10 mg/kg BW caused by mice has insulin resistance might be due to a result of long-term insulin administration. Keywords : Human insulin, insulin resistance, Type 2 diabetes animal models
POTENSI HIPOGLIKEMIK EKSTRAK ETANOLIK DAUN SRIKAYA Yance Anas; Kenyo Alexandra Oktaviani; Suharjono Suharjono
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 7 NO. 2 DESEMBER 2010
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (269.252 KB) | DOI: 10.31942/jiffk.v7i2.643

Abstract

ABSTRACT Active compounds in the leaves of sugar apple is believed to lower blood sugar levels, so it can be used as an oral hypoglycemic agent in the treatment of diabetes. The purpose of this research is to prove the hypoglycemic effect of ethanol extract of sugar apple leaves in Wistar male rats. The research was conducted by using oral glucose test in the group of rats who received treatment doses of sugar apple leaves etanolik extract (75.6, 151.2 and 302.4) mg / KgBW and control groups. Test materials were given 30 minutes before loading 2g/KgBB glucose orally. Research data is the blood glucose level every time which is converted into data AUC0-300 and % hypoglycemic effect. Potential hypoglycemic effects (ED50) were measured using probit analysis. Statistical analysis performed using Kruskal-Wallis test followed by Mann-Whitney test at the level of 95%. In addition, also identified the active compound flavonoid with qualitative chemical analysis method. The results showed that ethanol extract of leaves of sugar apple dose (75.6, 151.2 and 302.4) mg / kg has a hypoglycemic effect on male wistar rats subjected to glucose (P <0.05), with the percentage hipogllikemik effect amounts to (11.05, 23, 01 and 42.793)%. Potency (ED50) etanolik extract sugar apple leaves as hypoglycemic agents amounted to 339 mg / KgBW. In this study, ethanol extract of sugar apple leaves positive active compounds containing flavonoid. Key words: hypoglycemic, sugar apple
AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN RANDU (Ceiba petandra L. Gaern.) PADA MENCIT JANTAN GALUR Balb/C yance yance; risha fillah fithria; Yulia Ayu Purnamasari; Kusuma Arum Ningsih; Andri Geger Noviantoro; Suharjono Suharjono
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.098 KB) | DOI: 10.31942/jiffk.v9i2.860

Abstract

ABSTRACTTraditionally, cottonwood's leaves have been used to treat diarrhea. The objective of the study was to investigate antidiarrheal properties of cottonwood’s leaves ethanol extract (EEDR). In addition, this study also wants to reveal the action mechanism of EEDR as antidiarrheal through its activities as antisecretory and antimotility in Balb/C strain male mice. An experimental study performed with randomized matched two-group post test only design approach. EEDR (200-800) mg/kg BW was administered orally to three groups of mice to evaluate the activity of extract as antidiarrheal and antisecretory on castor oil induced diarrhea model in mice. To evaluate the extract as antimotility, EEDR (1.0, 2.0 and 4.0) g/kg BW was provided orally to Balb/C strain male mice. Two other groups received NaCl 0.9 % 20 mL/Kg BW and Loperamide HCl 50 mg/Kg BW. The results showed the EEDR have pharmacological effects as antidiarrhea on Balb/C strain male mice with a mechanism of action as antisecretory and antimotility. The results of this study have been successfully providing the scientific basis of the use of cottonwood’s leaves as antidiarrhea by Indonesian people.Key words : cottonwood’s leaves ethanol extract, castor oil, antidiarrhea, antisecretory
POTENSI FRAKSI n-HEKSAN EKSTRAK ETANOL RIMPANG LENGKUAS [Alpinia galanga (L.) Swartz.] DALAM MENINGKATKAN KUALITAS SPERMA DAN SPERMATOGENESIS Yance Anas; Imam Faozi; Suharjono Suharjono
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (626.77 KB) | DOI: 10.31942/jiffk.v0i0.1338

