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All Journal JURNAL PENELITIAN SAINTIKA Journal of Agromedicine and Medical Sciences Jurnal Mirai Management Paediatrica Indonesiana Jurnal Surya Medika JURNAL PENELITIAN PENDIDIKAN MIPA Jambura Journal of Chemistry PREPOTIF : Jurnal Kesehatan Masyarakat Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Aisyah : Jurnal Ilmu Kesehatan Journal of Pharmaceutical and Health Research International Journal Of Science, Technology & Management (IJSTM) Indonesian Journal of Chemical Science and Technology Journal of Economics and Business UBS Jurnal Kesehatan Tambusai Al-Sharf: Jurnal Ekonomi Islam JOURNAL LA MEDIHEALTICO Jurnal Pengabdian Masyarakat (ABDIRA) Indonesian Journal of Pharmaceutical Education JUKESHUM: Jurnal Pengabdian Masyarakat FORTE JOURNAL Jurnal Pusat Studi Pendidikan Rakyat (PUSDIKRA) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmanesia Jurnal Sains dan Teknologi Journal of Health and Medical Science International Journal of Public Health Excellence (IJPHE) International Journal of Health and Pharmaceutical (IJHP) SENTRI: Jurnal Riset Ilmiah Jurnal Farmasi Klinik dan Sains Cross-border Eduvest - Journal of Universal Studies FARMASAINKES Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Usada Nusantara: Jurnal Kesehatan Tradisional Journal of Pharmaceutical and Sciences. Jurnal Penelitian Pendidikan MIPA Medic Nutricia : Jurnal Ilmu Kesehatan Media Farmasi Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Seroja Husada: Jurnal Kesehatan Masyarakat Indonesian Journal of Science and Pharmacy Jurnal Bakti Nusantara Jurnal Akademika Kimia Jurnal Sains dan Kesehatan MAFEBIS: Jurnal Manajemen, Akuntansi dan Bisnis Jurnal Kesehatan (JK) All Fields of Science Journal Liaison Academia and Sosiety
Ridwanto Ridwanto
Universitas Muslim Nusantara AL-Washliyah Medan, Indonesia
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PENENTUAN KADAR ALKALOID EKSTRAK KULIT KAYU RARU SERTA UJI AKTIVITAS ANTIBAKTERI ISOLAT NON POLAR Anny Sartika Daulay; Sri Wahyuni; Ridwanto; Ihsan Fadhilah; Shakila Salwa
JURNAL FARMASI, SAINS, dan KESEHATAN Vol. 6 No. 1 (2026): FARMASAINKES: JURNAL FARMASI, SAINS dan KESEHATAN
Publisher : Fakultas Farmasi Universitas Muslim Nusantara Al Washliyah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/farmasainkes.v6i1.6822

Abstract

Kulit kayu raru yang memiliki senyawa bioaktif yang dapat digunakan sebagai antidiabetes. Penelitian ini bertujuan untuk menentukan kadar alkaloid dalam ekstrak Kulit Kayu Raru (Cotylelobium lanceolatum Craib) dengan pelarut etanol dan metanol serta menentukan aktivitas antibakteri isolat dengan pelarut non polar. Penelitian yang dilakukan meliputi ekstraksi simplisia kulit kayu raru dengan metode maserasi menggunakan pelarut etanol dan metanol. Ekstrak yang dihasilkan diekstraksi cair-cair dengan pelarut kloroform untuk mendapatkan isolat alkaloid. Kemudian isolat diuji aktivitasnya terhadap uji antibakteri. Penelitian ini merupakan fundamental yang direncanakan dilakukan dalam satu tahun dan merupakan kelanjutan penelitian tahun sebelumnya. Penelitian ini menggunakan dana internal Universitas Muslim Nusantara Al-Washliyah. Adapun Tingkat Kesiapan Teknologi dalam penelitian ini adalah 2. Hasil penelitian ini adalah senyawa alkaloid dari ekstrak kulit kayu raru dapat difraksinasi dengan ekstraksi cair-cair pelarut kloroform. Hasil fraksinasi diidentifikasi menggunakan spektroskopi FT-IR hasil identifikasi mengandung gugus fungsi N-H, C-N, C=O, C=C Aromatik, dan C=O Tajam, yang menandakan teridentifikasi mengandung senyawa alkaloid. Kadar senyawa alkaloid ditentukan dengan Spektrofotometri UV, fraksi kloroform ekstrak etanol dan metanol masing-masing adalah 18,9491± 0,09222956, dan 21,0325 ± 0,098274937 µg/g. Fraksi alkaloid ekstrak kulit kayu raru memiliki aktivitas antibakteri terhadap bakteri Escherichia coli dan Staphylococcus aureus dengan zona hambat terbaik yaitu konsentrasi 50%
Penentuan Kadar Etanol Dan Asam Laktat Dari Hasil Fermentasi Susu Kefir Kambing Annisa Utami; Anny Sartika Daulay; Ridwanto Ridwanto; Ainil Fithri Pulungan
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1812

