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All Journal Jurnal Kesehatan Acta Pharmaciae Indonesia : Acta Pharm Indo PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Sehat Mandiri INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Pendidikan dan Konseling Jurnal Integrasi Kesehatan dan Sains LOSARI: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Wahana Pendidikan Jurnal EduHealth Jurnal Kesehatan Innovative: Journal Of Social Science Research Journal of Sustainable Community Service Analit: Analytical and Environmental Chemistry Journal of Pharmaceutical and Sciences. Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Dedikasi Olahraga Dan Kesehatan Analit: Analytical And Environmental Chemistry
Munir Alinu Mulki
Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Singaperbangsa Karawang, Karawang, Jawa Barat, Indonesia.
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Veterinary Other

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Review Artikel: Analisis Kandungan Cemaran Logam Berat pada Ikan yang Berada di Sungai Indonesia Indriyani, Yuni Lili; Mulki, Munir Alinu
Jurnal Sehat Mandiri Vol 19 No 1 (2024): Jurnal Sehat Mandiri, Volume 19, No.1 Juni 2024
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v19i1.1383

Abstract

Fisheries production in Indonesia will reach 24.74 million tonnes in 2023 and will increase compared to 2022 which was only 22.26 million tonnes. Increased production is in line with increased consumption which cannot be separated from food safety problems, especially the problem of heavy metal contamination originating from domestic waste and factory waste. The purpose of this review article is to provide information for knowledge and awareness to the public regarding the fish they consume. This review was carried out using searches via Google Scholar and Researchgate published in the last 10 years (2014-2024). The total articles used were 11 scientific articles. The research results show that there is heavy metal contamination such as lead, mercury, cadmium, arsenic, copper, manganese, chrome, cobalt, argentum, zinc and tin at different levels in each location. The most heavy metal contamination is lead (Pb) with the highest level of 4,242 mg/kg in tilapia fish in the Tenggang River, Semarang at the location of the first testing station, namely the upstream area with coordinates 6°57'49.8"S and 110° 27’04.6”E. In conclusion, the pollution is thought to be due to contamination of the environment because there is a Small Industrial Environment (LIK) and a lot of rubbish is drifting along the river. The suggestion is that it is necessary to enforce waste management regulations and effective supervision for the sake of public health and environmental safety, especially regarding industrial waste.
Narrative Review: Parameter dalam Metode Analisis untuk Identifikasi Rhodamin B dalam Lipstik Prihasti, Nurlita Dwi Putri; Mulki, Munir Alinu; Hidayat, Muhammad Naufal Nurhadi
Jurnal Sehat Mandiri Vol 19 No 1 (2024): Jurnal Sehat Mandiri, Volume 19, No.1 Juni 2024
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v19i1.1385

Abstract

Rhodamine B is a synthetic dye used in the paper and textile industries, attracting attention due to its potential health hazards. It is used in various cosmetic products, although the Regulation of the Minister of Health of Indonesia No. 445/MENKES/PER/V/1998 prohibits its use in cosmetics due to risks of irritation, liver damage, and cancer. This article reviews the parameters of analytical methods for identifying Rhodamine B in lipstick. A narrative review was conducted using Google Scholar as a database over the past 10 years. The KLT method was found to be more widely used than HPLC or UV-Vis Spectrophotometry. Differences in Rf values in KLT are due to variations in the stationary phase. Parameter variations in HPLC system suitability tests are caused by operational conditions, sample conditions, and instrument performance. Analytical methods for identifying Rhodamine B in lipstick include KLT, HPLC/KCKT, and UV-Vis Spectrophotometry. It is concluded that each method has specific parameters that must be met: KLT is qualified if the Rf value comparison (standard vs. sample) is ≤ 0.2; HPLC/KCKT requires system suitability and validation tests; UV-Vis Spectrophotometry needs validation test parameters. KLT is preferred due to easy sample preparation and lower costs compared to HPLC and UV-Vis Spectrophotometry. It is recommended to consider necessary components when using these methods to maximize test results.
Aksi Mengenal dan Memilih Obat (AMMUBA) di Puskesmas Adiarsa Karawang Septiani, Dia; Mulki, Munir Alinu; Vriezka Mierza
LOSARI: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 2 (2023): Desember 2023
Publisher : LOSARI DIGITAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53860/losari.v5i2.177