Abstract

ABSTRACT Flavonoids and steroid's compounds have been identifying in the galangal rhizome [Alpinia galanga (L.) Swartz.]. This compound has hormonal and antioxidant effects and can improve the spermatogenesis and quality of spermatozoa. The purpose of this study is to find out the effects of the n-hexane fractions from galangal rhizome ethanol extract (HFGREE) on male Swiss mice spermatogenesis and quality of spermatozoa. This research is a laboratory experimental with randomized matched post test only controls group design. Twenty-four male Swiss mice (8-weeks old) divided among four groups: control groups (mice treated with CMC 1.0% 10 mL.kg-1.day-1), and three groups of mice treated with HFGREE (1.29; 2.58 and 5.16) mg.kg-1.day-1 for 30 days. All mice sacrificed at day 31. Furthermore, testicular tissue sections are used to calculate the score of spermatogenesis. Spermatozoa in the epididymis were used to assess the quality of spermatozoa. The results showed the HFRGEE (2.58 and 5.16) mg.kg-1.day-1 for 30 days, significantly elevate spermatogenesis score, and improve the spermatozoa count, spermatozoa motility, healthy and normal spermatozoa of male Swiss mice (p<0.05). Further studies can focus on the identification of active compounds in HFGREE that play a role in improving spermatogenesis and quality of spermatozoa. Key words: n-hexane fraction, galangal rhizome ethanol extract, spermatogenesis, quality of spermatozoa
PENGARUH PEMBERIAN JUS KECAMBAH KACANG HIJAU (Vigna radiata (L.) R. Wilczek)TERHADAP KUALITAS SPERMATOZOA DAN SPERMATOGENESIS MENCIT JANTAN GALUR SWISS Yance Anas; Nur Chakim; Suharjono Suharjono
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No. 1 Juni 2015
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (404.614 KB) | DOI: 10.31942/jiffk.v12i1.1394

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ABSTRACT Efficacy of mung bean sprouts as natural fertility enhancer for men was not widely investigated and published. The objective of  this  study  is  to  investigate  the effect of mung bean sprout’s  juice on male Swiss mice spermatozoa quality and spermatogenesis.  An  experimental  study  performed  with randomized  matched  two-group  post  test  only  design  approach.  Thirtymale  mice  were  dividedinto fivegroups randomly, which consist of a control group (CMC25mL/kg BW/day); d-α-tocopherol group (556 IU/kg BW/day) and three mung beans sproutjuice groups (33, 66 and 132) mg/kg BW/day. Mice treated  every  dayfor  20days  orally. Micewere  sacrificed;  testis  and  epididymis  were  collected  and examined.  The  spermatozoa  quality  (count,  progressive  motility  and  normal  morphology)  and spermatogenesis observed. The  results showedthatmung bean sproutsjuice  treatment  (33, 66 and 132) mg/Kg BW/day  for 20 days did not enhance male Swiss strain mice  fertility. Spermatogenesis score, count and normal morphology spermatozoa that receive treatment with mung bean sprout juice was not significantly  different  to  the  control group  (p>0.05). Conversely; mung  bean  sprouts  juice  treatment lead to decrease male Swiss strain mice spermatozoa progressive motility (p<0,05). Keywords:   Mung  bean  sprouts  (Vigna  radiata  (L.)  R.Wilczek)  juice,  spermatozoa  quality, spermatogenesis.
Interferons and its use in children with COVID-19: A narrative review Chairunnisa Chairunnisa; Suharjono Suharjono
Jurnal Ilmiah Farmasi Vol. 18 No. 2 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss2.art18

Abstract

Background: All ages, including children, are susceptible to the disease COVID-19. The severity of COVID-19 in children is mild than in adults. One of the recommended antiviral drugs for COVID-19 in children is interferon. Objective: To describe the efficacy and safety of using interferon in children with COVID-19 Method: The article is a narrative study. The main databases in the article search process in this literature review are PubMed and Google Scholar. Results: The articles could potentially be involved in this study were 28 articles. A total of 13 articles included the criteria, 9 articles discussed the use of interferon against respiratory syndrome, 4 articles on interferon in children, and one reference from a literature search. Conclusion: Interferon therapy in COVID-19 in children has a high cure rate but needs to be evaluated in a larger sample of pediatric patients.
Review: Perbandingan antara Standard Half-Life (SHL) dan Extended Half-Life (EHL) Replacement Therapy berbasis Real-World Evidence (RWE) Agriawan Sudirman; Suharjono Suharjono; Ahmad Nasir; Rudi Safarudin
Jurnal Sains Farmasi & Klinis Vol 9, No 3 (2022): J Sains Farm Klin 9(3), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.3.221-226.2022