Abstract

Goat-milk kefir contains lactic acid and ethanol formed through the symbiotic metabolism of lactic acid bacteria and yeasts; however, information on their changes during prolonged fermentation remains limited. This study aimed to characterize ethanol accumulation during six days of goat-milk kefir fermentation and to determine lactic acid after 24 h. Goat milk (250 mL) was heated at 75 °C, inoculated with 4% (w/v) kefir grains, and fermented at 25 ± 2 °C. Ethanol was screened using iodoform, acidified potassium dichromate, and esterification reactions, followed by visible spectrophotometric quantification at 443 nm after Conway microdiffusion. Lactic acid was quantified using HPLC-UV at 210 nm with 50 mM phosphate buffer (pH 2.8), a flow rate of 1 mL/min, and an injection volume of 20 µL. The pH decreased from 4.19 on day 1 to 2.15 on day 6, while ethanol increased from 0.227 to 0.657 g/dL (p<0.001). Commercial kefir contained 0.453 g/dL ethanol. The ethanol and lactic-acid calibration models showed R² values of 0.996; lactic acid in 24-h kefir was 3.923%. Prolonged fermentation therefore produced progressive acidification accompanied by ethanol accumulation, with the greatest change occurring during the first three days. These findings establish fermentation time as an important determinant of the metabolite profile of goat-milk kefir and provide a basis for subsequent studies using independent fermentation batches and fully validated analytical methods.
Uji Aktivitas Antioksidan Ekstrak dan Fraksinasi Daun Tekelan (Chromolaena odorata (L.) R.M.King & H.Rob) Serta Uji Antibakteri Terhadap Staphylococcus aureus dan Escherichia coli Anjarlit Romiyuliana Br Parapat; Ridwanto Ridwanto; Rafita Yuniarti; Zulmai Rani
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1059

Abstract

Background: Tekelan leaf (Chromolaena odorata (L.) R.M.King & H.Rob) is one of Indonesia's natural resources rich in bioactive compounds. Its traditional use for treating wounds, sore throats, diarrhea, and various other ailments is suspected to be linked to its antioxidant and antibacterial content. Objective: This research aimed to analyze the antioxidant activity of the ethanol extract, n-hexane fraction, and ethyl acetate fraction of tekelan leaves, and to test their antibacterial activity against Staphylococcus aureus and Escherichia coli. Method: The study used an experimental method. Antioxidant activity was tested using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method with a UV-Vis spectrophotometer, and the results were expressed as IC₅₀ values. The antibacterial test against S. aureus and E. coli was conducted using the disc diffusion method, and the inhibitory power was measured based on the inhibition zone diameter (mm). Results: The antioxidant test results showed that the ethanol extract and ethyl acetate fraction had strong activity with IC₅₀ values of 98.26 ppm and 75.43 ppm, respectively, while the n-hexane fraction showed weak activity (IC₅₀ 110.54 ppm). In the antibacterial test at a 40% concentration, the ethanol extract, n-hexane fraction, and ethyl acetate fraction inhibited the growth of both bacteria with strong to very strong categories. The highest average inhibition zones against E. coli and S. aureus were 19.03 mm and 21.36 mm (ethanol extract), 10.56 mm and 12.13 mm (n-hexane fraction), and 13.60 mm and 15.40 mm (ethyl acetate fraction), respectively. This activity was still lower than the positive control chloramphenicol, which produced inhibition zones of 28.23 mm (E. coli) and 27.43 mm (S. aureus). Conclusion: It was concluded that the extract and ethyl acetate fraction of tekelan leaves have strong antioxidant activity, while the n-hexane fraction is classified as weak. All samples (extract, n-hexane fraction, and ethyl acetate fraction) showed strong antibacterial activity against E. coli and S. aureus, although they have not matched the effectiveness of chloramphenicol.
Uji Aktivitas Antioksidan dan Antibakteri Ekstrak dan Hasil Fraksinasi Daun Bandotan (Ageratum conyzoides L.) Terhadap Bakteri Escherichia coli Dan Staphylococcus aureus Sumiyarni Harahap; Ridwanto Ridwanto; Ainil Fithri Pulungan; Zulmai Rani
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1060

