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All Journal E-Jurnal Medika Udayana Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Brawijaya Medula Juke Jurnal Pengabdian Kepada Masyarakat Sakai Sambayan Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Kesehatan Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kedokteran Ibnu Nafis Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran JOURNAL OF Qualitative Health Research & Case Studies Reports Health & Medical Sciences JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Jurnal Ilmu Kedokteran dan Kesehatan Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Essentia: Journal of Medical Practice and Research
Indri Windarti
Universitas Lampung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Medula

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Eksplorasi Imunoterapi dan Terapi Gen dalam Pengobatan Tumor Otak: Literature Review Hana Muthi'a Putri; Windarti, Indri; Mayasari, Diana; Susianti, Susianti
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1378

Abstract

Brain tumors are a significant neurological disorder with a high mortality rate, especially in cases of glioblastoma, which is highly aggressive and difficult to treat. Conventional treatment methods, such as surgery, radiation therapy, and chemotherapy, are often not effective enough, particularly in advanced stages. This study aims to explore two innovative approaches, namely immunotherapy and gene therapy, as alternative treatments for brain tumors. Immunotherapy works by enhancing the immune system's ability to fight cancer cells through methods such as checkpoint inhibitors, cancer vaccines, and CAR-T therapy. However, the success of immunotherapy is often hindered by the blood-brain barrier (BBB), which limits the delivery of therapy to the brain. On the other hand, gene therapy offers a solution by modifying genetic material, either to repair damaged genes or to directly destroy cancer cells. Approaches such as the use of oncolytic viruses, CRISPR technology, and nanoparticles have shown promising results in preclinical research and early clinical trials, particularly for glioblastoma. The combination of immunotherapy and gene therapy opens new opportunities to enhance treatment effectiveness by strengthening the immune response and targeting tumors more specifically. However, challenges remain, including treatment resistance, side effects, and limitations in brain delivery methods. Further research is needed to ensure the safety, efficacy, and widespread application of this combination therapy. Immunotherapy and gene therapy have great potential as breakthroughs in the future treatment of brain tumors. Relevant literature, including articles and journals from both national and international sources, were gathered through online searches in various databases, such as Google Scholar, PubMed, and NCBI, and used to compile this article.
Pengaruh Pemberian Ekstrak Etanol Buah Pare (Momordica Charantia L) Terhadap Gambaran Histopatolgi Arteri Koronaria Tikus Putih (Rattus Norvegicus) Jantan Galur Sprague Dawley Yang Diinduksikan Minyak Jelant Joni, Agnesia Priskila; Windarti, Indri; Oktarlina, Rasmi Zakiah; Susianti, Susianti
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1392

Abstract

Coronary heart disease is one of the main causes of death in the world, with more than 17 million deaths every year due to heart and blood vessel diseases, with around 8.7 million of them caused by coronary heart disease and around 15 out of 1000 residents in Indonesia which is equivalent to around 2,78,064 people suffer from coronary heart disease. The high frequency of use of cooking oil means that cooking oil is often used repeatedly. Repeated use of cooking oil can cause damage to various body organs such as the liver, heart, kidneys and arteries. Exposure to free radicals and free fatty acids obtained from used cooking oil if it enters the body will result in oxidative stress. The atherosclerosis process is characterized by the change of k-LDL to Ox-LDL which triggers endothelial dysfunction and the formation of atherosclerotic plaque on the walls of blood vessels. The high fatty acid content in used cooking oil can easily stick to the walls of blood vessels, so that it will accumulate and form atherosclerotic plaque. One of the alternative antioxidants that comes from herbs is bitter melon (Momordica Charantia L). Bitter melon contains flavonoid compounds. Flavonoids are secondary metabolites which are antioxidants that can inhibit free radical activity and can prevent atherosclerosis. Antioxidant compounds can reduce atherosclerosis by inhibiting LDL metabolism in secondary atherosclerotic lesions to prevent LDL oxidation in these lesions.
Pengaruh Pemberian Ekstrak Etanol Lada Hitam (Piper nigrum L) Terhadap Kadar Gula Darah dan Jumlah Spermatogonia Model Diabetes Tikus Putih Jantan (Rattus norvegicus) Galur Sprague dawley Talin, Jinan Naura; Hadibrata, Exsa; Rudiyanto, Waluyo; Windarti, Indri
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1431

