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All Journal Jurnal Kesehatan Acta Pharmaciae Indonesia : Acta Pharm Indo PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Sehat Mandiri INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Pendidikan dan Konseling Best Journal (Biology Education, Sains and Technology) Jurnal Integrasi Kesehatan dan Sains LOSARI: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Wahana Pendidikan Jurnal EduHealth Jurnal Kesehatan Innovative: Journal Of Social Science Research Journal of Sustainable Community Service Journal of Pharmaceutical and Sciences. Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Dedikasi Olahraga Dan Kesehatan Jurnal Adiguna Pengabdian Masyarakat Kolaborasi Masyarakat PharmaCine: Journal of Pharmacy, Medical and Health Science Analit: Analytical And Environmental Chemistry
Munir Alinu Mulki
Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Singaperbangsa Karawang, Karawang, Jawa Barat, Indonesia.
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Veterinary Other

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Review Artikel: Analisis Kandungan Cemaran Logam Berat pada Ikan yang Berada di Sungai Indonesia Yuni Lili Indriyani; Munir Alinu Mulki
Jurnal Sehat Mandiri Vol 19 No 1 (2024): Jurnal Sehat Mandiri, Volume 19, No.1 Juni 2024
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v19i1.1383

Abstract

Fisheries production in Indonesia will reach 24.74 million tonnes in 2023 and will increase compared to 2022 which was only 22.26 million tonnes. Increased production is in line with increased consumption which cannot be separated from food safety problems, especially the problem of heavy metal contamination originating from domestic waste and factory waste. The purpose of this review article is to provide information for knowledge and awareness to the public regarding the fish they consume. This review was carried out using searches via Google Scholar and Researchgate published in the last 10 years (2014-2024). The total articles used were 11 scientific articles. The research results show that there is heavy metal contamination such as lead, mercury, cadmium, arsenic, copper, manganese, chrome, cobalt, argentum, zinc and tin at different levels in each location. The most heavy metal contamination is lead (Pb) with the highest level of 4,242 mg/kg in tilapia fish in the Tenggang River, Semarang at the location of the first testing station, namely the upstream area with coordinates 6°57'49.8"S and 110° 27’04.6”E. In conclusion, the pollution is thought to be due to contamination of the environment because there is a Small Industrial Environment (LIK) and a lot of rubbish is drifting along the river. The suggestion is that it is necessary to enforce waste management regulations and effective supervision for the sake of public health and environmental safety, especially regarding industrial waste.
Narrative Review: Parameter dalam Metode Analisis untuk Identifikasi Rhodamin B dalam Lipstik Nurlita Dwi Putri Prihasti; Munir Alinu Mulki; Muhammad Naufal Nurhadi Hidayat
Jurnal Sehat Mandiri Vol 19 No 1 (2024): Jurnal Sehat Mandiri, Volume 19, No.1 Juni 2024
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v19i1.1385

Abstract

Rhodamine B is a synthetic dye used in the paper and textile industries, attracting attention due to its potential health hazards. It is used in various cosmetic products, although the Regulation of the Minister of Health of Indonesia No. 445/MENKES/PER/V/1998 prohibits its use in cosmetics due to risks of irritation, liver damage, and cancer. This article reviews the parameters of analytical methods for identifying Rhodamine B in lipstick. A narrative review was conducted using Google Scholar as a database over the past 10 years. The KLT method was found to be more widely used than HPLC or UV-Vis Spectrophotometry. Differences in Rf values in KLT are due to variations in the stationary phase. Parameter variations in HPLC system suitability tests are caused by operational conditions, sample conditions, and instrument performance. Analytical methods for identifying Rhodamine B in lipstick include KLT, HPLC/KCKT, and UV-Vis Spectrophotometry. It is concluded that each method has specific parameters that must be met: KLT is qualified if the Rf value comparison (standard vs. sample) is ≤ 0.2; HPLC/KCKT requires system suitability and validation tests; UV-Vis Spectrophotometry needs validation test parameters. KLT is preferred due to easy sample preparation and lower costs compared to HPLC and UV-Vis Spectrophotometry. It is recommended to consider necessary components when using these methods to maximize test results.
Studi In Silico Prediksi Potensi Senyawa Bahan Alam sebagai Anti-Inflamasi dalam Menghambat COX-2 Velieana Laurent Sanjaya; Munir Alinu Mulki
Jurnal Sehat Mandiri Vol 19 No 2 (2024): Jurnal Sehat Mandiri, Volume 19 Nomor 2 Desember 2024
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v19i2.1712

