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All Journal Medula Juke Jurnal Dunia Kesmas Jurnal Kreativitas PKM JURNAL PENELITIAN PERAWAT PROFESIONAL Jurnal Medika Hutama Essential: Essence of Scientific Medical Journal Prosiding Konferensi Nasional PKM-CSR Journal of Comprehensive Science Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Journal of Student Research Sains Medisina Jurnal Farmasi SYIFA Medic Nutricia : Jurnal Ilmu Kesehatan Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Majority Jurnal Riset Multidisiplin Edukasi JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Galen: Jurnal Ilmu Farmasi dan Kesehatan SNTE JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Rani Himayani
Unknown Affiliation
Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Medula

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Identifikasi Kandungan Senyawa Aktif Antibakteri Ekstrak Bawang Putih dalam Menghambat Pertumbuhan Bakteri Cutibacterium acnes Penyebab Acne Vulgaris Aprianti, Shervia Dwi; Sibero, Hendra Tarigan; Aditya, Muhammad; Himayani, Rani
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1302

Abstract

Introduction: The cases of antibiotic resistance in the treatment of acne vulgaris have been steadily increasing. A study conducted by the Dermatology Clinic of Hanyang University Hospital, South Korea, showed an increase in antibiotic resistance cases in the management of acne vulgaris, with resistance rates of 30% for clindamycin and 26.7% for erythromycin. One adjunctive therapy believed to be a breakthrough in anticipating the increase in antibiotic resistance causing acne vulgaris is the use of garlic extract. This study aims to conduct antibacterial phytochemical screening of garlic extract in inhibiting the growth of Cutibacterium acnes. Methods: The antibacterial active compounds in garlic plants were identified through phytochemical screening. Meanwhile, the antibacterial test was conducted using the well diffusion method with garlic extract concentrations of 25%, 50%, 75%, and 100%. Clindamycin was used as the positive control. Results: The phytochemical screening results of garlic extract in this study revealed the presence of flavonoids, alkaloids, tannins, phenols, and terpenoids. In the antibacterial test using the well diffusion method, the largest inhibition zone was observed with clindamycin treatment, while the smallest inhibition zone diameter was recorded with 25% garlic extract concentration. Discussion: The active antibacterial compounds found in garlic extract, including flavonoids, alkaloids, tannins, phenols, and terpenoids, have been proven to inhibit the growth of Cutibacterium acnes, as indicated by the formation of inhibition zone diameters in the antibacterial test.
Faktor Risiko Personal dan Lingkungan dalam Kejadian Demam Tifoid Kurniawan, Diva Ardhana; Apriliana, Ety; Sutarto, Sutarto; Himayani, Rani
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1328

Abstract

Typhoid fever is one of the infectious diseases that has a fairly high morbidity and mortality rate, especially in developing countries, especially in Indonesia. Typhoid fever is an infectious disease caused by the bacteria Salmonella typhi. This disease can be transmitted through consuming water or food contaminated with urine and feces from typhoid fever sufferers, for example, water that will be used for drinking, cooking, or washing food ingredients. There are more serious clinical symptoms, such as high fever or hyperthermia, remittent fever, and decreased level of consciousness that can lead to coma or delirium. Further complications such as dehydration and acidosis can also occur, which have negative impacts in cases of typhoid fever. The purpose of this review article is to determine what personal and environmental risk factors are present in the occurrence of typhoid fever. The method used in this study is a review article with specific research of various articles found, then combined and a summary conclusion is drawn. The journals used have been published for the past 5 years (2019-2024). The results and conclusions show that several personal and environmental risk factors in the occurrence of typhoid fever include age, gender, personal hygiene, and clean water sources.
Peran Terapi Farmakologi dan Non-Farmakologi dalam Pengelolaan Dry Eye Disease Sitanggang, Grety; Himayani, Rani; Iyos, Rekha Nova; Mutiara, Hanna
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1469

