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All Journal Jurnal Kesehatan Jurnal Sehat Mandiri INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Pendidikan dan Konseling Jurnal Integrasi Kesehatan dan Sains LOSARI: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Wahana Pendidikan Jurnal EduHealth Jurnal Kesehatan Innovative: Journal Of Social Science Research Journal of Sustainable Community Service Analit: Analytical and Environmental Chemistry Journal of Pharmaceutical and Sciences. Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Dedikasi Olahraga Dan Kesehatan Analit: Analytical And Environmental Chemistry
Munir Alinu Mulki
Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Singaperbangsa Karawang, Karawang, Jawa Barat, Indonesia.
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Veterinary Other

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The Relationship Between Knowledge Level And Cold Cough Self-Medication Behavior In Students Of The University Of Singaperbangsa Karawang Hidayat, Sofianti; Mally Ghinan Sholih; Munir Alinu Mulki
Jurnal EduHealth Vol. 15 No. 03 (2024): Jurnal EduHealt (September), Year 2024
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Self-medication for coughing up a cold is common, especially among students. Factors such as stress, lack of sleep, unhealthy diet, and poor hygiene can increase the risk of developing a cold cough. The availability of drugs on the market significantly facilitates students to self-medicate the symptoms of the disease they experience, because it is considered faster, economical, and practical without the need for medical consultation. This study aims to determine the relationship between respondents' characteristics on the level of knowledge and self-medication behavior of cold cough and determine the relationship between the level of knowledge on cold cough self-medication behavior in active students of Singaperbangsa University Karawang. The method used was descriptive analytic with Cross Sectional approach and involved 390 randomly selected respondents. The study was conducted from February to March 2024. The results of this study showed that 59.5% of respondents had good knowledge of cold cough self-medication, and 40.5% had poor knowledge. Then the self-medication behavior of cold cough showed that 58.2% of respondents had good behavior, and 41.8% had bad behavior. There is a relationship between the characteristics of respondents to the level of knowledge and self-medication behavior of cold cough, namely faculty with a p-value knowledge level of 0.004 < 0.050, and there is a relationship between faculty and behavior obtained p-value of 0.005 < 0.050. The results of the study The Relationship of Knowledge Level to Behavior was tested using a chi-square p-value test of 0.001 < 0.050. It can be concluded that there is a significant relationship between the level of knowledge and the self-medication behavior of cold cough.
Penyuluhan Hormon Paratiroid, Kalsitonin, dan Obat yang Bekerja pada Tulang di SMAN 1 Karawang Munir Alinu Mulki; Rizki Rava Dwi Putra; Jasmine Rahma Saputri; Siti Rosilfa Marisa; Ihsan Alfiandri
Jurnal Dorkes (Dedikasi Olahraga dan Kesehatan) Vol 1 No 2 (2023): DORKES Edisi September 2023
Publisher : Fakultas Ilmu Kesehatan UNSIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/dorkes.v1i2.10449

Abstract

Kalsium merupakan mineral yang paling penting bagi berbagai fungsi di dalam tubuh. Kelenjar paratiroid dan tiroid bertanggung jawab mengatur kadar kalsium dalam tubuh dengan cermat. Penyusunan jurnal ini ditujukan untuk mengamati pengetahuan siswa SMAN 1 Karawang terkait pengetahuan tentang hormon paratiroid, kalsitonin beserta obat yang bekerja pada tulang, karena berdasarkan survei yang telah dilakukan diketahui bahwa siswa-siswa SMAN 1 Karawang kurang memahami mengenai pengetahuan hormon paratiroid, kalsitonin beserta obatx yang bekerja pada tulang. Metode yang diterapkan adalah metode tes untuk menguji kemampuan responden berupa pemberian Pre-Test dan Post-Test, data tes tersebut diolah menggunakan aplikasi SPSS. Hasil Post-Test menggambarkan bahwa terdapat kenaikan nilai sebanyak 18,4% setelah dilakukan kegiatan penyampaian materi. Hal ini dapat diketahui dari nilai hasil rata-rata Pre-test 5,58 dan setelah dilakukan penyuluhan terdapat peningkatan nilai rata-rata Post-test menjadi 7,42. Dengan demikian, dapat disimpulkan bahwa penyuluhan kesehatan memiliki dampak signifikan terhadap pengetahuan siswa-siswi di SMAN 1 Karawang mengenai hormon paratiroid, kalsitonin beserta obat yang bekerja pada tulang.
Studi In Silico Prediksi Potensi Senyawa Bahan Alam sebagai Anti-Inflamasi dalam Menghambat COX-2 Sanjaya, Velieana Laurent; Mulki, Munir Alinu
Jurnal Sehat Mandiri Vol 19 No 2 (2024): Jurnal Sehat Mandiri, Volume 19 Nomor 2 Desember 2024
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v19i2.1712

