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All Journal Sains Olahraga : Jurnal Ilmiah Ilmu Keolahragaan Buletin Farmatera Journal of Epidemiology and Public Health Indonesian Journal of Medicine Contagion: Scientific Periodical Journal of Public Health and Coastal Health Best Journal (Biology Education, Sains and Technology) Jurnal Prima Medika Sains Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) Jurnal Pengabdian Pada Masyarakat METHABDI Majalah Ilmiah METHODA Cermin Dunia Kedokteran Jurnal Kedokteran Methodist
Siahaan, Jekson Martiar
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BRAIN NATRIURETIC PEPTIDE (BNP) SEBAGAI BIOMARKER GAGAL JANTUNG KONGESTIF Budi Darmanta Sembiring; Jekson Martiar Siahaan
Majalah Ilmiah METHODA Vol. 10 No. 3 (2020): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (837.223 KB) | DOI: 10.46880/methoda.Vol10No3.pp130-138

Abstract

Brain Natriuretic Peptide (BNP) is mainly secreted by the heart ventricles and acts as an antagonist to Renin-Angiotensin-Aldosterone. BNP is secreted as pre-proBNP which is broken down into BNP and proBNP in circulation. The BNP examination is done by measuring the levels of BNP or N-Terminal-proBNP depending on the method and the manufacturer. Increased levels of BNP and NT-proBNP indicate heart failure so that BNP and NT-proBNP are considered markers of heart failure. This examination is also indicated to help establish the diagnosis, monitoring, and prognosis of heart failure. Natriuretic peptide examination can be done by several methods such as radioimmunoassay (RIA), Enzyme immunoassay (EIA), Fluorescence immunoassay (FIA), and Sandwich Electro Chemiluminescence Immuno Assay (Sandwich ECLIA).
TINJAUAN BIOMOLEKULER DAN KLINIS OCULAR COVID-19 Lylys Surjani; Jekson Martiar Siahaan
Majalah Ilmiah METHODA Vol. 10 No. 2 (2020): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (402.386 KB) | DOI: 10.46880/methoda.Vol10No2.pp53-66

Abstract

The clinical manifestations of Covid -19 are not only in the airway but are also found in eyes with conjunctival epithelium and ACE-2 receptors as their entry points. The most common clinical manifestation is conjunctivitis, therefore it is not easy to make a diagnosis if it relies on clinical findings because it is similar to a common viral infection. This infection has clinical manifestations in the airway that triggers the immune response leading to a cytokine storm with fatal consequences. There is no specific treatment up to this time. The most important thing is to prevent infection.
ALVEOLAR SOFT PART SARCOMA Sanggam B. Hutagalung; Jekson Martiar Siahaan
Majalah Ilmiah METHODA Vol. 8 No. 3 (2018): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methoda.Vol8No3.pp7-13

Abstract

Alveolar Soft Part Sarcoma (ASPS) is a rare sarcoma, this sarcoma accours around 0,2 – 0,9% of all soft tissue sarcomas. This tumour can occur at any age, but the peak incidence is in the age range of 15 – 35 years, rarely under the age of 5 years and after the age of 50 years. In adults, ASPS most often occur in deep soft tissues in the lower extremites, especially the anterior part of the thighs and buttocks. But in children and infants these tumours often occur in the area of the head and neck, especially the tongue and eyes. Tumours that occur in the head and neck are usually smaller in size may be due to earlier detection. Diagnostic of ASPS can be through CT – Scan/MRI examination, Fnab Citology, Histopathology, and Immunophenotype.
PATOFISIOLOGI GASTROPATI NSAID Salomo Garda Utama Simanjuntak; Jekson Martiar Siahaan
Majalah Ilmiah METHODA Vol. 8 No. 2 (2018): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methoda.Vol8No2.pp73-82

Abstract

NSAIDs are first line therapy for arthritis and widely used in cases of trauma, postoperative pain and other aches. But in the use of NSAID drugs whether it is needed as an analgesic or as an anti-inflammatory all have more or less side effects on the gastrointestinal. The occurrence of side effects of NSAIDs on the gastrointestinal tract can be caused by the direct toxic effects of NSAIDs on the gastric mucosa so the mucosa becomes damaged. While the systemic effect is due to the ability of NSAIDs to inhibit the work of COX-1 which catalyzes the formation of prostaglandins. Prostaglandins in the gastrointestinal mucosa function to maintain mucosal integrity, regulate blood flow, mucous secretion, bicarbonate, epithelial proliferation, and mucosal resistance to damage. The clinical spectrum of NSAID gastropathy includes a wide range of clinical conditions, ranging from the mildest form of gastrointestinal discontrol. Endoscopically mucous congestion will occur, small erosions sometimes accompanied by bleeding
PEDOMAN DALAM PENANGANAN KANDIDIASIS Jadeny Sinatra; Jekson Martiar Siahaan
Majalah Ilmiah METHODA Vol. 8 No. 1 (2018): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methoda.Vol8No1.pp50-61