Abstract

Bandotan (Ageratum conyzoides L.) is a plant distributed worldwide, especially in tropical and subtropical regions. Bandotan can be used as a traditional medicine because it contains beneficial phytochemical compounds such as terpenoids, alkaloids, essential oils, saponins, and phenolics that play a role in inhibiting bacterial growth and serving as natural antioxidants. The objective of this research was to determine the antioxidant and antibacterial activity of the extract, n-hexane fraction, and ethyl acetate fraction from bandotan leaves. This research used an experimental method. It included antioxidant testing of the ethanol extract fractions of bandotan leaves (Ageratum conyzoides L.) using the DPPH method and antibacterial testing using Escherichia coli and Staphylococcus aureus bacteria. The phytochemical screening results showed that bandotan leaves contain alkaloids, saponins, tannins, flavonoids, and glycosides. The antioxidant testing for DPPH radical scavenging revealed that the bandotan leaf extract had an IC50 value of 499.3633 μg/ml, the n-hexane fraction had an IC50 value of 945.7837 μg/ml, and the ethyl acetate fraction had an IC50 value of 382.9216 μg/ml, all categorized as very weak antioxidants. Antibacterial testing indicated that the extract, n-hexane fraction, and ethyl acetate fraction of bandotan (Ageratum conyzoides L.) exhibited antibacterial activity, inhibiting the growth of Escherichia coli and Staphylococcus aureus, with strong activity at the highest concentration of 40% and moderate activity at the lowest concentration of 10%. In conclusion, bandotan leaves have very weak antioxidant activity due to the low content of flavonoids and strong antibacterial activity at 40% concentration and weak activity at 10% concentration.
Penentuan Kadar Protein Beberapa Jenis Kacang (Kacang Merah, Hijau, Kedelai Segar) Untuk Penanganan Stunting Dengan Metode Kjeldahl Dan Spektrofotometri Visible Fatin Fairuz Pasaribu; Anny Sartika Daulay; Ridwanto Ridwanto; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1085

Abstract

Protein helps the body to grow and maintain tissue and replace damaged cells. If the intake of protein in toddlers is insufficient during their growth period, the growth and development of toddlers can be delayed and nutritional problems related to stunting can arise. And the level of protein adequacy affects the occurrence of stunting. One of the highly nutritious and easily accessible local foods that can be used as additional food is green beans, soybeans have the best source of vegetable protein, red beans have a protein content of between 16% and 20%, and are also a source of minerals and vitamins. The objective of the research was to determine the protein content in several types of beans (red beans, green beans, fresh soybeans) for handling stunting using the kjeldahl method and visible spectrophotometry. The method used in this research used the kjeldahl method, a simple way to determine total nitrogen in samples of several types of beans. This research also used a spectrophotometric method that can determine specific protein levels, had high accuracy and could measure small substances. The protein content obtained in the samples using the Kjeldahl method is Fresh Soybeans 35,19 gram, Green Beans 33,7 gram and Red Beans 28,6 gram divided by 100 grams of sample. The spectrophotometric method is Fresh Soybeans 29,09 gram, Green Beans 17,82gram and Red Beans 13,63 gram divided by 100 grams of sample. The protein content in the samples, namely fresh soybeans, green beans and red beans can be used in handling stunting because the levels obtained in the three samples can meet daily protein.
Pemanfaatan Bayam Merah Amaranthus Gengiticus L Sebagai Pewarna Alami pada Makanan Basah Denni Bahari; Ridwanto Ridwanto; Minda Sari Lubis
All Fields of Science Journal Liaison Academia and Sosiety Vol. 1 No. 3: September 2021
Publisher : Lembaga Komunikasi dan Informasi Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58939/afosj-las.v1i3.210