Abstract

Infection or tissue injury induces inflammation, which causes pain. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are commonly used anti-inflammatory agents but can cause adverse effects on the stomach, kidneys, and liver when used long-term. As a result, efforts have been made to discover new drugs from natural sources to minimize these risks. With advances in technology, the search for new drug candidates using computational modeling, such as molecular docking, has become increasingly common. The aim of this systematic literature review is to predict and evaluate the potential of natural compounds as anti-inflammatory agents through in silico analysis. A systematic literature review of 10 recent articles, selected from an initial 376 articles on the topic of natural plant compounds' anti-inflammatory potential in silico, published between 2020 and 2023, was conducted using the PubMed and Springer databases. The conclusion from the review of the structural analysis of secondary plant metabolites shows that all 45 compounds tested demonstrated the ability to interact with the COX-2 enzyme, which plays a key role in inflammation and pain. Among these compounds, catechin, a member of the flavonoid group, was identified as the best candidate based on in silico analysis.
Perbandingan Efektivitas Antibiotik Terhadap Durasi Terapi Demam Tifoid Sholih, Mally Ghinan; Mulki, Munir Alinu; Nurhadis, Nurhadis; Akifah, Muthia Nur; Aprillia, Cantika; Maharani, Puteri Rahma; Subekti, Firli Reisya; Affandhy, Adhwa'a Kaylla
Jurnal Ilmiah Wahana Pendidikan Vol 11 No 1.D (2025): Jurnal Ilmiah Wahana Pendidikan 
Publisher : Peneliti.net

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Abstract

Demam tifoid merupakan penyakit yang sering terjadi di Indonesia, disebabkan oleh bakteri Salmonella typhi yang menyebar melalui jalur fecal-oral. Prevalensi demam tifoid di Indonesia mencapai 1,60%, dengan prevalensi tertinggi pada anak-anak berusia 5 hingga 14 tahun karena kebiasaan jajan sembarangandan kurangnya perhatian terhadap kebersihan diri . Pengobatan demam tifoid melibatkan pemberian antibiotik yang tepat dan perawatan suportif. Studi ini bertujuan untuk menganalisisefektivitas antibiotik dalam mengurangi durasi terapidemam tifoid, dengan fokus pada antibiotik seperticeftriaxone, cefotaxime, azithromycin, ciprofloxacin, kloramfenikol, dan tiamfenikol. Metode yang digunakan dalam penelitian initermasuk dalam jenis penelitian systematics literature review. Penelitian menunjukkan bahwa ceftriaxone lebih efektif dari pada kloramfenikol dalam mengatasi demam tifoid, dan kombinasi antibiotik seperti tiamfenikol dan ceftriaxone dapat mengurangi lama rawat inap. Azitromisin juga efektif untuk kasus tanpa komplikasi. Penggunaanantibiotik yang tepat penting untuk mengurangi case fatality rate. Terapi kombinasi dapat memperluas spektrumaktivitas antimikroba dan mencegah resistensi. Studi ini memberikan wawasan tentang pengobatan demam tifoiddengan antibiotik yang efektif, seperti ceftriaxone, azithromycin, dan kombinasi antibiotik tertentu. Pentingnya edukasi tentang kebersihan pribadi dan lingkungan juga disorot untuk mencegah penyebaran infeksi lebih lanjut. Dengan pemahaman yang lebih baiktentang efektivitas antibiotik dalam pengobatan demam tifoid, diharapkan dapat meningkatkan penanganan kasusdemam tifoid dan mengurangi dampak negatifnya.Kata kunci: Demam tifoid, Lama pengobatan, Terapi antibiotik, Efikasi obat, dan Efektivitas perbandingan
Review Artikel: Pengaruh Perbandingan Fase Gerak Dalam Analisis Senyawa Hidrokuinon Pada Sediaan Kosmetik Menggunakan Metode High Performance Liquid Chromatography (HPLC) Basmalah, Nur; Hariadi , Nayla Nur Azkia; Mulki , Munir Alinu
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.687