Abstract

Dry Eye Disease (DED) is a multifactorial disorder of the ocular surface characterized by tear system imbalance, inflammation, and tissue damage, often leading to discomfort, visual disturbances, and a decline in quality of life. Managing DED requires a holistic approach that integrates both pharmacological and non-pharmacological therapies to alleviate symptoms while addressing underlying causes. Pharmacological treatments, such as artificial tears, anti-inflammatory agents (corticosteroids and cyclosporine), diquafosol tetrasodium, and oral pilocarpine, aim to restore ocular surface homeostasis. Non pharmacological approaches, including punctal plugs, lifestyle modifications, intense pulsed light (IPL) therapy, and nutritional supplementation with vitamin D and omega-3, are increasingly recognized for their supportive role in treatment. A comprehensive understanding of these therapeutic strategies is expected to improve DED management, enhance patients' quality of life, and prevent further complications.
Co-Authors Ad-Dhuha, Rahmah Maziyah Adelia, Anggi Adrifianie, Femmy Ahmad Duta Al-Ihya Alfina Indah Nabila Amalia Febriyanti Ambarwati, Endah Amelia, Erry Rizki Amira Nabila Andrifianie, Femmy Angelica Philia Christy Anggraeni Janar Wulan Anindia Syafia Halimathus Sa'dyah Aprianti, Shervia Dwi Ardella, Karina Belinda Ardika, Okta Besti Ari Wahyuni Ari Wahyuni ari wahyuni Arif Yudho Prabowo Asep Sukohar Betta Kurniawan, Betta Brigitta Shinta dewi Cahyana, Adinda Husna Carissa Aprilia Y Chindy Annisa Putri Mandala Sempaga Cut Karel Dithia Daffa Fahreiza Damayanti, Ervina Devina Hardianto Devira Fitriani Kamal Dewayanti, Wahyu Dwi Anjani, Galuh Dwi Indria Anggraini Edward Sintong Samosir Ellysa Angguman Putri Ety Apriliana Ety Apriliana Evan Christian Christian Fadhilah, Fuad Fadilah Alwiyah Fairuz Hanan, Sifa’Syaharani Faisal Rohmadhiyaul Haq Faisol Rohmadhiyaul Haq Faridi Pani Farraz Kanya Syahra Fauzan Hafizh, Ahmad Fauziani, Andra Nabila Fayza Syachrani Febri Nadyanti Febrianti, Arlin Fernadya Sylvia Nurindi Firsandini, Firsandini Fitria Saftarina Ghaitsa Lulua Ghifari, Ghaza Ahmad Al Ghiffari, Fahman Ghina Salsabila Fenty PNR Gigaramadan Sema Gigih Forda Nama Giska Tri Putri Graceciela, Yohana Eva Hana Qanitah Hanifah Qollama Astrid Hanna Mutiara, Hanna Happy, Terza Aflika Helmi Ismunandar Helmi Ismunandar Hendra Tarigan Sibero Hery Dian Septama Ida Laila Ihsanti Dwi Rahayu Ika Agustin Putri Haryant Imtinan Khoirunnisa Intan Kusumaningtyas Intanri Kurniati Junando, Mirza Junita, Aulia Kadek Elvina Kusuma Putri Kamila Nastiti Keziah Tirtawijaya Khairun Nisa Kurnia Fithrananda Kurniawan, Diva Ardhana Lintang Lestari Cahya Sawitri Lubna Farhana M Yusran M. Revo Artmando L M. Yusran Maharani , Mentari Putri Mallarangeng, Andi Nafisah Tendri Adjeng Mardiana Mardiana Maretta, Alvina Christy Maureen Angelica Melni Armadani Mentari Putri Maharani Mochamad Fauzan Dava Muhammad Aditya, Muhammad Muhammad Arsy Kamal Faadhil Muhammad Maulana Muhammad Maulana Muhammad Yusran Muhartono Muhartono Mukhlis Imanto Nabila Alsa Sagia Nabila Rayhan Yasmin Nadhia Wihelga Nahrassyiah Rahma Putri Naila Fathiya Isnanto Nashwa Faadillah Nasyim Natanael, Jessica Neli Salsabila Ni Made Karenina Rini Dwi Cintawan Noval Ramadirta Nur Fadillah, Astri Nurhaliza, Rahma Nurul Fadhilah Az-zahro Nurul Purna Mahardika Nurul Utami Okki Muhammad Fajar Muthahhari oktadiani, Isna Oktafany, Oktafany Oktaryona Trisera Oktoba, Zulpakor Prayogi, Norbertus Marcell Putu Ristyaning Ayu RA Genta Syakira Hatta Rachel Agustin Inggrid Zefanya Rahmah, Nisrina Nur Ramadhan Triyandi Ramadhina, Farrasyifa Ramdini, Dwi Aulia Rasmi Zakiah Oktarlina Regita Dwi M Rekha Nova Iyos, Rekha Nova Rengganis Wardani, Dyah Wulan Sumekar Renitta Anggraeni Rifka Putri Dewi Riska Azzahra Risti Graharti Ristyaning Ayu Sangging, Putu Rizki Hanriko Rizqiani Astrid Nasution Rudiyanto, Waluyo Ruth Leria Noverika Salsabila Haqya Kusuma Sangging, Putu Ristyaning Ayu Saphira Murfi Septiani, Linda Serafina Subagio Shifa Azzahra, Nimas Sitanggang, Grety Soraya Rahmanisa Suharmanto Susanti, Andani Dewanti Sutarto Sutarto Sutarto Sutarto Syachrani , Fayza Syahrani Alya Murfi Syazili Mustofa Syiva Ulhayah T. Adjeng, Andi Nafisah Thamara Az Zahra Tri Umiana Sholeha Tri Umiana Soleha Tri Umiana Soleha Tsurayya Fathma Zahra Vania Widyadhari Damayanti Widjaja, Jovan Wildan Kautsar Irawan Wiwi Febriani Yashila Rahimah Yasmin, Deffina Widya Yuliant, Titin Yusran, M Zenith Puspitawati Zheva Aprillia Yozevi