Abstract

Bayam merah merupakan tumbuhan yang banyak memiliki manfaat Bayam merah dapat bermanfaat dalam produksi pangan sebagai pewarna makanan alami karena bayam merah mengandung antioksidan salah satunya adalah antosianin Tujuan penelitian ini adalah memanfaatkan zat warna alami bayam merah sebagai pewarna alami makanan dalam bentuk serbuk Metode penelitian ini dilakukan dengan cara bayam merah dihaluskan dengan menggunakan blender kemudian disaring dan diambil filtratnya lalu dikeringkan dilemari pengering lalu digerus sampai homogen Kesimpulan bayam merah Amaranthus gengiticus L dapat dijadikan serbuk Zatwarna yang diperoleh dari bayam merah diaplikasikan pada makanan dengan perbandingan 12 5 g dan 25 g Hasil uji kesukaan Hedonic Test aplikasi zat warna yang paling disukai panelis pada sediaan kue klepon yaitu sediaan 25 g dengan persentase 4 29 Persen dan pada sediaan kue bolu yaitu sediaan 25 g dengan persentase 4 29 Persen
Optimalisasi Peran Mahasiswa KKN Sebagai Tenaga Ahli dalam Meningkatkan Pelayanan di Desa Bangun Sari Baru Kecamatan Tanjung Morawa Kabupaten Deli Serdang M. Saleh Sitompul; Fadya Azzahra; Medhy Ardhita Aprilia; Fiqri Hermawan; Sarinah Hasibuan; Marissa Tasya Adawiyah; Muhammad Al Hudawi; Muhammad Al Qodri; Annisa Fadilah Amir; Ridwanto Ridwanto; Alkausar Saragih
All Fields of Science Journal Liaison Academia and Sosiety Vol. 4 No. 4: Desember 2024
Publisher : Lembaga Komunikasi dan Informasi Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58939/afosj-las.v4i4.569

