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Journal : Medical Laboratory Technology Journal

Interaction Between Agricultural Environmental Exposure and Inflammatory Biomarkers in Breast Cancer Risk Abdussalam, Arrizqi Hafidh; Kurniati, Yuni Prastyo; Romadhon, Yusuf Alam; Permatasari, Happy Kurnia; Sutrisna, Em
Medical Laboratory Technology Journal Vol. 11 No. 2 (2025): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v11i2.675

Abstract

Breast cancer remains the most common malignancy among women worldwide, and environmental exposures may contribute to breast carcinogenesis through inflammatory pathways such as NLR, PLR, and interferon-γ. This study aimed to examine the association between agricultural environmental exposure, represented by rice field area, and inflammatory biomarkers including the Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Interferon-γ in breast cancer. A case–control method was applied to 128 histopathologically confirmed samples consisting of 100 malignant (Invasive Carcinoma NST) and 28 benign (Fibroadenoma Mammae) breast tumors; hematologic indices were derived from preoperative blood tests, IFN-γ expression was analyzed immunohistochemically, and rice field proportions near participants’ residences were obtained from national statistics, with data analyzed using Chi-square and multivariate logistic regression. The results showed that agricultural exposure (rice field ≥60%) was not significantly associated with breast cancer (p = 0.703), whereas elevated NLR (OR = 4.89, p = 0.014), PLR (OR = 12.13, p = 0.017), and IFN-γ expression ≥20% (aOR = 23.94, p = 0.049) were significantly associated with malignancy. In conclusion, although agricultural land area was not a direct risk factor, inflammatory and immune biomarkers—particularly IFN-γ—served as strong predictors of breast cancer, indicating their potential utility in risk stratification for agrarian populations.
Co-Authors Abdussalaam, Arrizqi Hafidh Abdussalam, Arrizqi Hafidh Adang Muhammad Gugun Aflit Nuryulia Praswati Almansyah, Wanda Emdia Alyssa Sindy Jatiningtyas andi hermawan Andriani, Jatri Amellcia Anggitaratri, Zakia Novi Anika Candrasari Anton Agus Setyawan Arfa Bima Firizqina Arfa Bima Firizqina, Arfa Bima Arismar, Fiqi Rahardian Arrantissi, Syauqi Hanif Arrizqi Hafidh Abdussalaam Aryati, Mandarini Dwi Putri Asti Nurhayati Asyari, Aulya Rahmanisa Paramitha Aulia Mega Safira Ayuningrum, Nyovita Azenta, Moch. Tabriz Aziz, Yusuf Abdullah Azizah Fatmawati Azizah, Restu Noor Azzahra, Hanifah Insyiroh Bachuroh Fasda Binuko, Raafika Studiviani Dwi Burhannudin Ichsan Darmawan, Alvien Davina, Aifa Putri Desi Ekawati Devi Usdiana Rosyidah Dwi Budi Santoso Eka Pramudian Rismayanti Em Sutrisna Erna Herawati Erna Herawati, Erna Faradisa, Nida Faricha Kurnia Illahi Farida, Dany Farma, Aufa Faza Fauzan Fasda, Bachuroh Fiftin Desy Auliafadina Fiftin Desy Auliafadina, Fiftin Desy Firda, Fathiyyatu Assadiy Firdausi, Nida Faradisa Fithriyah, Sa'idatul Flora Ramona Sigit Prakoeswa Futana, Ninda Pradani Geraldo Zikri Azmi Ramadhan Hadi, Cahyono Handayani, Alya Nurkinasih Putri Happy Kurnia Permatasari Hasabi, Faris Hasmeinda Marindratama Hasmeinda Marindratama, Hasmeinda Hasna, Bilqis Herdian Alfiya Hilyati, Nor Ihsan, Rizki Muhammad Imronudin Imronudin, Imronudin Iskandar Iskandar Iskandar Iskandar Iwan Setiawan Jatri Amellcia Andriani Khairunnisa, Edgina Kumala, Aswa Arsa Kurniawati, Yuni Prastyo Latifah, Lisanul Lestari, Nining Lili Puspadewi Listiana Masyita Dewi Mahabhagawati, Iga Kustin Marti Eka Ning Tias Maulana, Taqwa Ziyan Mayangsari, Ayu Meilianda, Chellin Muhajiriansyah, Muhajiriansyah Muhamad Nur Sidiq Muhammad Adnan Muhammad Irvan Muyassar, Ziyad Agung Muzakar Isa Nadya Dwi Puspitasari Nendika Dyah Ayu Murika Sari Nida Faradisa Fauziyah Nurhayani nurhayani Nurnawati Soga Parawansa, Karmila Indar Parawansa Praswati, Aflit Puspadewi, Lili Puspitasari, Nadya Dwi Restu Noor Azizah Retno Sintowati - Retno Wulandari Retno Wulandari Rismayanti, Eka Pramudian Rosyita, Fadhilla Jihan S Sulistyani Safira, Aulia Mega Saiful Hidayat Salsabila, Naura Sania Nurul Qurrata Sari, Dhony Nurlita Sari, Nur Amalia Sari, Winda Atika Setyawan, Ari Bambang Sidiq, Muhamad Nur Soga, Nurnawati Sri Wahyuni Subiantoro Subiantoro Sulastijah, Siti Sulistyani , S Sulistyani Sulistyani Sulistyani Sulistyani Sulistyani, S Sulthon, Pradestya Achmad Sumbaga, Utari Anggit Suryanto Susanto, Syarafina Ayu Putri Syawaliyah, Ainun Nimah Tias, Marti Eka Ning Tri Agustina Tuanaya, Muhammad Rizqy Noer Udiani, Asih Arifah Wasifah, Wasifah Widodo, Dhito Widodo, Dhito Putranto Dwi Widyananda, Honesty Trisna Wiyadi Wiyadi Yunandar, Rio Yuni Prastyo Kurniati Yunus Yunus Zahrani, Ayu Zahro, Ikhya' Izatus Zakaria, Revalina Adinda