Abstract

Candida species is an important cause of nosocomial infection that lead to death and prolonged hospital stay. The number of immunocompromised patients, at greater risk of fungal infection, treated in intensive care units (ICUs) has increased considerably. The widespread use of invasive monitoring , therapeutic equipment and treatment with broad spectrum antibiotic increases the risk of fungal colonization and infection. An acute awareness of the increasing incidence of Candida as a pathogen and of the associated morbidity and mortality is necessary. Guidelines management of candidiasis by Infectious Disesase Society of America(IDSA) in 2009 previously, was revised. There have been new data pertaining to diagnosis, prevention, and treatment for proven or suspected invasive candidiasis, leading to significant modification in treatment recommendations, which released in 2016. This article provides a summary of the most recent guideline for the management of candidiasis.
POTENSI LABU SIAM SEBAGAI ANALGETIK Sinatra, Jadeny; Siahaan, Jekson M.
Majalah Ilmiah METHODA Vol. 14 No. 1 (2024): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pain is an unpleasant emotional sensation. Pain can begin after inflammation and/or after tissue damage. The use of analgesic or anti-pain drugs so far has undesirable side effects, so people have begun to look for alternative traditional medicines as a substitute. One of the plants that can be used as an alternative medicine for analgesics is chayote (S. edule). The purpose of this review is to provide information about chayote as an analgesic. This study focused on reviewing articles on experimental studies conducted in vivo and its bioactive components.
PENYULUHAN PEMBERDAYAAN MASYARAKAT DALAM PENCEGAHAN STUNTING DESA AJIJULU, KABUPATEN KARO Siahaan, Jekson Martiar; Silitonga, Hendrika Adriana; Lim, Hadyanto; Pasaribu, Sumihar M. R.; Tarigan, Menang Bastanta; Jamnasi, Juli; Sinatra, Jadeny; Simanjuntak, Salomo Garda Utama; Sembiring, Budi Darmanta; Pakpahan, Edwin Anto; Hutagalung, Sanggam B.; Sinurat, Suryati; Br. T. Tambun, Gita Sradha; Hakim, Enggrek Pelita
Jurnal Pengabdian Pada Masyarakat METHABDI Vol 3 No 1 (2023): Jurnal Pengabdian Pada Masyarakat METHABDI
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methabdi.Vol3No1.pp11-14

Abstract

Community Service (PKM) conducted by the Faculty of Medicine at the Indonesian Methodist University provides counseling on stunting prevention. PKM was held on April 14-16 2023 in Ajijulu Village, Tigapanah District, Karo Regency, North Sumatra. Lectures, discussions and motivations are used as orientation methods. Question and answer discussions were held with the aim of gaining insight, understanding and solutions to solve the problems and limitations faced by the local community. The results of the PKM suggestions and research are very effective, considering that there are still many people who are ignorant of stunting prevention. This counseling increases public awareness about stunting prevention. Residents of Ajijulu must be aware and know the importance of preventing stunting, starting from the time of pregnancy and the first 1000 days of life for toddlers.
Effectiveness of Ethanol Extract and Ethyl Acetate Fraction of Breadfruit Leaves (Artocarpus altilis) as Antihyperglycemia Daulay, Agus Husein; Siahaan , Jekson Martiar; Syahrir, Lesmana; Tambunan, Ronald Tunggul Hotmarojahan
Indonesian Journal of Medicine Vol. 9 No. 3 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.3.753

Abstract

Background: The rising diabetes mellitus (DM) population is a public health concern. Pharmaco­therapy for DM can cause side effects and is often inaccessible, necessitating alternative therapies like medicinal plants. Breadfruit leaves (Artocarpus altilis) have antidiabetic effects. This study aimed to examine the antihyperglycemic effect of ethanol extract and ethyl acetate fraction of bread­fruit leaves on alloxan-induced diabetic male white rats (Rattus norvegicus). Subjects and Method: This was a randomized controlled trial. Sample was 35 male white Wistar rats (Rattus norvegicus sp.) divided into 7 groups. The study was conducted at the Phytochemical Laboratory and Animal House, Faculty of Medicine, Indonesian Methodist University, from April to May 2023. The dependent variables were body weight, blood glucose levels, and diameter of the islets of Langerhans. The independent variables were variations in the dose of ethanol extract and ethyl acetate fraction of breadfruit leaves. Body weight was measured by scales. Blood glucose was measured using glucometer. Diameter of the islets of Langerhans was measured using computer-based image analysis system. Data were analyzed using Anova and Kruskal-Wallis tests. Results: Weight loss was better in the group given the ethyl acetate fraction at a dose of 200 mg/kgBW compared to the other groups. Administration of ethanol extract at a dose of 200 mg/kgBW showed a better reduction in blood glucose levels compared to the other groups, where P < 0.05 between K4 and K3, K5, and K7 on day 5. Ethanol extract at a dose of 200 mg/kgBW was able to improve the diameter of the islets of Langerhans induced by alloxan. Conclusion: A 200 mg/kg BW dose of ethyl acetate fraction reduces body weight. A 200 mg/kg BW dose of ethanol extract reduces blood glucose and improves pancreatic islet diameter.
Effect of Moringa Leaf Infusion (Moringa oleifera) on Reducing Blood Glucose and Total Cholesterol Levels in Mice (Mus musculus) with Diabetic Ulcers Napitupulu, Helen Debora; Siahaan, Jekson Martiar; Simangunsong, Batara
Indonesian Journal of Medicine Vol. 9 No. 4 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.9.4.799