Abstract

Program Kuliah Kerja Nyata KKN memiliki potensi besar untuk meningkatkan kualitas pelayanan di desa melalui kontribusi mahasiswa sebagai tenaga ahli Penelitian ini bertujuan untuk mengoptimalkan peran mahasiswa KKN jurusan Manajemen dalam memberikan solusi strategis terhadap permasalahan pelayanan publik di Desa Bangun Sari Baru Kecamatan Tanjung Morawa Kabupaten Deli Serdang Pendekatan yang digunakan melibatkan analisis kebutuhan desa penyusunan strategi manajerial serta implementasi program pelayanan berbasis partisipasi masyarakat Hasil penelitian menunjukkan bahwa intervensi mahasiswa KKN mampu meningkatkan efisiensi kualitas layanan serta partisipasi warga desa dalam pengelolaan pelayanan Temuan ini merekomendasikan peningkatan kolaborasi antara perguruan tinggi pemerintah desa dan masyarakat untuk keberlanjutan program serupa
Co-Authors Abdullah, Husaini Adawiyah, Marissa Tasya Adyani Maulinda Afrizani, Afrizani Agus Priyadi Ainil Fithri Pulungan Akbar, Windi Hari Al Hudawi, Muhammad Al Qodri, Muhammad Alistraja Dison Silalahi Alkausar Saragih Alviana, Liya Amin Nasution, Muhammad Amir, Annisa Fadilah Andi Syahputra, Ricky Ani Sutiani Anjarlit Romiyuliana Br Parapat Annisa Fadilah Amir Annisa Utami Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Aprilia, Hijjatun Aprilia, Medhy Ardhita Arifin, Khairil Fikri Arjuniadi, Arjuniadi Asep Trizaldi Audry Pratiwi Audry Pratiwi Azhar, Gustika Azri, Atika Azzahra, Fadya Bangun Lubis Cici Andriani Claudy Friesta Melanie Dahlia Hasibuan Dahnia Ayu Fitria Dalimunthe, Gabena Indriyani Damanik, Sumayyah Daniel Happy Putra Daulay , Anny Sartika Daulay, Ani Sartika Daulay, Anny S. Denni Bahari Dikki Miswanda Dina Suciati Saragih Elma Natasya Endang D. Hamid Fadhilah M, Ihsan Fadhlah Al-Uyun Nasution Fadya Azzahra Fajri, Fajrilda Aqilah Fathur Rahman Fathur Rahman Fathur Rahman Harun Fatin Fairuz Pasaribu Fatur Rahman Fiqri Hermawan Fithri Pulungan, Ainil FRANSISKA, EVA Gabena Indrayani Dalimunthe Hafizha, Putri Hakimi Hakimi Harahap, Ade Try Atwinda Harahap, Siti Salimah Haris Munandar Nasution Haris Munandar Nst Harun , Fatur Rahman Harun, Fathur Rahman Hasanah, Qori Hasibuan , Nabila Hasim Hasibuan, Sarinah Hasibuan, Supia Indah Hazizah, Mautia Hermawan, Fiqri Humairah, Dwina Angelina Ihsan Fadhilah Imelda Natasia Br S Meliala Indra B. Hutagalung Irvan Andreansyah Irwan Misbach Isnaria, Vita Khairunnisa Khairunnisa Lastri Afni Lince Bulutoding Lubis, Minda Sari M. Naufal Rifqi M. Saleh Sitompul Maghfirah , Dini Makhfirah Malahayati Malahayati Mambang, D Elysa Putri Manik, Umi Chairani Manurung, Aisyah Baddriah Marissa Tasya Adawiyah Maryanti Yuza Maya Syafira Medhy Ardhita Aprilia Melinda, Reni Meliyana Meliyana Merani Phaustina Lumban Gaol Mirna Mirna Muchlis, Syaiful Muhammad Al Hudawi Muhammad Al Qodri Muhammad Alfariz Baihaqi Siregar Muhammad Amin Nasution Muhammad Amin Nasution Muhammad Wahyuddin Abdullah Muhammad Wahyudi Munthe, Ariska Munthe, Herlina Nada, Dina Qatrun Nadila Indra Sepvina Nasri Nasri, Nasri Nasution, Kartika Zsaskia Nasution, M. Amin Nasution, Shamila Sufi Aulia Nazirah, Nazirah Ningtias, Anggitha Nomi Noviani Nur Ainun Nuraida Nuraida Nurhayati Nurhayati Nurliansyah, Nurliansyah Nurmazela, Virda Pitaloka, Syifa Amilia Pulungan, Ainil Fitri Puteri, Cut Intan Annisa Putri Intan Sari Putri Khairani Putri Theresia Harianja Putri Yupa Hasibuan Putriyana Putriyana Qisti Pristiwani Rafita Yuniarti Rahayu , Yayuk Putri Rahayu Rahayu Rahmadani , Adevika Rahmadani Rahmadani Rahmah, Ruhiya Rahmayanti, Putri Reza Irma Ricky Andi Syahputra Ricky Andi Syahputra Rika Yuliana, Rika Riski Mulyani, Riski Risma Fauziah Pasaribu Rizki, Dewi Rizki, Rahmad Robiatun Rambe Rosaldi, Hikmah Rossa, Aliffa S Sumarlin Sagala , Vipi Zetiara Salwa, Shakhila Sari, Farida Sarinah Hasibuan Sartika Daulay, Anny Sasnita, Merida Selfia Lestary Shakila Salwa Shilvia, Fatin Sinaga, Novita Yulianti Siradjuddin Siregar , Anisah Siti Rahmasari Sitompul, M. Saleh Sitorus, Dara Indah Sri Wahyuni Sri Wahyuni Sumiyarni Harahap Syahfitri , Adelya Syahputra, Ricky Andi Syalsabila Putri Syarifah, Aulia Tamara Army Tambupolon, Sanya Tanika Utama, Fazrul Amin Vera Estefania Kaban Wijiyaningsih, Dinda Yanti, Rahma Yayuk Putri Rahayu Yulia Nanda Putri Yuniarti , Rafita Yuniarti, Rafita Ziza Putri Aisyia Fauzi Zulmai Rani