Abstract

Hydroquinone is a compound that is often used in cosmetic products because of its ability to brighten the skin by inhibiting melanin production. However, its use can cause dangerous side effects such as irritation, hyperpigmentation and the risk of cancer, so its use in cosmetics has been limited by BPOM. High Performance Liquid Chromatography (HPLC) is an analytical method commonly used to detect hydroquinone in cosmetic preparations because of its sensitivity and ability to separate compounds with high complexity. This article is a literature review which aims to determine the effect of mobile phase comparison on hydroquinone analysis using the HPLC method. The research results show that selecting the right mobile phase is very important to guarantee accurate, precise and efficient analysis results. The combination of a polarity-based mobile phase that matches the properties of hydroquinone provides good resolution, high sensitivity, and optimal retention time. This research is expected to provide guidance in optimizing the HPLC method for hydroquinone analysis, and is expected to support cosmetic safety monitoring.
Tinjauan Literatur: Pengaruh Parameter Metode Kromatografi Lapis Tipis untuk Identifikasi Kafein dalam Kopi Hariadi, Nayla Nur Azkia; Basmalah, Nur; Laprilski , Dewi Hanun; Azzahra , Khaerunisa; Mulki , Munir Alinu
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.683

Abstract

Background: The rising consumption of coffee in Indonesia necessitates reliable methods for caffeine analysis to ensure product quality and safety. Thin Layer Chromatography (TLC) is a simple, effective, and polarity-based technique widely used for the qualitative identification of compounds like caffeine in coffee. However, the results of TLC analysis are highly dependent on several methodological parameters. Objectives: This literature review aims to identify and analyze the critical parameters of the TLC method—including the mobile phase, stationary phase, visualization techniques, and sample preparation—that influence the effectiveness of caffeine identification in coffee. Methods: A systematic literature review was conducted using online databases (Google Scholar, PubMed, Semantic Scholar, and Crossref). Articles from the last ten years were selected based on inclusion and exclusion criteria, resulting in nine primary studies for in-depth analysis. Results: The review confirms that silica gel 60 F254 is the most effective stationary phase. The composition of the mobile phase is crucial; a mixture of dichloromethane:methanol (9.5:0.5) was found to be optimal for separating caffeine, yielding Rf values within the ideal range of 0.3–0.7. Visualization under UV light at 254 nm successfully detected caffeine as dark spots. Sample preparation techniques, particularly reflux and ultrasonic extraction, significantly enhanced extraction efficiency and detection sensitivity. Factors such as mobile phase stability, spotting technique, and sample matrix were also identified as key influencers on the chromatographic results. Conclusion: TLC is an efficient and cost-effective method for the qualitative identification of caffeine in coffee. Its success is determined by the optimization of critical parameters, primarily the mobile phase composition. While excellent for initial screening, TLC requires complementary techniques for precise quantitative analysis. Future work should focus on standardizing these parameters to improve the reproducibility and reliability of caffeine analysis using TLC.
Literature Review : Analisis Senyawa Kimia sebagai Kandidat Obat Kanker Paru Menggunakan Metode Molecular Docking Hidayat, Muhammad Naufal Nurhadi; Alinu Mulki, Munir; Dwiputri Prihasti, Nurlita
Jurnal Sehat Mandiri Vol 20 No 2 (2025): Jurnal Sehat Mandiri, Volume 20, No.2 Desember 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i2.1869

Abstract

Lung cancer is the leading cause of death worldwide, so the development of effective drugs is urgently needed. This study aims to identify potential chemical compounds as lung cancer drug candidates through molecular docking analysis. This study used a narrative literature review method with data collected from PubMed using specific keywords such as "Molecular docking," "Lung cancer," "Drug candidate," "Chemistry," and "Compound" for articles published between 2019 and 2024. Inclusion criteria included studies that analyzed chemical compounds as lung cancer drug candidates using molecular docking and met certain quantitative criteria. Of the initial 123 articles, 10 articles met the inclusion criteria and were analyzed further. The results showed significant interactions between several chemical compounds and lung cancer-related protein targets such as P-glycoprotein, NEK7, EGFR, VEGFR-2, and topoisomerase II, with high binding affinity. Overall, the results of this review highlight compound 762, SIQ17, and compound 7 as lead candidates with high therapeutic potential, which deserve further development through in vitro and in vivo tests to support their application in lung cancer therapy.
Molecular identification and antibacterial activity of endophytic bacteria from Bambusa vulgaris leaves as antibacterial potential against phatogenic microoganism Malau, Jekmal; Mierza, Vriezka; Mulki, Munir Alinu; Urbaningrum , Lestari Mahardika; Hasna, Vina Luthfiana; Debora, Priscinya Christiana
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 7 No 2 (2025): From Natural Compounds to Disease Mechanisms: An Integrated Research Outlook
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v7i2.6538

