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All Journal Jurnal Kesehatan Acta Pharmaciae Indonesia : Acta Pharm Indo PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Sehat Mandiri INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Pendidikan dan Konseling Best Journal (Biology Education, Sains and Technology) Jurnal Integrasi Kesehatan dan Sains LOSARI: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Wahana Pendidikan Jurnal EduHealth Jurnal Kesehatan Innovative: Journal Of Social Science Research Journal of Sustainable Community Service Journal of Pharmaceutical and Sciences. Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Dedikasi Olahraga Dan Kesehatan Jurnal Adiguna Pengabdian Masyarakat Kolaborasi Masyarakat PharmaCine: Journal of Pharmacy, Medical and Health Science Analit: Analytical And Environmental Chemistry
Munir Alinu Mulki
Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Singaperbangsa Karawang, Karawang, Jawa Barat, Indonesia.
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Veterinary Other

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GERAKAN PEDULI KEBERSIHAN MANDIRI (KALI BERSAMA) Indah Laily Hilmi; Salman Salman; Hadi Sudarjat; Gun Gun Gumilar; Munir Alinu Mulki
JOURNAL OF SUSTAINABLE COMMUNITY SERVICE Vol. 3 No. 1 (2022): DECEMBER
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/jscs.v3i1.636

Abstract

The Gerakan Peduli Kebersihan Mandiri (Kali Bersama) is an initiative carried out by the Pharmacy students of Singaperbangsa University Karawang with the aim of raising awareness among teenagers in Citra Kebun Mas Housing, Karawang about clean and healthy living behaviors, especially handwashing with soap. This research aims to improve teenagers' understanding of Clean and Healthy Living Behavior (PHBS) and proper handwashing techniques. The method used in this research is counseling, which includes education on the importance of PHBS and demonstration of proper handwashing techniques. The questionnaire results conducted after the counseling show that the majority of teenagers are aware of PHBS and apply it in their daily lives, but there is still a gap between knowledge and PHBS practices. Based on these results, it is recommended to adjust the timing of activities, involve faculty leaders, and provide adequate facilities for the handwashing program with soap in future activities.
Analytical agreement between CEDIA immunoassay and HPLC for therapeutic drug monitoring of carbamazepine: a narrative review Munir Alinu Mulki; Nariyyah Fitriana; Yuniar Fathil Ilmi; Marsah Rahmawati Utami
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 13 No 1 (2025): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2025.13.1.16526

Abstract

speed, simplicity, and cost, but the extent of its agreement with HPLC across diverse clinical contexts requires careful evaluation. Method: This narrative review synthesizes evidence from nine studies identified through Scopus and Google Scholar to assess the analytical agreement and clinical validity of CEDIA and related immunoassay platforms compared to HPLC and advanced chromatographic methods. Results: The reviewed evidence demonstrates strong inter-method correlation, although systematic positive bias in immunoassay results is consistently observed, particularly in patients receiving enzyme-inducing co-medications where carbamazepine-10,11-epoxide accumulation affects antibody cross-reactivity. CEDIA is analytically acceptable for routine CBZ TDM in stable patients on monotherapy. HPLC and LC-MS/MS remain preferable when metabolite quantification, polytherapy monitoring, or precise measurement near therapeutic boundaries is clinically required. Conclusion: Method selection should be guided by the clinical question, patient population characteristics, and available laboratory resources.
Hilirisasi Limbah Kelapa Sawit: Potensi Fraksi Tak Tersabunkan sebagai Bahan Aktif Anti-Aging dan Pelembap Alami dalam Industri Kosmetik Modern Chantiara Farida Makussy Muini; Munir Alinu Mulki
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1700