Abstract

Background: Diabetes mellitus is a chronic disease in the form of metabolic disorders, which is characterized by blood glucose levels (KGD) that exceed normal limits and are accompanied by impaired metabolism of carbohydrates, lipids, and proteins, as a result of abnormalities in insulin secretion. Diabetics are known to have slow wound healing. Moringa oleifera leaves or moringa plants contain flavonoid compounds, which can decrease glucose absorption. This study aims to determine the effect of moringa leaf infusion on blood sugar levels, glucose tolerance, cholesterol levels, body weight, and wound healing speed in mouse model animals. Subject and Method: This study is experimental using a posttest only controlled group design, using 25 male mice (Mus musculus) divided into 5 groups. The study was conducted at the Phytochemistry and Animal House Laboratory, Faculty of Medicine, Methodist University Indonesia from March to May 2022. The bound variables were body weight measured using a scale, current blood glucose levels and blood glucose levels with glucose loading measured with strips and glucometers, total cholesterol levels measured using strips and cholesterol measuring devices, and the length of mice wounds measured using a ruler. The free variable is the variation in the dose of moringa leaf infusion. The data were analyzed using the Anova and Kruskal-Wallis tests. Results: The administration of moringa leaf infusion had a significant effect on the reduction of the levels of each variable, namely a dose of 10% in body weight, a dose of 30% in KGD, 20% in KGD with glucose loading, 20% in cholesterol, and 20% in wound closure, which was proven based on the results of statistical tests. Conclusion: Moringa leaf infusion can lower blood sugar levels, blood sugar levels by glucose depletion, cholesterol levels, body weight, and accelerate wound healing in sucrose-induced mice, high fat diet, and PTU.
Edukasi Kesehatan Prostat untuk Meningkatkan Kesadaran Deteksi Dini pada Jemaat GMI Manna Helvetia Medan Anto, Endy Juli; Siahaan, Jekson Martiar; Fauzi, Tengku M.; Normi, Siti; Panjaitan, Maludin; Hutapea, Kenal P.; Panataria, Lince Romauli; Simanjuntak, Pantas; Sihombing, Parsaoran; Saragih, Meylin Kristina; Manurung, Agnes Imelda; Sitorus, Efbertias; Sitorus, Ragnar Oktavianus; Simatupang, Jones T.; Nababan, Manaor Bismar Posman; Simatupang, Aditia Erick Cantona; Sirait, Kilian; Silalahi, Veraci
Jurnal Pengabdian Pada Masyarakat METHABDI Vol 4 No 2 (2024): Jurnal Pengabdian Pada Masyarakat METHABDI
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methabdi.Vol4No2.pp215-218