Abstract

Drugs are an important element in health administration efforts, both preventive, promotive, curative, and rehabilitative. Errors in the selection and use of drugs can cause harm to public health and the environment. Educational actions have been carried out for the community in recognizing and choosing the right medicine, through health facilities at Puskesmas Adiarsa, Kabupaten Karawang. A total of 20 people were persuasively educated and given a pre-test questionnaire and an educational post-test questionnaire to measure the increase in knowledge and understanding. The results of this activity are known to people who are visiting the Puskesmas Adiarsa Karawang increased their understanding by 49% in recognizing and choosing drugs so that it can be said that educational activities to recognize and choose drugs are successful and people are smarter in using drugs.
ANTIOXIDANT ACTIVITY TEST OF BALAKACIDA LEAVES (Chromolaena odorata L) WITH DPPH (2,2-difenil-1-pikrilhidrazil) METHOD Martia, Elsya; Mulki, Munir Alinu; Nurfadhila, Lina
Analit : Analytical and Environmental Chemistry Vol. 9, No. 01 April (2024) Analit : Analytical and Environmental Chemistry
Publisher : Jurusan Kimia FMIPA Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/analit.v9i01.170

Abstract

Balakacida leaves (Chromolaena odorata L) are plants known for their allelopathic properties, which can be utilized as natural herbicides. Empirically, they are used as wound healing agents, mouthwash, anti-diarrheal, antimicrobial, and anti-inflammatory medicines. The leaves are processed by squeezing them to extract their liquid, which is then applied to skin wounds for treatment (Marianne, 2014). Flavonoid components in balakacida leaves have antimicrobial effects. The focus of this research is to determine the IC50 value of balakacida leaves and characterize their antioxidant ability. Multi-step maceration using polarity-based solvents (n-hexane, ethyl acetate, and ethanol) is employed for extraction. The DPPH technique is utilized to evaluate antioxidant capacity. Phytochemical analysis has revealed active secondary metabolites with antioxidant properties in the plant, including tannins, flavonoids, alkaloids, and steroids. The IC50 values for n-hexane, ethyl acetate, and ethanol extracts are 35.58, 14.24, and 12.73 ppm respectively, indicating very high antioxidant activity. According to Fitrah (2017), crude balakacida leaf extract exhibits antioxidant effects. These effects are attributed to the high content of flavonoids, which possess antioxidant activity capable of inhibiting the oxidation process.  
Review Artikel: Karakterisasi Dan Uji Efektivitas Antikanker Nanopartikel Emas (AuNPs) Dan Nanopartikel Perak (AgNPs) Dengan Ekstrak Kunyit (Curcuma spp.) Sebagai Bioreduktor Haura, Izmi; Mulki, Munir Alinu
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.678

Abstract

Cancer is one of the leading causes of death in the world with major challenges in the form of therapeutic side effects, poor selectivity, and drug resistance. Nanotechnology, particularly the use of gold (AuNPs) and silver (AgNPs) nanoparticles, offers a promising alternative to improve the effectiveness of cancer therapy. This article reviews recent developments in the synthesis of AuNPs and AgNPs using turmeric as a natural, environmentally friendly bioreductor. Characterization of nanoparticles through UV-Vis, TEM, SEM, and FT-IR methods showed particle sizes ranging from 1-100 nm, spherical or hexagonal morphology, and the presence of functional groups such as -OH and C=O that support stability and bioactivity. Anticancer studies show that these nanoparticles are effective against various types of cancer cells, including breast (MCF-7, MDA-MB-231), lung (A549, NCI-H661, NCI-H1975, NCI-H1573, NCI-H1563), cervical (HeLa), and epithelial (Hep-2) cancers.
Aktivitas Antidiabetes Infusa Buah Mengkudu (Morinda Citrifolia L.) pada Mencit Jantan terinduksi Aloksan Mulki, Munir Alinu; Amelia , Tiara Cinta
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1247