Abstract

Diabetes mellitus that is not treated properly can result in infertility. The piperine content in black pepper can help in the quality of spermatogenesis process and blood sugar levels. This study aims to determine the effect of black pepper (P. nigrum L) ethanol extract on blood sugar levels and the number of spermatogonia in a diabetes model of male white rats (R. norvegicus) Sprague dawley strain. The study used a Posttest-only Randomized Control Group on 24 rats divided into 4 groups. All groups were induced with alloxan 150 mg/kgBW except for KN. P1 and P2 were given 122.5 mg/kgBW and 245 mg/kgBW black pepper ethanol extract. Blood sugar levels were checked using Easy Touch GCU with a normal limit of 50-135 mg/dL. The number of spermatogonia was calculated using a tool, namely ImageJ. The data were analyzed using the Shapiro- Wilk normality test and homogeneity test, followed by the Kruskal Wallis non-parametric test and the Post Hoc test. The statistical results of blood sugar levels obtained normally distributed data p>0.05, non-homogeneous data p<0.05, significant Kruskal-Wallis test results and continued Post Hoc test obtained significant results at P2 and K-. The number of spermatogonia obtained normally distributed data p>0.05, non-homogeneous data p<0.05. The results of the Kruskal-Wallis test were significant p<0.05 and continued Post Hoc test obtained significant results at P2 and P1. There was a decrease in blood sugar levels in the administration of black pepper ethanol extract (P. nigrum L) in the diabetes model of male white rats (R. norvegicus) Sprague dawley strain. However, there was no effect of administering black pepper ethanol extract (P. nigrum L) on the number of spermatogonia in the diabetes model of male white rats (R. norvegicus) Sprague dawley strain.
Tinjauan Pustaka: Pengaruh Obesitas, Resistensi Insulin dan Sindrom Metabolik dengan Fungsi Tiroid Fala, Arzety Rifda; Windarti, Indri; Jausal, Anisa Nuraisa; Sukohar, Asep
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1459

Abstract

The thyroid gland, located in the neck, is crucial for regulate metabolism, growth, and development by producing hormones like thyroxine (T4) and triiodothyronine (T3). These hormones influence various body functions, including heart rate, temperature control, energy production, and fat metabolism. When the thyroid gland doesn't function properly, it can cause conditions like hypothyroidism or hyperthyroidism. Factors such as obesity, insulin resistance, and metabolic syndrome can disrupt thyroid function. Obesity, characterized by excessive fat accumulation, is a global issue. This study examines how obesity, insulin resistance, and metabolic syndrome affect thyroid function. A review of fourteen relevant articles found that Thyroid Stimulating Hormone (TSH) levels are positively correlated with Body Mass Index (BMI), insulin resistance, and metabolic syndrome. The underlying mechanism is increased levels of leptin and inflammatory cytokines, which affect TSH production and thyroid function through disruption of T3 feedback. The findings indicate that obesity, insulin resistance, and metabolic syndrome lead to increased TSH as a compensatory response. This study highlights the importance of understanding the relationship between these conditions for better prevention and health management.
Merokok dan Vaping Sebagai Faktor Resiko Terjadinya Gangguan pada Hati Mubarak, Raka Anzil; Windarti, Indri; Yunianto, Andi Eka
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1463