Abstract

Hemophilia is a common hereditary coagulation blood disorder due to the deficiency activity of clotting factors. Hemophilia is divided into two, namely hemophilia A and hemophilia B. Among all treatments, standard half-life (SHL) and extended half-life (EHL) factor replacement products are the most commonly used. This study aimed to review real-world evidence on the comparison of SHL and EHL. A literature search was conducted in PubMed and google scholar published from 2017 to 2021. There were 10 articles that met the criteria. Based on the synthesis results, the total proportion of patients using EHL factor concentrates for both on‐demand and prophylactic factor replacement therapy increased. Recent evidence reveals that EHL may reduce the number of infusions, increase factor trough levels, and substantially decrease the annual bleeding rate. Efficacy-wise, EHLs unquestionably have better performances than SHLs; however, the EHL products seem to be too expensive to be utilized as the primary standard of care for hemophilia. However, the economic aspect of the replacement factor switching still required more in-depth studies.
Updates Therapy for Covid-19 Patients in Pregnant and Lactating Women Review Journal Liziyyannida Liziyyannida; Suharjono Suharjono
Malahayati Nursing Journal Vol 5, No 6 (2023): Volume 5 Nomor 6 2023
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v5i6.8883

Abstract

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes the coronavirus disease 2019 (Covid-19). On January 30, 2020 WHO declared Covid-19 a Public Health Emergency of international concern, and caused millions of deaths worldwide. COVID-19 infection can increase in patients who are pregnant. Changes in the immune system and physiology in pregnant women can increase the risk of complications from COVID-19 infection. Pregnancy can compromise the immune system and potentially SARS-CoV-2 infection can increase the risk of pneumonia in pregnant women compared to non-pregnant women. Pregnant women are often excluded from trials because of the risk of toxicity or side effects, resulting in a lack of knowledge about drug use and care during pregnancy. Great uncertainty in therapy due to lack of appropriate treatment information along with the increasing development of changes to the covid19 therapy guidelines. this review aims to gather existing knowledge on currently available drug treatments for COVID-19 in pregnant and lactating women, and produce an analysis of drugs with acceptable safety profiles in the treatment of pregnant and lactating women with COVID-19. This article series uses Mendeley, Google Scholar, ScienceDirect, and PubMed from the NCBI database during October - December 2022. Variables associated with the incidence of under-five malnutrition were maternal nutrition knowledge (p= 0,000; OR = 17,000), parenting and feeding patterns (p= 0,003; OR = 13,500), and family income (p= 0,002; OR = 12,000), while the availability of clean water (p= 0.449; OR = 2.429) was found unrelated with the incidence of under-five malnutrition. In conclusion, the availability of clean water is not related to the incidence of under-five malnutrition, while the other three variables studied are related. So, to prevent under-five malnutrition, it is necessary for mothers to take active action in seeking information on nutritious food, cultivating local food to increase family income and food supply and keep water clean. Further research needs to develop other variables that were not examined by researchers, namely food availability in the family and history of low birth weight babies. Researchers hope that mothers are active in seeking information about nutritious foods, utilizing existing local food to increase family income and food supply so that they are able to serve healthy nutritious food to families, especially toddlers. In addition, keep the water clean by treating drinking water properly so that it does not become a source of spreading disease Keywords: Toddlers, Malnutrition, Income, Knowledge of Nutrition, Parenting  ABSTRAK Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) merupakan     virus yang berperan atas penyakit coronavirus 2019 (Covid-19). Pada tanggal 30 Januari 