Abstract

Noni (Morinda citrifolia L.) is traditionally consumed for diabetes, yet in vivo evidence for water-based infusion remains limited. This study aimed to evaluate the antihyperglycemic effect of a standardized noni fruit infusion in alloxan-induced male mice. Dried fruit simplicia were quality-controlled according to the Indonesian Herbal Pharmacopoeia. Mice were induced with alloxan (140 mg/kg, i.p.) and randomized (n=5/group) to vehicle (0.5% Na-CMC), metformin (1.3 mg/20 g BW), or noni infusion at low (103), normal (123), or high (144 mg/20 g BW) for 21 days in two divided doses per day. Fasting blood glucose was measured at baseline, day 0, and days 7, 14, and 21. Paired t-tests assessed within-group changes, while between-group comparisons used one-way ANOVA with Levene’s test (Tukey HSD) and Welch ANOVA as sensitivity analysis. Phytochemical screening indicated alkaloids, saponins, triterpenoids, and flavonoids. All groups showed significant reductions from day 0 to day 21 (p<0.05). From day 0 to day 14, the normal-dose infusion decreased glucose by 45.7% (172.8 to 93.8 mg/dL), compared with 33.3% for metformin (134.0 to 89.4 mg/dL). By day 21, reductions were 48.3–49.6% in the normal/high-dose infusion groups and 36.4% with metformin. Between-group differences were evident at days 7 and 14 but not at day 21 (p>0.05). Standardized noni infusion exhibits antihyperglycemic activity in the alloxan model; confirmation of mechanisms, additional metabolic endpoints, and subchronic safety evaluation are required before clinical relevance can be inferred.
GERAKAN PEDULI KEBERSIHAN MANDIRI (KALI BERSAMA) Hilmi, Indah Laily; Salman, Salman; Sudarjat, Hadi; Gumilar, Gun Gun; Mulki, Munir Alinu
JOURNAL OF SUSTAINABLE COMMUNITY SERVICE Vol. 3 No. 1 (2022): DECEMBER
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/jscs.v3i1.636

Abstract

The Gerakan Peduli Kebersihan Mandiri (Kali Bersama) is an initiative carried out by the Pharmacy students of Singaperbangsa University Karawang with the aim of raising awareness among teenagers in Citra Kebun Mas Housing, Karawang about clean and healthy living behaviors, especially handwashing with soap. This research aims to improve teenagers' understanding of Clean and Healthy Living Behavior (PHBS) and proper handwashing techniques. The method used in this research is counseling, which includes education on the importance of PHBS and demonstration of proper handwashing techniques. The questionnaire results conducted after the counseling show that the majority of teenagers are aware of PHBS and apply it in their daily lives, but there is still a gap between knowledge and PHBS practices. Based on these results, it is recommended to adjust the timing of activities, involve faculty leaders, and provide adequate facilities for the handwashing program with soap in future activities.
Analytical agreement between CEDIA immunoassay and HPLC for therapeutic drug monitoring of carbamazepine: a narrative review Mulki, Munir Alinu; Fitriana, Nariyyah; Ilmi, Yuniar Fathil; Utami, Marsah Rahmawati
Acta Pharmaciae Indonesia Vol 13 No 1 (2025): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2025.13.1.16526

Abstract

speed, simplicity, and cost, but the extent of its agreement with HPLC across diverse clinical contexts requires careful evaluation. Method: This narrative review synthesizes evidence from nine studies identified through Scopus and Google Scholar to assess the analytical agreement and clinical validity of CEDIA and related immunoassay platforms compared to HPLC and advanced chromatographic methods. Results: The reviewed evidence demonstrates strong inter-method correlation, although systematic positive bias in immunoassay results is consistently observed, particularly in patients receiving enzyme-inducing co-medications where carbamazepine-10,11-epoxide accumulation affects antibody cross-reactivity. CEDIA is analytically acceptable for routine CBZ TDM in stable patients on monotherapy. HPLC and LC-MS/MS remain preferable when metabolite quantification, polytherapy monitoring, or precise measurement near therapeutic boundaries is clinically required. Conclusion: Method selection should be guided by the clinical question, patient population characteristics, and available laboratory resources.
Artikel Tinjauan: Perbandingan Metode KLT, KCKT, dan Spektrofotometri UV-VIS untuk Deteksi dan Kuantifikasi Paraben Pada Kosmetik Widodo, Hanifah Nur; Mulki, Munir Alinu; Ramadhani, Biandra Cinta; Ramadani, Salsabila
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1193

