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All Journal Nurse Media Journal of Nursing Nusa: Jurnal Ilmu Bahasa dan Sastra JeLAST : Jurnal Teknik Kelautan , PWK , Sipil, dan Tambang Althea Medical Journal Jurnal Online Mahasiswa (JOM) Bidang Keguruan dan Ilmu Pendidikan Toleransi: Media Ilmiah komunikasi Umat Beragama SITEKIN: Jurnal Sains, Teknologi dan Industri Jurnal Kedokteran Equilibrium: Jurnal Pendidikan AGASTYA: JURNAL SEJARAH DAN PEMBELAJARANNYA Indonesian Journal of Cancer Insaniyat: Journal of Islam and Humanities Jurnal Dinamika Sosial Budaya Indonesian Journal of Obstetrics & Gynecology Science Medicinus : Jurnal Kedokteran Martabe : Jurnal Pengabdian Kepada Masyarakat JURNAL PERTANIAN Fajar Historia: Jurnal Ilmu Sejarah dan Pendidikan Academy of Education Journal Hadharah: Jurnal Keislaman dan Peradaban Dielektrika : Jurnal Ilmiah Kajian Teori dan Aplikasi Teknik Elektro Jurnal Abdi Insani JOURNAL OF INFORMATION SYSTEM RESEARCH (JOSH) Journal of Classroom Action Research TIN: TERAPAN INFORMATIKA NUSANTARA Historia Madania: Jurnal Ilmu Sejarah Unilib: Jurnal Perpustakaan Journal of Industrial Engineering & Management Research (JIEMAR) Tax Literacy and Leadership Agility: Indigenous Peoples Awareness in Paying Taxes Jurnal Nuansa Akademik: Jurnal Pembangunan Masyarakat Jurnal El Tarikh: Journal of History, Culture, and Islamic Civilization Daluang: Journal of Library and Information Science Majalah Ilmiah Tabuah: Ta`limat, Budaya, Agama dan Humaniora Khazanah: Jurnal Sejarah dan Kebudayaan Islam Indonesian Journal of Innovation Studies BEES: Bulletin of Electrical and Electronics Engineering eScience Humanity Journal KNOWLEDGE: Jurnal Inovasi Hasil Penelitian dan Pengembangan Jurnal Informatika Teknologi dan Sains (Jinteks) Jurnal Pendidikan dan Ilmu Sosial Prosiding Simposium Nasional Rekayasa Aplikasi Perancangan dan Industri Siginjai: Jurnal Sejarah Istoria : Jurnal Ilmiah Pendidikan Sejarah Universitas Batanghari Dharma Pengabdian Perguruan Tinggi (DEPATI) JURNAL PARADIGMA: Journal of Sociology Research and Education Jurnal Pepadu Innovative: Journal Of Social Science Research Jurnal Salamata Jurnal Rekayasa elektrika Jurnal Pengabdian Inovasi Masyarakat Indonesia Prosiding SEMNAS INOTEK (Seminar Nasional Inovasi Teknologi) Journal of Philology and Historical Review At-Tajdid: Journal of Islamic Studies Al Fikrah: Jurnal Pemikiran dan Pendidikan Islam JPAP (Jurnal Praktisi Administrasi Pendidikan) JEITECH (JOURNAL OF ELECTRICAL ENGINEERING AND INFORMATION TECHNOLOGY) Deka in Medicine Jurnal Talenta Psikologi Jurnal Sosiologi USK (Media Pemikiran & Aplikasi)
Budi Darmawan
Department of Nuclear Medicine Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung
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Journal : Jurnal Kedokteran

 1 
PEPTIDE RECEPTOR RADIONUCLIDE THERAPY Hidayatullah, Rian; Budiawan, Hendra; Darmawan, Budi; Affandi, Erwin
Jurnal Kedokteran Vol 10 No 1 (2021): volume 10 nomor 1 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i1.480

Abstract

Peptide receptor radionuclide therapy (PRRT) is an effective and usually well-tolerated treatment for unresectable or metastatic neuroendocrine tumors expressing somatostatin receptors. Somatostatin analog which is labeled by ?- or ?-emitting radionuclide binds specifically to SSTRs abnormally expressed in NETs. The two radiopharmaceuticals most commonly used for PRRT are 90Y-DOTATOC and 177Lu-DOTATATE which have been demonstrated to provide an effective tumor response and symptom relief with positive impact on survival. Chronic side effects on the kidneys and bone marrow are generally mild. The radiopharmaceuticals is internalized into the cell for the irradiation. Furthermore, the long half-life of the analog maintains a persistent therapeutic effect. Different approaches are now under evaluation to improve PRRT efficacy, it may be expected that the use of PRRT will increase in the coming years.
Somatostatin Hidayatullah, Rian; Budiawan, Hendra; Darmawan, Budi; Affandi, Erwin
Jurnal Kedokteran Vol 10 No 2 (2021): Jurnal Kedokteran Juni 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i2.482