Abstract

Infection or tissue injury induces inflammation, which causes pain. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are commonly used anti-inflammatory agents but can cause adverse effects on the stomach, kidneys, and liver when used long-term. As a result, efforts have been made to discover new drugs from natural sources to minimize these risks. With advances in technology, the search for new drug candidates using computational modeling, such as molecular docking, has become increasingly common. The aim of this systematic literature review is to predict and evaluate the potential of natural compounds as anti-inflammatory agents through in silico analysis. A systematic literature review of 10 recent articles, selected from an initial 376 articles on the topic of natural plant compounds' anti-inflammatory potential in silico, published between 2020 and 2023, was conducted using the PubMed and Springer databases. The conclusion from the review of the structural analysis of secondary plant metabolites shows that all 45 compounds tested demonstrated the ability to interact with the COX-2 enzyme, which plays a key role in inflammation and pain. Among these compounds, catechin, a member of the flavonoid group, was identified as the best candidate based on in silico analysis.
Literature Review : Analisis Senyawa Kimia sebagai Kandidat Obat Kanker Paru Menggunakan Metode Molecular Docking Muhammad Naufal Nurhadi Hidayat; Munir Alinu Mulki; Nurlita Dwiputri Prihasti
Jurnal Sehat Mandiri Vol 20 No 2 (2025): Jurnal Sehat Mandiri, Volume 20, No.2 Desember 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i2.1869