Abstract

The increasing prevalence of antibiotic-resistant bacteria poses a critical global health concern, necessitating the exploration of novel antibacterial solutions. Endophytic bacteria, which colonize plant tissues without causing harm, have gained attention as potential sources of bioactive metabolites. This study aimed to isolate and characterize endophytic bacteria from Bambusa vulgaris leaves and evaluate their antibacterial potential against pathogenic microorganisms. Leaf samples were collected from Bekasi, West Java, and subjected to a surface sterilization process prior to bacterial isolation. A total of 12 bacterial strains were successfully obtained and screened for antibacterial activity against Bacillus subtilis, Propionibacterium acnes, Pseudomonas aeruginosa, and Staphylococcus epidermidis using the agar well diffusion assay. Three isolates exhibited notable inhibitory activity, with P8 demonstrating the strongest antibacterial effects against B. subtilis, P. acnes, and S. epidermidis. The two most potent isolates, P8 and K3, were characterized via 16S rRNA gene sequencing. Genomic DNA extraction was performed, followed by Polymerase Chain Reaction (PCR) amplification using the universal primers 27F (5′-AGAGTTTGATYMTGGCTCAG-3′) and 1492R (5′-GGTTACCTTGTTACGACTT-3′). Sequencing and The Basic Local Alignment Search Tool (BLAST) analysis confirmed that isolate P8 exhibited 100% similarity to B. subtilis strain LZH-H1, whereas isolate K3 shared 99.85% similarity with Pantoea stewartii subsp. indologenes strain SR2-12. These findings suggest that endophytic bacteria from B. vulgaris endohytic bacteria hold promise as potential sources of antibacterial compounds. Further research is necessary to purify and characterize these bioactive metabolites for potential pharmaceutical applications.
Literature Review : Study of molecular mechanism level of NSAID class of drugs as COX-2 inhibitors Zakiyah, Wildani; Sukma Wibowo, Sepvia Putri; Elyyana, Nina; Nur Darmawan, Shiyami Aulia; Lestari, Sepiyani Ayu; Sa'diyyah, Nur; Malau, Jekmal; Mulki, Munir Alinu
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (388.745 KB)

Abstract

NSAIDs (Non-Steroid Anti-Inflammatory Drugs) are drugs that can treat pain and inflammation. The therapeutic effect of NSAIDs as anti-inflammatory analgesics is that they have the ability to inhibit the biosynthesis of prostaglandins which are pain mediators. This prostaglandin has a major role in inhibiting the COX enzyme (cyclooxygenase) in which COX has two isoforms, namely COX1 isoenzyme (non-selective) and COX2 isoenzyme (selective). Tricyclic COX-2 selective inhibitors work by blocking COX-2. COX-2 binds to PD-L1 via the PGE2 pathway and affects macrophages in suppressing myeloid. COX-2 has functions including producing reactive oxygen species that are responsible for DNA damage, activating substances that deviate from intracellular pathways such as the MAPK and PI3 K/AKT pathways, activating STAT3, inducing Bcl-2, and producing growth factors including growth factors. epidermal (EGF)) and fibroblast growth factor (FGF).
Review artikel: analisis faktor yang mempengaruhi kejadian pneumonia pada bayi dan balita Sholih, Mally Ghinan; Mulki, Munir Alinu; Julianti, Nurlia; Jannah, Roudotul; Indriyani, Yuni Lili
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 2 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i2.386

