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Aktivitas Antidiabetes Kulit Batang Arcangelisia flava dari Sulawesi Tenggara, Indonesia Secara In Vivo Terintegrasi dengan Analisis Farmakologi Jaringan A Sida, Nurramadhani; Rifa’atul mahmudah; Hasnawati; Henny Kasmawati; Nurull Hikmah
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal (January - June)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v10i1.49750

Abstract

The Arcangelisia flava plant has previously been reported to reduce blood glucose levels in experimental animals. However, there have been no reports on the antidiabetic activity of its stem bark. This study aimed to evaluate the antidiabetic activity of A. flava extracts and fractions, identify their bioactive compounds, and explore the mechanistic pathways involved using the network pharmacology approach. The chemical constituents of the n-hexane fraction were analyzed using gas chromatography mass spectrometry (GC-MS). The in vivo antidiabetic test was conducted on Mus musculus induced with streptozotocin/niacinamide. Blood glucose levels were measured using the oral glucose tolerance test (OGTT) The antioxidant activity of the extracts and fractions was determined using the ABTS assay. The result showed that the GC-MS analysis of the n-hexane fraction identified 18 compounds belonging to seven chemical groups, namely aromatic hydrocarbons, ketones and alcohols, phenolic aldehydes, sulfur compounds, terpenes, fatty acid derivatives, and alkaloids. The highest percentage of blood glucose reduction was observed in the group treated with ethanolic extract 500 mg/kg BW (50.25%), followed by glibenclamide (43.53%), ethyl acetate fraction 125 mg/kg BW (42.82%), ethanolic extract 250 mg/kg BW (41.88%), n-hexane fraction 125 mg/kg BW (34.96%), butanol fraction 125 mg/kg BW (34.28%), and ethanolic extract 125 mg/kg BW (34.14%), respectively. The ABTS assay produced IC₅₀ values for vitamin C, ethanolic extract, n-hexane fraction, ethyl acetate fraction, and butanol fraction of 8.00, 49.80, 110.25, 10.20, and 18.44 µg/mL, respectively. Network pharmacology analysis of compound 7 and compound 17 from the n-hexane fraction revealed antidiabetic potential through inhibition of the AGE–RAGE signaling pathway in diabetic complications. The key target proteins involved included MAPK1, MMP2, MAPK14, MAPK3, PIK3CA, and TGFBR1. In conclusion, the extracts and fractions of Arcangelisia flava exhibit strong potential as antidiabetic and antioxidant agents. The n-hexane fraction, in particular, is presumed to exert its antidiabetic activity through inhibition of the AGE–RAGE signaling pathway, which plays a critical role in diabetic complications.
Co-Authors ,, Suryani Abd Rafid Abd Rafid Adryan Fristiohady Agung Wibawa Mahatva Yodha Aisah Fitriani Aksan Aisyah Aisyah Amilia Primawanty Andi Hikma Jaya Andi Muammar Zayed Andi Srie Muniati T Anwar, Irvan Arba, Muhammad Arfan Arfan Ari Sartinah Arifah Indar Cahyani Asniar Pascayantri Aspadiah, Vica Astrid Indalifiany Aswani Aswani Aswani Aswani Aswani Aswani Aswani Azis, Nurul Ella Kholifatul Dian Munasari Solo Dian Munasari Solo Diana Hijrah Edy Meiyanto Evi Apriyani Firdarini Evi Silvia Fadhliah Malik Farisyah, Astrid Risky Fauziah, Nining Fery Indradewi Fifi Nirmala Fitrawan, La Ode Muhammad Halik Hardianti, Nia Hasnawati Hasnawati Hasnawati Hasnawati Hasnawati Hasnawati Hasnawati Hasnawati Henny Kasmawati Hikmah, Nurull - Idrus, Loly Subhiaty Indalifiany, Astrid Indiarti, Elsi Irnawati Irnawati Irvan Irvan Anwar Irvan Anwar Irvan Irvan jamaluddin hos Kasmawati, Henny La Ode Muh. Fitrawan La Ode Muhammad Diman Loly Subhiaty Idrus Loly Subhiaty Idrus Loly Subhiaty Idrus Loly Subhiyati Idrus Mahmudah, Rifa’atul Malina, Rachma Maulana, Wa Ode Asriani Mega Fatimah Rosana Muhammad Abdillah Muhammad Bagas Rahya Arafat Muhammad Handoyo Sahumena Muhammad Jefriyanto B Muhammad Syamsir Mulya, Elzah Mulyono Muthi Ikawati Nada Shofa Nafiah, Afifatun Nasruddin Nasruddin Nita Trinovitasari Nita Trinovitasari Nita Trinovitasari Normaidah, Normaidah Nur Hijrianti Akib Nur Illiyyin Akib Nur Illiyyin Akib Nur Illiyyin Akib Nur Rayani Nuralifah Nuralifah Nuralifah Nuralifah Nuralifah Nuralifah Nuralifah, Nuralifah Nurul Azizah Putri Herina Nurul Hikmah Nurul Jannah, Sitti Raodah Nurull Hikmah Nurull Hikmah Nurull Hikmah Ocha Olyvia Parawansah Parawansah Parawansah Parawansah, Parawansah Prasetyo, Eko Juni Pratiwi, Dinda Puriandani, Ketut Ayu Purnama, Seftiawati Itha Putri, Egi Alisa Rachma Malina Rachma Malina Rahmadani, Ulfa Novianti Ratna Asmah Susidarti Restu Nur Hasanah Rifa'atul Mahmudah Rifa'atul Mahmudah Rifa'atul Mahmudah Rifa’atul Mahmudah Rifa’atul Mahmudah Rifa’atul Mahmudah Rifa’atus Shalihah Rifa’atus Shalihah Rifa’atus Shalihah Rina Andriani Risma Risnawati Risnawati Risqa Mutiara Rustan Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin Ruslin, Ruslin Rusman, Arman SABARUDIN Sabarudin Sabarudin Sabarudin Sabarudin Sahidin Sahidin Sarida Sarida Shalihah, Rifa’atus Siti Nurma Siti Sarmila Dewi Sitti Raodah Nurul Jannah Sitti Raodah Nurul Jannah Sitti Raodah Nurul Jannah Suryani Syamsiar, Syamsiar Tahis, Ita Priati Trihafsari, Hanin Trinovitasari, Nita Umi Kalsum Muhammad Vinarti Ramdhayani Wa Ode Asdia Wa Ode Asriani Wa Ode Dian Indrayanti Wa Ode Nur Asriani Sirza Wa Ode Nurhayati Basri Wa Ode Sinta Hasrawati Wa Ode Sitti Zubaydah Wahyuni Wahyuni Widari, Niluh Putri Sri Wiwin Putri Wulandari Yamin Yamin Yamin, Yamin