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Evaluation of Acute Toxicity of Ethanol Extract of Pirdot Leaf (Saurauia vulcani Korth.) in Rats Simanjuntak, Nerly Juli Pranita; Rosidah; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 2 (2020): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v3i2.4303

Abstract

Traditionally pirdot leaves are used to treat various diseases. The purpose of this study was to determine determine the potential for acute toxicity of ethanolic extract of pirdot leaf (Saurauia vulcani Korth.) with value LD50 and hematological Parameters in rats. The acute toxicity of ethanolic extract of pirdot leaf was evaluated by OECD guidelines. The number of animals used in this research were 15 female rats. The control group was given Na CMC 0.5%, the treatment groups were given ethanolic extract of pirdot leaves with doses 2000 and 5000 mg/kg bw. The results showed that ethanolic extract of pirdot leaves with doses of 2000 and 5000 mg/kg bw did not show any toxicity signs. There was no mortality was observe. The ethanolic extract of pirdot leaves did not cause any changes in hematological parameters, these include red blood cells (RBC), hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet, white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils, and basophils levels as compared to normal control (P>0.05). It was estimated that LD50 of ethanolic extract of pirdot leaves was higher than 5000 mg/kg bw and the extract were practically non-toxic. The ethanolic extract of pirdot leaves did not cause any toxic effect on hematological parameters.
Immunomodulator Activity of Puguntano (Picria fel-terrae Lour.) Extract in White Male Mice By Carbon Clearance Method Rezza Fikrih Utama; Rosidah; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 2 (2020): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v3i2.4306

Abstract

Poguntano Herb Plants (Picria fel-terrae Lour.) contains flavonoids compounds that have been potentially to developed into immunomodulators. The purpose of this study was to determine the immunomodulatory activity of Poguntano herb extract (Picria fel-terrae Lour.), with the method of carbon clearance. n-hexane extract puguntano herb(ENHHP), extract of ethyl acetate of Poguntano herb (EEAHP), and ethanol extract of puguntano herb(EEHP) Poguntano multistage results in the test of immunomodulatory activity with a method of carbon clearance. Results showed that the EEHP 200 mg/kg BB showed a strong immunostimulation effect, EEAHP 200 mg/kg BB showed strong immunostimulation effect, ENHP 200 mg/kg BB demonstrated strong immunostimulation effect. It is thought that extract N-hexane herb Poguntano (ENHHP), extracts of ethyl herb acetate Poguntano (EEAHP), and herb ethanol extract Poguntano (EEHP) Poguntano herb may increase phagocytosis activity. Extract of ethyl acetate Poguntano herb 200 mg/kg bw (EEAHP) has the best phagocytosis activity with a value of 2.376 which indicates there is a significant difference (P < 0.05) with another treatment group.
Poguntano Herba Extract Immunostimulant Activities (Picriafel-terraeLour). in Immunosupression Rats Infected by Staphylococcus aureus Against Total Leukocytes and Differential Leukocytes Ningtias, Anggitha; Rosidah; Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 1 (2021): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v4i1.5378

Abstract

Poguntano (Picriafel-terraeLour.) is a medicinal plant in North Sumatra that has been used in traditional medicine to treat degenerative diseases.Poguntano extract contains flavonoid compounds that have the potential to be developed into immunomodulators. This study showed the immunostimulant activity of poguntano herb n-hexane extract (PHNHE), poguntano herb ethyl acetate extract (PHEAE) and poguntano herb ethanol extract (PHEE) in immunosuppressed rats infected with Staphylococcus aureus. The evidence of poguntano herb as an immunomodulator was carried out by testing total leukocytes and differential leukocytes. Poguntano herb n-hexane extract (PHNHE) can not increase the total and differential leukocytes; Poguntano herb ethyl acetate extract (PHEAE) and poguntano herb ethanol extract (PHEE) can increase the total and differential leukocytes in immunosuppressed rats induced by Staphylococcus aureus.
The Lipid Profile and Aorta Histopathology On Hyperlipidemic Rat by Saurauia vulcani Korth. Leaves Extract Octora, Debi Dinha; Rosidah; Silalahi, Jansen; Satria, Denny
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 1 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i1.6521

