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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia Jurnal Teknologi Dan Industri Pangan ACTA VETERINARIA INDONESIANA MEDIA KONSERVASI Jurnal Primatologi Indonesia Hemera Zoa Forum Pasca Sarjana Jurnal Sain Veteriner Buletin Peternakan Jurnal Veteriner Microbiology Indonesia Jurnal Ilmu dan Teknologi Hasil Ternak Jurnal Penelitian Hasil Hutan Jurnal Teknologi Pangan agriTECH JURNAL BIOLOGI INDONESIA The Indonesian Biomedical Journal Jurnal Aplikasi Teknologi Pangan JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Psikologi Sosial Jurnal Respirologi Indonesia JURNAL KAJIAN VETERINER ZOOTEC Makara Journal of Science The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Kedokteran Hewan Jurnal Penelitian Hasil Hutan
Dondin Sajuthi
Departemen Klinik, Reproduksi, Dan Patologi, Fakultas Kedokteran Hewan, Institut Pertanian Bogor Jl. Raya Dramaga, Babakan, Dramaga, Bogor, Jawa Barat, Indonesia 16680
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Journal : Forum Pasca Sarjana

 1 
The oxidation of low-density lipoprotein (LDL) is believed to be the initiating factor for the development and progression of atherosclerosis.  Curcuminoid, the metabolite of Zingiberaceae family such as temu mangga (Curcuma mangga), has been shown to reduce the susceptibility of LDL to oxidation. In this study, we examined the effect of curcuminoid extracted from temu mangga on copper ion-induced lipid peroxidation of low density lipoprotein (LDL) in mice’s macrophages and Macaca nemestrina’s m Trini i Susmiat; Sulistiyani .; Dondin Sajuthi; Latifah K. Darusman
Forum Pasca Sarjana Vol. 33 No. 1 (2010): Forum Pascasarjana
Publisher : Forum Pasca Sarjana