Abstract

Parabens are widely used preservatives in cosmetic products to inhibit microbial growth; however, excessive exposure has been associated with endocrine disruption and skin irritation. This study reviews and compares analytical methods used for the identification and quantification of parabens in cosmetic products, namely Thin Layer Chromatography (TLC), UV–Vis spectrophotometry, and High-Performance Liquid Chromatography (HPLC). Literature searching was conducted through PubMed and Google Scholar for studies published between 2015 and 2025. Ten articles met the inclusion criteria as original research utilizing one of the three analytical methods. TLC is effective for preliminary qualitative identification based on Rf values but is less suitable for quantitative analysis. UV–Vis spectrophotometry allows rapid determination of paraben levels within a λmax range of 254–258 nm and provides reliable results for relatively simple matrices. HPLC generally demonstrates the highest sensitivity, specificity, and accuracy, commonly employing C18 columns, methanol–aquadest mobile phases, retention times of 3–11 minutes, and high linearity (R² ≥ 0.999). Several studies also reported paraben levels exceeding the safety limits established by BPOM RI, highlighting the importance of chromatographic confirmation in cosmetic surveillance. Therefore, the selection of analytical methods should follow a fit-for-purpose approach based on analytical objectives, matrix complexity, and regulatory requirements to ensure product safety.
Pengaruh Asupan Vitamin K terhadap Stabilitas Rasio Normalisasi Internasional dan Efektivitas Terapi Warfarin Yuniar Fathil Ilmi; Nariyyah Fitriana; Munir Alinu Mulki; Indah Laily Hilmi
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 22 No. 02 Desember 2025
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Warfarin memiliki indeks terapi sempit dengan variabilitas respons tinggi. Fluktuasi asupan vitamin K dapat menyebabkan ketidakstabilan INR, namun hubungannya masih kontroversial. Tinjauan ini bertujuan untuk mengevaluasi pengaruh asupan vitamin K terhadap stabilitas INR dan efektivitas terapi warfarin. Tinjauan sistematis mengikuti PRISMA 2020 melalui PubMed (2010-2025). Dari 6.573 artikel, 9 studi di sertakan (4 RCT, 5 observasional) dengan penilaian kualitas menggunakan Cochrane RoB 2 dan Newcastle-Ottawa Scale. Hasil menunjukkan konsistensi asupan vitamin K lebih penting dibanding jumlah absolut dalam menjaga stabilitas INR. Suplementasi dosis rendah (150 mcg/hari) efektif menurunkan fluktuasi ekstrem INR. Pemberian vitamin K untuk INR tinggi (≥4) aman dan efektif menurunkan risiko perdarahan serta mortalitas tanpa meningkatkan tromboembolisme. Dapat disimpulkan bahwa konsistensi konsumsi vitamin K merupakan faktor kunci efektivitas terapi warfarin. Edukasi harus menekankan konsistensi daripada pembatasan ketat. Diperlukan RCT berskala besar dengan tindak lanjut lebih panjang dan integrasi data genetik.