Abstract

Pneumonia is an infection of the lower respiratory tract which is the main cause of death in toddlers and children. Although there is a lot of information about risk factors for pneumonia, there is information that is not presented in detail and specifically. The purpose of this review article is to provide insight into the risk factors that cause pneumonia in babies and toddlers, making us more alert and aware of the importance of preventing and treating pneumonia, especially in babies and toddlers. The review method for this article is a literature review. The database comes from national and international journals via Google Scholar and PubMed databases published in the years 2013-2023. The results and discussion of this review include information about pneumonia, risk factors for pneumonia, and factors causing pneumonia in infants and toddlers. Based on the articles that have been reviewed, it shows that the factors that influence the incidence of pneumonia are exposure to cigarette smoke, LBW, nutritional status, gender, and history of exclusive breastfeeding. 
Co-Authors Affandhy, Adhwa'a Kaylla Afifah Rusyda Sani Ain Luthfiannisa Akifah, Muthia Nur Aldila Divana Sarie Alfina Oktavianti Amanda Maharani Angel Novia Fransiska Anggi Ayu Pratama Anisa Aula Rahma Anisa Fauziah Annisa Frastica Septi Aprillia, Cantika Arline Rahmadianti Kusumawardhani Asman Hitopik Asri Yuniar Aurora Fatimatuz Zahro Azzahra , Khaerunisa Basmalah, Nur Cantika Nurul Sa&#039;adah Chalisya Vanya Advaita Choerunnisa Choerunnisa Datu Muhammad Cordova Debora, Priscinya Christiana Diva Afiah Hanifa Irawan Dwiputri Prihasti, Nurlita Elvira Julia Ariyanto Elyyana, Nina Elzandra Imola Vioniken Eriyanti Astika Esti Syahrin Faizal Auladi Rivianto Fathina Annajla Febry Nola Odhia Fikri Aldebaran Misbah Azizi Giga Anugerah Arsylrakhmatika Gun Gun Gumilar Hariadi , Nayla Nur Azkia Hariadi, Nayla Nur Azkia Hasna, Vina Luthfiana Haura, Izmi Herdiana Verliani Hidayat, Muhammad Naufal Nurhadi Hidayat, Sofianti Ibtisamah Haura Ihsan Alfiandri Indah Laily Hilmi Indah Laily Hilmi Indriyani, Yuni Lili Irene Virda Sakina Isyana S alsabila Jasmine Rahma Saputri Jekmal Malau Jekmal Malau Julianti, Nurlia Karlina Dwi Samratul Jannah Laprilski , Dewi Hanun Lestari, Sepiyani Ayu Madame Marselly Sebayang Maharani, Puteri Rahma Mally Ghinan Sholih Mally Ghinan Sholih Mally Ghinan Sholih Marsah Rahmawati Utami Martia, Elsya Meliana Sari Melisa Intan Barliana Mierza, Vriezka Mochamad Galuh Ryandha Moza Aulia Syifni Muhammad Fajri Maariz Muhammad Ja'far Ash Shidiq Muhammad Naufal Nurhadi Hidayat Muhammad Raka Tresna Mulidini Mulidini Mutia Desvi Putri Mutiara Alfiyah Najah Fatihatul Arifia Najla Yusiana Wahyudi Nanda Diva Meilani Nariyyah Fitriana Nissa Khalida Hanum Nolla Olipia Elva Megrian Nur Darmawan, Shiyami Aulia Nur Komala Fitri Nurfadhila, Lina Nurfirah Mubarok Nurhadis, Nurhadis Nurlia Julianti Nurlita Dwi Putri Prihasti Nurma Dwi Rahmawati Pratama, Reza Prihasti, Nurlita Dwi Putri Priscinya Christiana Debora Putri Setya Tyasna Putri Wahyu Primasti Putri Wulanbirru Rachel Noveriachristie Balapadang Ratu Siti Robiatul Awaliyah Rifa Nur Alia Rima Putri Ramadhani Riska Shafira Rizki Rava Dwi Putra Roudotul Jannah Roudotul Jannah Sa'adah, Cantika Nurul Sa'diyyah, Nur Saarah Hamidah Asmara Indratno Safira Rosyidah Salma Alviyah Salman Salman Salsabila Granadha Nibullah Sanjaya, Velieana Laurent Saputro, M. Ramadhan Septiani, Dia Shafira Intan Anggraini Shalum Putriyani Shinta Puspa Dwiyanti Sholih, Mally Ghinan Siska Bela Safitri Siti Nafisa Siti Nur Istiqomah Siti Nuriah Siti Rohmah Siti Rosilfa Marisa Sofianti Hidayat Sophy Wulandari Sri Rahayu Subekti, Firli Reisya Sudarjat, Hadi Sukma Wibowo, Sepvia Putri Sulistiawati Sulistiawati Syelziva Yonda Atwita Syifa Khairunnisa TIANA MILANDA Tiara Cinta Amelia Tiara Nurayuni Tintia Rafika Putri Tiwi Ambarati Urbaningrum , Lestari Mahardika Vriezka Mierza Welly Windari Yumareta Anggun Yuni Lili Indriyani Yuniar Fathil Ilmi Zakiyah, Wildani Zuyyinna Alya Abbas