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Abstract

The oxidation of low-density lipoprotein (LDL) is believed to be the initiating factor for the development and progression of atherosclerosis.  Curcuminoid, the metabolite of Zingiberaceae family such as temu mangga (Curcuma mangga), has been shown to reduce the susceptibility of LDL to oxidation. In this study, we examined the effect of curcuminoid extracted from temu mangga on copper ion-induced lipid peroxidation of low density lipoprotein (LDL) in mice’s macrophages and Macaca nemestrina’s monocytes.  Analyses were done by measuring the formation of thiobarbituric acid reactive substance (TBARS) as malonaldehyde (MDA).  LDL were harvested and isolated from 5 adult female Macaca fascicularis  fed aterogenic diet for 3 months.  LDL oxidation by mice macrophage incubated for 4 hours were inhibited by curcuminoid at concentration of 8 ppm.  There was decreased 17% (P<0.01) in the concentration of MDA compared to control without curcuminoid (31.99B±0. vs 36.77A±0.9 nmol/mg protein LDL, respectively).  Inhibiton of LDL oxidation in M. nemestrina macrophage were highest by curcuminoid at 8 ppm for 4 hours and 6 hours incubation.  There was 14.8% and 23% inhibiton (P<0.01) (23.768 ± 0.095A vs 27.111B±0.972 and 23.37B±0.12 vs 30.87A±2.49 nmol/mg LDL protein, respectively).  These data suggest that curcuminoid of temu mangga were able to inhibit LDL oxidation in the cellular level, therefore offer protection against oxidation of LDL.   Key words: LDL, atherosclerosis, curcuminoid, Curcuma mangga
Co-Authors . Permanawati Achmad - Taher Achmad Taher Achmad Taher Achmad, Taher Adi Winarto Agus Harsoyo Agus Harsoyo Agus Lelana Agus Wijaya Agus Wijaya Ahmad Kamal Nasution Alexander Nater Anita Esfandiari Annisa Dewi, Fitriya Nur Antonius Suwanto Anwar Wardy Warongan Arief Boediono Aryo Tedjo Bambang Purwantara Bayu Febram Prasetyo Bayu Rosadi Budiman Bela C Hanny Wijaya C. Hany Wijaya Cecep Kusmana CHAIRIN N MAROEF Chusnul Choliq Chusnul Choliq Chusnul Choliq Cucu K Sajuthi Dadang Makmun Daldiyono Daldiyono Daldiyono Daldiyono Dedi Rahmat Setiadi DEWI APRI ASTUTI Dewi, Fitriya Nur Annisa DIAH ISKANDRIATI Diah Iskandriati DIAH ISKANDRIATI Diah Iskandriati Diah Iskandriati Diah Iskandriati Diah Iskandriati Diah Iskandriati Douglas M. Bowden Dwi Atmoko Agung Nugroho DYAH PERWITASARI -FARAJALLAH Ekowati Handharyani Entang Iskandar Entang Iskandar Entang Iskandar Erdiansyah Rahmi ERIC HAYES Eric Hayes Eric Hayes ERLIN LISTIYANINGSIH Erni Sulistiawati ESTHER ARIFIN Fauzi Abdurrahman Munggaran Fhady Risckhy Loe Fransiska R Zakaria FUNGKEY HOETAMA Gede Eko Darmono Gregory K. Wilkerson Hadi S Alikodra Hajrawati Hajrawati Harrold Halilintar MR Subu Taopan Henny Nuraini HERA MAHESHWARI Huda S Darusman Huda Shalahuddin Darusman Huda Shalahudin Darusman I Gusti Agung Arta Putra I Gusti Ngurah Sudisma I Ketut Sutama I NENGAH BUDIARSA I Nengah Budiarsa I Nengah Budiarsa I wayan Teguh Wibawan IETJE WIENTARSIH Iis Afriantini Iman Rusmana Iman Supriatna IMELDA WINOTO Indra Bachtiar Indra Bachtiar Irawan Jusuf Irma H Suparto Irma H Suparto Irma H Suparto Irma Herawati Suparto Irma Isnafia Arief Irma Suparto J. Mark Cline Jansen Manansang Jansen Manansang Jayusman Arsiyanti Joesoef JONATHAN STURGIS Kanti Rahmi Fauziyah Kartika Sari KATHARINA JESSICA KEVIN RANDALL PORTER Koeswinarning Sigit Latifah K. Darusman Latifah K. Darusman Leni Maylina Lina Elfita Lina Elfita Luluk Lailatul Hasanah LUTHFIRALDA SJAHFIRDI Luthfiralda Sjahfirji M Agus Setiadi MARYATI SURYA Maxs Urias Ebenheizer Sanam Michael Krützen MOSES AFFANDI Mozes R. Tolihere Muchidin Noordin MUHAMMAD AGIL Nanik Hidayatik Nur Hidayati Nurhidayat . Nurul Oktaviani Oktaviani, Nurul Oriza Savitri Ariantie Paini Sri Widyati Pamungkas, Joko PATRICK J BLAIR Peni Harjosworo PENI SUPRAPTI HARDJOSWORO Permanawati Permanawati Permanawati Permanawati PERMANAWATI PERMANAWATI PERMANAWATI, PERMANAWATI Pijoh, Deyv Praira, Willy Pudji Astuti Pudji Astuti PUDJI ASTUTI Puji Rianti Puspita Sari Putri, Zulfitra Utami R. Iis Arifiantini R.P Agus Lelana RATNA TAN Retno Wulansari Reviany Widjajakusuma Reviany Widjajakusuma Ria Oktarina RICHARD F GRANT Rini Widayanti Rumlaklak, Yanse Yane Sajuthi, Cucu K Sela S Mariya Sela S. Mariya SELA SEPTIMA MARIYA Sela Septima Mariya Septi Iriani Setyaningsih Rambu Liwa Setyaningsih Rambu Liwa Setyo Widi Nugroho Setyo Widodo SILMI MARIYA SILMI MARIYA Silmi Mariya Silmi Mariya Silmi Mariya Silmi Mariya Silvia Triwidyaningtyas Sony Hartono Wijaya Sri Rahmatul Laila Sri Soepraptini Mansjoer Sri Supraptini Mansjoer Srihadi Agungpriyono Subu Taopan, Harrold Halilintar MR Suharyanto Suharyanto Suharyanto Suharyanto Sulistiyani Sulistiyani . SULISTIYANI SULISTIYANI Sulistiyani Sulistiyani SULISTIYANI SULISTIYANI Sulistiyani, Sulistiyani Suparto, Irma Sus Derthi Widhyai Sus Derthi Widhyari SUSAN SOKA SUSANA WIDJAJA Suzy Tomongo Taher, Achmad TARUNI SRI PRAWAST MIEN KAOMINI ANY ARYANI DEDY DURYADI SOLIHIN Teguh Ari Prabowo Teguh Budipitojo Tejasari . Thomas Mata Hine Tiara Widyaputri Tri Wahyu Pangestiningsih Trini i Susmiat Trini Susmiati Tuti Suryati Tuty L Yusuf Tuty Laswardi Yusuf Tuty Laswardy Yusuf Unang Supratman Uus Saefullah UUS SAEPULOH Uus Saepuloh Uus Saepuloh Uus Saepuloh Uus Saepuloh UUS SAEPULOH Vetnizah Juniantito Villiandra Villiandra Villiandra Villiandra Villiandra Villiandra Vincentia Trisna Yoelinda Willy Praira Yanse Yanne Rumlaklak Yanti . Yanti Yanti Yasmina A Pramastri Yasmina A. Paramastri Yasmina Arditi Pramastri YASMINA PARAMASTRI Yoga Yuniadi Yohana Tri Hastuti Yohana Tri Hastuti Yohana Tri Hastuti Yuli Purwandari Kristiangingrum Yundari, Yundari Zulfitra Utami Putri Zulfitra Utami Putri Zuraida Zuraida Zuraida