Abstract

Lung cancer is the leading cause of death worldwide, so the development of effective drugs is urgently needed. This study aims to identify potential chemical compounds as lung cancer drug candidates through molecular docking analysis. This study used a narrative literature review method with data collected from PubMed using specific keywords such as "Molecular docking," "Lung cancer," "Drug candidate," "Chemistry," and "Compound" for articles published between 2019 and 2024. Inclusion criteria included studies that analyzed chemical compounds as lung cancer drug candidates using molecular docking and met certain quantitative criteria. Of the initial 123 articles, 10 articles met the inclusion criteria and were analyzed further. The results showed significant interactions between several chemical compounds and lung cancer-related protein targets such as P-glycoprotein, NEK7, EGFR, VEGFR-2, and topoisomerase II, with high binding affinity. Overall, the results of this review highlight compound 762, SIQ17, and compound 7 as lead candidates with high therapeutic potential, which deserve further development through in vitro and in vivo tests to support their application in lung cancer therapy.
Co-Authors Affandhy, Adhwa'a Kaylla Afifah Rusyda Sani Ain Luthfiannisa Akifah, Muthia Nur Aldila Divana Sarie Alfina Oktavianti Amanda Maharani Amelia , Tiara Cinta Angel Novia Fransiska Anggi Ayu Pratama Anisa Amanda Putri Anisa Aula Rahma Anisa Fauziah Annisa Frastica Septi Aprillia, Cantika Arline Rahmadianti Kusumawardhani Asman Hitopik Asri Yuniar Aurora Fatimatuz Zahro Azzahra , Khaerunisa Basmalah, Nur Biandra Cinta Ramadhani Cantika Nurul Sa'adah Cantika Nurul Sa'adah Chalisya Vanya Advaita Choerunnisa Choerunnisa Datu Muhammad Cordova Dia Septiani Diva Afiah Hanifa Irawan Dzaky Teguh Ramadhani Elsya Martia Elvira Julia Ariyanto Elyyana, Nina Elzandra Imola Vioniken Eriyanti Astika Esti Syahrin Faizal Auladi Rivianto Fathina Annajla Febry Nola Odhia Fikri Aldebaran Misbah Azizi Fitriana, Nariyyah Giga Anugerah Arsylrakhmatika Gun Gun Gumilar Hanifah Nur Widodo Hariadi , Nayla Nur Azkia Hariadi, Nayla Nur Azkia Haura, Izmi Herdiana Verliani Hidayat, Sofianti Ibtisamah Haura Ihsan Alfiandri Ilmi, Yuniar Fathil Indah Laily Hilmi Indah Laily Hilmi Indah Laily Hilmi Indriyani, Yuni Lili Iqbal Ramdhani Asa’af Irene Virda Sakina Isyana S alsabila Izmi Haura Syahida Jasmine Rahma Saputri Jekmal Malau Jekmal Malau Julianti, Nurlia Karlina Dwi Samratul Jannah Laprilski , Dewi Hanun Lestari Mahardika Urbaningrum Lestari, Sepiyani Ayu Lina Nurfadhila Madame Marselly Sebayang Maharani, Puteri Rahma Mally Ghinan Sholih Mally Ghinan Sholih Mally Ghinan Sholih Mally Ghinan Sholih Marsah Rahmawati Utami Marsah Rahmawati Utami Martia, Elsya Meliana Sari Melisa Intan Barliana Mochamad Galuh Ryandha Moza Aulia Syifni Muhammad Fajri Maariz Muhammad Ja'far Ash Shidiq Muhammad Naufal Nurhadi Hidayat Muhammad Naufal Nurhadi Hidayat Muhammad Naufal Nurhadi Hidayat Muhammad Raka Tresna Mukarromah Dita Putri Mulidini Mulidini Mutia Desvi Putri Mutiara Alfiyah Najah Fatihatul Arifia Najla Yusiana Wahyudi Nanda Diva Meilani Nariyyah Fitriana Nissa Khalida Hanum Nolla Olipia Elva Megrian Nur Asyifa Rizkia Navisa Nur Darmawan, Shiyami Aulia Nur Komala Fitri Nurfadhila, Lina Nurfirah Mubarok Nurhadis, Nurhadis Nurlia Julianti Nurlita Dwi Putri Prihasti Nurlita Dwi Putri Prihasti Nurlita Dwiputri Prihasti Nurma Dwi Rahmawati Pratama, Reza Priscinya Christiana Debora Priscinya Christiana Debora Puteri Rahma Maharani Putri Setya Tyasna Putri Wahyu Primasti Putri Wulanbirru Rachel Noveriachristie Balapadang Rahma Amalia Ratu Siti Robiatul Awaliyah Rifa Nur Alia Rima Putri Ramadhani Riska Shafira Rizki Rava Dwi Putra Roudotul Jannah Roudotul Jannah Sa'adah, Cantika Nurul Sa'diyyah, Nur Saarah Hamidah Asmara Indratno Safira Rosyidah Salma Alviyah Salman Salman Salsabila Granadha Nibullah Salsabila Ramadani Saputro, M. Ramadhan Septiani, Dia Shafira Intan Anggraini Shalum Putriyani Shinta Puspa Dwiyanti Sholih, Mally Ghinan Siboro, Dewi Pratiwi Purba Siska Bela Safitri Siti Nafisa Siti Nur Istiqomah Siti Nuriah Siti Rohmah Siti Rosilfa Marisa Sofianti Hidayat Sophy Wulandari Sri Rahayu Subekti, Firli Reisya Sudarjat, Hadi Sukma Wibowo, Sepvia Putri Sulistiawati Sulistiawati Syelziva Yonda Atwita Syifa Khairunnisa TIANA MILANDA Tiara Cinta Amelia Tiara Nurayuni Tintia Rafika Putri Tiwi Ambarati Velieana Laurent Sanjaya Vina Luthfiana Hasna Vriezka Mierza Vriezka Mierza Vriezka Mierza Welly Windari Yesica Natalia Lawrence Yumareta Anggun Yuni Lili Indriyani Yuni Lili Indriyani Yuniar Fathil Ilmi Zahra Dwi Prameswari Zakiyah, Wildani Zhafira Aulia Hasanah Zuyyinna Alya Abbas