Abstract

Abstract. Dyslipidemia is a pathological condition characterized by increased levels of total cholesterol, triglycerides and LDL and decreased levels of HDL. Dyslipidemia causes cardiovascular disease risk factors by increasing cholesterol levels, increasing triglyceride levels, lowering HDL levels, and increasing LDL levels, as well as decreasing the proliferation of cardiac aortic cells in dyslipidemic rats. The pirdot plant (Saurauia vulcani Korth.) has long been known by the Simalungun, Toba and Karo communities to have the potential to treat various diseases caused by disruption of lipid processes in the body. Pirdot leaves contain bioactive compounds of flavonoids, tannins and saponins that have the potential to improve lipid profiles and prevent cardiovascular disease. This study aims to determine the activity of EEDP on the lipid profile of dyslipidemic rats. Pirdot leaf simplicia powder was extracted by maceration with 96% ethanol solvent and the extract was used on 30 dyslipidemic rats which were divided into 6 groups. Group 1 (Na-CMC), group 2 (Atorvastatin), group 3, 4, 5, 6 EEDP doses of 50, 100, 200, 400 mg/kg BW were administered orally for 21 days. At the end of the treatment, the levels of total cholesterol (TC) and aortic cell proliferation were measured. The results showed that Saurauia vulcani Korth had water content (6.23%), water soluble extract (10.50%), simplicia content soluble in ethanol (14.77%), total ash content (7.05%) and acid insoluble ash content (0.48%). From the antidyslipidemic study it was shown that EEDP 400 mg/kg BW improved blood lipand to increase aortic cell proliferation dyslipidemic rats was 69.84±0.27. Based on the explanation above, it is concluded that EEDP has an antidyslipidemic effect.
Desa Digital: Pentingnya Memperkokoh Ketangguhan Desa di Era Digital Manoby, Worry Mambusy; Afriyanni; Fitri, Suci Emilia; Pranasari, Melati Ayuning; Setyaningsih, Eny; Rosidah; Saksono, Herie
Jurnal Bina Praja Vol 13 No 1 (2021)
Publisher : Research and Development Agency Ministry of Home Affairs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21787/jbp.13.2021.53-63

Abstract

The village is the lowest government level located in the administrative area of districts/cities municipalities throughout Indonesia. The rapid advancement of digital technology has brought global changes that require villages to carry out transformation and adaptation. In responding to this, what should be done for the sustainability of the values of life, preserving traditions, culture, and local wisdom, and building human capital to improve the welfare of its citizens? This study aims to find an extraordinary strategy to realize rural resilience through a digital village. The study used a qualitative method with case studies in two villages: i) Cijengkol Village and ii) Sepakung Village. This study finds the importance of digitalization starting from the village. The apparatus and community of Cijengkol Village are increasingly enjoying the benefits of digitization to complete various daily affairs. Meanwhile, Sepakung Village has published its natural wealth and tourism digitally. The digital village is one of the ideal solutions for rural resilience in the digital era. Human capital is the main factor. Advances in digital technology and digitalization of villages help manage village government, including the development of social life in the community in the village. Second, the village has a global presence, where digitalization has helped change the village's image and the lives of its people. It is hoped that the government will be able to initiate a participatory digital village that is responsive to the dynamics of digitalization, inclusive development, the anticipation of disasters, and digital-based environmental sustainability.
Desain Kebijakan Pengentasan Kemiskinan Ekstrem di Kabupaten Lombok Barat Purwadi; Yaarozatulo Harefa, Herman; Suhendra, Adi; Halik, Abdul; Santoso, Catur Wibowo Budi; Rosidah; Putra, Imam Radianto Anwar Setia; Apriani, Tini; Manoby, Worry Mambusy; Sutanto, Hari Prasetyo
Jurnal Bina Praja Vol 15 No 3 (2023)
Publisher : Research and Development Agency Ministry of Home Affairs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21787/jbp.15.2023.605-619