Co-Authors Affandhy, Adhwa'a Kaylla Afifah Rusyda Sani Ain Luthfiannisa Akifah, Muthia Nur Aldila Divana Sarie Alfina Oktavianti Amanda Maharani Amelia , Tiara Cinta Angel Novia Fransiska Anggi Ayu Pratama Anisa Aula Rahma Anisa Fauziah Annisa Frastica Septi Aprillia, Cantika Arline Rahmadianti Kusumawardhani Asman Hitopik Asri Yuniar Aurora Fatimatuz Zahro Azzahra , Khaerunisa Basmalah, Nur Cantika Nurul Sa&#039;adah Chalisya Vanya Advaita Choerunnisa Choerunnisa Datu Muhammad Cordova Debora, Priscinya Christiana Diva Afiah Hanifa Irawan Dwiputri Prihasti, Nurlita Elvira Julia Ariyanto Elyyana, Nina Elzandra Imola Vioniken Eriyanti Astika Esti Syahrin Faizal Auladi Rivianto Fathina Annajla Febry Nola Odhia Fikri Aldebaran Misbah Azizi Fitriana, Nariyyah Giga Anugerah Arsylrakhmatika Gun Gun Gumilar Hariadi , Nayla Nur Azkia Hariadi, Nayla Nur Azkia Hasna, Vina Luthfiana Haura, Izmi Herdiana Verliani Hidayat, Muhammad Naufal Nurhadi Hidayat, Sofianti Ibtisamah Haura Ihsan Alfiandri Ilmi, Yuniar Fathil Indah Laily Hilmi Indah Laily Hilmi Indriyani, Yuni Lili Irene Virda Sakina Isyana S alsabila Jasmine Rahma Saputri Jekmal Malau Jekmal Malau Julianti, Nurlia Karlina Dwi Samratul Jannah Laprilski , Dewi Hanun Lestari, Sepiyani Ayu Madame Marselly Sebayang Maharani, Puteri Rahma Mally Ghinan Sholih Mally Ghinan Sholih Mally Ghinan Sholih Marsah Rahmawati Utami Martia, Elsya Meliana Sari Melisa Intan Barliana Mierza, Vriezka Mochamad Galuh Ryandha Moza Aulia Syifni Muhammad Fajri Maariz Muhammad Ja'far Ash Shidiq Muhammad Naufal Nurhadi Hidayat Muhammad Raka Tresna Mulidini Mulidini Mutia Desvi Putri Mutiara Alfiyah Najah Fatihatul Arifia Najla Yusiana Wahyudi Nanda Diva Meilani Nariyyah Fitriana Nariyyah Fitriana Nissa Khalida Hanum Nolla Olipia Elva Megrian Nur Darmawan, Shiyami Aulia Nur Komala Fitri Nurfadhila, Lina Nurfirah Mubarok Nurhadis, Nurhadis Nurlia Julianti Nurlita Dwi Putri Prihasti Nurma Dwi Rahmawati Pratama, Reza Prihasti, Nurlita Dwi Putri Priscinya Christiana Debora Putri Setya Tyasna Putri Wahyu Primasti Putri Wulanbirru Rachel Noveriachristie Balapadang Ramadani, Salsabila Ramadhani, Biandra Cinta Ratu Siti Robiatul Awaliyah Rifa Nur Alia Rima Putri Ramadhani Riska Shafira Rizki Rava Dwi Putra Roudotul Jannah Roudotul Jannah Sa'adah, Cantika Nurul Sa'diyyah, Nur Saarah Hamidah Asmara Indratno Safira Rosyidah Salma Alviyah Salman Salman Salsabila Granadha Nibullah Sanjaya, Velieana Laurent Saputro, M. Ramadhan Septiani, Dia Shafira Intan Anggraini Shalum Putriyani Shinta Puspa Dwiyanti Sholih, Mally Ghinan Siska Bela Safitri Siti Nafisa Siti Nur Istiqomah Siti Nuriah Siti Rohmah Siti Rosilfa Marisa Sofianti Hidayat Sophy Wulandari Sri Rahayu Subekti, Firli Reisya Sudarjat, Hadi Sukma Wibowo, Sepvia Putri Sulistiawati Sulistiawati Syelziva Yonda Atwita Syifa Khairunnisa TIANA MILANDA Tiara Cinta Amelia Tiara Nurayuni Tintia Rafika Putri Tiwi Ambarati Urbaningrum , Lestari Mahardika Vriezka Mierza Welly Windari Widodo, Hanifah Nur Yumareta Anggun Yuni Lili Indriyani Yuniar Fathil Ilmi Yuniar Fathil Ilmi Zakiyah, Wildani Zuyyinna Alya Abbas