2020 WHO menetapkan Covid-19 sebagai Public Health Emergency yang menjadi perhatian Internasional, dan menyebabkan jutaan kematian di seluruh dunia. Infeksi COVID-19 dapat meningkat pada pasien dengan kondisi hamil. Perubahan sistem imun dan fisiologi pada wanita hamil dapat meningkatkan risiko komplikasi infeksi COVID-19. Kehamilan dapat membahayakan sistem kekebalan tubuh dan berpotensi infeksi SARS-CoV-2 dapat meningkatkan risiko pneumonia pada wanita hamil dibandingkan dengan wanita yang tidak hamil. Wanita hamil sering dikeluarkan dari uji coba karena terdapat risiko toksisitas atau efek samping, yang mengakibatkan kurangnya pengetahuan tentang penggunaan obat dan perawatan selama kehamilan. Ketidakpastian terapi yang besar karena kurangnya informasi pengobatan yang tepat seiring dengan meningkatknya perkembangan perubahan pedoman terapi  covid19. Kajian ini bertujuan untuk mengumpulkan pengetahuan yang ada tentang perawatan obat yang tersedia saat ini untuk COVID-19 pada wanita hamil dan menyusui, dan menghasilkan analisis obat-obatan dengan profil keamanan yang dapat diterima dalam pengobatan wanita hamil dan menyusui dengan COVID-19. Suran artikel ini menggunakan Mendeley, Google Scholar, ScienceDirect, dan PubMed dari database NCBI selama Oktober - Desember 2022. A search for this article using Mendeley, Google Scholar, ScienceDirect, and PubMed from the NCBI database during October - December 2022 Administration of drugs to pregnant and nursing patients who are exposed to COVID-19 must be seriously considered. Some therapies are not recommended because they can harm the fetus. Safe therapy given to pregnant and lactating patients who are exposed to COVID 19, namely vitamin c, vitamin d, paracetamol, nac, azithromycin, ramdesivir, dexamethasone, enoxaparine, UFH, and vaccines require special attention and close monitoring. Every pregnant woman has the right to have a safe and positive birth experience, including if they are confirmed to have contracted COVID 19 or not. Pregnant women are more susceptible to a number of infectious diseases, including Covid-19. Pregnant women infected with Covid-19 are more at risk of experiencing high levels of severity, requiring ventilators or intensive care. In addition, pregnant women are more susceptible to Covid-19 infection because their pregnancy puts the body in a state of immunosuppression. Immunosuppression is a state of reduced capacity of the immune system. So that the risk of complications increases such as pre-eclampsia, coagulopathy, preterm labor (increased premature birth), miscarriage (neonatal mortality) to death. Given the importance of reducing the risk of COVID-19 for pregnant and lactating women and their neonates, it is important to determine the safety profile of all drugs in real time. So that it can provide accurate data expectations according to the expectations of all pregnant and lactating women in the world. The following types of treatments are presented as safe during pregnancy and lactation, without teratogenic effects and minimal exposure to breastfed infants, namely Azithromycin, Ramdesivir, Dexamethasone, Enoxaparine, and UFH require special attention and close monitoring. As well as additional therapy according to symptoms that arise in pregnant and lactating female patients with COVID-19, namely Vitamin C, Vitamin D, Paracetamol, and NAC. Regarding vaccination, it is strongly recommended that all pregnant women in their second and third trimesters receive the COVID-19 vaccine. The administration of the first dose of vaccination begins in the second trimester of pregnancy and the administration of the second dose is carried out according to the interval of the type of vaccine. The COVID-19 vaccine (either mRNA or viral vector) does not contain replicating virus, so it is highly recommended for pregnant and lactating women with a high risk of exposure. coronavirus continues to undergo COVID-19 vaccination. Keywords: SARS-CoV-2, COVID-19, Pregnant Women, Lactating Woman, Pharmacological Treatment 
UJI STABILITAS SEDIAAN AMPISILLIN SULBAKTAM SETELAH REKONSTITUSI I Gede Edy Sagitha; Suharjono Suharjono; Yulistiani Yulistiani; Isnaeni Isnaeni
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i1.4333