Abstract

This study aims to analyze the design of extreme poverty reduction policies in West Lombok District. The design of the policy refers to the substance/content of the policies developed for the reduction/prevention of extreme poverty used by the regions. A case study research approach is used to explore the design of extreme poverty alleviation policies. The West Lombok Regency government's policy on poverty alleviation contains various local government programs synergized in accelerating the acceleration of extreme poverty reduction. In addition, it is in the form of efforts to assist the poor for a movement that is actualized in bridging aid recipients to get out of poverty immediately. The construction of extreme poverty reduction policies in West Lombok Regency adopts the concept of an innovation hub to accelerate cross-government programs that target basic services (health and education) in interventions for individual/family change as well as increasing the business capacity of community groups.
PERSEPSI GURU TERHADAP PERSIAPAN DIRI DALAM MENGHADAPI KURIKULUM MERDEKA DI SD NEGERI 13/1 MUARA BULIAN Rosidah; Yantoro; Suci Hayati
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 10 No. 03 (2025): Volume 10 No. 03 September 2025 Terbit
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v10i03.32125

Abstract

This study aims to (1) describe teachers’ perceptions of self-preparation in facing the Merdeka Curriculum at SD Negeri 13/1 Muara Bulian, and (2) identify the factors influencing teachers' self-preparation. This descriptive qualitative research involved interviews and documentation for data collection. The subjects were the principal, homeroom teachers, and subject teachers totaling four participants. The results show that teachers have a positive perception of the importance of self-preparation. Teachers have begun preparing by seeking information about the Merdeka Curriculum through the internet and the Merdeka Mengajar platform. They also attend school-facilitated seminars, engage in peer discussions, and improve their technological skills for teaching and assessment purposes. Influencing factors in teacher preparation include leadership, motivation to become engaging educators, student characteristics, relevant curriculum development, innovative teaching methods, professional growth, and collaboration with parents. Based on the findings, it is recommended that teachers continue to strengthen their understanding of the Merdeka Curriculum using available resources, and schools are encouraged to support teacher readiness through appropriate facilities and training opportunities.
Innovative Government Transformation in The Equalization of Teachers and Education Personnel Suhendra, Adi; Rosidah; Harefa, Herman Yaarozatulo
Tafkir: Interdisciplinary Journal of Islamic Education Vol. 5 No. 2 (2024): Integrative Islamic Education
Publisher : Pascasarjana Universitas KH. Abdul Chalim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31538/tijie.v5i2.513

Abstract

This article aims to develop video learning media specifically crafted to assist educators in presenting learning materials more tangibly and understandably, particularly within early childhood education. Guided by the Research and Development (R&D) process, the study focuses on two primary objectives: (1) elucidating the intricacies of developing STEAM-based video learning media for Early Childhood Education, incorporating Religious and Moral Values, and (2) evaluating the appropriateness and effectiveness of such media in the educational context. Adopting the ADDIE development model, the research encompasses five pivotal stages: Analysis, Design, Development, Implementation, and Evaluation. The validation process for the developed product entails collaboration with media, material, and design experts, complemented by feedback from colleagues. One-to-one tests, Small Group Tests, and Field Test methods are employed to assess the effectiveness of the media. Validation results from these experts affirm that the developed media aligns seamlessly with the criteria for successful application in educational settings. During the product implementation phase involving 15 students, it became evident that this development was an effective learning tool. The post-test scores surpassing the pre-test scores indicate the product's efficacy in enhancing the understanding of morning phenomena, instilling religious and moral values, and fostering STEAM creativity in early childhood education.
Human Rights and Military Health: A Review of Violations of International Criminal Law in Armed Conflict Hodijatussolihah; Rosidah; Purnomo, Hadi
Formosa Journal of Sustainable Research Vol. 3 No. 4 (2024): April, 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjsr.v3i4.8956

Abstract

Human Rights (HAM) are rights inherent in every individual, including in the context of military health in the midst of armed conflict. This article reviews violations of International Criminal Law (HPI) that occur in conflict situations, such as murder, torture and forced labor. Protection of human rights in the midst of armed conflict is important, especially regarding access to adequate health services and freedom from treatment that violates human rights. Serious efforts are needed to ensure that military health does not violate human rights principles, so that the world community can maintain their dignity and human rights, even in the midst of conflict-ridden situations
Criminal Crimes in Elections in Indonesia Hodijatussolihah; Rosidah; Ahmad Fatoni; Munib; Pipit Yuliarpan; Wiradirja, Hj. Imas Rosidawati
Formosa Journal of Sustainable Research Vol. 3 No. 5 (2024): May 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjsr.v3i5.9141