Abstract

Somatostatin, also known as growth hormone-inhibiting factor (GIF) or somatotropin release-inhibiting factor (SRIF), is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation. Somatostatin can be regarded as secretory pan-inhibitory,because it can inhibit secretion of almost all endocrine and exocrine glands. Somatostatin has 2 active forms (somatostatin-14 and 28), but the short half-life of the hormone was one of the reasons why the native hormone was not feasible for routine clinical practice. Somatostatin analog was synthesized for the first time in 1980-1982 and proved to be more resistant to degradation and more potent than native hormone. There are five somatostatin receptors (SSTR1-5). The genes encoding human SSTR1-5 are located in chromosome 14q13, 17q24, 22q13.1, 20p11.2 and 16p13.3. SSTR expression pattern and complex signaling make somatostatin be such an extraordinary neurotransmitter and hormone. The potent inhibitory action of SSTR on cellular processes such as secretion, proliferation, and apoptosis is the reason for somatostatin to be the target for therapy development. Radiopharmaceuticals used for therapy consist of three parts: somatostatin analog, chelator, and radionuclide (alpha or beta-emitting). Combinations of different peptides, chelators, and radionuclides have been tested in vitro and/or in vivo for their use in peptide receptor radionuclide therapy (PRRT). These compounds are able to irradiate tumors and their metastases via the internalization through a specific receptor subtype which is generally overexpressed on the cell membrane.
Co-Authors ', Ramadi A. Sjamsjiar Rachman Afrinaldi, Rori Agus H, Prasetiyo Ahmilurrizqi D, M. Akhyar, Lalu Tohirul Alhuzaini, Muhammad Anggraini, Riri Ardiah Juita Ardini S. Raksanagara, Ardini S. Ariandi A Zulkarnain Ariessaputra, Suthami Ariksa, Jeri Arlene Angelina Arvionita, Diah Ashab, Faizal Azizah, Faras Puji Baehaqi Barep Prasetyo, Zanuar Basuki Hidayat Berlian Isnia Fitrasanti Cahyani Nazra, Endah Regita Ch, Syafarudin Chairunnisa, - Chaniago, Danil Mahmud Danar Putra Pamungkas, Danar Putra Danistian, Angga Diyah Fatmasari Djul Fikry Budiman, Djul Fikry Drasthya Zarisha, Drasthya Efendi Efendi Eka Putra Wirman Eka Sari Wijianti Elsa Pudji Setiawati ERMAN ERMAN Erwin Affandi Fahruddin Fahruddin Faras Puji Azizah Fitri Rahmawati Habibi, Aazamzain Hasibuan, Nur Anisah Hendra Budiawan, Hendra Hendriana, Andri Herza, Herza Hidayat, Ahmad Taufik Hidayat, Novendra Hidayati Hidayati I Made Ginarsa Iqra Pandu Wijaya Irno Irno, Irno Iskandar, Andri KARDINAH KARDINAH, KARDINAH Kartamihardja, A. Hussein S. Komaruddin Komaruddin Kurniawan Yuniarto Kusumahstuti, Kharisma Lukmanul Hakim Mahdiyah, Umi Maijar, Lidia Mardjuki, Edihan Mulana, Nina Mustari, Mohamad Muvianto, Cahyo Mustiko Okta Nababan, Sabar Nazra, Endah Regita Cahyani Nelmawarni, Nelmawarni Nengsih, Fitria Nopriyasman Nova, Chelsea Novendra Hidayat Novyandra Ilham Bahtera Nugraha , Dany Wira Nugroho, Fajar Listyo Adi Nur Faizza Tunnisa Nur Khotimah Handayani Nurfalina, Yuliana Nurhayati Nurhayati Nurus Shalihin, Nurus Paniran Paniran Paniran Praja Nata, Zaki Pramesty, Kinkin Ayu Pramesty Prasetya , Wirawan Ady Prasetyo, Nora A. Pratama S., Putra Pratama, Nicholas Pratiwi, Nana Novita Priyatna, Insan Adhibuana Puji Azizah, Faras Purwasih, Rati Rahmad Putra, Gennta Ramadhan, Muh. Riski Ramadhani , Lalu Thoriq Ramadhani, Dian Eka Ramadhani, Tiara Rasyda, Muhammad Afrizal G. Regita Cahyani Nazra, Endah Rian Hidayatullah Riani, Mutiara Riza, Yulfira rizky, Febrian Ronny Ronny ROSALINA HASAN, ROSALINA RR. Ella Evrita Hestiandari Rr. Sri Endang Pujiastuti Saparin, Saparin Saputra, Putra Pratama Saputra, Suthami Aries Saputra, Yandi SARININGSIH HIKMAWATI, SARININGSIH Shukor, Khairunnisa Binti A Siaw Carwen, Siaw Sri Lestari Sudi Mariyanto Al Sasongko Sugandi, Rafid Suhendra, Agung Suksmadana, I Made Budi Supriyantoro, Wowo Sya'rani, Ilvina Syafaruddin Ch Syahputra, Firman Syamsi, Hans Riadhi Syhabudin, Noval Aziz Tanjaya, Hendri Utami, Wulandari Nurul Waluyo, Untung Widhiono MZ, Imam Wijaya, Iqra Pandu Wilda Afriani Wilujeng, Panggio Restu Wiriastro, Giri Wahyu wrindi, Warindi Yudi Setiawan Zainal Zainal ‎Supriono, Supriono