Abstract

Background: The Indonesian palm oil industry generates substantial waste, one of which is Palm Fatty Acid Distillate (PFAD), which has been predominantly utilized as a low-value industrial raw material or discarded as waste. However, PFAD contains an unsaponifiable fraction rich in high-value bioactive compounds such as vitamin E (tocotrienols and tocopherols), squalene, phytosterols, and carotenoids, which possess significant potential as natural cosmetic active ingredients. Objective: This study aims to examine the potential of palm oil waste downstreaming, particularly the unsaponifiable fraction of PFAD, as a source of bioactive compounds for anti-aging and moisturizing applications in the modern cosmetics industry. Methods: This research is a Systematic Literature Review (SLR) employing a qualitative descriptive approach. Literature searches were conducted through Google Scholar, PubMed, and Science Direct databases using keywords related to palm oil waste, PFAD, and unsaponifiable fraction, with publication restrictions set for the last five years (2021–2026). From 210 initially identified articles, 9 articles were selected after screening processes based on titles, abstracts, and full-text eligibility. Data were analyzed using a descriptive meta-synthesis approach. Results: The findings indicate that PFAD contains significant bioactive compounds, with total tocotrienol reaching 2,136 ppm and vitamin E levels up to 12,282 ppm after purification processes. The most effective extraction methods were achieved through supercritical CO₂ with ethanol as a co-solvent (30.03 ± 0.03 mg/g) and ionic liquid [C₄MIM]Ac (75.41% efficiency). The bioactive compounds of the unsaponifiable fraction demonstrated potent antioxidant activity (IC₅₀ up to 23.3 ppm), which plays a role in inhibiting oxidative stress—a primary factor in premature aging—while also maintaining skin moisture through emollient mechanisms. Formulation studies revealed that nanoemulsion applications increased skin moisture from 51% to 62.5% and elasticity from 85% to 98.5%, while palm lipid-based body butter, cream, and lotion preparations exhibited good physical stability with skin-safe pH (5–6) and no irritation. Conclusion: The unsaponifiable fraction of palm oil waste has strategic potential to be developed as a modern cosmetic active ingredient, supporting the concept of a circular economy and national cosmetic raw material self-sufficiency. However, further research is still required for clinical validation of anti-aging and moisturizing effects on human skin, as well as optimization of sustainable processing technologies.
Review Artikel: Karakterisasi Dan Uji Efektivitas Antikanker Nanopartikel Emas (AuNPs) Dan Nanopartikel Perak (AgNPs) Dengan Ekstrak Kunyit (Curcuma spp.) Sebagai Bioreduktor Izmi Haura; Munir Alinu Mulki
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.678

Abstract

Cancer is one of the leading causes of death in the world with major challenges in the form of therapeutic side effects, poor selectivity, and drug resistance. Nanotechnology, particularly the use of gold (AuNPs) and silver (AgNPs) nanoparticles, offers a promising alternative to improve the effectiveness of cancer therapy. This article reviews recent developments in the synthesis of AuNPs and AgNPs using turmeric as a natural, environmentally friendly bioreductor. Characterization of nanoparticles through UV-Vis, TEM, SEM, and FT-IR methods showed particle sizes ranging from 1-100 nm, spherical or hexagonal morphology, and the presence of functional groups such as -OH and C=O that support stability and bioactivity. Anticancer studies show that these nanoparticles are effective against various types of cancer cells, including breast (MCF-7, MDA-MB-231), lung (A549, NCI-H661, NCI-H1975, NCI-H1573, NCI-H1563), cervical (HeLa), and epithelial (Hep-2) cancers.
Aktivitas Antidiabetes Infusa Buah Mengkudu (Morinda Citrifolia L.) pada Mencit Jantan terinduksi Aloksan Munir Alinu Mulki; Tiara Cinta Amelia
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1247