Abstract

Criminal crimes in elections in Indonesia pose a serious threat to democracy and nation building. Political, social and economic factors are the main drivers, with weak law enforcement exacerbating the situation. Comprehensive efforts from the government, Bawaslu, Gakkumdu, Polri, Prosecutor's Office, community and civil organizations are needed to take action against perpetrators, improve political education and strengthen coordination between institutions. Further research is needed to analyze the modus operandi, actors involved, and the impact of election crimes on democracy
Co-Authors Abd. Rahman Abdi Fithria Abdul Halik Abdul Rahman Adi Suhendra, Adi Aditama Agustian Affan Solihin Afriyanni Agus Waluyo Ahmad Dwi Priyatno Ahmad Fatoni Ahmad Talib Ahmad Yamani Ainun, Rezki Awalia Akhmad Affandi Akis, Dwi Ihza Sari Aldiano Rahmadya Ali Harokan Anaguna, Nursyam Andi Baso Kaswar Andi Baso Kaswar Andi Dio Nurul Awalia Andi Rhyta Samantha Valda Andika Isma Andina Ainayah Naim Annajmi Rauf Annesya Atma Battya Aprisal Arfa Agustina Rezekiah Arie Wahyudi Arieb Shintami, Rica Asham Bin Jamaluddin asmaun, asmaun Asriadi Asriwan Catur Wibowo Budi Santoso, Catur Wibowo Budi Dary Mochamad Rifqie Della Fadhilatunisa Denalis Rohaningsih Denny Satria, Denny Desi Arianti Devi Miftahul Jannah Devina Elma Nurjannah Eny Setyaningsih, Eny Erlisya Puspandhani, Mitha Fadhil Zil Ikram Fajar Arwadi Farihah, Nailil Gt Syeransyah Rudy Hadi Purnomo Hamda Hanifah Nurus Sopiany Hardiansyah Harefa, Herman Yaarozatulo Hasibuan, Poppy Anjelisa Zaitun Herie Saksono, Herie Hisyam Ihsan Hodijatussolihah Ilham Minggi Ilyas , Syafruddin Imam Radianto Anwar Setia Putra, Imam Radianto Anwar Setia Imas Rosidawati Wiradirja Indah Sari Israwati Hamsar Jansen Silalahi Kunnati Layn, Muhamad Ruslan M. Miftach Fakhri Mahatma Kresnha Radityo Manoby, Worry Mambusy Mar Athul Wazithah T. Margareta Rahayuningsih Misbahuljannah Muafan, Wildan Muh. Yusril Anam Muhalim Muhammad Ansori Muhammad Fajar B Muhammad Fardan Muhammad Takwin Machmud Munib Musaytir Husain Nasution , Pandapotan Nia Asdina Ningtias, Anggitha Norma Rizki Silviana Novitasari, Anik Eko Nur Hidayat Nur Ilmi Nur Rahayu Utami Nur Rahmah Sari Nurjannah, Elma Nurmasitoh Nurrahmah Agusnaya Nursyam Anaguna Nurwati Djam’an Nuryani, Yuni Ocsirendi Octora, Debi Dinha Parida Marjuliana Perez, Liann Camille Davalos Pipit Yuliarpan Pradika, Rizka Ardhi Pranasari, Melati Ayuning Purwadi Putri Nirmala Rasyid, Aliy Refika Adinda Inka Relita Novianti Rezza Fikrih Utama Riqqah Dhian Shefira Rismayanti rita apriliani Rizky Aulia Roffi Grandiosa Roffi Grandiosa Herman Sabri Sahid Shera Afidatunisa Silvia Syavira Simanjuntak, Nerly Juli Pranita Siti Aisyah Siti Fathonah SITI KHODIJAH Siti Nurmar Laela Sri Mulyani Sri Yuyun Suci Emilia Fitri Suci Hayati Sudarmanto Jayanegara Sugiarti Surojo Sutanto, Hari Prasetyo SUWARTI Syafirah Audiwinanda Syam’ani D Ali Syukur, Pramudya Asoka Talib, Dr. Ahmad Tini Apriani, Tini Usman Mulbar Usman Mulbar WAHYUDI Wahyuniar Pamungkas Walim Lili Widyawati Yaarozatulo Harefa, Herman Yanto Lesmana Yantoro Yashinta Nur Shiba Yuandani Yuanita B Yudhi Alfian