Abstract

Prostate disease is a significant health concern affecting men, particularly those over 35 years old. This community service activity aimed to increase knowledge and awareness about prostate disease among the congregation of GMI Manna Helvetia Medan through health education. The methods included educational presentations, motivational sessions, and question-and-answer discussions. The activity was attended by 45 participants aged 35-70 years. Results showed improved participant understanding of prostate disease symptoms, risk factors, and the importance of early detection. About 70% of participants committed to undergo prostate examination within the next 6 months. The educational approach through church community proved effective in delivering sensitive health information and raising awareness about the importance of regular check-ups.
Co-Authors Ade Setiowati Agnes Imelda Manurung Ahmad Abiyyu Muda Lubis Ainun, Nur Azizah Ardinata, Dedi - Ariani, Peny Ariescha, Putri Ayu Yessy Atmawidjaja, Rachmat Bahar, Dinillah Salsabila Br Purba, Debora May Sary Br. T. Tambun, Gita Sradha Budi Darmanta Sembiring Butar-Butar, Harry Chalil, M. Jalaluddin A. Cristian Marito Siregar Damanik, Irene Daulay, Agus Husein Diani Nazma Dina Riani Purba Dona Pasaribu Dwi Lunarta Doderina Siahaan Efbertias Sitorus Eka Samuel P. Hutasoit Elvana, Ayu Endy Juli Anto Endy Juli Anto endyjulianto endyjulianto Fadinie, Wulan FAHDI, FIRDAUS Fauzi, Tengku M. Fauzi, Tengku Muhammad Frengky S. Manullang Hadyanto Lim Hadyanto Lim Hakim, Enggrek Pelita Hamdi, Tasrif Hendrika A. Silitonga Hendrika Silitonga Hutagalung, Mangatas Halomoan Parluhutan Hutagalung, Sanggam B. Hutagalung, Sanggam Bangun Hutapea, Kenal P. Hutasoit, Eka Samuel P. Ilyas, Syaffrudin Imelda Montes Monika Simanungkalit Indra Satrio Anantha Hasugian Irfan Hamdani, Irfan Irina, Sinta Jadeny Sinatra Jadeny Sinatra Jan Pieter Sihombing Jenita Oktavia Panjaitan Jones Simatupang Juli Anto, Endy Juli Jamnasi Juli Jamnasi Juli Jamnasi Juli Y. Mega kenvin rusli Laura Octavina Siagian Lesmana Syahrir Lesmana Syahrir, Lesmana Lubis, Andriamuri P. Maestro B. U. Simanjuntak Maludin Panjaitan Manik, Widya Dayanti Feronika Manullang, Frengky S. Maria, Lasma Menang Bastanta Tarigan Momot, Estela Salomina Nababan, Manaor Bismar Posman Nababan, Titus Imanuel Nadapdap, Thomson P. Nainggolan, Ranatha NH Nainggolan, Serevina Napitupulu, Helen Debora Natalie S., Karen Noviola Sari Kusuma Sagala Nurmala Sari Pakpahan, Edwin Anto Panataria, Lince Romauli Panjaitan, Bintang Andika Panjaitan, Goklas Parhusip, Rudolf S. Pasaribu, Sumihar M. R. Pasaribu, Sumihar Maurist Rantos Pasaribu, Sumihar MR Paul Saut Marganda L Tobing Pengarapen Tarigan Perangin-angin, Guntur Pratiwi, Ade Dwi Purba, Amril Putri C. Eyanoer Putri Chairani Eyanoer Putri Chairani Eyanoer, Putri Chairani Ria Oktavia Ricke Loesnihari Rifqi Aufan Rimbun, Surjadi Ronald T. H. Tambunan Ronald T. H. Tambunan Sagala, Daniela Salamon, Yuda Monang Salomo G. U. Simanjuntak Salomo Garda Utama Simanjuntak Sanggam B Hutagalung Sanggam B. Hutagalung SARAGIH, MEYLIN KRISTINA Sari, Nur Mala Sembiring, Bob Agustinus Sembiring, Budi Darmanta Sembiring, Mikael Siahaan, Dwi Lunarta D. S. Sihaloho, Kerin Repaskatri Sihaloho, Lovian Nauli Sihombing, Amordekhai Imvan Parlindungan Sihombing, Parsaoran Sihotang, Ruth Wydia Wati Sijabat, Kesia Silaen, Ester L. R. Silalahi, Veraci Silangit, Thomas Silitonga, Hendrika Adriana Silitonga, Hendrika Andriana Silitonga, Hendrika Andriani Simangunsong, Batara Simanjuntak , Salomo G. U. Simanjuntak, Jeremia Simanjuntak, Maestro Simanjuntak, Maestro Bina Utama Simanjuntak, Pantas Simanjuntak, Salomo Garda Utama Simanjuntak, Salomo Garda Utama Simatupang, Aditia Erick Cantona Simbolon, Boyke M. Sinatra, Jadeny Sinurat, Suryati Sirait, Kilian Sitepu, John Frans Siti Normi, Siti Sitompul, Michael Sabatino Sitorus, Ragnar Oktavianus Situngkir, Jesica Damayanti Stephanie S., Kezia Sucipto Sucipto Surjani, Lylys Suryati Sinurat Syahputra, Fahmi Tambunan, Nur Lela E. Tambunan, Ronald T. H. Tambunan, Ronald Tunggul Hotmarojahan Tampubolon, Ruth Septianna Br. Tanjung, Qodri F. Tarigan, Gracecilia Tarigan, Juliyanti Tarigan, Leonardo Tarigan, Menang Bastanta Tengku M. Fauzi Tengku M. Fauzi Tengku Muhammad Fauzi Tiji, Widjaya Taufik Tiji, Wijaya Taufik Tim Lions Club Medan Angkasa Tobing, Paul S. M. L. Urip Harahap Vandem Samuel Purba Vivian Vivian Widjaya Taufik Tiji Wijaya, Mega Yohanna Agustina Sinaga YUNAFRI, ANDRI Zainumi, Cut M.