Abstract

Conventional cigarettes and e-cigarettes (vaping) has a significant impact to health issues worldwide. There are more than 1.1 billion active smokers in the world and 8 million people die each year due to tobacco consumption. E-cigarette use is also increasing. The liver is responsible for metabolism and detoxification, so it is highly vulnerable to the toxic effects of chemical compounds from conventional cigarettes and e-cigarettes. This article is a literature study using secondary data from articles in national and international journals sourced from Google Scholar, NCBI, and PubMed. The purpose of this article is to review the relation between smoking, vaping, and the risk of liver disease, with a focus on the components of cigarettes and the mechanisms of liver damage. There are 4000 chemicals contained in cigarettes, including nicotine which are addictives and stimulants. The effects of smoking on the liver are caused by toxic, immunologic, and oncogenic mechanisms. The use of e-cigarettes or vaping is gaining popularity as a safe alternative to conventional cigarettes. However, each e-liquid solution can contain up to 60 chemicals that are harmful to the body. The effects of e-cigarettes on the liver are explained by complex mechanisms such as oxidative stress, inflammation, mitochondrial dysfunction and impaired lipid metabolism in the liver. Smoking affects the progression of liver diseases such as Hepatitis, Non Alcoholic Fatty Liver Diseases (NAFLD), Primary Billier Cholangitis (PBC), and Hepatocellular carcinoma (HCC). Vaping has an association with the incidence of NAFLD and HCC, but there is not yet strong enough evidence to associate it with the progression of Hepatitis and PBC.
Co-Authors - Muhartono Agustyas Tjiptaningrum Aisyah Lubis, Aisyah Ajipurnomo, Adhari Alwiyah, Fadilah Amalia, Salsabila Ambarwati, Yuli ananti, anggini tasyakurillah Andreas Infianto Apri Lyanda Asep Sukohar Ayu Tiara FItri Bayu Putra Danan Jaya, Bayu Putra Danan Bayu Putra DJ Cyntithia, L. Gita Danan Jaya, Bayu Putra Devya Aulia Dewi Nur Fiana Diah Septia Liantari, Diah Septia Dwi Indria Anggraini Ekawati, Diyan Endah Setyaningrum, Endah Endang SR Hardjolukito Ety Apriliana Exsa Hadibrata Fadila Gustiani Daraz Fadly, Ahmad Aulia Fala, Arzety Rifda Firdaus, Elman Dani Fitria Saftarina Gatot Sudiro Hendarto, Gatot Sudiro Hadibrata, Exsa Haikal Shiddiq Ham, Maria Francisca Hana Muthi'a Putri Hanna Mutiara, Hanna Helmi Ismunandar Hendri Busman Hendri Tarigan S I Gede Eka Widayana Infianto, Andreas Inna Kurniaji Intanri Kurniati Islami, Andi Rassya Daffa Iswandi Darwis Janar Wulan, Anggraini Jausal, Anisa Nuraisa Jhons Fatriyadi Suwandi Joni, Agnesia Priskila Khairun Nisa Kusumajati, Pusparini Kusumaningtyas, Aditya Laisa Azka Liana Sidharti Lusina, Septia Eva M. Aqmal Hidayah Marzel, Rivaldi Mayasari, Diana Mubarak, Raka Anzil Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Sudarmo Kasban Novita Carolia Nur Irawati Nurmayeni Nurmayeni Nurmayeni Nurul Islamy Oktadoni Saputra Qurani, Istiqomatul rahmawati, selvi Rajagukguk, Nanda Frisila Ramadhana Komala Rasmi Zakiah Oktarlina Ratna, Maya Ganda Reni Zuraida Resti Arania Rian Hendriyana Dwi Imanta Rika Lisiswati Risal Wintoko Risti Graharti Rizki Hanriko Rodiani, Rodiani Rosbhaiti Chodijah Rudiyanto, Waluyo Sangging, Putu Ristyaning Ayu Septiani, Linda Setiorini, Anggi Sezia Marina Sinaga, Fransisca T.Y. Siregar, Bintang Abadi Soemarwoto, Retno Ariza S Suryadi Islami Susianti Susianti Susianti Susianti, Susianti Sutarto Sutarto Sutarto Sutarto SYAIFUL BAHRI Syazili Mustofa Talin, Jinan Naura Tri Umiana Soleha Tubagus Djumhana Atmakusuma Wahdah, Annisa Shohifatul Waluyo Rudiyanto Wardani, Nanda Fitri Wibawa, fatah Satya Wulan, Anggraini Janar Wulyo Rajabto Yolanda Fratiwi Yunianto, Andi Eka Zulfa, Fathimah