Abstract

Repeated use of antibiotic ampicillin sulbactam after reconstitution, therefore in storage various many factor can affect it stability such as type of solvent used, storage temperature and storage time. Objective of study is to analyze the chemical stability product of ampicillin sulbactam in repeated use with the parameters of the solvent and storage temperature Sample products were weighed and reconstituted using WFI and NS solvents, diluted ad 20 ppm and put into sterile vials. Then stored at room temperature (25-30 ° C) and refrigerator temperature (4-8 ° C). Storage is carried out for 24 hours which is divided into 4 -time series, namely 0, 1, 4 and 24 hours. Each time series is microbiological tested and after 18 hours incubation the inhibition zone is observed and its diameter measured using calipers. Result of study is at 0th hour showed a significant difference in different solvents. Samples dissolved with NS solvents have a greater inhibition zone than those dissolved using WFI. This happens because there is a primary salt effect that occurs with the influence of electrolytes (salt) or variations in the strength of ions can affect the coefficient of activity that affects the reaction rate. From the statistical analysis at the 1st and 4th hours, the storage temperature that provides significant result, storage in the refrigerator produces better results compared to storage at room temperature. At 24 hours the temperature and solvent did not give the significant result on the stability of the sulbactam ampicillin sample. Conclusion is NS solvents give better results than WFI solvents. Samples are more stable if stored in a refrigerator. After 4 hours based on the above study the sample no longer meets the requirements of Indonesian Pharmacopoeia 5th edition
Co-Authors A.A. Ketut Agung Cahyawan W Achmad Ridwan Achmad Ridwan, Achmad Agriawan Sudirman Ahmad Nasir ahmad, abraham Aliviyanti, Dian Andri Geger Noviantoro Anita Purnamayanti Aprillia Wijaya, Stefani Arfani, Nurfitri Ari Wibowo Arief Bachtiar Arina Dery Puspitasari Assiddiqy, Miftah Farid Atmajani, Wanudya Bagiyo, Harry Bagiyo, Harry Bagyo Yanuwiadi Bambang Eko Wahyono Bambang Sidharta Bambang Sudarmanto Budi Suprapti Budiatin, Aniek Setya Budiatin, Aniek Setya Catur Retnaningdyah Chairunnisa Chairunnisa Chris Alderman Chrismawan A, Chrismawan A Chrismawan Ardianto Dea Ayu Nabilah Debora Shinta Liana Dewi Wara Shinta Didik Hasmono Dinda Monika Nusantara Ratri Diniah, Melisa Nur Djafar, Zaenab Dliyauddin, Moh Dwiyatna, Surya Ekanita Desiani Elvan Dwi Widyadi Emiliana Kasmudjiastuti Emy Sulistyo Astuti Endang Arisoesilaningsih Endang Retnowati Eni Susanti Faizah, Mamluatul Faizal Mustamin Fandyka Yufriza Ali Fasich Fasich Fransiska Maria Christianty Gratia, Veronica Hari Prasetyo Hasria Alang Heru Purwanto Hubby, Hubby I Gede Edy Sagitha I Ketut Mandikin Ilham Rizqy Isnain Imam Faozi Imam Susilo Indira D. Kharismawati Irfan Mustafa Irma Novrianti Irma Novrianti Irvina Harini Isnaeni Jaka Susila Jikrona, Rafi Joni Kusnadi Joni Wahyuhadi, Joni Jufri Ubrusun Junaidi Khotib Kenyo Alexandra Oktaviani Khaerani Khaerani Khusnul Fitri Hamidah Kusuma Arum Ningsih Kuwatno Kuwatno Lestiono, . Lestiono, . Lewi Tigor Simorangkir Lisa Narulita Lisa Narulita Liziyyannida Liziyyannida M. Yusuf Assegaf Mahardian R, Mahardian R Mahardian Rahmadi Mahfudz Mahfudz Makitalentu, Feybe Marcha Debby Saraswati Mareta Rindang Andarsari Masyrobatin, Masyrobatin Medina, Farah Meita Rafika Fitriani Melasari, Wulan Panduwi Mohammad Akram Muhammad Aminuddin, Muhammad Muhammad Fathoni, Muhammad Mulja Hadi Santosa Narulita, Lisa Nasir, Ahmad Neldi, Vina Nia Kurniawan Nur Afni NUR CHAKIM Nur ‘Azah Nurmainah Nurmainah Nurrofik, Agus Octaviany, Evi Paramita, Angggun Putri Paulus Sugianto Prasetyanti, Intan Kris Prastuti Asta Wulaningrum Pratita, Dian Galuh Pratiwi, Esti Rizkiana Primadi Avianto Purwanto, Diyna Rusayliya Rahman, Gilang Mauladi Rahmawati Raising Ria Rositasati Riefkah Bilal risha fillah fithria Risthanti, Reine Risa Rodiyati Azrianingsih Rosdiana, Eva Rudi Safarudin Rudi Wardana Rusdiana, Silvia Rusdiana, Silvia Safarudin, Rudi Sahayuna, Dara Demi Samirah Samirah Samirah Samirah, Samirah Samsulhadi, Wiwid Sanita Suriani Sari, Erni A Semedi S J Shafira Muti Ardiana Shahroni, Abdul Mutholib Shofia Ummu, Lathifa Simorangkir, Lewi Tigor Sindy, Sulih Probo Sinuraya, Sabarita SJ, Semedi Soemarno Soemarno Solihin, Imron Sudirman, Agriawan Sukardiman Sumarno . Sumarno Sumarno Suryadi Suryadi Susilo, Dwi Hari Sutrisnaningsih, Evy Sari Suwardi Suwardi Toetik Aryani Tri Ardyati Umami, Zahra Veronica Gratia WENNY PUTRI NILAMSARI Widhiati Widhiati Widyadi, Elvan Dwi Wiwid Samsulhadi Wulan Panduwi Melasari Yance Anas yance yance Yen Yen Ari Indrawijaya YOGA DWI JATMIKO Yogiarto Yogiarto Yulia Ayu Purnamasari Yulistiani Yulistiani Yulistiani Yulistiani, Yulistiani Yulistiani, . Yuniati T Yuniati T Yuniati T, Yuniati Yusfar, Yunarti Yustiana Yustiana, Yustiana Zamrotul Izzah Zulfiana, Risa