Abstract

Noni (Morinda citrifolia L.) is traditionally consumed for diabetes, yet in vivo evidence for water-based infusion remains limited. This study aimed to evaluate the antihyperglycemic effect of a standardized noni fruit infusion in alloxan-induced male mice. Dried fruit simplicia were quality-controlled according to the Indonesian Herbal Pharmacopoeia. Mice were induced with alloxan (140 mg/kg, i.p.) and randomized (n=5/group) to vehicle (0.5% Na-CMC), metformin (1.3 mg/20 g BW), or noni infusion at low (103), normal (123), or high (144 mg/20 g BW) for 21 days in two divided doses per day. Fasting blood glucose was measured at baseline, day 0, and days 7, 14, and 21. Paired t-tests assessed within-group changes, while between-group comparisons used one-way ANOVA with Levene’s test (Tukey HSD) and Welch ANOVA as sensitivity analysis. Phytochemical screening indicated alkaloids, saponins, triterpenoids, and flavonoids. All groups showed significant reductions from day 0 to day 21 (p<0.05). From day 0 to day 14, the normal-dose infusion decreased glucose by 45.7% (172.8 to 93.8 mg/dL), compared with 33.3% for metformin (134.0 to 89.4 mg/dL). By day 21, reductions were 48.3–49.6% in the normal/high-dose infusion groups and 36.4% with metformin. Between-group differences were evident at days 7 and 14 but not at day 21 (p>0.05). Standardized noni infusion exhibits antihyperglycemic activity in the alloxan model; confirmation of mechanisms, additional metabolic endpoints, and subchronic safety evaluation are required before clinical relevance can be inferred.
Co-Authors Affandhy, Adhwa'a Kaylla Afifah Rusyda Sani Ain Luthfiannisa Akifah, Muthia Nur Aldila Divana Sarie Alfina Oktavianti Amanda Maharani Angel Novia Fransiska Anggi Ayu Pratama Anisa Amanda Putri Anisa Aula Rahma Anisa Fauziah Annisa Frastica Septi Aprillia, Cantika Arline Rahmadianti Kusumawardhani Asman Hitopik Asri Yuniar Aurora Fatimatuz Zahro Azzahra , Khaerunisa Basmalah, Nur Biandra Cinta Ramadhani Cantika Nurul Sa&#039;adah Cantika Nurul Sa'adah Chalisya Vanya Advaita Chantiara Farida Makussy Muini Choerunnisa Choerunnisa Datu Muhammad Cordova Dia Septiani Diva Afiah Hanifa Irawan Dzaky Teguh Ramadhani Elsya Martia Elvira Julia Ariyanto Elyyana, Nina Elzandra Imola Vioniken Eriyanti Astika Esti Syahrin Faizal Auladi Rivianto Fathina Annajla Febry Nola Odhia Fikri Aldebaran Misbah Azizi Giga Anugerah Arsylrakhmatika Gun Gun Gumilar Gun Gun Gumilar Hadi Sudarjat Hanifah Nur Widodo Hariadi , Nayla Nur Azkia Hariadi, Nayla Nur Azkia Herdiana Verliani Hidayat, Sofianti Ibtisamah Haura Ihsan Alfiandri Indah Laily Hilmi Indah Laily Hilmi Indah Laily Hilmi Indah Laily Hilmi Indriyani, Yuni Lili Iqbal Ramdhani Asa’af Irene Virda Sakina Isyana S alsabila Izmi Haura Izmi Haura Syahida Jasmine Rahma Saputri Jekmal Malau Jekmal Malau Julianti, Nurlia Karlina Dwi Samratul Jannah Laprilski , Dewi Hanun Lestari Mahardika Urbaningrum Lestari, Sepiyani Ayu Lina Nurfadhila Madame Marselly Sebayang Maharani, Puteri Rahma Mally Ghinan Sholih Mally Ghinan Sholih Mally Ghinan Sholih Mally Ghinan Sholih Marsah Rahmawati Utami Marsah Rahmawati Utami Marsah Rahmawati Utami Martia, Elsya Meliana Sari Melisa Intan Barliana Mochamad Galuh Ryandha Moza Aulia Syifni Muhammad Fajri Maariz Muhammad Ja'far Ash Shidiq Muhammad Naufal Nurhadi Hidayat Muhammad Naufal Nurhadi Hidayat Muhammad Naufal Nurhadi Hidayat Muhammad Raka Tresna Mukarromah Dita Putri Mulidini Mulidini Mutia Desvi Putri Mutiara Alfiyah Najah Fatihatul Arifia Najla Yusiana Wahyudi Nanda Diva Meilani Nariyyah Fitriana Nariyyah Fitriana Nariyyah Fitriana Nissa Khalida Hanum Nolla Olipia Elva Megrian Nur Asyifa Rizkia Navisa Nur Darmawan, Shiyami Aulia Nur Komala Fitri Nurfadhila, Lina Nurfirah Mubarok Nurhadis, Nurhadis Nurlia Julianti Nurlita Dwi Putri Prihasti Nurlita Dwi Putri Prihasti Nurlita Dwiputri Prihasti Nurma Dwi Rahmawati Pratama, Reza Priscinya Christiana Debora Priscinya Christiana Debora Puteri Rahma Maharani Putri Setya Tyasna Putri Wahyu Primasti Putri Wulanbirru Rachel Noveriachristie Balapadang Rahma Amalia Ratu Siti Robiatul Awaliyah Rifa Nur Alia Rima Putri Ramadhani Riska Shafira Rizki Rava Dwi Putra Roudotul Jannah Roudotul Jannah Sa'adah, Cantika Nurul Sa'diyyah, Nur Saarah Hamidah Asmara Indratno Safira Rosyidah Salma Alviyah Salman Salman Salman Salman Salsabila Granadha Nibullah Salsabila Ramadani Saputro, M. Ramadhan Septiani, Dia Shafira Intan Anggraini Shalum Putriyani Shinta Puspa Dwiyanti Sholih, Mally Ghinan Siboro, Dewi Pratiwi Purba Siska Bela Safitri Siti Nafisa Siti Nur Istiqomah Siti Nuriah Siti Rohmah Siti Rosilfa Marisa Sofianti Hidayat Sophy Wulandari Sri Rahayu Subekti, Firli Reisya Sudarjat, Hadi Sukma Wibowo, Sepvia Putri Sulistiawati Sulistiawati Syelziva Yonda Atwita Syifa Khairunnisa TIANA MILANDA Tiara Cinta Amelia Tiara Cinta Amelia Tiara Nurayuni Tintia Rafika Putri Tiwi Ambarati Velieana Laurent Sanjaya Vina Luthfiana Hasna Vriezka Mierza Vriezka Mierza Vriezka Mierza Welly Windari Yesica Natalia Lawrence Yumareta Anggun Yuni Lili Indriyani Yuni Lili Indriyani Yuniar Fathil Ilmi Yuniar Fathil Ilmi Yuniar Fathil Ilmi Zahra Dwi Prameswari Zakiyah, Wildani Zhafira Aulia Hasanah Zuyyinna Alya Abbas